围绝经期雌激素补充疗法对阿尔兹海默病防治的影响研究
|
摘要
阿尔茨海默病(AD)为较为常见的神经退行性疾病,其发病除与衰老密切相关外,还与多种因素影响有关。研究表明在超过65岁的人群中,女性发生AD的可能性比男性更高;而因手术或其它原因导致绝经的妇女(<45岁)其轻度认知功能障碍(MCI)和AD发病风险也明显增加。已有大量文献报道,雌激素补充疗法可预防因绝经导致的AD发生并改善AD患者的认知功能障碍,是防治AD的重要措施之一。笔者就围绝经期的雌激素补充疗法(ERT)对AD的防治作用进行综述。
引文
[1] Singhmanoux A,Kivimaki M,Glymour M M,et al.Timing of onset of cognitive decline:results from Whitehall II prospective cohort study[J].Bmj,2012,344(44):d7622.
[2] Goveas JS,Rapp SR,Hogan PE,et al.Predictors of Optimal Cognitive Aging in 80+Women:The Women's Health Initiative Memory Study[J]. Journals of Gerontology,2016,71 Suppl 1(Suppl 1):S62.
[3] Pike C J.Sex and the development of Alzheimer’s disease[J].Journal of Neuroscience Research,2017,95(1-2):671-680.
[4]章婷婷,刚君,方小玲.雌激素替代疗法的利与弊[J].医学与哲学(临床决策论坛版),2006,27(1):46-47.
[5] Amen DG,Trujillo M,David K. Gender-Based Cerebral Perfusion Differences in 46,034 Functional Neuroimaging Scans[J].Journal of Alzheimer's Disease,2017,60(2):605-614
[6] Georgakis MK,Thomopoulos TP,Diamantaras AA,et al.Association of Age at Menopause and Duration of Reproductive Period With Depression After Menopause:A Systematic Review and Meta-analysis.[J].Jama Psychiatry,2016,73(2):139-149.
[7] Bian C,Zhu H,Zhao Y,et al.Intriguing roles of hippocampus-synthesized 17β-estradiol in the modulation of hippocampal synaptic plasticity[J].J Mol Neurosci,2014,54(2):271-281.
[8] Wilson CA,Davies DC.The control of sexual differentiation of the reproductive system and brain[J]. Reproduction,2007,133(2):331-359.
[9] Scott E,Zhang QG,Wang R,et al.Estrogen neuroprotection and the critical period hypothesis[J]. Frontiers in Neuroendocrinology,2012,33(1):85-104.
[10] Sherwin BB.Steroid hormones and cognitive functioning in aging men:a mini-review[J].J Mol Neurosci,2003,20(3):385-393.
[11] Yue X,Lu M,Lancaster T,et al.Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(52):19 198-19 203.
[12] Santacruz K,Lewis J,Spires T,et al.Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function[J].Science,2005,309(5 733):476-481.
[13] Haass C,Selkoe DJ.Soluble protein oligomers in neurodegeneration:lessons from the Alzheimer's amyloid beta-peptide[J]. Nature Reviews Molecular Cell Biology,2007,8(2):101-112.
[14]毕丹蕾,文朗,熊伟,等.阿尔茨海默病的可能药物靶点和临床治疗研究进展[J].中国药理学与毒理学杂志,2015,29(4):507-536.
[15] Braak H,Thal DR,Ghebremedhin E,et al.Stages of the pathologic process in Alzheimer disease:age categories from 1 to 100 years[J].Journal of Neuropathology&Experimental Neurology,2011,70(11):960-969.
[16]瞿娜.雌激素在AD样tau蛋白异常磷酸化中的作用及机制研究[D].华中科技大学,2010.
[17] Qu N,Wang L,Liu ZC,et al.Oestrogen receptorαagonist improved long-term ovariectomy-induced spatial cognition deficit in young rats[J]. Int J Neuropsychopharmacol,2012,16(5):1 071-1 082.
[18] Singh M,Setalo GJ,Guan X,et al.Estrogen induced activation of mitogen activated protein kinase in cerebral cortical explants:convergence of estrogen and neurotrophin signaling pathways[J]. J Neurosci,1999,19(4):1 179-1 188.
[19] Kantarci K,Lowe VJ,Lecnick TG,et al.Early postmenopausal transdermal 17β-estradiol therapy and amyloid-βdeposition[J].J Alzheimers Dis,2016,53(2):547-556.
[20] Pike CJ.Estrogen modulates neuronal Bcl-x L expression and beta-amyloid-induced apoptosis:relevance to Alzheimer's disease[J]. J Neurochem,1999,72(4):1 552-1 563.
[21] Mukai H,Kimoto T,Hojo Y,et al.Modulation of synaptic plasticity by brain estrogen in the hippocampus.[J].Biochimica Et Biophysica Acta General Subjects,2010,1 800(10):1 030-1 044.
[22] Pike CJ,Carroll JC,Rosario ER,et al.Protective actions of sex steroid hormones in Alzheimer's disease[J].Frontiers in Neuroendocrinology,2009,30(2):239-258.
[23] Phan A,Suschkov S,Molinaro L,et al.Rapid increases in immature synapses parallel estrogen-induced hippocampal learning enhancements[J]. Proceedings of the National Academy of Sciences of the United States of America,2015,112(52):16 018-16 023.
[24] Brake WG,Alves SE,Dunlop JC,et al.Novel target sites for estrogen action in the dorsal hippocampus:an examination of synaptic proteins[J]. Endocrinology,2001,142(3):1 284-1 289.
[25] Tohgi H,Abe T,Hashiguchi K,et al.Remarkable reduction in acetylcholine concentration in the cerebrospinal fluid from patients with Alzheimer type dementia[J].Neurosci Lett,1994,177(1-2):139-142.
[26]石红婷,董亚贤,钟高贤,等.雌激素对阿尔茨海默病大鼠学习记忆的影响[J].吉林医学,2016,37(9):2 122-2 124.
[27] Henderson VW,St John JA,Hodis HN,et al.Cognition,mood,and physiological concentrations of sex hormones in the early and late postmenopause[J]. Proceedings of the National Academy of Sciences of the United States of America,2013,110(50):20 290-20 295.
[28] Shuster LT,Gostout BS,Grossardt BR,et al.Prophylactic oophorectomy in premenopausal women and long-term health[J].Menopause International,2008,14(3):111-116.
[29] Riley B,Elizabeth S,Lori C.Early Surgical Menopause Is Associated with a Spectrum of Cognitive Decline[J].Neurology,2013,80(7 Supplement).
[30]岳赟,左萍萍,胡凌,等.绝经后妇女长期低剂量激素替代疗法的研究——II.对apo Eε4基因携带者海马的保护作用[J].生殖医学杂志,2008,17(4):81-84.
[31]岳赟,左萍萍,胡凌,等.绝经后妇女长期低剂量激素替代疗法的研究——I.对海马体积与认知的影响[J].生殖医学杂志,2008,17(2):241-245.
[32]胡霁玲,宋阳,周坚红,等.雌激素与女性认知功能关系的研究进展[J].生殖与避孕,2016,36(6):511-515.
[33] Emanuele P,Joshua Tavernier,Ryan Parker,et al. The Neural Correlates of Anomia in the Conversion from Mild Cognitive Impairment to Alzheimers Disease[J].Neuroradiology,2016,58(1):59-67.
[34] Greendale GA,Derby CA,Maki PM.Perimenopause and Cognition[J]. Obstetrics&Gynecology Clinics of North America,2011,38(3):519-535.
[35] Mielke MM,Prashanthi V,Rocca WA.Clinical epidemiology of Alzheimer's disease:assessing sex and gender differences[J].Clinical Epidemiology,2014,6:37-48.
[36] Li R,Singh M.Sex Differences in Cognitive Impairment and Alzheimer's Disease[J]. Frontiers in Neuroendocrinology,1995,7(3):367-376.
[37] Rebekah S,Christian J. Gender,sex steroid hormones,and Alzheimer's disease[J]. Hormones&Behavior,2013,63(2):301-307.
[38] Zhou W,He KH,Chen MH.Correlation between polymorphisms in the estrogen receptorαgene and coronary heart disease:A meta-analysis[J].Genetics&Molecular Research Gmr,2016,15(3):1-8.
[39] Yang XP,Reckelhoff JF.Estrogen,hormonal replacement therapy and cardiovascular disease[J]. Journal of International Obstetrics&Gynecology,2011,20(2):133-138.
[2] Goveas JS,Rapp SR,Hogan PE,et al.Predictors of Optimal Cognitive Aging in 80+Women:The Women's Health Initiative Memory Study[J]. Journals of Gerontology,2016,71 Suppl 1(Suppl 1):S62.
[3] Pike C J.Sex and the development of Alzheimer’s disease[J].Journal of Neuroscience Research,2017,95(1-2):671-680.
[4]章婷婷,刚君,方小玲.雌激素替代疗法的利与弊[J].医学与哲学(临床决策论坛版),2006,27(1):46-47.
[5] Amen DG,Trujillo M,David K. Gender-Based Cerebral Perfusion Differences in 46,034 Functional Neuroimaging Scans[J].Journal of Alzheimer's Disease,2017,60(2):605-614
[6] Georgakis MK,Thomopoulos TP,Diamantaras AA,et al.Association of Age at Menopause and Duration of Reproductive Period With Depression After Menopause:A Systematic Review and Meta-analysis.[J].Jama Psychiatry,2016,73(2):139-149.
[7] Bian C,Zhu H,Zhao Y,et al.Intriguing roles of hippocampus-synthesized 17β-estradiol in the modulation of hippocampal synaptic plasticity[J].J Mol Neurosci,2014,54(2):271-281.
[8] Wilson CA,Davies DC.The control of sexual differentiation of the reproductive system and brain[J]. Reproduction,2007,133(2):331-359.
[9] Scott E,Zhang QG,Wang R,et al.Estrogen neuroprotection and the critical period hypothesis[J]. Frontiers in Neuroendocrinology,2012,33(1):85-104.
[10] Sherwin BB.Steroid hormones and cognitive functioning in aging men:a mini-review[J].J Mol Neurosci,2003,20(3):385-393.
[11] Yue X,Lu M,Lancaster T,et al.Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(52):19 198-19 203.
[12] Santacruz K,Lewis J,Spires T,et al.Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function[J].Science,2005,309(5 733):476-481.
[13] Haass C,Selkoe DJ.Soluble protein oligomers in neurodegeneration:lessons from the Alzheimer's amyloid beta-peptide[J]. Nature Reviews Molecular Cell Biology,2007,8(2):101-112.
[14]毕丹蕾,文朗,熊伟,等.阿尔茨海默病的可能药物靶点和临床治疗研究进展[J].中国药理学与毒理学杂志,2015,29(4):507-536.
[15] Braak H,Thal DR,Ghebremedhin E,et al.Stages of the pathologic process in Alzheimer disease:age categories from 1 to 100 years[J].Journal of Neuropathology&Experimental Neurology,2011,70(11):960-969.
[16]瞿娜.雌激素在AD样tau蛋白异常磷酸化中的作用及机制研究[D].华中科技大学,2010.
[17] Qu N,Wang L,Liu ZC,et al.Oestrogen receptorαagonist improved long-term ovariectomy-induced spatial cognition deficit in young rats[J]. Int J Neuropsychopharmacol,2012,16(5):1 071-1 082.
[18] Singh M,Setalo GJ,Guan X,et al.Estrogen induced activation of mitogen activated protein kinase in cerebral cortical explants:convergence of estrogen and neurotrophin signaling pathways[J]. J Neurosci,1999,19(4):1 179-1 188.
[19] Kantarci K,Lowe VJ,Lecnick TG,et al.Early postmenopausal transdermal 17β-estradiol therapy and amyloid-βdeposition[J].J Alzheimers Dis,2016,53(2):547-556.
[20] Pike CJ.Estrogen modulates neuronal Bcl-x L expression and beta-amyloid-induced apoptosis:relevance to Alzheimer's disease[J]. J Neurochem,1999,72(4):1 552-1 563.
[21] Mukai H,Kimoto T,Hojo Y,et al.Modulation of synaptic plasticity by brain estrogen in the hippocampus.[J].Biochimica Et Biophysica Acta General Subjects,2010,1 800(10):1 030-1 044.
[22] Pike CJ,Carroll JC,Rosario ER,et al.Protective actions of sex steroid hormones in Alzheimer's disease[J].Frontiers in Neuroendocrinology,2009,30(2):239-258.
[23] Phan A,Suschkov S,Molinaro L,et al.Rapid increases in immature synapses parallel estrogen-induced hippocampal learning enhancements[J]. Proceedings of the National Academy of Sciences of the United States of America,2015,112(52):16 018-16 023.
[24] Brake WG,Alves SE,Dunlop JC,et al.Novel target sites for estrogen action in the dorsal hippocampus:an examination of synaptic proteins[J]. Endocrinology,2001,142(3):1 284-1 289.
[25] Tohgi H,Abe T,Hashiguchi K,et al.Remarkable reduction in acetylcholine concentration in the cerebrospinal fluid from patients with Alzheimer type dementia[J].Neurosci Lett,1994,177(1-2):139-142.
[26]石红婷,董亚贤,钟高贤,等.雌激素对阿尔茨海默病大鼠学习记忆的影响[J].吉林医学,2016,37(9):2 122-2 124.
[27] Henderson VW,St John JA,Hodis HN,et al.Cognition,mood,and physiological concentrations of sex hormones in the early and late postmenopause[J]. Proceedings of the National Academy of Sciences of the United States of America,2013,110(50):20 290-20 295.
[28] Shuster LT,Gostout BS,Grossardt BR,et al.Prophylactic oophorectomy in premenopausal women and long-term health[J].Menopause International,2008,14(3):111-116.
[29] Riley B,Elizabeth S,Lori C.Early Surgical Menopause Is Associated with a Spectrum of Cognitive Decline[J].Neurology,2013,80(7 Supplement).
[30]岳赟,左萍萍,胡凌,等.绝经后妇女长期低剂量激素替代疗法的研究——II.对apo Eε4基因携带者海马的保护作用[J].生殖医学杂志,2008,17(4):81-84.
[31]岳赟,左萍萍,胡凌,等.绝经后妇女长期低剂量激素替代疗法的研究——I.对海马体积与认知的影响[J].生殖医学杂志,2008,17(2):241-245.
[32]胡霁玲,宋阳,周坚红,等.雌激素与女性认知功能关系的研究进展[J].生殖与避孕,2016,36(6):511-515.
[33] Emanuele P,Joshua Tavernier,Ryan Parker,et al. The Neural Correlates of Anomia in the Conversion from Mild Cognitive Impairment to Alzheimers Disease[J].Neuroradiology,2016,58(1):59-67.
[34] Greendale GA,Derby CA,Maki PM.Perimenopause and Cognition[J]. Obstetrics&Gynecology Clinics of North America,2011,38(3):519-535.
[35] Mielke MM,Prashanthi V,Rocca WA.Clinical epidemiology of Alzheimer's disease:assessing sex and gender differences[J].Clinical Epidemiology,2014,6:37-48.
[36] Li R,Singh M.Sex Differences in Cognitive Impairment and Alzheimer's Disease[J]. Frontiers in Neuroendocrinology,1995,7(3):367-376.
[37] Rebekah S,Christian J. Gender,sex steroid hormones,and Alzheimer's disease[J]. Hormones&Behavior,2013,63(2):301-307.
[38] Zhou W,He KH,Chen MH.Correlation between polymorphisms in the estrogen receptorαgene and coronary heart disease:A meta-analysis[J].Genetics&Molecular Research Gmr,2016,15(3):1-8.
[39] Yang XP,Reckelhoff JF.Estrogen,hormonal replacement therapy and cardiovascular disease[J]. Journal of International Obstetrics&Gynecology,2011,20(2):133-138.