血管性血友病因子与肺栓塞的研究进展
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摘要
肺栓塞(pulmonary embolism,PE)是我国发病率及死亡率较高的疾病,其形成机制主要为血流动力学改变、气体交换障碍、慢性血栓栓塞性肺动脉高压等。血管性血友病因子(von Willebrand factor,v WF)是在A型血友病中发现的血浆蛋白,为巨核细胞和内皮细胞中合成的一种具有粘附功能的大分子糖蛋白;随着对v WF研究的深入,发现其在出凝血疾病及凝血过程中具有一定作用。作者就v WF与PE的研究进展进行综述。
Pulmonary embolism( PE) is a high incidence of morbidity and mortality in China. The mechanism of PE mainly includes hemodynamic changes,gas exchange barriers,chronic thromboembolic pulmonary hypertension,etc. von Willebrand factor( vWF) is a plasma protein which was found in type A hemophilia. It is a macromolecular glycoprotein with adhesion function synthesized in megakaryocytes and endothelial cells. With the deepening of the research on vWF,we found it has a certain role in the coagulation disease and coagulation process. This review summarizes the progress of v WF and PE.
Pulmonary embolism( PE) is a high incidence of morbidity and mortality in China. The mechanism of PE mainly includes hemodynamic changes,gas exchange barriers,chronic thromboembolic pulmonary hypertension,etc. von Willebrand factor( vWF) is a plasma protein which was found in type A hemophilia. It is a macromolecular glycoprotein with adhesion function synthesized in megakaryocytes and endothelial cells. With the deepening of the research on vWF,we found it has a certain role in the coagulation disease and coagulation process. This review summarizes the progress of v WF and PE.
引文
[1]葛均波,徐永健.内科学[M].8版.北京:人民卫生出版社,2013:99-106.
[2]李雪美,江淼,赵益明.血管性血友病因子的研究进展[J].中国实验血液学杂志,2013,21(3):801-805.
[3] Cheuk BL,Cheung GC,Cheng SW.Epidemiology of venous thromboembolism in a Chinese population[J]. Br J Surg,2004,91(4):424-428.
[4]蔡柏蔷,徐凌,郭淑静,等.北京协和医院肺栓塞基础病因的变迁[J].中华结核和呼吸杂志,2001,24(12):715-717.
[5] Yang Y,Liang L,Zhai Z,et al.Pulmonary embolism incidence and fatality trends in Chinese hospitals from 1997 to2008:a multicenter registration study[J].Plos One,2011,6(11):e26861.
[6] Cohen AT,Agnelli G,Anderson F A,et al.Venous thromboembolism(VTE)in Europe. The number of VTE events and associated morbidity and mortality[J].Thromb Haemost,2007,98(4):756-764.
[7]程显声,何建国.肺栓塞(1)肺栓塞的流行病学[J].中国循环杂志,1998,13(2):65-66.
[8]房延凤,李王平,张红军,等.肺栓塞危险因素和联合检测c Tn T、BNP、CRP、D-二聚体的临床分析[J].中华肺部疾病杂志(电子版),2017,10(2):130-132.
[9]冯玉倩,张少韶,余淼,等.下肢深静脉血栓合并肺栓塞的危险因素分析[J].华中科技大学学报(医学版),2016,45(3):319-323.
[10] Esmon CT.The interactions between inflammation and coagulation[J].Br J Haematrol,2005,131(4):417-430.
[11] Konstantinides SV,Torbicki A,Agnelli G,et al.2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism[J]. Eur Heart J,2014,35(43):3033-3069.
[12] Wagner DD.Cell biology of von Willebrand factor[J]. Annu Rev Cell Biol,1990,6:217-246.
[13] Weiss HJ,Sussman II,Hoyer LW. Stabilization of factor VIII in plasma by the von Willebrand factor:studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand’s disease[J]. J Clin Invest,1977,60(2):390-404.
[14] Ruggeri ZM.Von Willebrand factor,platelets and endothelial cell interactions[J].J Thromb Haemost,2003,1(7):1335-1342.
[15] Tsai AW,Cushman M,Rosamond WD,et al. Coagulation factors,inflammation markers,and venous thromboembolism:the longitudinal investigation of thromboembolism etiology(LITE)[J].Am J Med,2002,113(8):636-642.
[16] Koster T,Blann AD,Bri3t E,et al.Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis[J].Lancet,1995,345(8943):152-155.
[17] Andre P,Denis CV,Ware J,et al.Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins[J].Blood,2000,96:3322-3328.
[18]张琦,耿洁,赵建国.急性脑梗死患者血浆Hcy、hsCRP、v WF检测的临床意义[J].国际检验医学杂志,2014,35(18):2444-2445.
[19] Pendu R,Terraube V,Christophe OD,et al. P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor[J].Blood,2006,108(12):3746-3752.
[20] Bernardo A,Ball C,Nolasco L,et al. Platelets adhered to endothelial cell-bound ultra-large von Willebrand factor strings support leukocyte tethering and rolling under high shear stress[J].J Thromb Haemost,2005,3:562-570.
[21] Petri B,Broermann A,Li H,et al.von Willebrand factor promotes leukocyte extravasation[J]. Blood,2010,116(22):4712-4719.
[22] Kehrel B,Wiewrille S,Clemetson KJ,et al. Glycoprotein VI is a major collagen receptor for platelet activation:it recognizes the platelet-activating quaternary structure of collagen,whereas CD36,glycoprotein IIb/IIIa,and von Willebrand factor do not[J].Blood,1998,91(2):49-499.
[23]杨冀萍,刘新峰,吴雅莉,等.不同栓塞面积肺血栓栓塞症患者血管性假血友病因子及α颗粒膜蛋白-140的变化[J].中国急救医学,2007,27(3):275-277.
[24] De Meyer SF,Stoll G,Wagner DD,et al. von Willebrand factor:an emerging target in stroke therapy[J]. Stroke,2012,43(2):599-606.
[2]李雪美,江淼,赵益明.血管性血友病因子的研究进展[J].中国实验血液学杂志,2013,21(3):801-805.
[3] Cheuk BL,Cheung GC,Cheng SW.Epidemiology of venous thromboembolism in a Chinese population[J]. Br J Surg,2004,91(4):424-428.
[4]蔡柏蔷,徐凌,郭淑静,等.北京协和医院肺栓塞基础病因的变迁[J].中华结核和呼吸杂志,2001,24(12):715-717.
[5] Yang Y,Liang L,Zhai Z,et al.Pulmonary embolism incidence and fatality trends in Chinese hospitals from 1997 to2008:a multicenter registration study[J].Plos One,2011,6(11):e26861.
[6] Cohen AT,Agnelli G,Anderson F A,et al.Venous thromboembolism(VTE)in Europe. The number of VTE events and associated morbidity and mortality[J].Thromb Haemost,2007,98(4):756-764.
[7]程显声,何建国.肺栓塞(1)肺栓塞的流行病学[J].中国循环杂志,1998,13(2):65-66.
[8]房延凤,李王平,张红军,等.肺栓塞危险因素和联合检测c Tn T、BNP、CRP、D-二聚体的临床分析[J].中华肺部疾病杂志(电子版),2017,10(2):130-132.
[9]冯玉倩,张少韶,余淼,等.下肢深静脉血栓合并肺栓塞的危险因素分析[J].华中科技大学学报(医学版),2016,45(3):319-323.
[10] Esmon CT.The interactions between inflammation and coagulation[J].Br J Haematrol,2005,131(4):417-430.
[11] Konstantinides SV,Torbicki A,Agnelli G,et al.2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism[J]. Eur Heart J,2014,35(43):3033-3069.
[12] Wagner DD.Cell biology of von Willebrand factor[J]. Annu Rev Cell Biol,1990,6:217-246.
[13] Weiss HJ,Sussman II,Hoyer LW. Stabilization of factor VIII in plasma by the von Willebrand factor:studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand’s disease[J]. J Clin Invest,1977,60(2):390-404.
[14] Ruggeri ZM.Von Willebrand factor,platelets and endothelial cell interactions[J].J Thromb Haemost,2003,1(7):1335-1342.
[15] Tsai AW,Cushman M,Rosamond WD,et al. Coagulation factors,inflammation markers,and venous thromboembolism:the longitudinal investigation of thromboembolism etiology(LITE)[J].Am J Med,2002,113(8):636-642.
[16] Koster T,Blann AD,Bri3t E,et al.Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis[J].Lancet,1995,345(8943):152-155.
[17] Andre P,Denis CV,Ware J,et al.Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins[J].Blood,2000,96:3322-3328.
[18]张琦,耿洁,赵建国.急性脑梗死患者血浆Hcy、hsCRP、v WF检测的临床意义[J].国际检验医学杂志,2014,35(18):2444-2445.
[19] Pendu R,Terraube V,Christophe OD,et al. P-selectin glycoprotein ligand 1 and beta2-integrins cooperate in the adhesion of leukocytes to von Willebrand factor[J].Blood,2006,108(12):3746-3752.
[20] Bernardo A,Ball C,Nolasco L,et al. Platelets adhered to endothelial cell-bound ultra-large von Willebrand factor strings support leukocyte tethering and rolling under high shear stress[J].J Thromb Haemost,2005,3:562-570.
[21] Petri B,Broermann A,Li H,et al.von Willebrand factor promotes leukocyte extravasation[J]. Blood,2010,116(22):4712-4719.
[22] Kehrel B,Wiewrille S,Clemetson KJ,et al. Glycoprotein VI is a major collagen receptor for platelet activation:it recognizes the platelet-activating quaternary structure of collagen,whereas CD36,glycoprotein IIb/IIIa,and von Willebrand factor do not[J].Blood,1998,91(2):49-499.
[23]杨冀萍,刘新峰,吴雅莉,等.不同栓塞面积肺血栓栓塞症患者血管性假血友病因子及α颗粒膜蛋白-140的变化[J].中国急救医学,2007,27(3):275-277.
[24] De Meyer SF,Stoll G,Wagner DD,et al. von Willebrand factor:an emerging target in stroke therapy[J]. Stroke,2012,43(2):599-606.