糖尿病合并甲状腺机能亢进症患者血清IGF-1水平的变化
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摘要
(1)目的分析糖尿病甲状腺机能亢进症患者血清胰岛素样生长因子-1(IGF-1)水平的变化及其相关因素。(2)方法选取100例2型糖尿病患者按甲状腺功能水平分为两组:糖尿病组、糖尿病合并甲状腺机能亢进症组,每组各50例。用化学发光法检测血清IGF-1水平的含量,分析其与血糖、胰岛素、甲状腺功能等指标的相关性。(3)结果 2型糖尿病合并甲状腺机能亢进患者血清IGF-1含量低于糖尿病组(P <0.01);血清IGF-1水平与血清中TT3、TT4、FT3、FT4水平呈负相关(r=-0.28,-0.32,-0.37,-0.45,P <0.01),与空腹血糖、餐后2小时血糖、空腹胰岛素、餐后2小时胰岛素、空腹C肽、餐后2小时C肽、促甲状腺激素(TSH)含量呈正相关(r=0.86,0.27,0.64,0.53,0.57,0.47,0.46,P<0.05)。(4)结论糖尿病患者发生甲状腺机能亢进症血清IGF-1下降,与甲状腺激素水平呈负相关变化。
Objective To analyze the changes of serum insulin-like growth factor(IGF-1)and its related factors in diabetic patients with hyperthyroidism.Methods A total of 100 patients with type 2diabetes were divided into two groups according to the level of thyroid function:diabetic group,diabetic group combined with hyperthyroidism group,50 patients in each group.The content of serum IGF-1level was detected by chemiluminescence method,and its correlation with blood glucose,insulin and thyroid function was analyzed.Results The serum IGF-1content of type 2diabetes mellitus with hyperthyroidism was lower than that of diabetes group(P <0.01).Serum levels of IGF-1and serum TT3,TT4,FT3,FT4 levels showed a negative correlation(r =0.28,0.32,0.27,0.28,P <0.01),and fasting glucose,2hpostprandial blood glucose,fasting insulin,2hpostprandial insulin,fasting C peptide,2hpostprandial C-peptide,TSH levels were positively correlated(r=0.86,0.27,0.64,0.53,0.57,0.47,0.46,P <0.05).Conclusion Serum IGF-1decreased in diabetic patients with hyperthyroidism.
Objective To analyze the changes of serum insulin-like growth factor(IGF-1)and its related factors in diabetic patients with hyperthyroidism.Methods A total of 100 patients with type 2diabetes were divided into two groups according to the level of thyroid function:diabetic group,diabetic group combined with hyperthyroidism group,50 patients in each group.The content of serum IGF-1level was detected by chemiluminescence method,and its correlation with blood glucose,insulin and thyroid function was analyzed.Results The serum IGF-1content of type 2diabetes mellitus with hyperthyroidism was lower than that of diabetes group(P <0.01).Serum levels of IGF-1and serum TT3,TT4,FT3,FT4 levels showed a negative correlation(r =0.28,0.32,0.27,0.28,P <0.01),and fasting glucose,2hpostprandial blood glucose,fasting insulin,2hpostprandial insulin,fasting C peptide,2hpostprandial C-peptide,TSH levels were positively correlated(r=0.86,0.27,0.64,0.53,0.57,0.47,0.46,P <0.05).Conclusion Serum IGF-1decreased in diabetic patients with hyperthyroidism.
引文
[1]蒋正,陈敏华.糖尿病合并甲状腺功能异常的相关危险因素研究[J].中国医学工程,2018,26(3):4-6
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[5]Eleni Bekiari.Thyroid dysfunction among greek patients with type 1and type 2diabetes mellitus as a disregarded comorbidity[J].Journal of Diabetes Research,2017,10:12-14
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[7]Elettra Mancuso,Gaia C,Mannino 1.Insulin-like growth factor-1is a negative modulator of glucagon secretion[J].Oncotarget,2017,8(31):51719-51732
[8]张秀梅,陆卫平.2型糖尿病合并非酒精性脂肪肝病患者IGF-1与胰岛素抵抗关系研究[J].现代生物医学进展,2012,10(27):1998-2000
[9]王秀清,席文琪.住院2型糖尿病患者合并甲状腺疾病的回顾性研究[J].内蒙古医学杂志,2014,46(6):686-688
[10]何健,陈秋.Graves病131I治疗前后Ghrelin及胰岛素样生长因子-1的变化及临床意义[J].中国当代医药,2016,7(23):60-62
[11]Sorina Martin,Anca Sirbu,Minodora Betivoiu,et al.IGF1deficiency in newly diagnosed Graves'disease patients[J].Hormones,2015,14(4):651-659
[12]闫红娟,陈涛.C反应蛋白、肿瘤坏死因子、白细胞介素及胰岛素样生长因子检测在2型糖尿病患者中的意义[J].国际检验医学杂志,2017,2(38):344-347
[13]吴佳力,郑莹莹.甲亢患者血清中IGF-1、IL-8水平的变化[J].贵州医药,2010,3(34):224-225
[2]许晓燕,李肃宁.2型糖尿病合并甲状腺疾病的临床分析[J].宁夏医学杂志,2016,9(38):795-797
[3]王红梅.2型糖尿病合并甲状腺疾病的临床调查[J].基层医学论坛,2015,1(2):3832-3834
[4]李丽芳,刘静芹,贾振祥.1194例糖尿病住院患者甲状腺疾病及甲状腺自身抗体患病率分析[J].中国卫生检验杂志,2012,10(22):2401-2402
[5]Eleni Bekiari.Thyroid dysfunction among greek patients with type 1and type 2diabetes mellitus as a disregarded comorbidity[J].Journal of Diabetes Research,2017,10:12-14
[6]魏合凤.56例T2DM合并甲状腺疾病的患病情况及临床意义[J].世界最新医学信息文摘,2016,16(47):79-81
[7]Elettra Mancuso,Gaia C,Mannino 1.Insulin-like growth factor-1is a negative modulator of glucagon secretion[J].Oncotarget,2017,8(31):51719-51732
[8]张秀梅,陆卫平.2型糖尿病合并非酒精性脂肪肝病患者IGF-1与胰岛素抵抗关系研究[J].现代生物医学进展,2012,10(27):1998-2000
[9]王秀清,席文琪.住院2型糖尿病患者合并甲状腺疾病的回顾性研究[J].内蒙古医学杂志,2014,46(6):686-688
[10]何健,陈秋.Graves病131I治疗前后Ghrelin及胰岛素样生长因子-1的变化及临床意义[J].中国当代医药,2016,7(23):60-62
[11]Sorina Martin,Anca Sirbu,Minodora Betivoiu,et al.IGF1deficiency in newly diagnosed Graves'disease patients[J].Hormones,2015,14(4):651-659
[12]闫红娟,陈涛.C反应蛋白、肿瘤坏死因子、白细胞介素及胰岛素样生长因子检测在2型糖尿病患者中的意义[J].国际检验医学杂志,2017,2(38):344-347
[13]吴佳力,郑莹莹.甲亢患者血清中IGF-1、IL-8水平的变化[J].贵州医药,2010,3(34):224-225