血清胃蛋白酶原Ⅰ、Ⅱ及其比值联合Hp抗体诊断老年早期胃癌
摘要
目的探讨血清胃蛋白酶原(PG)Ⅰ、Ⅱ及其比值联合幽门螺杆菌(Hp)抗体诊断老年早期胃癌的价值。方法老年早期胃癌患者284例作为胃癌组;同期120例慢性萎缩性胃炎患者为胃炎组和104例健康体检者为对照组。采用乳胶增强免疫比浊法对比3组血清PGⅠ、PGⅡ水平,酶联免疫吸附试验对比Hp抗体的表达,并分析PGⅠ和PGⅡ与Hp阳性率相关性。结果胃癌组血清PGⅠ和PGⅡ水平均显著低于胃炎组及对照组(P<0.05);胃炎组血清PGⅠ和PGⅡ水平显著低于对照组(P<0.05);3组PGⅠ/PGⅡ比值差异无统计学意义(P>0.05)。胃癌组Hp阳性率显著高于胃炎组和对照组(P<0.05),胃炎组Hp阳性率显著高于对照组(P<0.05)。PGⅠ和PGⅡ与Hp阳性率均呈显著负相关(r=-0.372 1、-0.689,P<0.05)。结论 PGⅠ、Ⅱ及比值联合Hp抗体可为老年早期胃癌临床诊断提供参考。
引文
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2 Hara K,Fukui H,Sun C,et al.Effect of REG I protein on angiogenesis in gastric cancer tissues[J].Oncol Rep,2015;33(5):2183-9.
3 Li B,Liu HY,Guo SH,et al.Detection of microsatellite instability in gastric cancer and dysplasia tissues[J].Int J Clin Exp Med,2015;8(11):21442.
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5 Qiang C,Wang Z,Wang S,et al.Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial-mesenchymal transition by regulating HIF-1α via miR-138[J].Open Biol,2017;7(1):160247.
6 Shida M,Kitajima Y,Nakamura J,et al.Impaired mitophagy activates mtROS/HIF-1 interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia[J].Int J Oncol,2016;48(4):1379.
7 Zhang C,Tian W,Meng L,et al.PRL-3 promotes gastric cancer migration and invasion through a NF-kB-HIF-1α-miR-210 axis[J].J Mol Med,2016;94(4):401-15.
8 Wu F,Ding S,Li X,et al.Elevated expression of HIF-l in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia[J].Oncotarget,2016;7(11):12053-62.
9 Yang HJ,Xu WJ,Guan YH,et al.Expression of Glut-1 and HK-Ⅱ in pancreatic cancer and their impact on prognosis and FDG accumulation[J].Transl Oncol,2016;9(6):583-91.
10 Yin S,Chao L,Hui P,et al.Expression of interleukin 1 in gastric cancer tissue and its effects on gastric cancer[J].Oncol Targets Ther,2016;9(1):31-5.
11 Eybpoosh S,Talebkhan Y,Saberi S,et al.Age-specific gastric cancer risk indicated by the combination of helicobacter pylori sero-status and serum pepsinogen levels[J].Iran Biom J,2015;19(3):133-42.
12 Iguchi M,Kato J,Yoshida T,et al.Serum pepsinogen levels can quantify the risk of development of metachronous gastric cancer after endoscopic resection[J].Int J Cancer,2016;139(5):1150.
13 Ankouane F,Noah DN,Enyime FN,et al.Helicobacter pylori and precancerous conditions of the stomach:the frequency of infection in a cross-sectional study of 79 consecutive patients with chronic antral gastritis in Yaounde,Cameroon[J].Pan Afr Med J,2015;20(3):189-97.
14 Jang BG,Kim HS,Kim KJ,et al.Distribution of intestinal stem cell markers in colorectal precancerous lesions[J].Histopathology,2016;68(4):567-77.
15 Bae SI,Park JG,Kim YI,et al.Genetic alterations in gastric cancer cell lines and their original tissues[J].Int J Cancer,2015;87(4):512-6.
16 Gao W,Xu J,Wang F,et al.Plasma membrane proteomic analysis of human gastric cancer tissues:revealing flotillin 1 as a marker for gastric cancer[J].Bmc Cancer,2015;15(1):1-14.
17 Wang W,Seeruttun SR,Fang C,et al.Prognostic significance of carcinoembryonic antigen staining in cancer tissues of gastric cancer patients[J].Ann Surg Oncol,2015;23(4):1244-51.