中国人群狂犬病疫苗Zagreb程序和Essen程序免疫效果Meta分析
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摘要
目的探讨中国人群狂犬病疫苗Zagreb程序和Essen程序免疫效果的差异。方法通过中国学术期刊全文数据库(CNKI)、万方数据库和美国国立生物技术信息中心Pubmed数据库检索中国人群狂犬病疫苗Zagreb程序和Essen程序免疫效果比较研究的文献,采用Stata 10.0软件进行Meta分析。结果共纳入8篇文献,Meta分析显示,采用Zagreb程序狂犬病疫苗首剂接种后第7d狂犬病抗体阳转率显著高于Essen程序(RR=1.20,95%CI:1.04-1.39);采用Zagreb程序首剂接种后第365d抗体阳转率显著低于Essen程序(RR=0.95,95%CI:0.90-1.00)。结论狂犬病疫苗Zagreb程序与Essen程序相比具有保护性抗体产生早但持续时间短的特点。
Objective To compare the immunogenicity of rabies vaccine administered with the Zagreb and Essen regimens in a Chinese population. Methods We used Chinese National Knowledge Inf rastructure(CNKI), Wangfang Database, and Pubmed Database of National Center for Biotechnology Information to identif y comparative studies on the immunogenicity of rabies vaccine given with Zagreb and Essen regimens to a Chinese population. We conducted a meta-analysis using Stata 10.0 sof tware. Results Eight studies were included. Meta-analysis showed that the seroconversion rate of rabies antibody was significantly higher at the 7 th day and was significantly lower at the 365 th day af ter the first dose of rabies vaccine administered using the Zagreb regimen compared with the Essen regimen(RR=1.20, 95%CI: 1.04-1.39; RR=0.95, 95%CI: 0.90-1.00). Conclusion The Zagreb regimen induced protective antibody levels earlier but with shorter duration compared with the Essen regimen.
Objective To compare the immunogenicity of rabies vaccine administered with the Zagreb and Essen regimens in a Chinese population. Methods We used Chinese National Knowledge Inf rastructure(CNKI), Wangfang Database, and Pubmed Database of National Center for Biotechnology Information to identif y comparative studies on the immunogenicity of rabies vaccine given with Zagreb and Essen regimens to a Chinese population. We conducted a meta-analysis using Stata 10.0 sof tware. Results Eight studies were included. Meta-analysis showed that the seroconversion rate of rabies antibody was significantly higher at the 7 th day and was significantly lower at the 365 th day af ter the first dose of rabies vaccine administered using the Zagreb regimen compared with the Essen regimen(RR=1.20, 95%CI: 1.04-1.39; RR=0.95, 95%CI: 0.90-1.00). Conclusion The Zagreb regimen induced protective antibody levels earlier but with shorter duration compared with the Essen regimen.
引文
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[2]吕治红,曹亚荀,高红琴.关于狂犬疫苗三种不同免疫程序有效性及安全性的研究[J].山西医科大学学报, 2011, 42(9):742-744.LüZhihong, CAO Yaxun, GAO Hongqin. Study on efficacy and safety of rabies vaccine by three different immunization programs[J]. Journal of Shanxi Medical University, 2011, 42(9):742-744.
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[9] SHI N, ZHANG Y, ZHENG H, et al. Immunogenicity,safety and antibody persistence of a purified Vero cell cultured rabies vaccine(Speeda)administered by the Zagreb regimen or Essen regimen in post-exposure subjects[J]. Hum Vaccin Immunother, 2017, 13(6):1-8.
[10] MA J, WANG H, LI J, et al. A randomized open-labeled study to demonstrate the non-inferiority of purif ied chickembryo cell rabies vaccine administered in the Zagreb regimen(2-1-1)compared with the Essen regimen in Chinese adults[J]. Hum Vaccin Immunother, 2014, 10(10):2805-2812.
[11] LI R, LI Y, WEN S, et al. Immunogenicity and safety of purified chick-embryo cell rabies vaccine under Zagreb2-1-1 or 5-dose Essen regimen in Chinese children 6 to17 years old and adults over 50 years:a randomized openlabel study[J]. Hum Vaccin Immunother, 2015, 11(2):435-442.
[12] FANG Y, CHEN L, LIU M, et al. Comparison of saf ety and immunogenicity of PVRV and PCECV immunized in patients with WHO Category II Animal Exposure:a study based on different age groups[J]. PLoS Negl Trop Dis,2014, 8(12):e3412.
[13] HUANG G, LIU H, TANG Q, et al. Making rabies prophylaxis more economical[J]. Hum Vaccin Immunother, 2014, 10(1):114-119.
[14] HAMPSON K, COUDEVILLE L, LEMBO T, et al.Estimating the global burden of endemic canine rabies[J].PLoS Negl Trop Dis, 2015, 9(4):e3709.
[15] REN J, YAO L, SUN J, et al. Zagreb regimen, an abbreviated intramuscular schedule for rabies vaccination[J]. Clin Vaccine Immunol, 2015, 22(1):1-5.
[16] ZHOU H, VONG S, LIU K, et al. Human rabies in China,1960-2014:a descriptive epidemiological study[J]. PLoS Negl Trop Dis, 2016, 10(8):e4874.
[17] BEYENE TJ, MOURITS MCM, REVIE CW, et al.Determinants of health seeking behaviour following rabies exposure in Ethiopia[J]. Zoonoses Public Health, 2018,65(4):443-453.
[18]何雪芬,蒋丽莉.狂犬病疫苗Essen与Zagreb接种程序的依从性比较[J].浙江预防医学, 2014, 26(5):490-491.HE Xuefen, JIANG Lili, Comparison on the compliance of rabies vaccine with Essen regimen and Zagreb regimen[J]. Zhejiang Journal of Preventive Medicine, 2014, 26(5):490-491.
[19] LIU SQ, TAO XY, YU PC, et al. The adverse effect of the2-1-1 regimen for rabies PEP in preschool children[J].Biomed Environ Sci, 2017, 30(5):373-375.
[2]吕治红,曹亚荀,高红琴.关于狂犬疫苗三种不同免疫程序有效性及安全性的研究[J].山西医科大学学报, 2011, 42(9):742-744.LüZhihong, CAO Yaxun, GAO Hongqin. Study on efficacy and safety of rabies vaccine by three different immunization programs[J]. Journal of Shanxi Medical University, 2011, 42(9):742-744.
[3]李俊华,叶凤,柴良梅.不同免疫程序人用狂犬病疫苗安全性和免疫原性观察[J].医学动物防制, 2012, 28(6):667-669.LI Junhua, YE Feng, CHAI Liangmei. Observation on the safety and immunogenicity of antirabic vaccine among different immune procedures[J]. Journal of Medical Pest Control, 2012, 28(6):667-669.
[4]刘晓彬.狂犬疫苗接种五针免疫程序与2-1-1四针免疫程序的对比观察[J].中国现代药物应用, 2011, 5(22):2-3.LIU Xiaobin. The comparative observation of wild dog vaccine immune program and five needle 2-1-1 four needles of immunization programs[J]. Chinese Journal of Modern Drug Application, 2011, 5(22):2-3.
[5] MAHENDRA BJ, NARAYANA DA, AGARKHEDKAR S,et al. Comparative study on the immunogenicity and safety of a purified chick embryo cell rabies vaccine(PCECV)administered according to two different simulated post exposure intramuscular regimens(Zagreb versus Essen)[J].Hum Vaccin Immunother, 2015, 11(2):428-434.
[6] LIU H. The immunogenicity and safety of vaccination with purified Vero cell rabies vaccine(PVRV)in China under a 2-1-1 regimen[J]. Hum Vaccin, 2014, 7(2):220-224.
[7] HU Q, LIU M, ZHU Z, et al. Comparison of safety and immunogenicity of purified chick embryo cell vaccine using Zagreb and Essen regimens in patients with category II exposure in China[J]. Hum Vaccin Immunother, 2014,10(6):1645-1649.
[8] WANG J, LUO F, FENG Z, et al. Immunogenicity and safety of purified vero cell rabies vaccine(PVRV)produced by Liaoning Cheng Da Co. under Zagreb 2-1-1 or5-dose Essen regimen in Chinese adults aged 50 and above[J]. Hum Vaccin Immunother, 2017, 13(1):144-150.
[9] SHI N, ZHANG Y, ZHENG H, et al. Immunogenicity,safety and antibody persistence of a purified Vero cell cultured rabies vaccine(Speeda)administered by the Zagreb regimen or Essen regimen in post-exposure subjects[J]. Hum Vaccin Immunother, 2017, 13(6):1-8.
[10] MA J, WANG H, LI J, et al. A randomized open-labeled study to demonstrate the non-inferiority of purif ied chickembryo cell rabies vaccine administered in the Zagreb regimen(2-1-1)compared with the Essen regimen in Chinese adults[J]. Hum Vaccin Immunother, 2014, 10(10):2805-2812.
[11] LI R, LI Y, WEN S, et al. Immunogenicity and safety of purified chick-embryo cell rabies vaccine under Zagreb2-1-1 or 5-dose Essen regimen in Chinese children 6 to17 years old and adults over 50 years:a randomized openlabel study[J]. Hum Vaccin Immunother, 2015, 11(2):435-442.
[12] FANG Y, CHEN L, LIU M, et al. Comparison of saf ety and immunogenicity of PVRV and PCECV immunized in patients with WHO Category II Animal Exposure:a study based on different age groups[J]. PLoS Negl Trop Dis,2014, 8(12):e3412.
[13] HUANG G, LIU H, TANG Q, et al. Making rabies prophylaxis more economical[J]. Hum Vaccin Immunother, 2014, 10(1):114-119.
[14] HAMPSON K, COUDEVILLE L, LEMBO T, et al.Estimating the global burden of endemic canine rabies[J].PLoS Negl Trop Dis, 2015, 9(4):e3709.
[15] REN J, YAO L, SUN J, et al. Zagreb regimen, an abbreviated intramuscular schedule for rabies vaccination[J]. Clin Vaccine Immunol, 2015, 22(1):1-5.
[16] ZHOU H, VONG S, LIU K, et al. Human rabies in China,1960-2014:a descriptive epidemiological study[J]. PLoS Negl Trop Dis, 2016, 10(8):e4874.
[17] BEYENE TJ, MOURITS MCM, REVIE CW, et al.Determinants of health seeking behaviour following rabies exposure in Ethiopia[J]. Zoonoses Public Health, 2018,65(4):443-453.
[18]何雪芬,蒋丽莉.狂犬病疫苗Essen与Zagreb接种程序的依从性比较[J].浙江预防医学, 2014, 26(5):490-491.HE Xuefen, JIANG Lili, Comparison on the compliance of rabies vaccine with Essen regimen and Zagreb regimen[J]. Zhejiang Journal of Preventive Medicine, 2014, 26(5):490-491.
[19] LIU SQ, TAO XY, YU PC, et al. The adverse effect of the2-1-1 regimen for rabies PEP in preschool children[J].Biomed Environ Sci, 2017, 30(5):373-375.