针刺足阳明胃经脑功能成像的小脑功能初探
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摘要
目的 :利用脑功能成像方法探讨针刺足阳明胃经后引发的小脑脑功能激活,以及小脑参与内脏功能调节的表现和途径。方法:足阳明胃经上足三里与上巨虚两穴配伍电针针刺健康志愿者,同时行脑功能成像,记录激活和抑制脑区并分析。结果:针刺右侧足三里与上巨虚2个穴位后,右侧小脑皮层和双侧丘脑出现激活,小脑呈同侧激活,而丘脑呈双侧激活。结论:小脑-下丘脑双向通路是小脑参与足阳明胃经调节胃肠功能的通路,可实现小脑的内脏调节功能。
Objective:To explore the effect of acupuncturing on the activation of cerebellum function by f MRI,and to explore the manifestation and pathways of cerebellar involvement in visceral function regulation. Methods:Twenty healthy volunteers were enrolled in the Stomach Meridian of Foot-Yang Ming,the compatibility of acupuncture Zusanli and Shangjuxu two acupoints,the activation area in the brain was recorded by f MRI and analyzed. Results:The right cerebellar cortex and bilateral hypothalamus were activated,the cerebellum was ipsilateral activation,and the hypothalamus was bilateral activation. Conclusion:The cerebellum-hypothalamic bi-directional pathway is that the cerebellum regulates gastrointestinal function by the Stomach Meridian of Foot-Yangming.
Objective:To explore the effect of acupuncturing on the activation of cerebellum function by f MRI,and to explore the manifestation and pathways of cerebellar involvement in visceral function regulation. Methods:Twenty healthy volunteers were enrolled in the Stomach Meridian of Foot-Yang Ming,the compatibility of acupuncture Zusanli and Shangjuxu two acupoints,the activation area in the brain was recorded by f MRI and analyzed. Results:The right cerebellar cortex and bilateral hypothalamus were activated,the cerebellum was ipsilateral activation,and the hypothalamus was bilateral activation. Conclusion:The cerebellum-hypothalamic bi-directional pathway is that the cerebellum regulates gastrointestinal function by the Stomach Meridian of Foot-Yangming.
引文
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[2]许建阳,王发强,王宏,等.针刺合谷与太冲f MRI脑功能成像的比较研究[J].中国针灸,2004,24(4):263-265.
[3]甄俊平,王峻,周冰,等.不同时辰针刺足阳明胃经中枢效应差异脑功能磁共振成像对比研究[J].中国药物与临床,2014,14(9):1198-1202.
[4]侯金文,黄蔚皓,王青,等.针刺镇痛的脑功能MRI研究[J].中华放射学杂志,2002,36(3):206-210.
[5]朱景宁,张月萍,王建军.小脑参与内脏活动调节的研究进展[J].中国神经科学杂志,2003,19(4):268-272.
[6]刘恩涛,王淑侠,赖新生,等.针刺外关穴对小脑响应机制的18FFDG PET脑功能成像研究[J].上海针灸杂志,2012,31(7):453-456.
[7]顾陈怿,胡军,蔡云彪.电针刺激参数的研究进展[J].中国针灸,2003,23(8):489-491.
[8]李春星,李华,周仪,等.静息态功能磁共振成像技术对右侧小脑参与语言功能的应用研究[J].国际放射医学核医学杂志,2014,38(4):211-215.
[9]Wu MT,Hsieh JC,Xiong J,et al.Central nervous pathway for acupuncture stimulation:localization of processing with functional MR imaging of the brain-preliminary experience[J].Radiology,1999,212:133-141.
[10]Dietrichs E,Haines DE,R ste GK,et al.Hypothalamocerebellar and cerebellohypothalamic projections--circuits for regulating nonsomatic cerebellar activity?[J].Histol Histopathol,1994,9:603-614.
[11]Hsieh JC,Tu CH,Chen FP,et al.Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human:a positron emission tomography study[J].Neurosci Lett,2001,307:105-108.
[12]Martner J.Cerebellar influences on autonomic mechanisms.An experimental study in the cat with special reference to the fastigial nucleus[J].Acta Physiol Scand Supp,1975,425:S1-S42.
[13]Wang Q,Mao L,Han J.The arcuate nucleus of hypothalamus mediates low but not high frequency electroacupuncture analgesia in rats[J].Brain Res,1990,513:60-66.
[14]Gao JH,Parsons LM,Bower JM,et al.Cerebellum implicated in sensory acquisition and discrimination rather than motor control[J].Science,1996,272:545-547.
[15]Sherman SM,Guillery RW.Functional organization of thalamocortical relays[J].J Neurophysiol,1996,76:1367-1395.