猪肠道微生物及其营养调控
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摘要
传统动物营养学主要关注营养物质在肠道中被直接消化、吸收和利用的部分,但忽视了肠道微生物的作用。近年来,四川农业大学动物营养研究所猪营养团队在此领域做了系统研究,文章将对此作一综述,以期为健康、高效、安全的动物生产提供新思路。
The direct digestion, absorption and utilization of nutrients in the gastrointestinal tract is mostly concerned in studies on traditional animal nutrition. However, the role of intestinal microorganisms has been ignored for a long time. In recent years, the interaction between dietary nutrients and gut microbes in pigs was systematically investigated by Team of Swine Nutrition, Institute of Animal Nutrition, Sichuan Agricultural University, and the main findings are summerized and reviewed in current paper in order to provide new ideas for healthy, efficient and safe animal production.
The direct digestion, absorption and utilization of nutrients in the gastrointestinal tract is mostly concerned in studies on traditional animal nutrition. However, the role of intestinal microorganisms has been ignored for a long time. In recent years, the interaction between dietary nutrients and gut microbes in pigs was systematically investigated by Team of Swine Nutrition, Institute of Animal Nutrition, Sichuan Agricultural University, and the main findings are summerized and reviewed in current paper in order to provide new ideas for healthy, efficient and safe animal production.
引文
[1]Diao H,Yan H L,Xiao Y,et al.Intestinal microbiota could transfer host Gut characteristics from pigs to mice[J].BMC Microbiology,2016,16(1):238.
[2]Diao H,Yan H L,Xiao Y,et al.Modulation of intestine development by fecal microbiota transplantation in suckling pigs[J].Rsc.Advances,2018,8(16):8709-8720.
[3]Yan H,Diao H,Xiao Y,et al.Gut microbiota can transfer fiber characteristics and lipid metabolic profiles of skeletal muscle from pigs to germ-free mice[J].Scientific Reports,2016,6:31786.
[4]Chen H,Wang W,Degroote J,et al.Arabinoxylan in wheat is more responsible than cellulose for promoting intestinal barrier function in weaned male piglets[J].Journal of Nutrition,2015,145(1):51.
[5]Chen H,Mao X,He J,et al.Dietary fibre affects intestinal mucosal barrier function and regulates intestinal bacteria in weaning piglets[J].Communications in Agricultural&Applied Biological Sciences,2013,110(10):1837-1848.
[6]Chen H,Mao X B,Che L Q,et al.Impact of fiber types on gut microbiota,gut environment and gut function in fattening pigs[J].Animal Feed Science&Technology,2014,195(9):101-111.
[7]Luo Y,Chen H,Yu B,et al.Dietary pea fibre alters the microbial community and fermentation with increase in fibre degradation-associated bacterial groups in the colon of pigs[J].Journal of Animal Physiology and Animal Nutrition,2017,102.
[8]罗玉衡,陈洪,余冰,等.短期或长期饲喂高水平豌豆纤维对猪盲肠微生物群落结构和代谢产物的影响[J].畜牧兽医学报,2017,48(8):1459-1467.
[9]Luo Y,Chen H,Yu B,et al.Dietary pea fiber increases diversity of colonic methanogens of pigs with a shift from Methanobrevibacter,to Methanomassiliicoccus-like genus and change in numbers of three hydrogenotrophs[J].BMC Microbiology,2017,17(1):17.
[10]赵瑶,张玲,陈代文,等.短期摄入不同纤维源对猪生长性能、胴体性状、肉品质的影响[J].四川农业大学学报,2018(2):117-125.
[11]赵瑶.日粮纤维源对生长猪生产性能和肠道健康的影响机制及肠道微生物的媒介作用[D].四川农业大学,2018.
[12]张玲.饲粮中短期内单独及混合添加高水平燕麦β-葡聚糖和微晶纤维素对小鼠生长性能、器官指数和粪便细菌群落结构的影响[D].四川农业大学,2017.
[13]陈婷婷.饲粮添加可溶性和不溶性纤维对断奶仔猪生长性能及肠道健康的影响[D].四川农业大学,2018.
[14]吴希颖.不同非淀粉多糖组分对断奶仔猪生长性能和肠道健康的影响及机制[D].四川农业大学,2018.
[15]Xiang Z,Qi H,Han G,et al.Real-time TaqMan polymerase chain reaction to quantify the effects of different sources of dietary starch on Bifidobacterium in the intestinal tract of piglets[J].African Journal of Biotechnology,2011,10(25):5059-5067.
[16]Han G Q,Xiang Z T,Yu B,et al.Effects of different starch sources on Bacillus spp.in intestinal tract and expression of intestinal development related genes of weanling piglets[J].Molecular Biology Reports,2012,39(2):1869-1876.
[17]Luo Y H,Yang C,Wright A D G,et al.Responses in ileal and cecal bacteria to low and high amylose/amylopectin ratio diets in growing pigs[J].Applied Microbiol Biotechnology,2015,99(24):10627-10638.
[18]Wan J,Jiang F,Xu Q,et al.Alginic acid oligosaccharide accelerates weaned pig growth through regulating antioxidant capacity,immunity and intestinal development[J].Rsc.Advances,2016,6(90):87026-87035.
[19]Mao X,Xiao X,Chen D,et al.Dietary apple pectic oligosaccharide improves gut barrier function of rotavirus-challenged weaned pigs by increasing antioxidant capacity of enterocytes[J].Oncotarget,2017,8(54):92420-92430.
[20]段旭东.饲粮添加甘露寡糖对母猪繁殖性能、免疫功能及后代生长、免疫和肠道微生物的影响[D].四川农业大学,2013.
[21]Wan J,Jiang F,Xu Q,et al.New insights into the role of chitosan oligosaccharide in enhancing growth performance,antioxidant capacity,immunity and intestinal development of weaned pigs[J].Rsc.Advances,2017,7(16):9669-9679.
[22]司马博锋,陈代文,黄志清,等.固态发酵复合蛋白质对猪肠道消化生理及养分消化率的影响研究[J].动物营养学报,2011,23(1):86-93.
[23]赵玉梅.低蛋白日粮不同必需氨基酸平衡模式对生长育肥猪的影响[D].四川农业大学,2018.
[24]刘忠臣.不同来源脂肪对仔猪的营养效应及对E.coli攻毒的保护作用研究[D].四川农业大学,2011.
[25]陈洪,余冰,陈代文,等.日粮中添加恩拉霉素对仔猪生产性能和肠道菌群的影响[J].中国畜牧杂志,2010,46(19):42-47.
[26]毛倩,陈代文,余冰,等.复合益生素对生长育肥猪生产性能、盲肠菌群及代谢产物的影响[J].中国畜牧杂志,2010,46(17):34-39.
[27]伏润奇.饲粮添加凝结芽孢杆菌和酵母水解物对断奶仔猪生长性能及肠道健康的影响[D].四川农业大学,2018.
[28]王茹.益生菌E.faecium NCIMB 10415对新生及断奶仔猪生长性能、肠道菌群及免疫功能的影[D].四川农业大学,2018.
[29]Diao H,Zheng P,Yu B,et al.Effects of dietary supplementation with benzoic acid on intestinal morphological structure and microflora in weaned piglets[J].Livestock Science,2014,167(1):249-256.
[30]Wan J,Li Y,Chen D,et al.Recombinant plectasin elicits similar improvements in the performance and intestinal mucosa growth and activity in weaned pigs as an antibiotic[J].Animal Feed Science and Technology,2016,211:216-226.
[31]叶楠,陈代文,毛湘冰,等.不同木聚糖水平饲粮中添加木聚糖酶对断奶仔猪生长性能及肠道微生态环境的影响[J].动物营养学报,2011,23(11):1961-1969.
[32]王利,何军,余冰,等.小麦基础饲粮中添加木聚糖酶对生长猪生长性能、血清生化指标及肠道微生物菌群的影响[J].动物营养学报,2012,24(10):1920-1927.
[33]何鑫.非淀粉多糖酶对饲粮养分消化和仔猪肠道健康的影响研究[D].四川农业大学,2018.
[34]Diao H,Jiao A R,Yu B,et al.Stimulation of intestinal growth with distal ileal infusion of short-chain fatty acid:a reevaluation in a pig model[J].Rsc.Advances,2017,7(49):30792-30806.
[35]Xiao Y,Yan H,Diao H,et al.Early gut microbiota intervention suppresses DSS-induced inflammatory responses by deactivating TLR/NLR signalling in pigs[J].Scientific Reports,2017,7(1):3224.
[36]肖熠.肠道微生物与宿主免疫应答及其互作机制[D].四川农业大学,2017.
[2]Diao H,Yan H L,Xiao Y,et al.Modulation of intestine development by fecal microbiota transplantation in suckling pigs[J].Rsc.Advances,2018,8(16):8709-8720.
[3]Yan H,Diao H,Xiao Y,et al.Gut microbiota can transfer fiber characteristics and lipid metabolic profiles of skeletal muscle from pigs to germ-free mice[J].Scientific Reports,2016,6:31786.
[4]Chen H,Wang W,Degroote J,et al.Arabinoxylan in wheat is more responsible than cellulose for promoting intestinal barrier function in weaned male piglets[J].Journal of Nutrition,2015,145(1):51.
[5]Chen H,Mao X,He J,et al.Dietary fibre affects intestinal mucosal barrier function and regulates intestinal bacteria in weaning piglets[J].Communications in Agricultural&Applied Biological Sciences,2013,110(10):1837-1848.
[6]Chen H,Mao X B,Che L Q,et al.Impact of fiber types on gut microbiota,gut environment and gut function in fattening pigs[J].Animal Feed Science&Technology,2014,195(9):101-111.
[7]Luo Y,Chen H,Yu B,et al.Dietary pea fibre alters the microbial community and fermentation with increase in fibre degradation-associated bacterial groups in the colon of pigs[J].Journal of Animal Physiology and Animal Nutrition,2017,102.
[8]罗玉衡,陈洪,余冰,等.短期或长期饲喂高水平豌豆纤维对猪盲肠微生物群落结构和代谢产物的影响[J].畜牧兽医学报,2017,48(8):1459-1467.
[9]Luo Y,Chen H,Yu B,et al.Dietary pea fiber increases diversity of colonic methanogens of pigs with a shift from Methanobrevibacter,to Methanomassiliicoccus-like genus and change in numbers of three hydrogenotrophs[J].BMC Microbiology,2017,17(1):17.
[10]赵瑶,张玲,陈代文,等.短期摄入不同纤维源对猪生长性能、胴体性状、肉品质的影响[J].四川农业大学学报,2018(2):117-125.
[11]赵瑶.日粮纤维源对生长猪生产性能和肠道健康的影响机制及肠道微生物的媒介作用[D].四川农业大学,2018.
[12]张玲.饲粮中短期内单独及混合添加高水平燕麦β-葡聚糖和微晶纤维素对小鼠生长性能、器官指数和粪便细菌群落结构的影响[D].四川农业大学,2017.
[13]陈婷婷.饲粮添加可溶性和不溶性纤维对断奶仔猪生长性能及肠道健康的影响[D].四川农业大学,2018.
[14]吴希颖.不同非淀粉多糖组分对断奶仔猪生长性能和肠道健康的影响及机制[D].四川农业大学,2018.
[15]Xiang Z,Qi H,Han G,et al.Real-time TaqMan polymerase chain reaction to quantify the effects of different sources of dietary starch on Bifidobacterium in the intestinal tract of piglets[J].African Journal of Biotechnology,2011,10(25):5059-5067.
[16]Han G Q,Xiang Z T,Yu B,et al.Effects of different starch sources on Bacillus spp.in intestinal tract and expression of intestinal development related genes of weanling piglets[J].Molecular Biology Reports,2012,39(2):1869-1876.
[17]Luo Y H,Yang C,Wright A D G,et al.Responses in ileal and cecal bacteria to low and high amylose/amylopectin ratio diets in growing pigs[J].Applied Microbiol Biotechnology,2015,99(24):10627-10638.
[18]Wan J,Jiang F,Xu Q,et al.Alginic acid oligosaccharide accelerates weaned pig growth through regulating antioxidant capacity,immunity and intestinal development[J].Rsc.Advances,2016,6(90):87026-87035.
[19]Mao X,Xiao X,Chen D,et al.Dietary apple pectic oligosaccharide improves gut barrier function of rotavirus-challenged weaned pigs by increasing antioxidant capacity of enterocytes[J].Oncotarget,2017,8(54):92420-92430.
[20]段旭东.饲粮添加甘露寡糖对母猪繁殖性能、免疫功能及后代生长、免疫和肠道微生物的影响[D].四川农业大学,2013.
[21]Wan J,Jiang F,Xu Q,et al.New insights into the role of chitosan oligosaccharide in enhancing growth performance,antioxidant capacity,immunity and intestinal development of weaned pigs[J].Rsc.Advances,2017,7(16):9669-9679.
[22]司马博锋,陈代文,黄志清,等.固态发酵复合蛋白质对猪肠道消化生理及养分消化率的影响研究[J].动物营养学报,2011,23(1):86-93.
[23]赵玉梅.低蛋白日粮不同必需氨基酸平衡模式对生长育肥猪的影响[D].四川农业大学,2018.
[24]刘忠臣.不同来源脂肪对仔猪的营养效应及对E.coli攻毒的保护作用研究[D].四川农业大学,2011.
[25]陈洪,余冰,陈代文,等.日粮中添加恩拉霉素对仔猪生产性能和肠道菌群的影响[J].中国畜牧杂志,2010,46(19):42-47.
[26]毛倩,陈代文,余冰,等.复合益生素对生长育肥猪生产性能、盲肠菌群及代谢产物的影响[J].中国畜牧杂志,2010,46(17):34-39.
[27]伏润奇.饲粮添加凝结芽孢杆菌和酵母水解物对断奶仔猪生长性能及肠道健康的影响[D].四川农业大学,2018.
[28]王茹.益生菌E.faecium NCIMB 10415对新生及断奶仔猪生长性能、肠道菌群及免疫功能的影[D].四川农业大学,2018.
[29]Diao H,Zheng P,Yu B,et al.Effects of dietary supplementation with benzoic acid on intestinal morphological structure and microflora in weaned piglets[J].Livestock Science,2014,167(1):249-256.
[30]Wan J,Li Y,Chen D,et al.Recombinant plectasin elicits similar improvements in the performance and intestinal mucosa growth and activity in weaned pigs as an antibiotic[J].Animal Feed Science and Technology,2016,211:216-226.
[31]叶楠,陈代文,毛湘冰,等.不同木聚糖水平饲粮中添加木聚糖酶对断奶仔猪生长性能及肠道微生态环境的影响[J].动物营养学报,2011,23(11):1961-1969.
[32]王利,何军,余冰,等.小麦基础饲粮中添加木聚糖酶对生长猪生长性能、血清生化指标及肠道微生物菌群的影响[J].动物营养学报,2012,24(10):1920-1927.
[33]何鑫.非淀粉多糖酶对饲粮养分消化和仔猪肠道健康的影响研究[D].四川农业大学,2018.
[34]Diao H,Jiao A R,Yu B,et al.Stimulation of intestinal growth with distal ileal infusion of short-chain fatty acid:a reevaluation in a pig model[J].Rsc.Advances,2017,7(49):30792-30806.
[35]Xiao Y,Yan H,Diao H,et al.Early gut microbiota intervention suppresses DSS-induced inflammatory responses by deactivating TLR/NLR signalling in pigs[J].Scientific Reports,2017,7(1):3224.
[36]肖熠.肠道微生物与宿主免疫应答及其互作机制[D].四川农业大学,2017.