年龄在不同分子分型乳腺癌患者中的预后价值
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摘要
目的分析年龄在不同分子分型乳腺癌患者中的预后价值。方法选取2003年1月-2008年12月于天津医科大学肿瘤医院就诊的2 658例乳腺癌患者,根据患者的年龄分为两组,年龄<35岁的141例作为年轻组,年龄≥35岁的2 517例作为年长组。通过生存分析研究年龄在不同分子分型乳腺癌中的预后价值。结果年龄是影响乳腺癌预后的重要因素之一,年轻组的患者总体预后要差于年长组,差异有统计学意义(P<0.01)。通过分层分析发现,年龄在Luminal A型和HER2过表达型中的预后区分价值不大,差异无统计学意义(P>0.05);而在Luminal B型和三阴性中,年轻组的预后要差于年长组,差异有统计学意义(P<0.01)。结论年龄是影响乳腺癌患者的重要因素之一,年轻乳腺癌患者的预后相对较差,尤其是在Luminal B型和三阴性乳腺癌患者中,对于此类乳腺癌患者应该进行积极的治疗和随访。
Objective To analyze the prognostic value of age in patients with different molecular types of breast cancer. Methods A total of 2 658 breast cancer patients who were admitted to Tianjin Medical University Cancer Hospital from January 2003 to December 2008 were selected and divided into two groups according to their age, 141 cases <35 years old as the younger group, and 2 517 cases ≥35 years old as the elderly group. The prognostic value of age in different molecular types of breast cancer was studied by survival analysis. Results Age was one of the important factors affecting the prognosis of breast cancer patients. The overall prognosis of the younger group was worse than that of the elderly group, the difference was statistically significant(P<0.01). There was no significant difference on the prognosis of age between the Luminal A group and the HER2 overexpression group(P>0.05). In Luminal B type and triple negative, the prognosis of the younger type was worse than that of the elderly type, the differences were statistically significant(P <0.01). Conclusion Age is one of the important factors affecting breast cancer patients. The prognosis of young breast cancer patients is relatively poor, especially in patients with Luminal B type and triple negative breast cancer. For such breast cancer patients, active treatment and follow-up should be given.
Objective To analyze the prognostic value of age in patients with different molecular types of breast cancer. Methods A total of 2 658 breast cancer patients who were admitted to Tianjin Medical University Cancer Hospital from January 2003 to December 2008 were selected and divided into two groups according to their age, 141 cases <35 years old as the younger group, and 2 517 cases ≥35 years old as the elderly group. The prognostic value of age in different molecular types of breast cancer was studied by survival analysis. Results Age was one of the important factors affecting the prognosis of breast cancer patients. The overall prognosis of the younger group was worse than that of the elderly group, the difference was statistically significant(P<0.01). There was no significant difference on the prognosis of age between the Luminal A group and the HER2 overexpression group(P>0.05). In Luminal B type and triple negative, the prognosis of the younger type was worse than that of the elderly type, the differences were statistically significant(P <0.01). Conclusion Age is one of the important factors affecting breast cancer patients. The prognosis of young breast cancer patients is relatively poor, especially in patients with Luminal B type and triple negative breast cancer. For such breast cancer patients, active treatment and follow-up should be given.
引文
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[2]艾勇彪,张丹峰,李文仿,等.青年和老年乳腺癌病理特征及预后差异的分析[J].现代肿瘤医学,2018,26(23):3764-3767.
[3] Kim SW,Chun M,Han S,et al.Young age is associated with increased locoregional recurrence in node-positive breast cancer with luminal subtypes[J].Cancer Research&Treatment,2017,49(2):484-493.
[4]王萍,何谦,唐丹萍,等.35岁以下女性乳腺癌的临床病理特征及其与预后的相关性[J].昆明医科大学学报,2018,39(10):105-110.
[5] Fredholm H,Magnusson K,Lindstr?m LS,et al.Long-term outcome in young women with breast cancer:A population-based study[J].Breast Cancer Research&Treatment,2016,160(1):131-143.