PLLA/CS-g-PCL电纺纤维膜的制备及结构性能表征
|
摘要
将自制的壳聚糖接枝聚己内酯(CS-g-PCL)与聚左旋乳酸(PLLA)分别溶解在二氯甲烷/N,N-二甲基甲酰胺(体积比为7∶3)共混溶剂中制备出相同质量浓度的均匀溶液,然后将两种溶液以不同的质量比共混制备PLLA/CS-g-PCL混合纺丝液,通过静电纺丝制备PLLA/CS-g-PCL电纺纤维膜,借助扫描电镜、傅里叶变换红外光谱、接触角测量仪及强度拉伸仪等测试手段对其结构和性能进行研究。结果表明:当PLLA/CS-g-PCL混合溶液的质量浓度为0.15 g/m L,PLLA与CS-g-PCL质量比8∶2时,PLLA/CS-g-PCL电纺纤维膜的纤维表面光滑,平均直径为760.1 nm,纤维膜的孔隙率为84.6%,接触角为73°,吸水率为482.2%,拉伸强度为3.54 MPa,拉伸模量为125.4 MPa,断裂伸长率为93.8%;相比于纯PLLA电纺纤维膜,PLLA/CS-gPCL电纺纤维膜的亲水性和吸水性得到了改善,模量和断裂伸长率也得到了提高。
A self-made chitosan-grafted polycaprolactone( CS-g-PCL) and poly( L-lactic acid)( PLLA) were separately dissolved in dichloromethane/N,N-dimethylformamide( volume ratio of 7 ∶3) blend solvent to prepare uniform solutions of the same mass concentration which were prepared into a PLLA/CS-g-PCL spinning solution by blending at different mass ratios. And a electrospun PLLA/CS-g-PCL fiber membrane was prepared by electrospinning process. The structure and properties of the electrospun PLLA/CS-g-PCL fiber membrane were studied by scanning electron microscopy,Fourier transform infrared spectrometry,contact angle detector and tensile tester. The results showed that the electrospun PLLA/CS-g-PCL fiber membrane had the smooth surface,the average diameter of 760. 1 nm,porosity 84. 6%,contact angle 73°,water adsorption 482. 2%,tensile strength3. 54 MPa,tensile modulus 125. 4 MPa and elongation at break 93. 8% when the mass concentration of PLLA/CS-g-PCL mixture solution was 0. 15 g/m L and the mass ratio of PLLA and CS-g-PCL was 8∶2; and as compared with pure electrospun PLLA fiber membrane,the electrospun PLLA/CS-g-PCL fiber membrane was better in the hydrophilicity,water adsorption,modulus and elongation at break.
A self-made chitosan-grafted polycaprolactone( CS-g-PCL) and poly( L-lactic acid)( PLLA) were separately dissolved in dichloromethane/N,N-dimethylformamide( volume ratio of 7 ∶3) blend solvent to prepare uniform solutions of the same mass concentration which were prepared into a PLLA/CS-g-PCL spinning solution by blending at different mass ratios. And a electrospun PLLA/CS-g-PCL fiber membrane was prepared by electrospinning process. The structure and properties of the electrospun PLLA/CS-g-PCL fiber membrane were studied by scanning electron microscopy,Fourier transform infrared spectrometry,contact angle detector and tensile tester. The results showed that the electrospun PLLA/CS-g-PCL fiber membrane had the smooth surface,the average diameter of 760. 1 nm,porosity 84. 6%,contact angle 73°,water adsorption 482. 2%,tensile strength3. 54 MPa,tensile modulus 125. 4 MPa and elongation at break 93. 8% when the mass concentration of PLLA/CS-g-PCL mixture solution was 0. 15 g/m L and the mass ratio of PLLA and CS-g-PCL was 8∶2; and as compared with pure electrospun PLLA fiber membrane,the electrospun PLLA/CS-g-PCL fiber membrane was better in the hydrophilicity,water adsorption,modulus and elongation at break.
引文
[1]刘呈坤.静电纺丝技术的研究进展[J].合成纤维工业,2012,35(2):53-56.Liu Chengkun.Research progress in electrospinning process[J].Chin Syn Fiber Ind,2012,35(2):53-56.
[2]Huang Zhengming,Zhang Yanzhong,Kotaki M,et al.A review on polymer nanofibers by electrospinning and their applications in nanocomposites[J].Compos Sci Technol,2003,63(15):2223-2253.
[3]Kumar P,Gupta A,Dhakate S R,et al.Covalent immobilization of xylanase produced from Bacillus pumilus SV-85S on electrospun polymethyl methacrylate nanofiber membrane[J].Biotechnol Appl Bioc,2013,60(2):162-169.
[4]Oktay B,Kayaman-Apohan N,Suleymanoglu M,et al.Zwitterionic phosphorylcholine grafted chitosan nanofiber:Preparation,characterization and in-vitro cell adhesion behavior[J].Mater Sci Eng C-Mater Biol Appl,2016,73:569-578.
[5]Tighzert W,Habi A,Ajji A,et al.Fabrication and characterization of nanofibers based on poly(lactic acid)/chitosan blends by electrospinning and their functionalization with phospholipase A1[J].Fiber Polym,2017,18(3):514-524.
[6]Sadeghi D,Karbasi S,Razavi S,et al.Electrospun poly(hydroxybutyrate)/chitosan blend fibrous scaffolds for cartilage tissue engineering[J].J Appl Polym Sci,2016,133(47):1252-1259.
[7]Wang Junhua,Wang Li,Yu Haojie,et al.Recent progress on synthesis,property and application of modified chitosan:An overview[J].Int J Biol Macromol,2016,88:333-344.
[8]Shahzad S,Shahzadi L,Mahmood N,et al.A new synthetic methodology for the preparation of biocompatible and organo-soluble barbituric and thiobarbituric acid based chitosan derivatives for biomedical applications[J].Mater Sci Eng C,2016,66:156-163.
[9]Hoveizi E,Nabiuni M,Parivar K,et al.Functionalisation and surface modification of electrospun polylactic acid scaffold for tissue engineering[J].Cell Biol Int,2014,38(1):41-49.
[10]Yan Wei,Zhang Xuehui,Song Yu,et al.Magnetic biodegradable Fe3O4/CS/PVA nanofibrous membranes for bone regeneration[J].Biomed Mater,2011,6(5):1-15.
[11]许永静,邹黎明,卢宏伟,等.PHBV/PEG电纺纤维膜的制备及其结构与性能表征[J].合成纤维工业,2016,39(6):1-4.Xu Yongjing,Zou Liming,Lu Hongwei,et al.Preparation and characterization of structure and properties of electrospun PHBV/PEG fiber membrane[J].Chin Syn Fiber Ind,2016,39(6):1-4.
[2]Huang Zhengming,Zhang Yanzhong,Kotaki M,et al.A review on polymer nanofibers by electrospinning and their applications in nanocomposites[J].Compos Sci Technol,2003,63(15):2223-2253.
[3]Kumar P,Gupta A,Dhakate S R,et al.Covalent immobilization of xylanase produced from Bacillus pumilus SV-85S on electrospun polymethyl methacrylate nanofiber membrane[J].Biotechnol Appl Bioc,2013,60(2):162-169.
[4]Oktay B,Kayaman-Apohan N,Suleymanoglu M,et al.Zwitterionic phosphorylcholine grafted chitosan nanofiber:Preparation,characterization and in-vitro cell adhesion behavior[J].Mater Sci Eng C-Mater Biol Appl,2016,73:569-578.
[5]Tighzert W,Habi A,Ajji A,et al.Fabrication and characterization of nanofibers based on poly(lactic acid)/chitosan blends by electrospinning and their functionalization with phospholipase A1[J].Fiber Polym,2017,18(3):514-524.
[6]Sadeghi D,Karbasi S,Razavi S,et al.Electrospun poly(hydroxybutyrate)/chitosan blend fibrous scaffolds for cartilage tissue engineering[J].J Appl Polym Sci,2016,133(47):1252-1259.
[7]Wang Junhua,Wang Li,Yu Haojie,et al.Recent progress on synthesis,property and application of modified chitosan:An overview[J].Int J Biol Macromol,2016,88:333-344.
[8]Shahzad S,Shahzadi L,Mahmood N,et al.A new synthetic methodology for the preparation of biocompatible and organo-soluble barbituric and thiobarbituric acid based chitosan derivatives for biomedical applications[J].Mater Sci Eng C,2016,66:156-163.
[9]Hoveizi E,Nabiuni M,Parivar K,et al.Functionalisation and surface modification of electrospun polylactic acid scaffold for tissue engineering[J].Cell Biol Int,2014,38(1):41-49.
[10]Yan Wei,Zhang Xuehui,Song Yu,et al.Magnetic biodegradable Fe3O4/CS/PVA nanofibrous membranes for bone regeneration[J].Biomed Mater,2011,6(5):1-15.
[11]许永静,邹黎明,卢宏伟,等.PHBV/PEG电纺纤维膜的制备及其结构与性能表征[J].合成纤维工业,2016,39(6):1-4.Xu Yongjing,Zou Liming,Lu Hongwei,et al.Preparation and characterization of structure and properties of electrospun PHBV/PEG fiber membrane[J].Chin Syn Fiber Ind,2016,39(6):1-4.