妊娠期糖尿病孕妇甲状腺功能异常与甲状腺自身抗体的相关性分析
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摘要
目的探讨妊娠期糖尿病孕妇甲状腺功能异常与甲状腺自身抗体的相关性及其临床应用价值。方法纳入于2015年1月-2016年12月在本院治疗的1 127例妊娠期糖尿病孕妇,应用非参数Spearman等级相关分析对甲状腺功能异常的妊娠期糖尿病孕妇甲状腺功能异常与甲状腺自身抗体的相关性进行分析。结果 1 127例妊娠期糖尿病孕妇中,TPO-Ab、甲状腺球蛋白抗体同时阳性检出率为8.5%(96/1 127),甲状腺自身抗体单独阳性检出率为4.1%(47/1 127),甲状腺球蛋白抗体单独阳性检出率为5.2%(59/1 127)。亚临床型甲状腺功能减退症检出率为26.6%(300/1 127),低甲状腺素血症检出率为1.8%(20/1 127),临床型甲状腺功能减退症检出率为8.4%(95/1 127)。甲状腺功能正常的孕妇中,甲状腺自身抗体阳性检出率为18.9%(143/755),甲状腺球蛋白抗体阳性检出率为20.5%(155/755)。结论妊娠糖尿病孕妇早期甲状腺功能指标检测不能够完全反应甲状腺功能,妊娠糖尿病孕妇早期甲状腺激素与甲状腺自身抗体的联合检测可完全反应妊娠糖尿病孕妇的甲状腺功能,具有重要的临床价值和意义。
Objective To discuss and analyze the correlation as well as its clinical value between thyroid dysfunction and thyroid autoantibodies in pregnant women with gestational diabetes mellitus. Methods A total of 1 127 pregnant women with gestational diabetes in our hospital from January 2015 to December 2016 were selected in this research, and the correlation between abnormal thyroid function and thyroid autoantibody in pregnant women with gestational diabetes mellitus was analyzed with nonparametric Spearman level correlation analysis. Results Among 1 127 pregnant women with gestational diabetes, the positive rate of TPO-Ab and thyroglobulin antibody was 8.5%(96/1 127), the positive rate of thyroid autoantibody was 4.1%(47/1 127), and the positive rate of thyroid globulin antibody was 5.2%(59/1 127). The detection rate of subclinical hypothyroidism was 26.6%(300/1 127), the detection rate of hypothyroxemia was 1.8%(20/1 127), and the detection rate of bed type hypothyroidism was 8.4%(95/1 127). In the pregnant women with normal thyroid function, the positive rate of thyroid autoantibody was 18.9%(143/755), the positive rate of thyroglobulin antibody was 20.5%(155/755). Conclusion The detection of early thyroid function index in pregnant women with gestational diabetes can't fully respond to thyroid function. The combined detection of thyroid hormone and thyroid autoantibody in pregnant women with gestational diabetes can fully respond to the thyroid function of pregnant women with gestational diabetes, which has important clinical value and significance.
Objective To discuss and analyze the correlation as well as its clinical value between thyroid dysfunction and thyroid autoantibodies in pregnant women with gestational diabetes mellitus. Methods A total of 1 127 pregnant women with gestational diabetes in our hospital from January 2015 to December 2016 were selected in this research, and the correlation between abnormal thyroid function and thyroid autoantibody in pregnant women with gestational diabetes mellitus was analyzed with nonparametric Spearman level correlation analysis. Results Among 1 127 pregnant women with gestational diabetes, the positive rate of TPO-Ab and thyroglobulin antibody was 8.5%(96/1 127), the positive rate of thyroid autoantibody was 4.1%(47/1 127), and the positive rate of thyroid globulin antibody was 5.2%(59/1 127). The detection rate of subclinical hypothyroidism was 26.6%(300/1 127), the detection rate of hypothyroxemia was 1.8%(20/1 127), and the detection rate of bed type hypothyroidism was 8.4%(95/1 127). In the pregnant women with normal thyroid function, the positive rate of thyroid autoantibody was 18.9%(143/755), the positive rate of thyroglobulin antibody was 20.5%(155/755). Conclusion The detection of early thyroid function index in pregnant women with gestational diabetes can't fully respond to thyroid function. The combined detection of thyroid hormone and thyroid autoantibody in pregnant women with gestational diabetes can fully respond to the thyroid function of pregnant women with gestational diabetes, which has important clinical value and significance.
引文
[1] 马少华,王晰,朱敏,等.妊娠早期甲状腺功能筛查研究及其临床意义[J].临床输血与检验,2016,18(4):356-359.
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[10] 周佳任,杜鹃,马冰,等.重度子痫前期孕妇甲状腺功能变化及其与重度子线前期发病的关系[J].中华妇产科杂志,2014,49(2):109-113.
[11] 林清兰,林晓岚,麦尚敏.妊娠期糖尿病孕妇甲状腺功能及甲状腺自身抗体的变化[J].广东医学,2014,35(9):1355-1359.
[12] 王晓雪,贾方,田晶,等.妊娠期碘营养、甲状腺自身抗体与甲状腺功能关系的研究[J].中华内分泌代谢杂志,2014,30(5):408-413.
[13] 陈爱月,李婕,李珠玉,等.妊娠糖尿病孕妇不同血糖指标异常与甲状腺功能变化的关系[J].中山大学学报:医学科学版,2017,38(3):443-445.
[14] 陈结贞,古文新,徐培娇,等.妊娠期甲状腺自身抗体检测对糖尿病产妇甲状腺功能评估的价值[J].国际检验医学杂志,2016,37(12):1657-1659.
[2] 孟祥颖,邢金芳,田伟芳,等.健康孕妇妊娠期甲状腺激素水平分析及参考范围研究[J].中国卫生检验杂志,2015,25(3):365-369.
[3] 凌丽燕,陆卫良,杨水贤,等.妊娠合并甲状腺功能异常分析[J].中国卫生检验杂志,2016,26(24):3546-3548.
[4] 许小凤,朱艳芳.甲状腺功能异常与妊娠结局相关性[J].中西医研究进展,2013,15(3):71-72.
[5] 陈宇,施新颜,沈一方,等.杭州地区不同孕期女性的甲状腺激素水平变化分析[J].中国卫生检验杂志,2016,26(6):838-853.
[6] 乔艳花,张丹丹,王倩.妊娠糖尿病与甲状腺自身免疫的相关性研究[J].国际内分泌代谢杂志,2015,35(4):242-246.
[7] 孙小燕.妊娠早期甲状腺功能异常对妊娠糖尿病的影响[J].中国卫生检验杂志,2016,26(22):3280-3283.
[8] 陈朝芬.妊娠糖尿病高危孕妇甲状腺功能变化分析[J].中华内分泌外科杂志,2015,9(5):419-421.
[9] 李力,颜耀华.妊娠合并甲状腺功能减退症对妊娠结局影响[J].中国实用妇科及产科杂志,2013,29(6):423-424.
[10] 周佳任,杜鹃,马冰,等.重度子痫前期孕妇甲状腺功能变化及其与重度子线前期发病的关系[J].中华妇产科杂志,2014,49(2):109-113.
[11] 林清兰,林晓岚,麦尚敏.妊娠期糖尿病孕妇甲状腺功能及甲状腺自身抗体的变化[J].广东医学,2014,35(9):1355-1359.
[12] 王晓雪,贾方,田晶,等.妊娠期碘营养、甲状腺自身抗体与甲状腺功能关系的研究[J].中华内分泌代谢杂志,2014,30(5):408-413.
[13] 陈爱月,李婕,李珠玉,等.妊娠糖尿病孕妇不同血糖指标异常与甲状腺功能变化的关系[J].中山大学学报:医学科学版,2017,38(3):443-445.
[14] 陈结贞,古文新,徐培娇,等.妊娠期甲状腺自身抗体检测对糖尿病产妇甲状腺功能评估的价值[J].国际检验医学杂志,2016,37(12):1657-1659.