注射用胸腺法新a1调节寻常型银屑病患者免疫功能的疗效分析
|
摘要
目的探讨注射用胸腺法新a1治疗寻常型银屑病的临床疗效及对患者免疫功能的影响。方法选取我院2016年7月～2018年6月皮肤科门诊治疗的92例寻常型银屑病患者,采用随机数字表法将患者分为对照组和观察组各46例。对照组患者给予阿维A胶囊治疗,观察组在对照组基础上给予注射用胸腺法新a1治疗。比较两组治疗前后外周血T淋巴亚群CD3+、CD4+、CD8+、CD4+/CD8+水平变化情况及临床疗效。结果治疗前,两组患者外周血CD3+、CD4+、CD8+及CD4+/CD8+水平比较,无显著性差异(P>0.05);治疗后,两组外周血CD3+、CD4+及CD4+/CD8+均明显升高,CD8+明显降低,且观察组治疗后外周血CD3+、CD4+及CD4+/CD8+均明显高于对照组,CD8+明显低于对照组,差异有统计学意义(P<0.05);观察组总有效率为97.83%(45/46)明显高于对照组总有效率84.79%(39/46),差异有统计学意义(P<0.05)。结论注射用胸腺法新a1治疗寻常型银屑病的临床疗效显著,可显著提高患者外周血CD3+、CD4+及CD4+/CD8+水平,值得推广应用。
Objective To investigate the clinical efficacy and immune function of thymic faxine A1 injection in the treatment of psoriasis vulgaris.Methods 92 patients with psoriasis vulgaris admitted to the dermatological clinic from July 2016 to June 2018 were selected as subjects.The patients were divided into control group and observation group by random number table grouping method,46 cases in each group.All patients were prohibited from smoking and drinking,diet adjustment and so on.Patients in the control group were treated with Avian A capsule, while those in the observation group were treated with thymus injection on the basis of the control group. The levels of CD3+, CD4+,CD8+,CD4+/CD8+in peripheral blood T lymphocyte subsets of the two groups were compared before and after treatment.Results There was no significant difference in the levels of CD3+,CD4+,CD8+and CD4+/CD8+in peripheral blood between the two groups before and after treatment(P>0.05).After treatment,the levels of CD3+,CD4+and CD4+/CD8+in peripheral blood of the two groups were significantly increased and CD8+was significantly decreased(P<0.05). The total effective rate was 97.83%(45/46) in observation group and 84.79%(39/46) in control group(P<0.05).Conclusion Thymosin A1 for injection can significantly increase the levels of CD3+,CD4+,and CD4+/CD8+in peripheral blood of patients with psoriasis vulgaris.The clinical effect is remarkable,and there is no obvious adverse reaction.It is worth popularizing and applying.
Objective To investigate the clinical efficacy and immune function of thymic faxine A1 injection in the treatment of psoriasis vulgaris.Methods 92 patients with psoriasis vulgaris admitted to the dermatological clinic from July 2016 to June 2018 were selected as subjects.The patients were divided into control group and observation group by random number table grouping method,46 cases in each group.All patients were prohibited from smoking and drinking,diet adjustment and so on.Patients in the control group were treated with Avian A capsule, while those in the observation group were treated with thymus injection on the basis of the control group. The levels of CD3+, CD4+,CD8+,CD4+/CD8+in peripheral blood T lymphocyte subsets of the two groups were compared before and after treatment.Results There was no significant difference in the levels of CD3+,CD4+,CD8+and CD4+/CD8+in peripheral blood between the two groups before and after treatment(P>0.05).After treatment,the levels of CD3+,CD4+and CD4+/CD8+in peripheral blood of the two groups were significantly increased and CD8+was significantly decreased(P<0.05). The total effective rate was 97.83%(45/46) in observation group and 84.79%(39/46) in control group(P<0.05).Conclusion Thymosin A1 for injection can significantly increase the levels of CD3+,CD4+,and CD4+/CD8+in peripheral blood of patients with psoriasis vulgaris.The clinical effect is remarkable,and there is no obvious adverse reaction.It is worth popularizing and applying.
引文
[1]李龙振,李萍.寻常型银屑病外用药物的研究进展[J].现代中西医结合杂志,2016,25(6):680-682.
[2]江从军,李烁,朱静,等.CD4^+CD25^+CD127^low/-调节性T细胞在寻常型银屑病发病机制中的作用[J].实用医学杂志,2016,32(4):541-544.
[3]徐文灿.皮肤性病学[M].长春:吉林科学技术出版社,2012.
[4]中国医师协会皮肤科医师分会中西医皮肤科亚专业委员会.中成药治疗寻常性银屑病专家共识(2014)[J].中华皮肤科杂志,2014,47(3):215-216.
[5]曾招林,卢井发,杨素娟,等.窄谱中波紫外线照射治疗寻常型银屑病的疗效及相关因素分析[J].中国医疗前沿,2013,8(16):61-62.
[6]罗雪菲,顾国龙,兰太进.余甘子叶提取物对荷瘤小鼠外周血T淋巴细胞CD4+、CD8+亚群的影响[J].广西中医药大学学报,2015,18(2):4-6.
[7]张进稳.儿童手足口病免疫球蛋白与T淋巴细胞亚群的检测意义与临床价值[J].医学检验与临床,2016,27(1):18-21.
[8]陈国生,沈观炘,黄育青,等.窄谱中波紫外线联合阿维A对寻常型银屑病患者T淋巴细胞免疫功能影响的探讨[J].中国医药导报,2014,11(17):46-49.
[9]丁琦,傅琳玲,符梅,等.T细胞亚群及其细胞因子在寻常型银屑病中的作用机制研究[J].重庆医学,2017,46(26):3711-3714.
[10]方喜斌,吴令杰,李淑娴,等.注射用胸腺法新对社区获得性重症肺炎老年患者体内T淋巴细胞亚群及血清免疫蛋白的影响[J].广东医学,2014,35(3):451-452.
[11]戴斌.胸腺法新对老年SCAP患者血清免疫蛋白及T淋巴细胞亚群的影响及疗效分析[J].海南医学院学报,2015,21(3):353-355,359.
[2]江从军,李烁,朱静,等.CD4^+CD25^+CD127^low/-调节性T细胞在寻常型银屑病发病机制中的作用[J].实用医学杂志,2016,32(4):541-544.
[3]徐文灿.皮肤性病学[M].长春:吉林科学技术出版社,2012.
[4]中国医师协会皮肤科医师分会中西医皮肤科亚专业委员会.中成药治疗寻常性银屑病专家共识(2014)[J].中华皮肤科杂志,2014,47(3):215-216.
[5]曾招林,卢井发,杨素娟,等.窄谱中波紫外线照射治疗寻常型银屑病的疗效及相关因素分析[J].中国医疗前沿,2013,8(16):61-62.
[6]罗雪菲,顾国龙,兰太进.余甘子叶提取物对荷瘤小鼠外周血T淋巴细胞CD4+、CD8+亚群的影响[J].广西中医药大学学报,2015,18(2):4-6.
[7]张进稳.儿童手足口病免疫球蛋白与T淋巴细胞亚群的检测意义与临床价值[J].医学检验与临床,2016,27(1):18-21.
[8]陈国生,沈观炘,黄育青,等.窄谱中波紫外线联合阿维A对寻常型银屑病患者T淋巴细胞免疫功能影响的探讨[J].中国医药导报,2014,11(17):46-49.
[9]丁琦,傅琳玲,符梅,等.T细胞亚群及其细胞因子在寻常型银屑病中的作用机制研究[J].重庆医学,2017,46(26):3711-3714.
[10]方喜斌,吴令杰,李淑娴,等.注射用胸腺法新对社区获得性重症肺炎老年患者体内T淋巴细胞亚群及血清免疫蛋白的影响[J].广东医学,2014,35(3):451-452.
[11]戴斌.胸腺法新对老年SCAP患者血清免疫蛋白及T淋巴细胞亚群的影响及疗效分析[J].海南医学院学报,2015,21(3):353-355,359.