小剂量阿司匹林对妊娠期高血压患者血清内皮素-1及肾功能的影响
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摘要
目的 小剂量阿司匹林对妊娠期高血压患者血清内皮素-1(ET-1)及肾功能的影响。方法 将该院2016年1月—2018年5月收治的88例妊娠期高血压患者根据治疗方案不同分组,对照组44例给予硫酸镁联合硝苯地平治疗,观察组44例在对照组基础上小剂量阿司匹林,对两种患者疗效、ET-1、肾功能等进行观察。结果 观察组患者治疗总有效率为97.73%,明显较对照组81.82%高(χ~2=6.064,P<0.05);两组治疗前的ET-1水平差异无统计学意义(P>0.05),观察组患者治疗后的ET-1明显低于对照组(P<0.05);观察组干预后的肾功能指标明显优于对照组(P<0.05)。结论 小剂量阿司匹林用于妊娠期高血压治疗中效果满意,可有效降低ET-1水平,改善患者肾功能,值得临床推广。
Objective Effects of low-dose aspirin on serum endothelin-1(ET-1) and renal function in patients with hypertensive disorder complicating pregnancy. Methods A total of 88 patients with gestational hypertension admitted to our hospital from January 2016 to May 2018 were grouped according to treatment options. In the control group, 44 patients were treated with magnesium sulfate com-bined with nifedipine, while the 44 patients in the observation group received small doses of aspirin on the basis of the control group.The efficacy, ET-1, and renal function of the two patients were observed. Results The total effective rate of the observation group was97.73%, which was significantly higher than that of the control group 81.82%(χ~2=6.064, P<0.05). There was no significant difference in ET-1 levels between the two groups before treatment(P>0.05). After treatment, the ET-1 in the observation group was significantly lower than that in the control group(P<0.05). After treatment, the renal function index of the observation group was significantly better than that of the control group(P<0.05). Conclusion Low-dose aspirin is effective in the treatment of hypertensive disorder in pregnan-cy, which can effectively reduce the level of ET-1 and improve the renal function of patients, which is worthy of clinical promotion.
Objective Effects of low-dose aspirin on serum endothelin-1(ET-1) and renal function in patients with hypertensive disorder complicating pregnancy. Methods A total of 88 patients with gestational hypertension admitted to our hospital from January 2016 to May 2018 were grouped according to treatment options. In the control group, 44 patients were treated with magnesium sulfate com-bined with nifedipine, while the 44 patients in the observation group received small doses of aspirin on the basis of the control group.The efficacy, ET-1, and renal function of the two patients were observed. Results The total effective rate of the observation group was97.73%, which was significantly higher than that of the control group 81.82%(χ~2=6.064, P<0.05). There was no significant difference in ET-1 levels between the two groups before treatment(P>0.05). After treatment, the ET-1 in the observation group was significantly lower than that in the control group(P<0.05). After treatment, the renal function index of the observation group was significantly better than that of the control group(P<0.05). Conclusion Low-dose aspirin is effective in the treatment of hypertensive disorder in pregnan-cy, which can effectively reduce the level of ET-1 and improve the renal function of patients, which is worthy of clinical promotion.
引文
[1]戴小萍.硫酸镁联合硝苯地平缓释片治疗妊娠期高血压综合征的临床研究[J].中国临床药理学杂志,2018,34(9):1018-1021.
[2]张小玲,尹国武.硝苯地平联合硫酸镁治疗妊娠期高血压与单用硫酸镁治疗效果比较[J].中国医刊,2015,50(11):86-89.
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[4]马清连,张宝侠,王玉娥,等.钙剂加肠溶阿司匹林对妊娠期高血压的疗效观察[J].中国妇幼健康研究,2015,28(2):363-366.
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[7]赵金梅.拉贝洛尔联合硫酸镁对妊娠期高血压孕妇血清炎性因子、肾功能及分娩结局的影响[J].中国药业,2016,25(1):20-22.
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[9]谷秋寒,毛红莉,马艳红,等.硫酸镁联合硝苯地平治疗妊娠期高血压患者的临床效果[J].中国生化药物杂志,2016,36(6):97-99.
[10]郑晓瑛,姚静,朱加美,等.丹参注射液联合小剂量阿司匹林对妊娠期高血压疾病患者氧自由基和血管内皮细胞功能的影响研究[J].中国妇幼保健,2015,30(18):2920-2922.
[11]张琳霞.小剂量阿司匹林与硫酸镁联用治疗妊娠期高血压疾病的临床疗效[J].临床医学研究与实践,2018,3(30):150-152.
[12]周琳.小剂量阿司匹林对妊娠期高血压患者24h尿蛋白定量的研究[J].实用药物与临床,2018,21(2):175-178.
[2]张小玲,尹国武.硝苯地平联合硫酸镁治疗妊娠期高血压与单用硫酸镁治疗效果比较[J].中国医刊,2015,50(11):86-89.
[3]李静芝.硫酸镁联合小剂量阿司匹林对妊娠期高血压的治疗效果[J].心血管康复医学杂志,2018,27(3):335-337.
[4]马清连,张宝侠,王玉娥,等.钙剂加肠溶阿司匹林对妊娠期高血压的疗效观察[J].中国妇幼健康研究,2015,28(2):363-366.
[5]周丽佳,陆月梅,王秀美,等.阿司匹林联合硫酸镁对轻度妊娠高血压患者血压控制、血液黏度、尿蛋白和尿素氮水平的影响[J].新疆医科大学学报,2018,41(8):957-959,963.
[6]王银玲,徐文婷,贾明旺,等.硫酸镁对重度妊娠期高血压TRF、mALB水平及血流动力学的影响[J].广东医学,2018,39(15):2373-2376.
[7]赵金梅.拉贝洛尔联合硫酸镁对妊娠期高血压孕妇血清炎性因子、肾功能及分娩结局的影响[J].中国药业,2016,25(1):20-22.
[8]王珊,张燕.硫酸镁联合硝苯地平治疗妊娠期高血压的疗效及其对患者尿液蛋白质的影响[J].海南医学,2016,27(13):2096-2098.
[9]谷秋寒,毛红莉,马艳红,等.硫酸镁联合硝苯地平治疗妊娠期高血压患者的临床效果[J].中国生化药物杂志,2016,36(6):97-99.
[10]郑晓瑛,姚静,朱加美,等.丹参注射液联合小剂量阿司匹林对妊娠期高血压疾病患者氧自由基和血管内皮细胞功能的影响研究[J].中国妇幼保健,2015,30(18):2920-2922.
[11]张琳霞.小剂量阿司匹林与硫酸镁联用治疗妊娠期高血压疾病的临床疗效[J].临床医学研究与实践,2018,3(30):150-152.
[12]周琳.小剂量阿司匹林对妊娠期高血压患者24h尿蛋白定量的研究[J].实用药物与临床,2018,21(2):175-178.