血清胱抑素C、尿液肾脏损伤分子1水平对高血压肾小管间质损伤程度的评估意义
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摘要
目的探讨血清Cys C、尿液KIM-1水平对高血压肾小管间质损伤程度的评估意义。方法选取原发性高血压患者85例为高血压组,30例无器质性病变的同期健康查体者为对照组。检测比较两组的血清Cys C、尿液KIM-1、尿NGAL水平,以及SBP、DBP。结果与对照组比较,高血压组患者的SBP、DBP、血清Cys C、尿液KIM-1、尿NGAL水平均升高(P<0.05)。高血压组中,与尿NGAL水平<131.7 ng/m L的患者比较,尿NGAL水平≥131.7 ng/m L患者的SBP、DBP、血清Cys C、尿液KIM-1水平均升高(P<0.05)。高血压患者的血清Cys C水平和尿液KIM-1水平与其SBP、DBP和尿NGAL水平均呈正相关(P<0.05)。结论高血压患者的血清Cys C水平和尿液KIM-1水平与其血压水平和肾小管间质损伤程度密切相关。
Objective To investigate the significance of serum Cys C and urine KIM-1 levels in evaluating renal tubule damage in patients with hypertension. Methods 85 cases of patients with primary hypertension were selected as the hypertension group, and 30 cases of healthy subjects with no organic lesion who received physical examination at the same period were selected as the control group. The levels of serum Cys C, urine KIM-1 and NGAL, as well as SBP and DBP of the two groups were detected and compared. Results The levels of SBP, DBP, serum Cys C, and urine KIM-1 and NGAL of the hypertension group were significantly higher than those of the control group(P <0.05). In the hypertension group, the levels of SBP, DBP, serum Cys C, and urine KIM-1 of patients with urine NGAL level ≥131.7 ng/m L were significantly higher than those of patients with urine NGAL level < 131.7 ng/m L(P <0.05). The levels of serum Cys C and urine KIM-1 of hypertension patients were positively correlated with SBP, DBP and urine NGAL levels(P <0.05). Conclusions The levels of serum Cys C and urine KIM-1 are closely related to the blood pressure level and degree of renal tubule damage.
Objective To investigate the significance of serum Cys C and urine KIM-1 levels in evaluating renal tubule damage in patients with hypertension. Methods 85 cases of patients with primary hypertension were selected as the hypertension group, and 30 cases of healthy subjects with no organic lesion who received physical examination at the same period were selected as the control group. The levels of serum Cys C, urine KIM-1 and NGAL, as well as SBP and DBP of the two groups were detected and compared. Results The levels of SBP, DBP, serum Cys C, and urine KIM-1 and NGAL of the hypertension group were significantly higher than those of the control group(P <0.05). In the hypertension group, the levels of SBP, DBP, serum Cys C, and urine KIM-1 of patients with urine NGAL level ≥131.7 ng/m L were significantly higher than those of patients with urine NGAL level < 131.7 ng/m L(P <0.05). The levels of serum Cys C and urine KIM-1 of hypertension patients were positively correlated with SBP, DBP and urine NGAL levels(P <0.05). Conclusions The levels of serum Cys C and urine KIM-1 are closely related to the blood pressure level and degree of renal tubule damage.
引文
[1]刘国安.滋阴降火通络汤联合保肾康治疗高血压早期肾损害的效果[J].世界临床医学,2017,11(9):149.
[2]彭俊华,张全华,赵勇,等.血清β2-MG、Cys-C及U-m ALB在高血压肾损伤中的应用[J].现代检验医学杂志,2014,29(4):147-149.
[3]肖鸯鸯,李秋月,张莉,等.尿肾损伤分子-1和中性粒细胞明胶酶相关载脂蛋白对高血压肾损害的诊断价值[J].广东医学,2015,36(5):705-708.
[4]刘青青,陈瑶,肖雨婷.卡维地洛和美托洛尔治疗高血压的疗效及其对糖脂代谢影响的对比分析[J].中国卫生产业,2013,16(11):1035-1037.
[5]刘秀萍.超声检查在高血压肾血管病变中的应用效果评价[J].中国医药指南,2016,14(32):156-157.
[6]万世希,吕政兵,陈晓平,等.原发性高血压患者肾小管间质损伤与肾小球损伤的关系[J].西部医学,2017,29(3):351-354.
[7]李宁,柴成国,吴风春,等.肾损伤分子1在常见肾脏病中的诊断价值[J].中国老年学,2016,36(7):1683-1684.
[2]彭俊华,张全华,赵勇,等.血清β2-MG、Cys-C及U-m ALB在高血压肾损伤中的应用[J].现代检验医学杂志,2014,29(4):147-149.
[3]肖鸯鸯,李秋月,张莉,等.尿肾损伤分子-1和中性粒细胞明胶酶相关载脂蛋白对高血压肾损害的诊断价值[J].广东医学,2015,36(5):705-708.
[4]刘青青,陈瑶,肖雨婷.卡维地洛和美托洛尔治疗高血压的疗效及其对糖脂代谢影响的对比分析[J].中国卫生产业,2013,16(11):1035-1037.
[5]刘秀萍.超声检查在高血压肾血管病变中的应用效果评价[J].中国医药指南,2016,14(32):156-157.
[6]万世希,吕政兵,陈晓平,等.原发性高血压患者肾小管间质损伤与肾小球损伤的关系[J].西部医学,2017,29(3):351-354.
[7]李宁,柴成国,吴风春,等.肾损伤分子1在常见肾脏病中的诊断价值[J].中国老年学,2016,36(7):1683-1684.