痛风患者血清hsCRP、CysC和血脂的检测意义
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摘要
目的探究原发性痛风患者血清超敏C反应蛋白(hsCRP)、胱抑素C (CysC)和血脂水平的检测意义。方法选取2016年9月至2017年2月在川北医学院附属医院风湿免疫科门诊及住院部就诊的123例男性原发性痛风性关节炎患者为痛风组,另选取同期于川北医学院体检中心行健康体检的115例男性健康体检者作为对照组,收集两组的临床资料和血清尿酸(sUA)、CysC、hsCRP、血脂及其他相关检测指标数据,并比较两组间的差异。结果痛风组和对照组年龄构成比较,差异无统计学意义(P>0.05)。痛风组患者白细胞(WBC)、中性粒细胞(GR)、单核细胞(Mo)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL)、sUA、葡萄糖(GLU)、肌酐、Cysc及hsCRP均明显高于对照组,差异均有统计学意义(P<0.01);高密度脂蛋白胆固醇(HDL)明显低于对照组,差异均有统计学意义(P<0.01)。结论痛风患者血清肌酐、CysC、hsCRP、GLU、TG、TC、LDL水平明显高于正常人群,表明痛风人群易发生血脂、血糖、肾功能指标的代谢异常。通过对这些指标的定期监测,可以对痛风患者是否合并代谢综合征进行综合判断和评价,值得临床推广使用。
Objective To explore the significance of detecting the levels of serum high sensitive C reactive protein(hsCRP),Cystatin C(CysC)and lipids in patients with primary gout.Methods A total of 123 patients with primary gout treated in Affiliated Hospital of North Sichuan Medical College from September of 2016 to February of 2017 were enrolled into the gout group,and the other 115 healthy males undergoing the physical examination over the corresponding period were selected into the control group.The clinical data and the relevant indicators including serum uric acid(sUA),CysC,hsCRP and lipids were collected in the two groups,and the differences between the two groups were compared.Results There was no significant difference in the composition ratio of age between the gout group and the control group(P>0.05).The levels of white blood cell(WBC),neutrophil granulocyte(GR),monocyte(Mo),triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),sUA,serum glucose(GLU),creatinine,Cysc and hsCRP in the gout group were significantly higher than those in the control group(P<0.01),while the high density lipoprotein cholesterol(HDL-C)was significantly lower in the gout group than in the control group(P<0.01).Conclusion The levels of serum creatinine,Cysc,hsCRP,GLU,TG,TC,and LDL-C are significantly higher in patients with gout than in the healthy population,which shows that gout patients tend to have the metabolic disorders of the indicators including serum lipids,serum glucose and renal function.The regular monitoring of those indicators can be used to comprehensively judge and evaluate whether gout patients have metabolic syndrome or not,so it is worthy of clinical promotion and application.
Objective To explore the significance of detecting the levels of serum high sensitive C reactive protein(hsCRP),Cystatin C(CysC)and lipids in patients with primary gout.Methods A total of 123 patients with primary gout treated in Affiliated Hospital of North Sichuan Medical College from September of 2016 to February of 2017 were enrolled into the gout group,and the other 115 healthy males undergoing the physical examination over the corresponding period were selected into the control group.The clinical data and the relevant indicators including serum uric acid(sUA),CysC,hsCRP and lipids were collected in the two groups,and the differences between the two groups were compared.Results There was no significant difference in the composition ratio of age between the gout group and the control group(P>0.05).The levels of white blood cell(WBC),neutrophil granulocyte(GR),monocyte(Mo),triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),sUA,serum glucose(GLU),creatinine,Cysc and hsCRP in the gout group were significantly higher than those in the control group(P<0.01),while the high density lipoprotein cholesterol(HDL-C)was significantly lower in the gout group than in the control group(P<0.01).Conclusion The levels of serum creatinine,Cysc,hsCRP,GLU,TG,TC,and LDL-C are significantly higher in patients with gout than in the healthy population,which shows that gout patients tend to have the metabolic disorders of the indicators including serum lipids,serum glucose and renal function.The regular monitoring of those indicators can be used to comprehensively judge and evaluate whether gout patients have metabolic syndrome or not,so it is worthy of clinical promotion and application.
引文
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[11]Tsai H T,Wang P H,Tee Y T,et al.Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease[J].Fertil Steril,2009,91(2):549-555.
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[14]陈灏珠,林果为,王吉耀.实用内科学[M].北京:人民卫生出版社,2013:1045-1055.
[15]Le Master E,Huang R T,Zhang C,et al.Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins[J].Arterioscler Thromb Vasc Biol,2018,38(1):64-75.
[2]王靖宇,常宝成.高尿酸血症/痛风流行病学特点及危险因素[J].国际内分泌代谢杂志,2016,36(2):78-81,88.
[3]Bagheri B,Zargari M,Meshkini F,et al.Uric Acid and Coronary Artery Disease,Two Sides of a Single Coin:ADeterminant of Antioxidant System or a Factor in Metabolic Syndrome[J].J Clin Diagn Res,2016,10(2):27-31.
[4]González-Senac N M,Bailén R,Torres R J,et al.Metabolic syndrome in primary gout[J].Nucleosides Nucleotides Nucleic Acids,2014,33(4-6):185-191.
[5]Jones G,Panova E,Day R.Guideline development for the management of gout:role of combination therapy with a focus on lesinurad[J].Drug Des Devel Ther,2017,11:3077-3081.
[6]Alexandrov P N,Kruck T P,Lukiw W J.Nanomolar aluminum induces expression of the inflammatory systemic biomarker C-reactive protein(CRP)in human brain microvessel endothelial cells(hBMECs)[J].J Inorg Biochem,2015,152:210-213.
[7]Hanriot D,Bello G,Ropars A,et al.C-reactive protein induces pro-and anti-inflammatory effects,including activation of the liver X receptor alpha,on human monocytes[J].Thromb Haemost,2008,99(3):558-569.
[8]Séronie-Vivien S,Delanaye P,Pieroni L,et al.Cystatin C:current step and future prospects[J].Ann Biol Clin(Paris),2008,66(3):301-323.
[9]王庆文,刘志红.高尿酸血症与慢性肾脏病的关系[J].中华医学杂志,2012,92(8):510-511.
[10]Zhou Q,Su J,Zhou T,et al.A study comparing the safety and efficacy of febuxostat,allopurinol,and benzbromarone in Chinese gout patients:a retrospective cohort study[J].Int JClin Pharmacol Ther,2017,55(2):163-168.
[11]Tsai H T,Wang P H,Tee Y T,et al.Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease[J].Fertil Steril,2009,91(2):549-555.
[12]Angelidis C,Deftereos S,Giannopoulos G,et al.Cystatin C:an emerging biomarker in cardiovascular disease[J].Curr Top Med Chem,2013,13(2):164-179.
[13]Hill C J,Cardwell C R,Patterson C C,et al.Chronic kidney disease and diabetes in the national health service:a crosssectional survey of the U.K.national diabetes audit[J].Diabet Med,2014,31(4):448-454.
[14]陈灏珠,林果为,王吉耀.实用内科学[M].北京:人民卫生出版社,2013:1045-1055.
[15]Le Master E,Huang R T,Zhang C,et al.Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins[J].Arterioscler Thromb Vasc Biol,2018,38(1):64-75.