肥胖儿童血清hs-CRP水平与代谢综合征的关系研究
摘要
目的分析肥胖儿童血清超敏C-反应蛋白(hs-CRP)水平与代谢综合征(MS)的关系。方法选取2015年8月-2017年8月成都市郫都区人民医院就诊的109例肥胖儿童为研究对象,按照有无合并MS将其分为肥胖伴MS组和肥胖不伴MS组。随机选取同期50例正常体重儿童为对照组。收集3组儿童的人口学资料,检测3组儿童的身高、体重、腰围、臀围、血压、血糖(FPG)、总胆固醇(TC)、总三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、hs-CRP水平。结果除HDL-C外,3组儿童BMI、SBP、DBP、FPG、TC、TG、LDL-C、hs-CRP水平比较差异均有统计学意义(均P<0. 05)。肥胖伴MS组和肥胖不伴MS组儿童BMI、SBP、DBP、FPG、TC、TG、LDL-C、hs-CRP水平均显著高于对照组(均P<0. 05)。肥胖伴MS组儿童BMI、SBP、DBP、TG、LDL-C、hs-CRP水平均显著高于肥胖不伴MS组(均P<0. 05)。随着hs-CRP水平增加,MS发生率呈逐渐上升趋势。BMI和hs-CRP是肥胖儿童发生MS的独立危险因素。结论血清hs-CRP与肥胖儿童MS发生有关,是预测肥胖儿童MS的重要指标。
引文
[1]席倩,许华山,吴志昊,等.儿童青少年超重、肥胖与代谢综合征的关系[J].蚌埠医学院学报,2011,36(6):602-605.
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[13]方昕,叶江枫,林小璎.儿童青少年超重及肥胖与代谢综合征的相关性研究[J].福建医科大学学报,2012,46(1):60-63.
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[16]Nishide R,Ando M,Funabashi H,et al.Association of serum hs-CRP and lipids with obesity in school children in a 12-month follow-up study in Japan[J].Environ Health Prev Med,2015,20(2):116-122.
[17]Dyson PA,Anthony D,Fenton B,et al.High rates of child hypertension associated with obesity:a community survey in China,India and Mexico[J].Paediatr Int Child Health,2014,34(1):43-49.
[18]儿童代谢综合征中国工作组.中国六城市学龄儿童代谢综合征流行现状研究[J].中华儿科杂志,2013,51(6):409-413.
[2]Das D,Bora K,Baruah B,et al.Prevalence and predictors of metabolic syndrome in schizophrenia patients from Assam[J].Indian JPsychiatry,2017,59(2):228-232.
[3]Ross SM.Obesity and metabolic syndrome:a complementary and integrative health approach[J].Holist Nurs Pract,2017,31(5):348-352.
[4]Mbata O,Abo El-Magd NF,El-Remessy AB.Obesity,metabolic syndrome and diabetic retinopathy:beyond hyperglycemia[J].World J Diabetes,2017,8(7):317-329.
[5]赵鹃,陈敏敏,彭端亮.老年肺炎患者超敏C反应蛋白与血常规的对比分析[J].实用医院临床杂志,2013,10(1):87-89.
[6]Bustos P,Rosas B,Roman P,et al.Association of C reactive protein levels with metabolic syndrome in adults:a population-based study[J].Rev Med Chil,2016,144(10):1239-1246.
[7]中国肥胖问题工作组,季成叶.中国学龄儿童青少年超重、肥胖筛查体重指数值分类标准[J].中华流行病学杂志,2004,25(2):10-15.
[8]中华医学会儿科学分会内分泌遗传代谢学组,中华医学会儿科学分会心血管学组,中华医学会儿科学分会儿童保健学组,等.中国儿童青少年代谢综合征定义和防治建议[J].中华儿科杂志,2012,50(6):420-422.
[9]陈友兰,杨晓剑,杜玉开,等.学龄期儿童肥胖干预对身高发育水平的影响[J].中国慢性病预防与控制,2011,19(4):356-359.
[10]徐旭,蒋莉,王喜平,等.儿童超重及肥胖与代谢综合征的相关性[J].现代预防医学,2013,40(5):852-854.
[11]Yeo R,Yoon SR,Kim OY.The association between food group consumption patterns and early metabolic syndrome risk in non-diabetic healthy people[J].Clin Nutr Res,2017,6(3):172-182.
[12]陈少科,罗静思,秦映芬,等.南宁地区儿童青少年肥胖与代谢综合征相关性的流行病学研究[J].中华流行病学杂志,2011,32(10):969-972.
[13]方昕,叶江枫,林小璎.儿童青少年超重及肥胖与代谢综合征的相关性研究[J].福建医科大学学报,2012,46(1):60-63.
[14]Mc Dade TW,Tallman PS,Madimenos FC,et al.Analysis of variability of high sensitivity C-reactive protein in lowland Ecuador reveals no evidence of chronic low-grade inflammation[J].Am JHum Biol,2012,24(5):675-681.
[15]Parish RC,Todman S,Jain SK.Resting heart rate variability,inflammation,and insulin resistance in overweight and obese adolescents[J].Metab Syndr Relat Disord,2016,14(6):291-297.
[16]Nishide R,Ando M,Funabashi H,et al.Association of serum hs-CRP and lipids with obesity in school children in a 12-month follow-up study in Japan[J].Environ Health Prev Med,2015,20(2):116-122.
[17]Dyson PA,Anthony D,Fenton B,et al.High rates of child hypertension associated with obesity:a community survey in China,India and Mexico[J].Paediatr Int Child Health,2014,34(1):43-49.
[18]儿童代谢综合征中国工作组.中国六城市学龄儿童代谢综合征流行现状研究[J].中华儿科杂志,2013,51(6):409-413.