结直肠癌PET/CT显像的应用与研究进展
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摘要
结直肠癌是我国居民恶性肿瘤发病与死亡的主要疾病之一,早期诊断及有效监测病程进展有助于提高结直肠癌治疗疗效,改善患者的生存质量。近年来,随着正电子发射计算机断层扫描仪(PET/CT)在临床的应用,~(18)F-FDG PET/CT有效弥补了传统诊断学方法对结肠癌诊断、分期及监测的不足,对改善结直肠癌患者的预后、提高患者的生存质量起着重要作用。本文就PET/CT在结直肠癌诊治中的应用与进展作一简要介绍,以期临床医生更全面地认识PET/CT对结直肠癌的诊疗意义,进一步提高结直肠癌的诊治效率。
Colorectal cancer is one of the major malignant tumor diseases of the morbidity and mortality in our country.Early diagnosis and effective monitoring the progress of colorectal cancer are helpful to improve the therapeutic effect and the quality of patientsʼ life.In recent years,with the clinical application and development of PET/CT,~(18)F-FDG PET/CT has effectively making up for the insufficiency of diagnosing,preoperative staging and monitoring by traditional diagnostic methods in colorectal cancer,and has been playing an important role in improving the prognosis and the quality of patientsʼ life.This article briefly introduces the application and research advancement of PET/CT in the diagnosis and treatment of colorectal cancer,hoping Clinicians have a more comprehensive understanding of the significance of PET/CT in diagnosing and treating in colorectal cancer and further improving the efficiency of its diagnosis and treatment.
Colorectal cancer is one of the major malignant tumor diseases of the morbidity and mortality in our country.Early diagnosis and effective monitoring the progress of colorectal cancer are helpful to improve the therapeutic effect and the quality of patientsʼ life.In recent years,with the clinical application and development of PET/CT,~(18)F-FDG PET/CT has effectively making up for the insufficiency of diagnosing,preoperative staging and monitoring by traditional diagnostic methods in colorectal cancer,and has been playing an important role in improving the prognosis and the quality of patientsʼ life.This article briefly introduces the application and research advancement of PET/CT in the diagnosis and treatment of colorectal cancer,hoping Clinicians have a more comprehensive understanding of the significance of PET/CT in diagnosing and treating in colorectal cancer and further improving the efficiency of its diagnosis and treatment.
引文
[1] Erreni M,Mantovani A,Allavena P.Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer [J].Cancer Microenviron,2011,4(2):141-154.
[2] Tang TT,Rendon DA,Zawaski JA,et al.Imaging Radiation-Induced Gastrointestinal,Bone Marrow Injury and Recovery Kinetics Using 18F-FDG PET [J].PLoS One,2017,12(1):e0169082.
[3] Ihn HC,Eun JK,Kyung AC,et al.Evaluation of clinicopathological and risk factors in advanced colorectal neoplasm incidentally detected by FDG PET/CT[J].J Nucl Med,2016,57:1590.
[4] Kim WS,Lee HS,Lee JM,et al.Fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography for the detection of proximal synchronous lesions in patients with obstructive colorectal cancer[J].J Gastroenterol Hepatol,2017,32(2):401-408.
[5] Soltau SR,Hess S,Nguyen T,et al.Clinical significance of incidental focal bowel uptake on 18F-FDG PET/CT as related to colorectal cancer[J].Hell J Nucl Med,2016,19(3):245-249.
[6] Boursi B,Gholami S,Houshmand S,et al.Physiologic colonic 18F-FDG uptake in assessing the risk for proximal colorectal neoplasia[J].J Nucl Med,2016,57:645.
[7] 王志忠,张婷,王钦媛,等.癌胚抗原对直结肠偶发高代谢灶良恶性判断[J].科学技术与工程,2016,16(22):1671-1815.
[8] Li W,Zhang G,Wang HL,et al.Analysis of expression of cyclin E,p27kip1 and Ki67 protein in colorectal cancer tissues and its value for diagnosis,treatment and prognosis of disease[J].Eur Rev Med Pharmacol Sci,2016,20(23):4874-4879.
[9] Su F,Li X,You K,et al.Expression of VEGF-D,SMAD4,and SMAD7 and their relationship with Lymphangiogenesis and prognosis in colon cancer[J].J Gastrointest Surg,2016,20(12):2074-2082.
[10] Shmidt E,Nehra V,Lowe V,et al.Clinical significance of incidental 18F-FDG uptake in the gastroinstinal tract on PET/CT imaging:a retrospective cohort study[J].BMC Gastroentrol,2016,16(1):125.
[11] Treglia G,Calcagni ML,Rufini V,et al.Clinical significance of incidental focal colorectal 18F-FDG uptake:our experience and a review of the literature[J].Colorectal Dis,2012,14(2):174-180.
[12] Liu T,Behr S,Khan S,et al.Focal colonic FDG activity with PET/CT:Guidelines for recommendation of colonoscopy[J].World journal of nuclear medicine,2015,14(1):25-30.
[13] Lee JY,Yoon SM,Kim JT,et al.Diagnostic and prognostic value of preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography for colorectal cancer:comparison with conventional computed tomography[J].Intest Res,2017,15(2):208-214.
[14] 任浩棠,王毅均,李瑞平.64层18F-FDG PET/CT在结肠癌N分期中的诊断价值[J].结肠癌肛门外科,2015,21(6):402-406.
[15] Mihailovic J,Ivanov O,Matovina E,et al.18F-FDG PET/CT Imaging in Primary Staging of Colorectal Cancer[J].J Nucl Med,2015,56:1337.
[16] 赵升,田墨涵,于丽娟,等.直肠癌原发灶PET/CT代谢参数和MRI-DWI预测区域淋巴结转移的研究[J].肿瘤学杂志,2017,23(06):489-495.
[17] Lee JH,Lee MR.Positron Emission Tomography/Computed Tomography in the Staging of Colon Cancer[J].Ann Coloproctol,2014,30(1):23-27.
[18] Squillaci E,Manenti G,Mancino S,et al.Staging of colon cancer:whole body MRI vs. whole body PET CT—initial clinical experience[J].Abdom Imaging,2008,33(6):676-688.
[19] Jones M,Hruby G,Solomon M,et al.The role of FDG-PET in the initial staging and response assessment of anal cancer:a systematic review and meta-analysis[J].Ann Surg Oncol,2015,22(11):3574-3581.
[20] 朱湘,宋秀宇,王健,等.18F-FDG PET/CT在行结肠癌检查时发现同时性重复癌的价值[J].Int J Med Radiol,2016,39(2):116-119.
[21] Byun BH,Moon SM,Shin US,et al.Prognostic value of 18F-FDG uptake by regional lymph nodes on pretreatment PET/CT in patients with resectable colorectal cancer[J].Eur J Nucl Med Mol Imaging,2014,41(12):2203-2211.
[22] Shim JR,Lee SD,Han SS,et al.Prognostic significance of 18F-FDG PET/CT in patients with colorectal cancer liver metastases after hepatectomy[J].Eur J Surg Oncol ,2018 ,44(5):670-677.
[23] Dimitrova EG,Chaushev BG,Conev NV,et al.Role of the pretreatment 18F-fluorodeoxyglucose positron emission tomography maximal standardized uptake value in predicting outcomes of colon liver metastases and that value?s association with Beclin-1 expression[J].Biosci Trends,2017,11(2):221-228.
[24] Ince S,Okuyucu K,Alagoz E,et al.Clinical significance of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in the follow-up of colorectal cancer:searching of approaches increasing specificity for detection of recurrence[J].Radiol Oncol,2017,51(4):378-385.
[25] Tejpar S,Stintzing S,Ciardiello F,et al.Prognostic and predictive relevance of primary tumor location in patients with RAS wild-type metastatic colorectal cancer retrospective analyses of the CRYSTAL and FIRE-3 trials[J].JAMA Oncol ,2017,3(2):194-201.
[26] Yoo ID, Lee SM,Lee JW,et al.Usefulness of metabolic activity of adipose tissue in FDG PET/CT of colorectal cancer[J].Abdominal Radiology (New York) ,2018,43(8):2052-2059.
[27] Lodge MA.Repeatability of Standardized Uptake Value in Oncologic 18F-FDG PET[J].J Nucl Med,2017,58(4):523-532.
[28] Cornelis F,Storchios V,Violari E,et al.18F-FDG PET/CT is an immediate imaging biomarker of treatment success after liver metastasis ablation[J].J Nucl Med?,2016,57(7):1052-1057.
[29] 韩安勤.功能解剖影像PET/CT在肿瘤诊断相关常见问题中的应用研究[D].济南:山东大学,2013.
[30] Odalovic S,Stojiljkovic M,Sobic-Saranovic D et al.Prospective study on diagnostic and prognostic significance of postoperative FDG PET/CT in recurrent colorectal carcinoma patients:comparison with MRI and tumor markers[J].Neoplasma,2017,64(6):954-961.
[31] Iwata K,Moriya T,Nakagawa S,et al.Evaluation of efficiencies on the gadoxetic acid-enhanced MRI for preoperative assessment of liver metastases from colorectal carcinoma[J],Nihon Hoshasen Gijutsu Gakkai Zasshi,2018,74(1):29-38.
[32] K Sivesgaard ,LP Larsen ,S kramer,et al.Diagnostic accuracy of CE-CT,MRI and FDG PET/CT for detecting colorectal cancer liver metastases in patients considered eligible for hepatic resection and/or local ablation[J].European Radiology,2018 :1-13
[33] 胡西刚.直肠癌术前同步放化疗前后18F-FDGPET/CT的SUV与TRG相关性的研究[D].济南:济南大学,2013.
[34] Okuno T,Kawai K,Koyama K,et al.Value of FDG-PET/CT volumetry after chemoradiotherapy in rectal cancer[J].Diseases of the colon and rectum,2018 ,61(3):320-327.
[35] Chiaravalloti A,Fiorentini A,Palombo E,et al.Evaluation of recurrent disease in the re-staging of colorectal cancer by 18F-FDG PET/CT:Use of CEA and CA 19-9 in patient selection[J].Oncol Lett,2016,12(5):4209-4213.
[36] Khan K,Athauda A,Aitken K,et al.Survival outcomes in asymptomatic patients with normal conventional imaging but raised carcinoembryonic antigen levels in colorectal cancer following positron emission tomography-computed tomography imaging[J].The Oncologist,2016,21(12):1502-1508.
[37] 刘玉奇.(18)F-FDG PET/CT显像在结直肠癌术后随访中的应用价值[D].苏州:苏州大学,2016.
[38] Kocael A,Vatankulu B,Simsek O,et al.Comparison of 18F-fluorodeoxyglucose PET/CT findings with vascular endothelial growth factors and receptors in colorectal cancer[J].Tumor Biol,2016,37(3):3871-3877.
[39] Zhao M,Yu Z,Li Z,et al.Expression of angiogenic growth factors VEGF,bFGF and ANG1 in colon cancer after bevacizumab treatment in vitro:A potential self-regulating mechanism[J].Oncol Rep,2017,37(1):601-607.
[40] 孙念龙.结肠癌18F-FDG PET/CT的SUV值与临床特征及肿瘤标志物的相关研究[D].长春:吉林大学,2014.
[41] Crandall JP,Tahari AK,Juergens RA,et al.A comparison of FLT to FDG PET/CT in the early assessment of chemotherapy response in stages IB-IIIA resectable[J].EJNMMI Res,2017,7(1):8.
[42] Weina X,Shupeng Y, Jun X,et al.18F-FLT and 18F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats[J].Exp Ther Med,2016,12(6):4154-4158.
[43] Xu HL,Li M,Zhang RJ,et al.Prediction of tumor biological characteristics in different colorectal cancer liver metastasis animal models using 18F-FDG and 18F-FLT[J].Hepatobiliary Pancreat Dis Int,2018,17(2):140-148.
[2] Tang TT,Rendon DA,Zawaski JA,et al.Imaging Radiation-Induced Gastrointestinal,Bone Marrow Injury and Recovery Kinetics Using 18F-FDG PET [J].PLoS One,2017,12(1):e0169082.
[3] Ihn HC,Eun JK,Kyung AC,et al.Evaluation of clinicopathological and risk factors in advanced colorectal neoplasm incidentally detected by FDG PET/CT[J].J Nucl Med,2016,57:1590.
[4] Kim WS,Lee HS,Lee JM,et al.Fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography for the detection of proximal synchronous lesions in patients with obstructive colorectal cancer[J].J Gastroenterol Hepatol,2017,32(2):401-408.
[5] Soltau SR,Hess S,Nguyen T,et al.Clinical significance of incidental focal bowel uptake on 18F-FDG PET/CT as related to colorectal cancer[J].Hell J Nucl Med,2016,19(3):245-249.
[6] Boursi B,Gholami S,Houshmand S,et al.Physiologic colonic 18F-FDG uptake in assessing the risk for proximal colorectal neoplasia[J].J Nucl Med,2016,57:645.
[7] 王志忠,张婷,王钦媛,等.癌胚抗原对直结肠偶发高代谢灶良恶性判断[J].科学技术与工程,2016,16(22):1671-1815.
[8] Li W,Zhang G,Wang HL,et al.Analysis of expression of cyclin E,p27kip1 and Ki67 protein in colorectal cancer tissues and its value for diagnosis,treatment and prognosis of disease[J].Eur Rev Med Pharmacol Sci,2016,20(23):4874-4879.
[9] Su F,Li X,You K,et al.Expression of VEGF-D,SMAD4,and SMAD7 and their relationship with Lymphangiogenesis and prognosis in colon cancer[J].J Gastrointest Surg,2016,20(12):2074-2082.
[10] Shmidt E,Nehra V,Lowe V,et al.Clinical significance of incidental 18F-FDG uptake in the gastroinstinal tract on PET/CT imaging:a retrospective cohort study[J].BMC Gastroentrol,2016,16(1):125.
[11] Treglia G,Calcagni ML,Rufini V,et al.Clinical significance of incidental focal colorectal 18F-FDG uptake:our experience and a review of the literature[J].Colorectal Dis,2012,14(2):174-180.
[12] Liu T,Behr S,Khan S,et al.Focal colonic FDG activity with PET/CT:Guidelines for recommendation of colonoscopy[J].World journal of nuclear medicine,2015,14(1):25-30.
[13] Lee JY,Yoon SM,Kim JT,et al.Diagnostic and prognostic value of preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography for colorectal cancer:comparison with conventional computed tomography[J].Intest Res,2017,15(2):208-214.
[14] 任浩棠,王毅均,李瑞平.64层18F-FDG PET/CT在结肠癌N分期中的诊断价值[J].结肠癌肛门外科,2015,21(6):402-406.
[15] Mihailovic J,Ivanov O,Matovina E,et al.18F-FDG PET/CT Imaging in Primary Staging of Colorectal Cancer[J].J Nucl Med,2015,56:1337.
[16] 赵升,田墨涵,于丽娟,等.直肠癌原发灶PET/CT代谢参数和MRI-DWI预测区域淋巴结转移的研究[J].肿瘤学杂志,2017,23(06):489-495.
[17] Lee JH,Lee MR.Positron Emission Tomography/Computed Tomography in the Staging of Colon Cancer[J].Ann Coloproctol,2014,30(1):23-27.
[18] Squillaci E,Manenti G,Mancino S,et al.Staging of colon cancer:whole body MRI vs. whole body PET CT—initial clinical experience[J].Abdom Imaging,2008,33(6):676-688.
[19] Jones M,Hruby G,Solomon M,et al.The role of FDG-PET in the initial staging and response assessment of anal cancer:a systematic review and meta-analysis[J].Ann Surg Oncol,2015,22(11):3574-3581.
[20] 朱湘,宋秀宇,王健,等.18F-FDG PET/CT在行结肠癌检查时发现同时性重复癌的价值[J].Int J Med Radiol,2016,39(2):116-119.
[21] Byun BH,Moon SM,Shin US,et al.Prognostic value of 18F-FDG uptake by regional lymph nodes on pretreatment PET/CT in patients with resectable colorectal cancer[J].Eur J Nucl Med Mol Imaging,2014,41(12):2203-2211.
[22] Shim JR,Lee SD,Han SS,et al.Prognostic significance of 18F-FDG PET/CT in patients with colorectal cancer liver metastases after hepatectomy[J].Eur J Surg Oncol ,2018 ,44(5):670-677.
[23] Dimitrova EG,Chaushev BG,Conev NV,et al.Role of the pretreatment 18F-fluorodeoxyglucose positron emission tomography maximal standardized uptake value in predicting outcomes of colon liver metastases and that value?s association with Beclin-1 expression[J].Biosci Trends,2017,11(2):221-228.
[24] Ince S,Okuyucu K,Alagoz E,et al.Clinical significance of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in the follow-up of colorectal cancer:searching of approaches increasing specificity for detection of recurrence[J].Radiol Oncol,2017,51(4):378-385.
[25] Tejpar S,Stintzing S,Ciardiello F,et al.Prognostic and predictive relevance of primary tumor location in patients with RAS wild-type metastatic colorectal cancer retrospective analyses of the CRYSTAL and FIRE-3 trials[J].JAMA Oncol ,2017,3(2):194-201.
[26] Yoo ID, Lee SM,Lee JW,et al.Usefulness of metabolic activity of adipose tissue in FDG PET/CT of colorectal cancer[J].Abdominal Radiology (New York) ,2018,43(8):2052-2059.
[27] Lodge MA.Repeatability of Standardized Uptake Value in Oncologic 18F-FDG PET[J].J Nucl Med,2017,58(4):523-532.
[28] Cornelis F,Storchios V,Violari E,et al.18F-FDG PET/CT is an immediate imaging biomarker of treatment success after liver metastasis ablation[J].J Nucl Med?,2016,57(7):1052-1057.
[29] 韩安勤.功能解剖影像PET/CT在肿瘤诊断相关常见问题中的应用研究[D].济南:山东大学,2013.
[30] Odalovic S,Stojiljkovic M,Sobic-Saranovic D et al.Prospective study on diagnostic and prognostic significance of postoperative FDG PET/CT in recurrent colorectal carcinoma patients:comparison with MRI and tumor markers[J].Neoplasma,2017,64(6):954-961.
[31] Iwata K,Moriya T,Nakagawa S,et al.Evaluation of efficiencies on the gadoxetic acid-enhanced MRI for preoperative assessment of liver metastases from colorectal carcinoma[J],Nihon Hoshasen Gijutsu Gakkai Zasshi,2018,74(1):29-38.
[32] K Sivesgaard ,LP Larsen ,S kramer,et al.Diagnostic accuracy of CE-CT,MRI and FDG PET/CT for detecting colorectal cancer liver metastases in patients considered eligible for hepatic resection and/or local ablation[J].European Radiology,2018 :1-13
[33] 胡西刚.直肠癌术前同步放化疗前后18F-FDGPET/CT的SUV与TRG相关性的研究[D].济南:济南大学,2013.
[34] Okuno T,Kawai K,Koyama K,et al.Value of FDG-PET/CT volumetry after chemoradiotherapy in rectal cancer[J].Diseases of the colon and rectum,2018 ,61(3):320-327.
[35] Chiaravalloti A,Fiorentini A,Palombo E,et al.Evaluation of recurrent disease in the re-staging of colorectal cancer by 18F-FDG PET/CT:Use of CEA and CA 19-9 in patient selection[J].Oncol Lett,2016,12(5):4209-4213.
[36] Khan K,Athauda A,Aitken K,et al.Survival outcomes in asymptomatic patients with normal conventional imaging but raised carcinoembryonic antigen levels in colorectal cancer following positron emission tomography-computed tomography imaging[J].The Oncologist,2016,21(12):1502-1508.
[37] 刘玉奇.(18)F-FDG PET/CT显像在结直肠癌术后随访中的应用价值[D].苏州:苏州大学,2016.
[38] Kocael A,Vatankulu B,Simsek O,et al.Comparison of 18F-fluorodeoxyglucose PET/CT findings with vascular endothelial growth factors and receptors in colorectal cancer[J].Tumor Biol,2016,37(3):3871-3877.
[39] Zhao M,Yu Z,Li Z,et al.Expression of angiogenic growth factors VEGF,bFGF and ANG1 in colon cancer after bevacizumab treatment in vitro:A potential self-regulating mechanism[J].Oncol Rep,2017,37(1):601-607.
[40] 孙念龙.结肠癌18F-FDG PET/CT的SUV值与临床特征及肿瘤标志物的相关研究[D].长春:吉林大学,2014.
[41] Crandall JP,Tahari AK,Juergens RA,et al.A comparison of FLT to FDG PET/CT in the early assessment of chemotherapy response in stages IB-IIIA resectable[J].EJNMMI Res,2017,7(1):8.
[42] Weina X,Shupeng Y, Jun X,et al.18F-FLT and 18F-FDG PET-CT imaging in the evaluation of early therapeutic effects of chemotherapy on Walker 256 tumor-bearing rats[J].Exp Ther Med,2016,12(6):4154-4158.
[43] Xu HL,Li M,Zhang RJ,et al.Prediction of tumor biological characteristics in different colorectal cancer liver metastasis animal models using 18F-FDG and 18F-FLT[J].Hepatobiliary Pancreat Dis Int,2018,17(2):140-148.