慢性阻塞性肺疾病与认知功能障碍相关性的研究进展
摘要
<正>慢性阻塞性肺疾病(COPD)是一种常见的肺部慢性炎症性疾病,以不完全可逆的气流受限为特征,目前普遍认为COPD是多系统疾病,临床中发现COPD患者随着病程的进展逐渐出现不同程度的认知障碍。据统计目前有近4 000万人患有痴呆,并且预计在将来的20年内这个数据将翻倍。所有类型的痴呆如阿尔茨海默病、血管性痴呆、混合性痴呆等都有前驱期。轻度认知障碍被认为是痴呆前驱期表现~([1]),并且每年有5%～10%的轻度认知障碍发展为痴呆~([2])。研究证实~([3])
引文
1 Villeneuve S,Pepin V,Rahayel S,et al.Mild cognitive impairment in moderate to severe COPD:a preliminary study[J].Chest,2012;142(6):1516-23.
2 Dodd JW.Lung disease as a determinant of cognitive decline and dementia[J].Alzheimers Res Ther,2015;7(1):32.
3 Hung WW,Wisnivesky JP,Siu AL,et al.Cognitive decline among patients with chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2009;180(2):134-7.
4 Martinez CH,Richardson CR,Han MK,et al.Chronic obstructive pulmonary disease,cognitive impairment,and development of disability:the health and retirement study[J].Ann Am Thorac Soc,2014;11(9):1362-70.
5 Wang C,Ding Y,Shen B,et al.Altered gray matter volume in stable chronic obstructive pulmonary disease with subclinical cognitive impairment:an exploratory study[J].Neurotox Res,2017;31(4):453-63.
6 Torres-Sanchez I,Rodriguez-Alzueta E,Cabrera-Martos I,et al.Cognitive impairment in COPD:a systematic review[J].J Bras Pneumol,2015;41(2):182-190.
7 Li J,Fei GH.The unique alterations of hippocampus and cognitive impairment in chronic obstructive pulmonary disease[J].Respir Res,2013;14:140.
8 Dodd JW,Getov SV,Jones PW.Cognitive function in COPD[J].Eur Respir J,2010,35(4):913-22.
9 Crisan AF,Oancea C,Timar B,et al.Cognitive impairment in chronic obstructive pulmonary disease[J].PLoS One,2014;9(7):e102468.
10 Thakur N,Blanc PD,Julian LJ,et al.COPD and cognitive impairment:the role of hypoxemia and oxygen therapy[J].Int J Chron Obstruct Pulmon Dis,2010;5:263-9.
11 Heaton RK,Grant I,McSweeny AJ,et al.Psychologic effects of continuous and nocturnal oxygen therapy in hypoxemic chronic obstructive pulmonary disease[J].Arch Intern Med,1983;143(10):1941-7.
12 Vidal JS,Aspelund T,Jonsdottir MK,et al.Pulmonary function impairment may be an early risk factor for late-life cognitive impairment[J].J Am Geriatr Soc,2013;61(1):79-83.
13 Cleutjens FA,Janssen DJ,Ponds RW,et al.COgnitive-pulmonary disease[J].Biomed Res Int,2014;2014:697825.
14 Kandikattu HK,Deep SN,Razack S,et al.Hypoxia induced cognitive impairment modulating activity of Cyperus rotundus[J].Physiol Behav,2017;175:56-65.
15 Alexandre F,Heraud N,Varray A.Is nocturnal desaturation a trigger for neuronal damage in chronic obstructive pulmonary disease[J]?Med Hypotheses,2015;84(1):25-30.
16 Glodzik L,Randall C,Rusinek H,et al.Cerebrovascular reactivity to carbon dioxide in Alzheimer′s disease[J].J Alzheimers Dis,2013;35(3):427-40.
17 Lahousse L,Vernooij MW,Darweesh SK,et al.Chronic obstructive pulmonary disease and cerebral microbleeds.The Rotterdam Study[J].Am J Respir Crit Care Med,2013;188(7):783-8.
18 Poels MM,Zaccai K,Verwoert GC,et al.Arterial stiffness and cerebral small vessel disease:the Rotterdam Scan Study[J].Stroke,2012;43(10):2637-42.
19 Sabit R,Bolton CE,Edwards PH,et al.Arterial stiffness and osteoporosis in chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2007;175(12):1259-65.
20 Zeki AHA,Yaffe K.Arterial stiffness and cognitive function in the elderly[J].J Alzheimers Dis,2014;42(Suppl 4):S503-S514.
21 Hughes TM,Craft S,Lopez OL.Review of ′the potential role of arterial stiffness in the pathogenesis of Alzheimer′s disease′[J].Neurodegener Dis Manag,2015;5(2):121-35.
22 McAllister DA,Maclay JD,Mills NL,et al.Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2007;176(12):1208-14.
23 Maclay JD,MacNee W.Cardiovascular disease in COPD:mechanisms[J].Chest,2013;143(3):798-807.
24 Dodd JW,Chung AW,van den Broek MD,et al.Brain structure and function in chronic obstructive pulmonary disease:a multimodal cranial magnetic resonance imaging study[J].Am J Respir Crit Care Med,2012;186(3):240-5.
25 Perera WR,Hurst JR,Wilkinson TM,et al.Inflammatory changes,recovery and recurrence at COPD exacerbation[J].Eur Respir J,2007;29(3):527-34.
26 Dodd JW,Charlton RA,van den Broek MD,et al.Cognitive dysfunction in patients hospitalized with acute exacerbation of COPD[J].Chest,2013;144(1):119-27.
27 Domino EF.Tobacco smoking and MRI/MRS brain abnormalities compared to nonsmokers[J].Prog Neuropsychopharmacol Biol Psychiatry,2008;32(8):1778-81.
28 Anstey KJ,von Sanden C,Salim A,et al.Smoking as a risk factor for dementia and cognitive decline:a meta-analysis of prospective studies[J].Am J Epidemiol,2007;166(4):367-78.
29 Swan GE,Lessov-Schlaggar CN.The effects of tobacco smoke and nicotine on cognition and the brain[J].Neuropsychol Rev,2007;17(3):259-73.
2 Dodd JW.Lung disease as a determinant of cognitive decline and dementia[J].Alzheimers Res Ther,2015;7(1):32.
3 Hung WW,Wisnivesky JP,Siu AL,et al.Cognitive decline among patients with chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2009;180(2):134-7.
4 Martinez CH,Richardson CR,Han MK,et al.Chronic obstructive pulmonary disease,cognitive impairment,and development of disability:the health and retirement study[J].Ann Am Thorac Soc,2014;11(9):1362-70.
5 Wang C,Ding Y,Shen B,et al.Altered gray matter volume in stable chronic obstructive pulmonary disease with subclinical cognitive impairment:an exploratory study[J].Neurotox Res,2017;31(4):453-63.
6 Torres-Sanchez I,Rodriguez-Alzueta E,Cabrera-Martos I,et al.Cognitive impairment in COPD:a systematic review[J].J Bras Pneumol,2015;41(2):182-190.
7 Li J,Fei GH.The unique alterations of hippocampus and cognitive impairment in chronic obstructive pulmonary disease[J].Respir Res,2013;14:140.
8 Dodd JW,Getov SV,Jones PW.Cognitive function in COPD[J].Eur Respir J,2010,35(4):913-22.
9 Crisan AF,Oancea C,Timar B,et al.Cognitive impairment in chronic obstructive pulmonary disease[J].PLoS One,2014;9(7):e102468.
10 Thakur N,Blanc PD,Julian LJ,et al.COPD and cognitive impairment:the role of hypoxemia and oxygen therapy[J].Int J Chron Obstruct Pulmon Dis,2010;5:263-9.
11 Heaton RK,Grant I,McSweeny AJ,et al.Psychologic effects of continuous and nocturnal oxygen therapy in hypoxemic chronic obstructive pulmonary disease[J].Arch Intern Med,1983;143(10):1941-7.
12 Vidal JS,Aspelund T,Jonsdottir MK,et al.Pulmonary function impairment may be an early risk factor for late-life cognitive impairment[J].J Am Geriatr Soc,2013;61(1):79-83.
13 Cleutjens FA,Janssen DJ,Ponds RW,et al.COgnitive-pulmonary disease[J].Biomed Res Int,2014;2014:697825.
14 Kandikattu HK,Deep SN,Razack S,et al.Hypoxia induced cognitive impairment modulating activity of Cyperus rotundus[J].Physiol Behav,2017;175:56-65.
15 Alexandre F,Heraud N,Varray A.Is nocturnal desaturation a trigger for neuronal damage in chronic obstructive pulmonary disease[J]?Med Hypotheses,2015;84(1):25-30.
16 Glodzik L,Randall C,Rusinek H,et al.Cerebrovascular reactivity to carbon dioxide in Alzheimer′s disease[J].J Alzheimers Dis,2013;35(3):427-40.
17 Lahousse L,Vernooij MW,Darweesh SK,et al.Chronic obstructive pulmonary disease and cerebral microbleeds.The Rotterdam Study[J].Am J Respir Crit Care Med,2013;188(7):783-8.
18 Poels MM,Zaccai K,Verwoert GC,et al.Arterial stiffness and cerebral small vessel disease:the Rotterdam Scan Study[J].Stroke,2012;43(10):2637-42.
19 Sabit R,Bolton CE,Edwards PH,et al.Arterial stiffness and osteoporosis in chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2007;175(12):1259-65.
20 Zeki AHA,Yaffe K.Arterial stiffness and cognitive function in the elderly[J].J Alzheimers Dis,2014;42(Suppl 4):S503-S514.
21 Hughes TM,Craft S,Lopez OL.Review of ′the potential role of arterial stiffness in the pathogenesis of Alzheimer′s disease′[J].Neurodegener Dis Manag,2015;5(2):121-35.
22 McAllister DA,Maclay JD,Mills NL,et al.Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2007;176(12):1208-14.
23 Maclay JD,MacNee W.Cardiovascular disease in COPD:mechanisms[J].Chest,2013;143(3):798-807.
24 Dodd JW,Chung AW,van den Broek MD,et al.Brain structure and function in chronic obstructive pulmonary disease:a multimodal cranial magnetic resonance imaging study[J].Am J Respir Crit Care Med,2012;186(3):240-5.
25 Perera WR,Hurst JR,Wilkinson TM,et al.Inflammatory changes,recovery and recurrence at COPD exacerbation[J].Eur Respir J,2007;29(3):527-34.
26 Dodd JW,Charlton RA,van den Broek MD,et al.Cognitive dysfunction in patients hospitalized with acute exacerbation of COPD[J].Chest,2013;144(1):119-27.
27 Domino EF.Tobacco smoking and MRI/MRS brain abnormalities compared to nonsmokers[J].Prog Neuropsychopharmacol Biol Psychiatry,2008;32(8):1778-81.
28 Anstey KJ,von Sanden C,Salim A,et al.Smoking as a risk factor for dementia and cognitive decline:a meta-analysis of prospective studies[J].Am J Epidemiol,2007;166(4):367-78.
29 Swan GE,Lessov-Schlaggar CN.The effects of tobacco smoke and nicotine on cognition and the brain[J].Neuropsychol Rev,2007;17(3):259-73.