基于数据挖掘对中医古籍眼科点眼方剂用药规律分析
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摘要
目的:基于数据挖掘技术分析中医古籍外治点眼方剂的组方规律。方法:从9部眼科专著及4部综合类医学著作中筛选出外治点眼方进行整理,并建立眼科外治点眼方剂基本数据库,借助计算机软软件,通过频数分析、穷举算法、关联规则等,对古代点眼方剂配伍特点和用药规律进行分析研究。结果:筛选出主治外障眼病的点眼方910个,包含中药472味,对使用频次累积百分比前80%的60味药物进行分析,主要以开窍发散、清热泻火、收湿敛疮、退翳明目、杀虫止痒药物为主;使用Bibxcel进行文本知识单元关联分析获得频次≥30的药对组合21对;基于Matlab穷举运算得到具体3、4、5味药物组合中前20位组合,并以此取得含高频药组的核心方药7首。结论:中医古籍收载的外障眼病点眼方侧重以清热泻火配伍收湿敛疮、拔毒生肌类药品,并重视引经药及介类明目之品的使用;核心药组多以黄连炉甘石散(黄连、炉甘石、冰片)为基础加减化裁而成。
Objective: To analyze the composition principles of eye-drop prescription for external treatment based on the ancient books of Chinese medicine. Methods: Screen out the eye-drop prescription for external treatment from 9 ophthalmological monographs and 4 comprehensive medical books; build the basic database for eye-drop prescription of ophthalmological external treatment; study the compatible characteristics and medicine law of the ancient eye-drop prescription with the help of computer software by frequency analysis, exhaustive algorithm and association rules. Results:Nine hundreds and ten eye-drop prescriptions for external oculopathy were screened out, including 472 kinds of herbal medicine. Analyzed 60 kinds, which was the first 80% of the cumulative percentage of usage frequency, found that most of them were for resuscitating and diverging, clearing heat and draining fire, removing nebula to improve vision, destroying parasites and relieving itching. Applied Bibxcel to unit correlation of text knowledge, and 21 pairs of medicine combination whose frequency≥30 were obtained through analysis. Based on the exhaustive algorithm of Matlab, first 20 combinations of the specific 3, 4 and 5 kinds of medicine combination were obtained and according to which 7 core prescriptions of the high-frequency combinations were also obtained. Conclusions: The eye-drop prescriptions for external oculopathy recorded in ancient books of Chinese medicine focus on the medicine of clearing heat and draining fire combined with astringing dampness and furuncle, removing toxic and regenerating tissue, as well as emphasizing the use of channel envoy, testacean and medicine of vision-improving. Core medicine combinations are mainly modified on the basis of Huanglian Luganshi San(Huanglian, Luganshi, Bingpian).
Objective: To analyze the composition principles of eye-drop prescription for external treatment based on the ancient books of Chinese medicine. Methods: Screen out the eye-drop prescription for external treatment from 9 ophthalmological monographs and 4 comprehensive medical books; build the basic database for eye-drop prescription of ophthalmological external treatment; study the compatible characteristics and medicine law of the ancient eye-drop prescription with the help of computer software by frequency analysis, exhaustive algorithm and association rules. Results:Nine hundreds and ten eye-drop prescriptions for external oculopathy were screened out, including 472 kinds of herbal medicine. Analyzed 60 kinds, which was the first 80% of the cumulative percentage of usage frequency, found that most of them were for resuscitating and diverging, clearing heat and draining fire, removing nebula to improve vision, destroying parasites and relieving itching. Applied Bibxcel to unit correlation of text knowledge, and 21 pairs of medicine combination whose frequency≥30 were obtained through analysis. Based on the exhaustive algorithm of Matlab, first 20 combinations of the specific 3, 4 and 5 kinds of medicine combination were obtained and according to which 7 core prescriptions of the high-frequency combinations were also obtained. Conclusions: The eye-drop prescriptions for external oculopathy recorded in ancient books of Chinese medicine focus on the medicine of clearing heat and draining fire combined with astringing dampness and furuncle, removing toxic and regenerating tissue, as well as emphasizing the use of channel envoy, testacean and medicine of vision-improving. Core medicine combinations are mainly modified on the basis of Huanglian Luganshi San(Huanglian, Luganshi, Bingpian).
引文
[1]马一民.中医眼科外用药的回顾与展望[J].浙江中医学院学报,1986,10(2):54-56.
[2]彭清华.中医眼科学[M].北京:中国中医药出版社,2012:53-54.
[3]葆光道人.秘传眼科龙木论[M].北京:人民卫生出版社,2006.
[4]佚名氏.银海精微[M].北京:人民卫生出版社,2006.
[5]倪维德.原机启微[M].北京:华夏出版社,1997.
[6]佚名.明目神验方[M].北京:中国中医药出版社,2015.
[7]傅仁宇.审视瑶函[M].北京:人民卫生出版社,2006.
[8]黄庭镜.目经大成[M].北京:人民卫生出版社,2006.
[9]顾锡.银海指南[M].北京:人民卫生出版社,1960.
[10]佚名氏.秘授眼科[M].郑州:中原农民出版社,2012.
[11]刘耀先.眼科金镜[M].北京:人民卫生出版社,2006.
[12]王肯堂.证治准绳[M].北京:人民卫生出版社,2014.
[13]张景岳.景岳全书[M].北京:人民卫生出版社,2006.
[14]吴谦.医宗金鉴[M].北京:人民卫生出版社,2006.
[15]朱橚,滕硕,刘醇,等.普济方[M].北京:人民卫生出版社,1959.
[16]高敏学.中药学[M].北京:人民卫生出版社,2014.
[17]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2015.
[18]杨维周.中医眼科历代方剂汇编[M].北京:科技文献出版社,1980.
[19]曹建辉.眼科外用中药与临床[M].北京:人民卫生出版社,1987.
[20]陈自明.妇人良方大全[M].太原:山西科学技术出版社,2012.
[21]段金廒,宿树兰,唐于平,等.中药药对配伍组合的现代认识[J].南京中医药大学学报,2009,25(5):330-333.
[22]肖国士,廖华,刘万里.炉甘石在眼科外用制剂中的应用[J].中国中医眼科杂志,1997,7(3):39-40.
[23]肖国士.眼科外用圣药——炉甘石[J].湖南中医学院学报,1997,17(1):67-69.
[24]陆经纬,陈秀红.论辛温发散法治疗外障眼病[J].中医药研究,2002,18(5):36.
[25]樊岚岚,唐由之,卢景,等.冰片对兔角膜上皮细胞膜促渗透作用的实验研究[J].中国中医眼科杂志,1998,8(2):4-6.
[26]汤成泳,李卿,周远大,等.麝香滴眼液在家兔眼内组织中的分布及药代动力学研究[J].中成药,2010,32(4):581-585.
[27]洪寅,彭倩倩,廖广辉.介类中药相关概念及“性/效/用”探讨[J].中华中医药学刊,2014,32(6):1376-1378.
[28]哈力,牟阳,李昊.鱼腥草壳聚糖滴眼液兔眼药动学研究[J].中国中医药科技,2010,17(5):428-429.
[2]彭清华.中医眼科学[M].北京:中国中医药出版社,2012:53-54.
[3]葆光道人.秘传眼科龙木论[M].北京:人民卫生出版社,2006.
[4]佚名氏.银海精微[M].北京:人民卫生出版社,2006.
[5]倪维德.原机启微[M].北京:华夏出版社,1997.
[6]佚名.明目神验方[M].北京:中国中医药出版社,2015.
[7]傅仁宇.审视瑶函[M].北京:人民卫生出版社,2006.
[8]黄庭镜.目经大成[M].北京:人民卫生出版社,2006.
[9]顾锡.银海指南[M].北京:人民卫生出版社,1960.
[10]佚名氏.秘授眼科[M].郑州:中原农民出版社,2012.
[11]刘耀先.眼科金镜[M].北京:人民卫生出版社,2006.
[12]王肯堂.证治准绳[M].北京:人民卫生出版社,2014.
[13]张景岳.景岳全书[M].北京:人民卫生出版社,2006.
[14]吴谦.医宗金鉴[M].北京:人民卫生出版社,2006.
[15]朱橚,滕硕,刘醇,等.普济方[M].北京:人民卫生出版社,1959.
[16]高敏学.中药学[M].北京:人民卫生出版社,2014.
[17]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2015.
[18]杨维周.中医眼科历代方剂汇编[M].北京:科技文献出版社,1980.
[19]曹建辉.眼科外用中药与临床[M].北京:人民卫生出版社,1987.
[20]陈自明.妇人良方大全[M].太原:山西科学技术出版社,2012.
[21]段金廒,宿树兰,唐于平,等.中药药对配伍组合的现代认识[J].南京中医药大学学报,2009,25(5):330-333.
[22]肖国士,廖华,刘万里.炉甘石在眼科外用制剂中的应用[J].中国中医眼科杂志,1997,7(3):39-40.
[23]肖国士.眼科外用圣药——炉甘石[J].湖南中医学院学报,1997,17(1):67-69.
[24]陆经纬,陈秀红.论辛温发散法治疗外障眼病[J].中医药研究,2002,18(5):36.
[25]樊岚岚,唐由之,卢景,等.冰片对兔角膜上皮细胞膜促渗透作用的实验研究[J].中国中医眼科杂志,1998,8(2):4-6.
[26]汤成泳,李卿,周远大,等.麝香滴眼液在家兔眼内组织中的分布及药代动力学研究[J].中成药,2010,32(4):581-585.
[27]洪寅,彭倩倩,廖广辉.介类中药相关概念及“性/效/用”探讨[J].中华中医药学刊,2014,32(6):1376-1378.
[28]哈力,牟阳,李昊.鱼腥草壳聚糖滴眼液兔眼药动学研究[J].中国中医药科技,2010,17(5):428-429.