转化生长因子-β1与认知障碍的相关性研究进展
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摘要
认知障碍指与学习、记忆、语言、思维、情感等有关的大脑高级智能加工过程出现异常,导致注意障碍、记忆障碍、执行障碍等,已经成为严重的社会公共健康问题,但目前仍缺乏安全有效疗法。转化生长因子β1(tansforming growth factor beta 1,TGF-β1)是TGF-β家族中的最重要成员之一,可通过多种途径改善认知功能,为认知障碍的治疗提供新的策略。作者对TGF-β1在认知障碍中的作用研究进展进行综述。
Cognitive dysfunction refers to abnormalities in the brain's advanced intelligent processing processes related to learning,memory,language,thinking and emotion,which leaded to attention,memory and executive dysfunction. It has become a serious social public health problem,but it still lacks of safe and effective therapy. Tansforming growth factor beta 1( TGF-β1) is one of the most important members of the TGF-β family,which can improve cognitive function through various ways and provide new strategies for the treatment of cognitive dysfunction. This paper reviews the research progress of the role of TGF-β1 in cognitive dysfunction.
Cognitive dysfunction refers to abnormalities in the brain's advanced intelligent processing processes related to learning,memory,language,thinking and emotion,which leaded to attention,memory and executive dysfunction. It has become a serious social public health problem,but it still lacks of safe and effective therapy. Tansforming growth factor beta 1( TGF-β1) is one of the most important members of the TGF-β family,which can improve cognitive function through various ways and provide new strategies for the treatment of cognitive dysfunction. This paper reviews the research progress of the role of TGF-β1 in cognitive dysfunction.
引文
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[24]程捷瑶,王美娟,马红,等.脂联素通过腺苷酸激活蛋白激酶途径抑制大鼠肝星状细胞氧化应激并调控转化生长因子β1和Ⅰ型胶原表达[J].中华肝脏病杂志,2015,23(1):69-72.
[2] Xu Q,Kopp JB.Retinoid and TGF-βfamilies:crosstalk in development,neoplasia,immunity,and tissue repair[J].Semin Nephrol,2012,287-294.
[3] Taylor RA,Chang CF,Goods BA,et al.TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage[J].J Clin Invest,2016,127(1):280-292.
[4] Seo JH,Maki T,Maeda M,et al.Oligodendrocyte precursor cells support blood-brain barrier integrity via TGF-βsignaling[J].PLoS One,2014,9(7):e103174.
[5] Feng Z,Ko CP.Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factorbeta1[J].J Neurosci,2008,28(39):9599-9609.
[6] Bosco P,Ferri R,Salluzzo MG,et al.Role of the transforming-growth-factor-β1 gene in late-onset Alzheimer’s disease:implications for the treatment[J]. Curr Genomics,2013,14(2):147-156.
[7] Yu Y,Li J,Zhou H,et al. Functional importance of the TGF-β1/Smad3 signaling pathway in oxygen-glucose-deprived(OGD)microglia and rats with cerebral ischemia[J].Int J Biol Macromol,2018,116:537-544.
[8] Wang Y,Zhu G,Briz V,et al.A molecular brake controls the magnitude of long-term potentiation[J].Nat Commun,2014,5:3051.
[9] Caraci F,Gulisano W,Guida CA,et al.A key role for TGF-β1 in hippocampal synaptic plasticity and memory[J].Sci Rep,2015,5:11252.
[10] Araujo AP,Diniz LP,Eller CM,et al. Effects of transforming growth factor beta 1 in cerebellar development:role in synapse formation[J].Front Cell Neurosci,2016,10:104.
[11] Bae JJ,Xiang YY,Martinez-Canabal A,et al. Increased transforming growth factor-β1 modulates glutamate receptor expression in the hippocampus[J].Int J Physiol Pathophysiol Pharmacol,2011,3(1):9-20.
[12] Neidert N,von Ehr A,Zller T,et al. Microglia-specific expression of Olfml3 is directly regulated by transforming growth factorβ1-induced Smad2 signaling[J]. Front Immunol,2018,9:1728.
[13] Chen JH,Ke KF,Lu JH,et al.Protection of TGF-β1 against neuroinflammation and neurodegeneration in Aβ1-42--induced Alzheimer’s disease model rats[J]. Plos One,2015,10(2):e0116549.
[14] Chen X,Liu Z,Cao BB,et al.TGF-β1 neuroprotection via inhibition of microglial activation in a rat model of Parkinson’s disease[J]. J Neuroimmune Pharmacol,2017,12(3):433-446.
[15] Li Y,Shen XZ,Li L,et al.Brain transforming growth factor-βresists hypertension via regulating microglial activation[J].Stroke,2017,48(9):2557-2564.
[16] Luo SX,Timbang L,Kim JI,et al.TGF-βsignaling in dopaminergic neurons regulates dendritic growth,excitatoryinhibitory synaptic balance,and reversal learning[J]. Cell Rep,2016,17(12):3233-3245.
[17] Tapia-González S,Giráldez-Pérez RM,Cuartero MI,et al.Dopamine andα-synuclein dysfunction in Smad3 null mice[J].Mol Neurodegener,2011,6:72.
[18] Koeglsperger T,Li S,Brenneis C,et al.Impaired glutamate recycling and Glu N2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS[J].Glia,2013,61(6):985-1002.
[19] Fong G,Backman LJ,Alfredson H,et al. The effects of substance P and acetylcholine on human tenocyte proliferation converge mechanistically via TGF-β1[J].Plos One,2017,12(3):e0174101.
[20] Sitarik AR,Bobbitt KR,Havstad SL,et al. Breast milk transforming growth factorβis associated with neonatal gut microbial composition[J].J Pediatr Gastroenterol Nutr,2017,65(3):e60-e67.
[21] Hill JM,Lukiw WJ.Microbial-generated amyloids and Alzheimers’ disease(AD)[J].Front Aging Neurosci,2015,7:9.
[22] Waragai M,Adame A,Trinh I,et al.Possible involvement of adiponectin,the anti-diabetes molecule,in the pathogenesis of Alzheimer’s disease[J]. J Alzheimers Dis,2016,52(4):1453-1459.
[23] HobzovM,Salzman R,Stejskal D,et al.Serum adiponectin level in obstructive sleep apnea:relation of adiponectin to obesity and long-term continuous positive airway pressure therapy[J].Adv Med Sci,2016,61(1):130-134.
[24]程捷瑶,王美娟,马红,等.脂联素通过腺苷酸激活蛋白激酶途径抑制大鼠肝星状细胞氧化应激并调控转化生长因子β1和Ⅰ型胶原表达[J].中华肝脏病杂志,2015,23(1):69-72.