正常高值血压患者心血管危险因素和中医体质的相关性研究
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摘要
目的:通过对正常高值血压患者进行中医体质分型,统计患者的血管紧张素Ⅱ(AngⅡ)等心血管危险因素,通过危险因素和中医体质的相关性分析,探讨高危人群的中医体质特征。方法:采用中医体质评分量表对150例正常高值血压患者进行中医体质分类,运用体质九分法,并记录患者的身高、体质量、吸烟史、饮酒史、家族史、血浆AngⅡ、血糖、低密度脂蛋白胆固醇(LDL-C)等,利用统计学方法处理数据,寻找AngⅡ、身体质量指数(BMI)、血糖、LDL-C、年龄、吸烟史、饮酒史、家族史等因素和中医体质之间的相关性,从而通过此类心血管危险因素筛选出正常高值血压人群中的高危体质。结果:不同中医体质人群在吸烟史、饮酒史、家族史方面,差异无统计学意义(P> 0. 05),痰湿质和湿热质人群的AngⅡ、BMI、血糖、LDL-C明显高于其他体质人群,差异有统计学意义(P <0. 05)。结论:痰湿质和湿热质属于高危体质,其发展为高血压病的风险比其他体质高,应予以早期干预。
Objective: To investigate the traditional Chinese medicine( TCM) constitution,cardiovascular risk factors including angiotensin II( AngII),and their association in patients with high-normal blood pressure,as well as the features of TCM constitution in high-risk population. Methods: The TCM constitution scoring scale was used to determine the TCM constitution of 150 patients with high-normal blood pressure based on the classification of nine TCM constitutions. Related data were recorded,including body height,body weight,smoking history,drinking history,family history,plasma AngII,blood glucose,and low-density lipoprotein cholesterol( LDL-C),and a statistical analysis was performed to investigate the association of AngII,body mass index( BMI),blood glucose,LDL-C,age,smoking history,drinking history,and family history with TCM constitution. Such cardiovascular risk factors were used to screen out high-risk TCM constitutions in the population with high-normal blood pressure. Results: There were no significant differences in smoking history,drinking history,and family history between the individuals with different TCM constitutions( P > 0. 05). The individuals with phlegm-dampness constitution and damp-heat constitution had significantly higher levels of AngII,BMI,blood glucose,and LDL-C than those with other constitutions( P < 0. 05). Conclusion: Phlegm-dampness constitution and damp-heat constitution are high-risk constitutions,and the individuals with such constitutions have a higher risk of hypertension than those with other constitutions. Therefore,early intervention should be performed.
Objective: To investigate the traditional Chinese medicine( TCM) constitution,cardiovascular risk factors including angiotensin II( AngII),and their association in patients with high-normal blood pressure,as well as the features of TCM constitution in high-risk population. Methods: The TCM constitution scoring scale was used to determine the TCM constitution of 150 patients with high-normal blood pressure based on the classification of nine TCM constitutions. Related data were recorded,including body height,body weight,smoking history,drinking history,family history,plasma AngII,blood glucose,and low-density lipoprotein cholesterol( LDL-C),and a statistical analysis was performed to investigate the association of AngII,body mass index( BMI),blood glucose,LDL-C,age,smoking history,drinking history,and family history with TCM constitution. Such cardiovascular risk factors were used to screen out high-risk TCM constitutions in the population with high-normal blood pressure. Results: There were no significant differences in smoking history,drinking history,and family history between the individuals with different TCM constitutions( P > 0. 05). The individuals with phlegm-dampness constitution and damp-heat constitution had significantly higher levels of AngII,BMI,blood glucose,and LDL-C than those with other constitutions( P < 0. 05). Conclusion: Phlegm-dampness constitution and damp-heat constitution are high-risk constitutions,and the individuals with such constitutions have a higher risk of hypertension than those with other constitutions. Therefore,early intervention should be performed.
引文
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[5]Whelton PK,Carey RM,Aronow WS,et al.2017ACC/AHA/AA-PA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCN A guideline for the prevention,detection,evaluation,and management of high blood pressure in adults:a report of the american college of cardiology/american heart association task force on clinical practice guidelines[J].J Am Coll Cardiol,2017,1097(17):41519-41523.
[2]Chobanian AV,Bakris GL,Black HR,et al.Seventh report of the joint national committee on prevention,detection,evaluation and treatment of high blood pressure[J].Hypertension,2003,42(6):1206-1255.
[3]罗晓佳,胡咏梅.正常高值血压临床研究进展[J].中华高血压杂志,2015,23(6):526-528.
[4]王琦.中国式的精准医学:九体医学健康计划[J].中华中医药杂志,2015,33(10):3407-3411.
[5]Whelton PK,Carey RM,Aronow WS,et al.2017ACC/AHA/AA-PA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCN A guideline for the prevention,detection,evaluation,and management of high blood pressure in adults:a report of the american college of cardiology/american heart association task force on clinical practice guidelines[J].J Am Coll Cardiol,2017,1097(17):41519-41523.