磷脂酰肌醇-4,5-二磷酸调控细胞迁移的研究进展
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摘要
磷脂酰肌醇-4,5-二磷酸(phosphatidylinositol-4,5-bisphosphate,PIP2)是细胞膜上一种重要的磷脂酰肌醇,通过作为第二信使前体及自身信号分子的作用,控制其效应物的靶向定位和活性从而调节细胞迁移、囊泡运输、细胞形态发生、信号传导等过程.细胞迁移异常会导致人类多种疾病包括神经发育异常、阿尔茨海默病、癌症和纤毛疾病等.作为细胞骨架的调节剂,PIP2在细胞迁移的关键作用已经被广泛证实,本文将从由PIP5KIs介导的PIP2产生与踝蛋白、Rho家族小GTP酶等效应物关联调节黏附作用和肌动蛋白聚合的角度,讨论PIP2在细胞迁移中发挥作用的具体机制.
Phosphatidylinositol-4, 5-bisphosphate(PIP2) is an important phosphatidylinositol on the cell membrane. By acting as a second messenger precursor and self-signaling molecule, it controls the targeted localization and activity of its effectors to regulate cells migration, vesicle transport, cell morphogenesis, signal transduction and other processes. Abnormal cell migration leads to a variety of human diseases in humans,including neurodevelopmental abnormalities, Alzheimer's disease, cancer and cilia disease. As the regulator of cytoskeleton, the pivotal role of PIP2 in cell migration has been widely confirmed. This review will discuss the specific mechanism of the role of PIP2 in cell migration from the point of PIP2 mediated by PIP5 KIs associated with talin, Rho family small GTPases and other effectors to regulate adhesion and actin polymerization.
Phosphatidylinositol-4, 5-bisphosphate(PIP2) is an important phosphatidylinositol on the cell membrane. By acting as a second messenger precursor and self-signaling molecule, it controls the targeted localization and activity of its effectors to regulate cells migration, vesicle transport, cell morphogenesis, signal transduction and other processes. Abnormal cell migration leads to a variety of human diseases in humans,including neurodevelopmental abnormalities, Alzheimer's disease, cancer and cilia disease. As the regulator of cytoskeleton, the pivotal role of PIP2 in cell migration has been widely confirmed. This review will discuss the specific mechanism of the role of PIP2 in cell migration from the point of PIP2 mediated by PIP5 KIs associated with talin, Rho family small GTPases and other effectors to regulate adhesion and actin polymerization.
引文
[1]Hammond G R V.Does Ptd Ins(4,5)P2 concentrate so it can multitask?.Biochemical Society Transactions,2016,44(1):228-233
[2]De Craene J O,Bertazzi D L,Bar S,et al.Phosphoinositides,major actors in membrane trafficking and lipid signaling pathways International Journal of Molecular Sciences,2017,18(3):634-654
[3]Patra M C,Choi S.Insight into phosphatidylinositol-dependen membrane localization of the innate immune adaptor protein toll interleukin 1 receptor domain-containing adaptor protein Frontiers in Immunology,2018,9:75
[4]Loo L,Wright B D,Zylka M J.Lipid kinases as therapeutic targets for chronic pain.Pain,2015,156(1):S2-10
[5]Chen X,Wan J,Yu B,et al.PIP5K1 alpha promotes myogenic differentiation via AKT activation and calcium release.Stem Cel Research&Therapy,2018,9(1):33
[6]Watanabe T,Noritake J,Kaibuchi K.Regulation of microtubules in cell migration.Trends in Cell Biology,2005,15(2):76-83
[7]Ridley A J.Life at the leading edge.Cell,2011,145(7):1012-1022
[8]Parsons J T,Horwitz A R,Schwartz M A.Cell adhesion integrating cytoskeletal dynamics and cellular tension.Nature Reviews Molecular Cell Biology,2010,11(9):633-643
[9]Thapa N,Anderson R A.PIP2 signaling,an integrator of cel polarity and vesicle trafficking in directionally migrating cells Cell Adhesion&Migration,2012,6(5):409-412
[10]Wang Y,Lian L,Golden J A,et al.PIP5KI gamma is required for cardiovascular and neuronal development.Proc Natl Sci USA2007,104(28):11748-11753
[11]Dyson J M,Conduit S E,Feeney S J,et al.INPP5E regulates phosphoinositide-dependent cilia transition zone function.The Journal of Cell Biology,2017,216(1):247-263
[12]Narkis G,Ofir R,Landau D,et al.Lethal contractural syndrome type 3(LCCS3)is caused by a mutation in PIP5K1C,which encodes PIPKI gamma of the phophatidylinsitol pathway American Journal of Human Genetics,2007,81(3):530-539
[13]Insall R H,Weiner O D.PIP3,PIP2,and cell movement--similar messages,different meanings?.Developmental Cell,2001,1(6)743-747
[14]Golub T,Caroni P.PI(4,5)P2-dependent microdomain assemblies capture microtubules to promote and control leading edge motility The Journal of Cell Biology,2005,169(1):151-165
[15]Ling K,Schill N J,Wagoner M P,et al.Movin'on up:the role of Ptd Ins(4,5)P(2)in cell migration.Trends in Cell Biology,2006,16(6):276-284
[16]Yin H L,Janmey P A.Phosphoinositide regulation of the actin cytoskeleton.Annual Review of Physiology,2003,65(1):761-789
[17]Sun Y,Thapa N,Hedman A C,et al.Phosphatidylinositol 4,5-bisphosphate:targeted production and signaling.Bio Essays:News and Reviews in Molecular,Cellular and Developmental Biology,2013,35(6):513-522
[18]Pinon P,Parssinen J,Vazquez P,et al.Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing.The Journal of Cell Biology,2014,205(2):265-281
[19]Kalli A C,Campbell I D,Sansom M S.Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helices.Plos Computational Biology,2013,9(10):e1003316
[20]Ling K,Doughman R L,Firestone A J,et al.Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.Nature,2002,420(6911):89-93
[21]Legate K R,Takahashi S,Bonakdar N,et al.Integrin adhesion and force coupling are independently regulated by localized Ptd Ins(4,5)2 synthesis.The EMBO Journal,2011,30(22):4539-4553
[22]Elliott P R,Goult B T,Kopp P M,et al.The structure of the talin head reveals a novel extended conformation of the FERM domain.Structure,2010,18(10):1289-1299
[23]Thapa N,Sun Y,Schramp M,et al.Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells.Developmental Cell,2012,22(1):116-130
[24]Calderwood D A,Campbell I D,Critchley D R.Talins and kindlins:partners in integrin-mediated adhesion.Nature Reviews Molecular Cell Biology,2013,14(8):503-517
[25]Hara Y,Fukaya M,Tamaki H,et al.Type I phosphatidylinositol 4-phosphate 5-kinase gamma is required for neuronal migration in the mouse developing cerebral cortex.The European Journal of Neuroscience,2013,38(5):2659-2671
[26]Le O T,Cho O Y,Tran M H,et al.Phosphorylation of phosphatidylinositol 4-phosphate 5-kinase gamma by Akt regulates its interaction with talin and focal adhesion dynamics.Biochimica et Biophysica Acta,2015,1853(10 Pt A):2432-2443
[27]Hammond G R,Fischer M J,Anderson K E,et al.PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity.Science,2012,337(6095):727-730
[28]Chao W T,Daquinag A C,Ashcroft F,et al.Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation.The Journal of Cell Biology,2010,190(2):247-262
[29]Halstead J R,Savaskan N E,Van Den Bout I,et al.Rac controls PIP5K localisation and Ptd Ins(4,5)P(2)synthesis,which modulates vinculin localisation and neurite dynamics.Journal of Cell Science,2010,123(Pt 20):3535-3546
[30]Porciello N,Kunkl M,Viola A,et al.Phosphatidylinositol 4-phosphate 5-kinases in the regulation of T cell activation.Frontiers in Immunology,2016,7:186
[31]Goicoechea S M,Awadia S,Garcia-Mata R.I'm coming to GEFyou:regulation of Rho GEFs during cell migration.Cell Adhesion&Migration,2014,8(6):535-549
[32]Rozelle A L,Machesky L M,Yamamoto M,et al Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3Current Biology:CB,2000,10(6):311-320
[33]Choi S,Thapa N,Hedman A C,et al.IQGAP1 is a nove phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration.The EMBO Journal,2013,32(19)2617-2630
[34]White C D,Erdemir H H,Sacks D B.IQGAP1 and its binding proteins control diverse biological functions.Cellular Signalling,2012,24(4):826-834
[35]Dixon M J,Gray A,Schenning M,et al.IQGAP proteins reveal an atypical phosphoinositide(a PI)binding domain with a pseudo C2domain fold.The Journal of Biological Chemistry,2012,287(27):22483-22496
[36]Rong Y,Liu M,Ma L,et al.Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation.Nature Cell Biology,2012,14(9):924-934
[37]Thapa N,Choi S,Hedman A,et al.Phosphatidylinositol phosphate5-kinase Igammai2 in association with Src controls anchorageindependent growth of tumor cells.The Journal of Biological Chemistry,2013,288(48):34707-34718
[2]De Craene J O,Bertazzi D L,Bar S,et al.Phosphoinositides,major actors in membrane trafficking and lipid signaling pathways International Journal of Molecular Sciences,2017,18(3):634-654
[3]Patra M C,Choi S.Insight into phosphatidylinositol-dependen membrane localization of the innate immune adaptor protein toll interleukin 1 receptor domain-containing adaptor protein Frontiers in Immunology,2018,9:75
[4]Loo L,Wright B D,Zylka M J.Lipid kinases as therapeutic targets for chronic pain.Pain,2015,156(1):S2-10
[5]Chen X,Wan J,Yu B,et al.PIP5K1 alpha promotes myogenic differentiation via AKT activation and calcium release.Stem Cel Research&Therapy,2018,9(1):33
[6]Watanabe T,Noritake J,Kaibuchi K.Regulation of microtubules in cell migration.Trends in Cell Biology,2005,15(2):76-83
[7]Ridley A J.Life at the leading edge.Cell,2011,145(7):1012-1022
[8]Parsons J T,Horwitz A R,Schwartz M A.Cell adhesion integrating cytoskeletal dynamics and cellular tension.Nature Reviews Molecular Cell Biology,2010,11(9):633-643
[9]Thapa N,Anderson R A.PIP2 signaling,an integrator of cel polarity and vesicle trafficking in directionally migrating cells Cell Adhesion&Migration,2012,6(5):409-412
[10]Wang Y,Lian L,Golden J A,et al.PIP5KI gamma is required for cardiovascular and neuronal development.Proc Natl Sci USA2007,104(28):11748-11753
[11]Dyson J M,Conduit S E,Feeney S J,et al.INPP5E regulates phosphoinositide-dependent cilia transition zone function.The Journal of Cell Biology,2017,216(1):247-263
[12]Narkis G,Ofir R,Landau D,et al.Lethal contractural syndrome type 3(LCCS3)is caused by a mutation in PIP5K1C,which encodes PIPKI gamma of the phophatidylinsitol pathway American Journal of Human Genetics,2007,81(3):530-539
[13]Insall R H,Weiner O D.PIP3,PIP2,and cell movement--similar messages,different meanings?.Developmental Cell,2001,1(6)743-747
[14]Golub T,Caroni P.PI(4,5)P2-dependent microdomain assemblies capture microtubules to promote and control leading edge motility The Journal of Cell Biology,2005,169(1):151-165
[15]Ling K,Schill N J,Wagoner M P,et al.Movin'on up:the role of Ptd Ins(4,5)P(2)in cell migration.Trends in Cell Biology,2006,16(6):276-284
[16]Yin H L,Janmey P A.Phosphoinositide regulation of the actin cytoskeleton.Annual Review of Physiology,2003,65(1):761-789
[17]Sun Y,Thapa N,Hedman A C,et al.Phosphatidylinositol 4,5-bisphosphate:targeted production and signaling.Bio Essays:News and Reviews in Molecular,Cellular and Developmental Biology,2013,35(6):513-522
[18]Pinon P,Parssinen J,Vazquez P,et al.Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing.The Journal of Cell Biology,2014,205(2):265-281
[19]Kalli A C,Campbell I D,Sansom M S.Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helices.Plos Computational Biology,2013,9(10):e1003316
[20]Ling K,Doughman R L,Firestone A J,et al.Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.Nature,2002,420(6911):89-93
[21]Legate K R,Takahashi S,Bonakdar N,et al.Integrin adhesion and force coupling are independently regulated by localized Ptd Ins(4,5)2 synthesis.The EMBO Journal,2011,30(22):4539-4553
[22]Elliott P R,Goult B T,Kopp P M,et al.The structure of the talin head reveals a novel extended conformation of the FERM domain.Structure,2010,18(10):1289-1299
[23]Thapa N,Sun Y,Schramp M,et al.Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells.Developmental Cell,2012,22(1):116-130
[24]Calderwood D A,Campbell I D,Critchley D R.Talins and kindlins:partners in integrin-mediated adhesion.Nature Reviews Molecular Cell Biology,2013,14(8):503-517
[25]Hara Y,Fukaya M,Tamaki H,et al.Type I phosphatidylinositol 4-phosphate 5-kinase gamma is required for neuronal migration in the mouse developing cerebral cortex.The European Journal of Neuroscience,2013,38(5):2659-2671
[26]Le O T,Cho O Y,Tran M H,et al.Phosphorylation of phosphatidylinositol 4-phosphate 5-kinase gamma by Akt regulates its interaction with talin and focal adhesion dynamics.Biochimica et Biophysica Acta,2015,1853(10 Pt A):2432-2443
[27]Hammond G R,Fischer M J,Anderson K E,et al.PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity.Science,2012,337(6095):727-730
[28]Chao W T,Daquinag A C,Ashcroft F,et al.Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation.The Journal of Cell Biology,2010,190(2):247-262
[29]Halstead J R,Savaskan N E,Van Den Bout I,et al.Rac controls PIP5K localisation and Ptd Ins(4,5)P(2)synthesis,which modulates vinculin localisation and neurite dynamics.Journal of Cell Science,2010,123(Pt 20):3535-3546
[30]Porciello N,Kunkl M,Viola A,et al.Phosphatidylinositol 4-phosphate 5-kinases in the regulation of T cell activation.Frontiers in Immunology,2016,7:186
[31]Goicoechea S M,Awadia S,Garcia-Mata R.I'm coming to GEFyou:regulation of Rho GEFs during cell migration.Cell Adhesion&Migration,2014,8(6):535-549
[32]Rozelle A L,Machesky L M,Yamamoto M,et al Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3Current Biology:CB,2000,10(6):311-320
[33]Choi S,Thapa N,Hedman A C,et al.IQGAP1 is a nove phosphatidylinositol 4,5 bisphosphate effector in regulation of directional cell migration.The EMBO Journal,2013,32(19)2617-2630
[34]White C D,Erdemir H H,Sacks D B.IQGAP1 and its binding proteins control diverse biological functions.Cellular Signalling,2012,24(4):826-834
[35]Dixon M J,Gray A,Schenning M,et al.IQGAP proteins reveal an atypical phosphoinositide(a PI)binding domain with a pseudo C2domain fold.The Journal of Biological Chemistry,2012,287(27):22483-22496
[36]Rong Y,Liu M,Ma L,et al.Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation.Nature Cell Biology,2012,14(9):924-934
[37]Thapa N,Choi S,Hedman A,et al.Phosphatidylinositol phosphate5-kinase Igammai2 in association with Src controls anchorageindependent growth of tumor cells.The Journal of Biological Chemistry,2013,288(48):34707-34718