ⅠA期肺癌诊治进展
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摘要
肺癌患者的预后与其发现时的临床分期密切相关,在我国肺癌患者5年生存率仅15%,而ⅠA期肺癌5年生存率达到80%～90%,因此肺癌早发现,早诊断,早治疗尤为重要,能显著降低肺癌患者病死率,提高5年生存率。随着低剂量螺旋CT筛查早期肺癌的运用,ⅠA期肺癌诊断率逐渐上升,从而推动了早期肺癌诊治的研究与进展。文章介绍了目前ⅠA期肺癌新型诊疗技术的进展。
The prognosis of lung cancer is closely related to the clinical stage when it is found. In China, the five-year survival rate of lung cancer is only 15%, while the five-year survival rate of stage ⅠA lung cancer reaches 80% to 90%. Therefore, early detection, diagnosis and treatment of lung cancer are particularly important, which can significantly reduce the mortality of lung cancer and improve the fiveyear survival rate. With the application of low-dose spiral CT screening for early stage lung cancer, the diagnosis rate of stage ⅠA lung cancer gradually increases, thus promoting the research and progress of the diagnosis and treatment of early stage lung cancer. This paper summarizes the progress of the current new diagnosis and treatment technology of stage ⅠA lung cancer.
The prognosis of lung cancer is closely related to the clinical stage when it is found. In China, the five-year survival rate of lung cancer is only 15%, while the five-year survival rate of stage ⅠA lung cancer reaches 80% to 90%. Therefore, early detection, diagnosis and treatment of lung cancer are particularly important, which can significantly reduce the mortality of lung cancer and improve the fiveyear survival rate. With the application of low-dose spiral CT screening for early stage lung cancer, the diagnosis rate of stage ⅠA lung cancer gradually increases, thus promoting the research and progress of the diagnosis and treatment of early stage lung cancer. This paper summarizes the progress of the current new diagnosis and treatment technology of stage ⅠA lung cancer.
引文
[1]Rami-Porta R,Bolejack V,Crowley J,et al.The IASLC Lung Cancer Staging Project:Proposals for the Revisions of the T Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer[J].J Thorac Oncol,2015,10(7):990-1003.
[2]Goldstraw P,Chansky K,Crowley J,et al.The IASLC Lung Cancer Staging Project:Proposals for Revision of the TNM Stage Groupings in the Forthcoming(Eighth)Edition of the TNM Classification for Lung Cancer[J].J Thorac Oncol,2016,11(1):39-51.
[3]National Lung Screening Trial Research Team,Aberle DR,Adams AM,et al.Reduced lung-cancer mortality with low-dose computed tomographic screening[J].N Engl J Med,2011,365(5):395-409.
[4]JWalter JE,Heuvelmans MA,de Jong PA,et al.Occurrence and lung cancer probability of new solid nodules at incidence screening with low-dose CT:analysis of data from the randomised,controlled NELSON trial[J].Lancet Oncol,2016,17(7):907-916.
[5]中华医学会呼吸病学分会肺癌学组,中国肺癌防治联盟专家组.肺结节诊治中国专家共识(2018年版)[J].中华结核和呼吸杂志,2018,41(10):763-771.
[6]MacMahon H,Naidich DP,Goo JM,et al.Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images:From the Fleischner Society 2017[J].Radiology,2017,284(1):228-243.
[7]涂文婷,范丽,刘士远.肺癌放射组学研究进展[J].中华肿瘤防治杂志,2018,25(8):604-608.
[8]Choi W,Oh JH,Riyahi S,et al.Radiomics analysis of pulmonary nodules in low-dose CT for early detection of lung cancer[J].Med Phys,2018,45(4):1537-1549.
[9]杨春然,郭翌,汪源源.基于影像组学的肺结节恶性程度预测[J].肿瘤影像学,2017,26(2):97-101.
[10]Gu Y,Lu X,Yang L,et al.Automatic lung nodule detection using a3D deep convolutional neural network combined with a multi-scale prediction strategy in chest CTs[J].Comput Biol Med,2018,103(1):220-231.
[11]Zhao XZ,Liu LY,Qi SL,et al.Agile convolutional neural network for pulmonary nodule classification using CT images[J].Int J Comput Assist Radio Surg,2018,13(4):585-595.
[12]Rivera MP,Mehta AC,Wahidi MM.Establishing the diagnosis of lung cancer:Diagnosis and management of lung cancer,3rd ed:American College of Chest Physicians evidence-based clinical practice guidelines[J].Chest,2013,143(5 Suppl):e142S-e65S.
[13]Ikezawa Y,Shinagawa N,Sukoh N,et al.Usefulness of Endobronchial Ultrasonography With a Guide Sheath and Virtual Bronchoscopic Navigation for Ground-Glass Opacity Lesions[J].Ann Thorac Surg2017,103(2):470-475.
[14]Haidong H,Yunye N,Wei Z,et al.Multiple guided technologies based on radial probe endobronchial ultrasound for the diagnosis of solitary peripheral pulmonary lesions:a single-center study[J].J Cancer,20178(17):3514-3521.
[15]Kato A,Yasuo M,Tokoro Y,et al.Virtual bronchoscopic navigation as an aid to CT-guided transbronchial biopsy improves the diagnostic yield for small peripheral pulmonary lesions[J].Respirology,201823(11):1049-1054.
[16]Ali MS,Trick W,Mba BI,et al.Radial endobronchial ultrasound for the diagnosis of peripheral pulmonary lesions:A systematic review and meta-analysis[J].Respirolgy,2017,22(3):443-453.
[17]Ginsberg RJ,Rubinstein LV.Randomized trial of lobectomy versus limited resection for T1N0 non-small cell lung cancer.Lung Cancer Study Group[J].Ann Thorac Surg,1995,60(3):615-622;discussion622-623.
[18]曾海康,刘洋,夏晓君,等.肺叶与亚肺叶切除治疗60岁以上Ia期小细胞肺癌的预后比较分析[J].中国肺癌杂志,201821(1):8-15.
[19]Cao J,Yuan P,Wang Y,et al.Survival Rates After Lobectomy Segmentectomy,and Wedge Resection for Non-Small Cell Lung Cancer[J].Ann Thorac Surg,2018,105(5):1483-1491.
[20]Tsutani Y,Miyata Y,Nakayama H,et al.Oncologic outcomes of segmentectomy compared with lobectomy for clinical stage IA lung adenocarcinoma:propensity score-matched analysis in a multicenter study[J].J Thorac Cardiovasc Surg,2013,146(2):358-364.
[21]Subramanian M,Mcmurry T,Meyers BF,et al.Long-Term Results for Clinical Stage IA Lung Cancer:Comparing Lobectomy and Sublobar Resection.[J].Ann Thorac Surg,2018,106(2):375-381.
[22]Song CY,Sakai T,Kimura D,et al.Comparison of perioperative and oncological outcomes between video-assisted segmentectomy and lobectomy for patients with clinical stage IA non-small cell lung cancer:a propensity score matching study[J].J Thorac Dis,2018,10(8):4891-4901.
[23]Tsutani Y,Miyata Y,Nakayama H,et al.Appropriate sublobar resection choice for ground glass opacity-dominant clinical stage IA lung adenocarcinoma:wedge resection or segmentectomy.[J].Chest,2014145(1):66-71.
[24]Xue W,Duan G,Zhang X,et al.Meta-analysis of segmentectomy versus wedge resection in stage IA non-small-cell lung cancer[J].Oncol Targets Ther,2018,11(undefined):3369-3375.
[25]刘文科,张林,张曙光.IA期非小细胞肺癌患者肺叶切除术及肺叶部分切除术的生存分析[J].中国胸心血管外科临床杂志2017,24(10):768-773.
[26]Chang JY,Senan S,Paul MA,et al.Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer:a pooled analysis of two randomised trials.[J].Lancet Oncol,201516(6):630-637.
[27]Sun B,Brooks ED,Komaki RU,et al.7-year follow-up after stereotactic ablative radiotherapy for patients with stage I non-small cell lung cancer:Results of a phase 2 clinical trial[J].J Cancer,2017,123(16):3031-3039.
[28]孙明亮,徐建宇,徐向英.早期非小细胞肺癌立体定向放疗的相关研究[J].实用肿瘤学杂志,2018,32(1):53-56.
[29]Dupuy DE,Fernando HC,Hillman S,et al.Radiofrequency ablation of stage IA non-small cell lung cancer in medically inoperable patients:Results from the American College of Surgeons Oncology Group Z4033(Alliance)trial[J].Cancer,2015,121(19):3491-3498.
[30]Huang BY,Li XM,Song XY,et al.Long-term results of CT-guided percutaneous radiofrequency ablation of inoperable patients with stage Ia non-small cell lung cancer:A retrospective cohort study[J].Int JSurg,2018,53(undefined):143-150.
[31]Lam A,Yoshida EJ,Bui K,et al.Patient and Facility Demographics Related Outcomes in Early-Stage Non-Small Cell Lung Cancer Treated with Radiofrequency Ablation:A National Cancer Database Analysis[J].J Vas Interv Radiol,2018,29(11):1535-1541.e2.
[32]Palussière J,Chomy F,Savina M,et al.Radiofrequency ablation of stage IA non-small cell lung cancer in patients ineligible for surgery:results of a prospective multicenter phase II trial[J].J Cardiothorac Surg2018,13(1):91.
[33]Narsule CK,Sridhar P,NAIR D,et al.Percutaneous thermal ablation for stage IA non-small cell lung cancer:long-term follow-up[J].JThorac Dis,2017,9(10):4039-45.
[34]Wang Y,Liu B,Cao P,et al.Comparison between computed tomography-g uided percutaneous microwave ablat ion and thoracoscopic lobectomy for stage I non-small cell lung cancer[J]Thorac Cancer,2018,9(11):1376-1382.
[35]Yao W,Lu M,Fan W,et al.Comparison between microwave ablation and lobectomy for stage I non-small cell lung cancer:a propensity score analysis[J].Int J Hyperthermia,2018,34(8):1329-1336.
[2]Goldstraw P,Chansky K,Crowley J,et al.The IASLC Lung Cancer Staging Project:Proposals for Revision of the TNM Stage Groupings in the Forthcoming(Eighth)Edition of the TNM Classification for Lung Cancer[J].J Thorac Oncol,2016,11(1):39-51.
[3]National Lung Screening Trial Research Team,Aberle DR,Adams AM,et al.Reduced lung-cancer mortality with low-dose computed tomographic screening[J].N Engl J Med,2011,365(5):395-409.
[4]JWalter JE,Heuvelmans MA,de Jong PA,et al.Occurrence and lung cancer probability of new solid nodules at incidence screening with low-dose CT:analysis of data from the randomised,controlled NELSON trial[J].Lancet Oncol,2016,17(7):907-916.
[5]中华医学会呼吸病学分会肺癌学组,中国肺癌防治联盟专家组.肺结节诊治中国专家共识(2018年版)[J].中华结核和呼吸杂志,2018,41(10):763-771.
[6]MacMahon H,Naidich DP,Goo JM,et al.Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images:From the Fleischner Society 2017[J].Radiology,2017,284(1):228-243.
[7]涂文婷,范丽,刘士远.肺癌放射组学研究进展[J].中华肿瘤防治杂志,2018,25(8):604-608.
[8]Choi W,Oh JH,Riyahi S,et al.Radiomics analysis of pulmonary nodules in low-dose CT for early detection of lung cancer[J].Med Phys,2018,45(4):1537-1549.
[9]杨春然,郭翌,汪源源.基于影像组学的肺结节恶性程度预测[J].肿瘤影像学,2017,26(2):97-101.
[10]Gu Y,Lu X,Yang L,et al.Automatic lung nodule detection using a3D deep convolutional neural network combined with a multi-scale prediction strategy in chest CTs[J].Comput Biol Med,2018,103(1):220-231.
[11]Zhao XZ,Liu LY,Qi SL,et al.Agile convolutional neural network for pulmonary nodule classification using CT images[J].Int J Comput Assist Radio Surg,2018,13(4):585-595.
[12]Rivera MP,Mehta AC,Wahidi MM.Establishing the diagnosis of lung cancer:Diagnosis and management of lung cancer,3rd ed:American College of Chest Physicians evidence-based clinical practice guidelines[J].Chest,2013,143(5 Suppl):e142S-e65S.
[13]Ikezawa Y,Shinagawa N,Sukoh N,et al.Usefulness of Endobronchial Ultrasonography With a Guide Sheath and Virtual Bronchoscopic Navigation for Ground-Glass Opacity Lesions[J].Ann Thorac Surg2017,103(2):470-475.
[14]Haidong H,Yunye N,Wei Z,et al.Multiple guided technologies based on radial probe endobronchial ultrasound for the diagnosis of solitary peripheral pulmonary lesions:a single-center study[J].J Cancer,20178(17):3514-3521.
[15]Kato A,Yasuo M,Tokoro Y,et al.Virtual bronchoscopic navigation as an aid to CT-guided transbronchial biopsy improves the diagnostic yield for small peripheral pulmonary lesions[J].Respirology,201823(11):1049-1054.
[16]Ali MS,Trick W,Mba BI,et al.Radial endobronchial ultrasound for the diagnosis of peripheral pulmonary lesions:A systematic review and meta-analysis[J].Respirolgy,2017,22(3):443-453.
[17]Ginsberg RJ,Rubinstein LV.Randomized trial of lobectomy versus limited resection for T1N0 non-small cell lung cancer.Lung Cancer Study Group[J].Ann Thorac Surg,1995,60(3):615-622;discussion622-623.
[18]曾海康,刘洋,夏晓君,等.肺叶与亚肺叶切除治疗60岁以上Ia期小细胞肺癌的预后比较分析[J].中国肺癌杂志,201821(1):8-15.
[19]Cao J,Yuan P,Wang Y,et al.Survival Rates After Lobectomy Segmentectomy,and Wedge Resection for Non-Small Cell Lung Cancer[J].Ann Thorac Surg,2018,105(5):1483-1491.
[20]Tsutani Y,Miyata Y,Nakayama H,et al.Oncologic outcomes of segmentectomy compared with lobectomy for clinical stage IA lung adenocarcinoma:propensity score-matched analysis in a multicenter study[J].J Thorac Cardiovasc Surg,2013,146(2):358-364.
[21]Subramanian M,Mcmurry T,Meyers BF,et al.Long-Term Results for Clinical Stage IA Lung Cancer:Comparing Lobectomy and Sublobar Resection.[J].Ann Thorac Surg,2018,106(2):375-381.
[22]Song CY,Sakai T,Kimura D,et al.Comparison of perioperative and oncological outcomes between video-assisted segmentectomy and lobectomy for patients with clinical stage IA non-small cell lung cancer:a propensity score matching study[J].J Thorac Dis,2018,10(8):4891-4901.
[23]Tsutani Y,Miyata Y,Nakayama H,et al.Appropriate sublobar resection choice for ground glass opacity-dominant clinical stage IA lung adenocarcinoma:wedge resection or segmentectomy.[J].Chest,2014145(1):66-71.
[24]Xue W,Duan G,Zhang X,et al.Meta-analysis of segmentectomy versus wedge resection in stage IA non-small-cell lung cancer[J].Oncol Targets Ther,2018,11(undefined):3369-3375.
[25]刘文科,张林,张曙光.IA期非小细胞肺癌患者肺叶切除术及肺叶部分切除术的生存分析[J].中国胸心血管外科临床杂志2017,24(10):768-773.
[26]Chang JY,Senan S,Paul MA,et al.Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer:a pooled analysis of two randomised trials.[J].Lancet Oncol,201516(6):630-637.
[27]Sun B,Brooks ED,Komaki RU,et al.7-year follow-up after stereotactic ablative radiotherapy for patients with stage I non-small cell lung cancer:Results of a phase 2 clinical trial[J].J Cancer,2017,123(16):3031-3039.
[28]孙明亮,徐建宇,徐向英.早期非小细胞肺癌立体定向放疗的相关研究[J].实用肿瘤学杂志,2018,32(1):53-56.
[29]Dupuy DE,Fernando HC,Hillman S,et al.Radiofrequency ablation of stage IA non-small cell lung cancer in medically inoperable patients:Results from the American College of Surgeons Oncology Group Z4033(Alliance)trial[J].Cancer,2015,121(19):3491-3498.
[30]Huang BY,Li XM,Song XY,et al.Long-term results of CT-guided percutaneous radiofrequency ablation of inoperable patients with stage Ia non-small cell lung cancer:A retrospective cohort study[J].Int JSurg,2018,53(undefined):143-150.
[31]Lam A,Yoshida EJ,Bui K,et al.Patient and Facility Demographics Related Outcomes in Early-Stage Non-Small Cell Lung Cancer Treated with Radiofrequency Ablation:A National Cancer Database Analysis[J].J Vas Interv Radiol,2018,29(11):1535-1541.e2.
[32]Palussière J,Chomy F,Savina M,et al.Radiofrequency ablation of stage IA non-small cell lung cancer in patients ineligible for surgery:results of a prospective multicenter phase II trial[J].J Cardiothorac Surg2018,13(1):91.
[33]Narsule CK,Sridhar P,NAIR D,et al.Percutaneous thermal ablation for stage IA non-small cell lung cancer:long-term follow-up[J].JThorac Dis,2017,9(10):4039-45.
[34]Wang Y,Liu B,Cao P,et al.Comparison between computed tomography-g uided percutaneous microwave ablat ion and thoracoscopic lobectomy for stage I non-small cell lung cancer[J]Thorac Cancer,2018,9(11):1376-1382.
[35]Yao W,Lu M,Fan W,et al.Comparison between microwave ablation and lobectomy for stage I non-small cell lung cancer:a propensity score analysis[J].Int J Hyperthermia,2018,34(8):1329-1336.