成体干细胞治疗压力性尿失禁的应用
摘要
压力性尿失禁(SUI)是一种女性常见的泌尿系统疾病。现今的手术治疗因存在较大的个体差异及手术相关并发症而效果不理想,因而寻找一种微创的替代疗法成为一项主要诉求。近年来,动物实验和临床试验广泛研究了女性SUI的干细胞疗法,取得了较满意的结果。目前大多数临床前试验使用的干细胞为肌肉源性和脂肪源性。此外,其他类型的细胞,如人羊水干细胞和人脐带间充质干细胞的应用变得越来越广泛。本文就不同来源的干细胞治疗SUI的最新临床前和临床研究进行综述,并评估比较其有效性、安全性及应用前景。尽管证据表明干细胞治疗是安全有效的,但仍需进一步研究以规范干细胞治疗操作技术,确定干细胞使用的适应症及安全有效范围。
引文
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[4] Reyes LM,Davenport MH.Exercise as a therapeutic intervention to optimize fetal weight[J].Pharmacol Res,2018,132(6):160-167
[5] ACOG Committee Obstetric Practice.ACOG Committee opinion.Number 267,January 2002:exercise during pregnancy and the postpartum period[J].Obstet Gynecol,2002,99(1):171-173
[6] Downs DS,Chasan-Taber L,Evenson KR,et al.Physical activity and pregnancy:past and present evidence and future recommendations[J].Res Q Exerc Sport,2012,83(4):485-502
[7] Evenson KR,Barakat R,Brown WJ,et al.Guidelines for physical activity during pregnancy:comparisons from around the world[J].Am J Lifestyle Med,2014,8(2):102-121
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[10] Mottola MF,Davenport MH,Ruchat SM,et al.2019 Canadian guideline for physical activity throughout pregnancy[J].Br J Sports Med,2018,52(21):1339-1346
[11] Ruchat SM,Mottola MF,Skow RJ,et al.Effectiveness of exercise interventions in the prevention of excessive gestational weight gain and postpartum weight retention:a systematic review and meta-analysis[J].Br J Sports Med,2018,52(21):1347-1356
[12] Davenport MH,McCurdy AP,Mottola MF,et al.Impact of prenatal exercise on both prenatal and postnatal anxiety and depressive symptoms:a systematic review and meta-analysis[J].Br J Sports Med,2018,52(21):1376-1385
[13] Watson SJ,Lewis AJ,Boyce P,et al.Exercise frequency and maternal mental health:Parallel process modelling across the perinatal period in an Australian pregnancy cohort[J].J Psychosom Res,2018,111:91-99
[14] 谈敏娟,李军.妊娠期运动和锻炼方式的研究进展[J].中华护理杂志,2011,46(2):199-201
[15] Bo K,Artal R,Barakat R,et al.Exercise and pregnancy in recreational and elite athletes:2016/2017 evidence summary from the IOC expert group meeting,Lausanne.Part 5.Recommendations for health professionals and active women[J].Br J Sports Med,2018,52(17):1080-1085