肠道病毒感染诱导宿主细胞自噬的研究进展
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摘要
细胞自噬是一种高度保守的生理代谢途径,是维持细胞稳态的重要过程。一些病毒已经进化出逃逸自噬依赖性降解的方法,甚至进化出利用自噬以促进自身复制的机制。肠道病毒感染细胞时,能激活自噬途径,诱导自噬体的形成。本文对肠道病毒感染与细胞自噬的研究概况与进展作一综述,为进一步解析肠道病毒感染与细胞自噬之间相互作用的机制提供参考。
Autophagy is important for the maintenance of cellular homeostasis. In recent years,studies have shown that enterovirus infection and cell autophagy have a close relationship. Some viruses have evolved mechanisms to escape from autophagy-dependent degradation and some have even evolved mechanisms that use autophagy to promote self-replication. Enterovirus infected-cells can activate the autophagy pathway to induce autophagosome formation. This review summarizes the research progress on autophagy and enterovirus infection.Thus,it provides a reference for further evaluation of the mechanism of the interaction between enterovirus infection and autophagy.
Autophagy is important for the maintenance of cellular homeostasis. In recent years,studies have shown that enterovirus infection and cell autophagy have a close relationship. Some viruses have evolved mechanisms to escape from autophagy-dependent degradation and some have even evolved mechanisms that use autophagy to promote self-replication. Enterovirus infected-cells can activate the autophagy pathway to induce autophagosome formation. This review summarizes the research progress on autophagy and enterovirus infection.Thus,it provides a reference for further evaluation of the mechanism of the interaction between enterovirus infection and autophagy.
引文
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[31]Bird S W,Maynard N D,Covert M W,Kirkegaard K.Nonlytic viral spread enhanced byautophagy components[J]. Proc Natl Acad Sci U S A,2014,111(36):13081-13086.
[32]Robinson S M,Tsueng G,Sin J,Mangale V,Rahawi S,Mclntyre L L,Williams W,Kha N,Cruz C,Han-cock B M,Nguyen D P,Sayen M R,Hilton B J,Doran K S,Segall A M,Wolkowicz R,Cornell C T,Whitton J L,Gottlieb R A,Feuer R. Coxsackievirus B exits the host cell in shed microvesicles displaying au-tophagosomal markers[J/OL]. PLoS Pathog,2014,10(4):e1004045.
[33]Green D R. Apoptotic pathways:ten minutes to dead[J]. Cell,2005,121(5):671-674.
[34]Xie K,Tian L,Guo X. BmATG5 and BmATG6 medi-ate apoptosis following autophagy induced by 20-hy-droxyecdysone or starvation[J]. Autophagy,2016,12(2):381-396.
[35]Shimizu S, Kanaseki T, Mizushima N, Mizuta T,Arkawa-Kobayashi S,Thompson C B,Tsujimoto Y.Role of Bcl-2 family proteins in a non-apoptotic pro-grammed cell death dependent on autophagy genes[J].Nat Cell Biol,2004,6(12):1221-1228.
[36]Xi X,Zhang X,Wang B,Wang T,Wang J,Jin Q,Zhao Z. The interplays between autophagy and apoptosis induced by enterovirus 71[J/OL]. PLoS One,2013,8(2):e56966.
[37]Xin L,Xiao Z,Ma X,He F,Yao H,Liu Z. Coxsackie-virus B3 induces crosstalk between autophagy and apop-tosis to benefit its release after replicating in autophago-somes through a mechanism involving caspase cleavage of autophagy-related proteins[J]. Infect Genet Evol,2014,26:95-102.
[38]Marino G,Niso-Santano M,Baehrecke E H,Kroemer G. Self-consumption:the interplay of autophagy and apoptosis[J]. Nat Rev Mol Cell Biol,2014,15(2):81-94.
[2] Yi E J,Shin Y J,Kim J H,Kim T G,Chang S Y. En-terovirus 71 infection and vaccines[J]. Clin Exp Vaccine Res,2017,6(1):4-14.
[3] Galluzzi L,Bravo-San P J,Levine B,Green D R,Kro-emer G. Pharmacological modulationof autophagy:ther-apeutic potential and persisting obstacles[J]. Nat Rev Drug Discov,2017,16(7):487-511.
[4] Song J,Hu Y,Li J,Zheng H,Wang J,Guo L,Shi H,Liu L,et al. Suppression of the toll-like receptor 7-de-pendent type I interferon production pathway by autopha-gy resulting from enterovirus 71 and coxsackievirus A16infections facilitates their replication[J]. Arch Virol,2018,163(1):135-144.
[5] Rozieres A,Viret C,Faure M. Autophagy in measles virus infection[J]. Viruses,2017,9(12):359.
[6] Yang A,Pantoom S,Wu Y W. Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ us-ing semisynthetic LC3 proteins[J/OL]. Elife,2017,6:e23905.
[7] Komatsu M,Ichimura Y. Physiological significance of selective degradation of p62 by autophagy[J]. FEBS Lett,2010,584(7):1374-1378.
[8] Deretic V,Levine B. Autophagy,immunity,and micro-bial adaptations[J]. Cell Host Microbe,2009,5(6):527-549.
[9] Wileman T. Aggresomes and pericentriolar sites of virus assembly:cellular defense or viraldesign?[J]. Annu Rev Microbiol,2007,61:149-167.
[10]Peng J,Zhu S,Hu L,Ye P,Wang Y,Tian Q,Mei M,Chen H,Guo X. Wild-type rabies virus induces au-tophagy in human and mouse neuroblastoma cell lines[J]. Autophagy,2016,12(10):1704-1720.
[11]Liu J,Wang H,Gu J,Deng T,Yuan Z,Hu B,Xu Y,Yan Y,Zan J,Liao M,DiCaprioE,Li J,Su S,Zhou J. BECN1-dependent CASP2 incomplete autophagy in-duction by binding to rabies virus phosphoprotein[J].Autophagy,2017,13(4):739-753.
[12]Guo X,Zhang M,Zhang X,Tan X,Guo H,Zeng W,Yan J,Memon A M,Li Z,Zhu Y,Zhang B,Ku X,Wu M,Fan S,He Q. Porcine epidemic diarrhea virus in-duces autophagy to benefit its replication[J]. Viruses,2017,9(3):53.
[13]Buckingham E M,Carpenter J E,Jackson W,Grose C.Autophagy and the effects of its inhibition on varicella-zoster virus glycoprotein biosynthesis and infectivity[J].J Virol,2014,88(2):890-902.
[14]Vallejo D,Crespo I,San-Miguel B,Alvarez M,Prieto J,Tunon M J,Gonzalez-Gallego J.Autophagic response in the rabbit hemorrhagic disease,an animal model of vi-rally-induced fulminant hepatic failure[J]. Vet Res,2014,45(1):15.
[15]Pei J,Deng J,Ye Z,Wang J,Guo H,Liu W,Zhao M,Liao M,Yi L,Chen J. Absenceof autophagy pro-motes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells[J]. Autophagy,2016,12(10):1738-1758.
[16]Zeng R,Cui Y,Hai Y,Liu Y. Pattern recognition re-ceptors for respiratory syncytial virusinfection and design of vaccines[J]. Virus Res,2012,167(2):138-145.
[17]Xu Y, Jagannath C, Liu X D, Sharafkhaneh A,Kolodziejska K E,Eissa N T. Toll-like receptor 4 is a sensor for autophagy associated with innate immunity[J]. Immunity,2007,27(1):135-144.
[18]Wu T T,Li W M,Yao Y M. Interactions between au-tophagy and inhibitory cytokines[J]. Int J Biol Sci,2016,12(7):884-897.
[19]Lee Y R,Wang P S,Wang J R,Liu H S. Enterovirus71-induced autophagy increases viral replication and pathogenesis in a suckling mouse model[J/OL]. J Biomed Sci,2014,21(1):80.
[20]Xi X,Zhang X,Wang B,Wang T,Wang J,Huang H,Wang J,Jin Q,Zhao Z. The interplays between autoph-agy and apoptosis induced by enterovirus 71[J]. PLoS One,2013,8(2):e56966.
[21]Lai J K,Sam I C,Chan Y F. The autophagic machinery in enterovirus infection[J]. Viruses,2016,8(2):32.
[22]Shi Y,He X,Zhu G,Tu H,Liu Z,LiW,Han S,Yin J,Peng B,Liu W. CoxsackievirusA16 elicits incom-plete autophagy involving the mTOR and ERK pathways[J/OL]. PLoS One,2015,10(4):e122109.
[23]Wu H,Zhai X,Chen Y,Wang R,Lin L,Chen S,Wang T,Zhong X,Wu X,Wang Y,Zhang F,Zhao W,Zhong Z. Protein 2B of coxsackievirus B3 induces autophagy relying on its transmembrane hydrophobic Se-quences[J]. Viruses,2016,8(5):131.
[24]Wang H,Li K,Ma L,Wu S,Hu J,Yan H,Jiang J,Li Y. Berberine inhibits enterovirus71 replication by downregulating the MEK/ERK signaling pathway and autophagy[J]. Virol J,2017,14(1):2.
[25]张晓延.肠道病毒71型诱导细胞自噬、凋亡及相互调控关系的研究[D].北京协和医学院,2011.
[26]Lai J,Sam I C,Verlhac P,Baguet J,Eskelinen E L,Faure M,Chan Y F. 2BC non-structural protein of en-terovirus A71 interacts with SNARE proteins to trigger autolysosome formation[J]. Viruses,2017,9(7):169.
[27]Wong J,Zhang J,Si X,Gao G,Mao I,McManus B M,Luo H. Autophagosome supports coxsackievirus B3replication in host cells[J]. J Virol,2008,82(18):9143-9153.
[28]Richards A L,Jackson W T. Intracellular vesicle acidifi-cation promotes maturation of infectious poliovirus parti-cles[J/OL]. PLoS Pathog,2012,8(11):e1003046.
[29]Alirezaei M,Flynn C T,Wood M R,Harkins S,Whit-ton J L. Coxsackievirus can exploitLC3 in both autopha-gy-dependent and-independent manners in vivo[J]. Au-tophagy,2015,11(8):1389-1407.
[30]Too I H,Yeo H,Sessions O M,Yan B,Libau E A,Howe J L C,Lim Z Q,Suku-Maran S,Ong W Y,Ch-uan K B,Wong B S,Chow V T K,Alonso S. Entero-virus 71 infection of motor neuron-like NSC-34 cells un-dergoes a non-lytic exit pathway[J]. Sci Rep,2016,6:36983.
[31]Bird S W,Maynard N D,Covert M W,Kirkegaard K.Nonlytic viral spread enhanced byautophagy components[J]. Proc Natl Acad Sci U S A,2014,111(36):13081-13086.
[32]Robinson S M,Tsueng G,Sin J,Mangale V,Rahawi S,Mclntyre L L,Williams W,Kha N,Cruz C,Han-cock B M,Nguyen D P,Sayen M R,Hilton B J,Doran K S,Segall A M,Wolkowicz R,Cornell C T,Whitton J L,Gottlieb R A,Feuer R. Coxsackievirus B exits the host cell in shed microvesicles displaying au-tophagosomal markers[J/OL]. PLoS Pathog,2014,10(4):e1004045.
[33]Green D R. Apoptotic pathways:ten minutes to dead[J]. Cell,2005,121(5):671-674.
[34]Xie K,Tian L,Guo X. BmATG5 and BmATG6 medi-ate apoptosis following autophagy induced by 20-hy-droxyecdysone or starvation[J]. Autophagy,2016,12(2):381-396.
[35]Shimizu S, Kanaseki T, Mizushima N, Mizuta T,Arkawa-Kobayashi S,Thompson C B,Tsujimoto Y.Role of Bcl-2 family proteins in a non-apoptotic pro-grammed cell death dependent on autophagy genes[J].Nat Cell Biol,2004,6(12):1221-1228.
[36]Xi X,Zhang X,Wang B,Wang T,Wang J,Jin Q,Zhao Z. The interplays between autophagy and apoptosis induced by enterovirus 71[J/OL]. PLoS One,2013,8(2):e56966.
[37]Xin L,Xiao Z,Ma X,He F,Yao H,Liu Z. Coxsackie-virus B3 induces crosstalk between autophagy and apop-tosis to benefit its release after replicating in autophago-somes through a mechanism involving caspase cleavage of autophagy-related proteins[J]. Infect Genet Evol,2014,26:95-102.
[38]Marino G,Niso-Santano M,Baehrecke E H,Kroemer G. Self-consumption:the interplay of autophagy and apoptosis[J]. Nat Rev Mol Cell Biol,2014,15(2):81-94.