脑血疏口服液联合硝苯地平治疗高血压脑出血患者临床疗效及对预后影响
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摘要
目的:探讨脑血疏口服液联合硝苯地平治疗高血压脑出血患者的临床效果以及对患者预后产生的影响。方法:选取2015年3月—2016年4月接受非手术治疗的高血压脑出血患者90例,采用随机数表法将患者分为两组,对照组患者给予硝苯地平治疗,观察组在此基础上给予患者脑血疏口服液治疗,详细记录患者治疗前后血肿量、血肿周围水肿量、血压、心率、NHISS评分、TNF-α以及炎症因子IL-4、IL-6表达,比较两组患者治疗后的临床效果。结果:治疗后,患者的血肿量、血肿周围水肿量均有降低,观察组低于对照组,两组对比差异显著(P<0.05);治疗后,患者的DBP、SBP均有降低,且观察组低于对照组,两组对比差异显著(P<0.05);治疗后,患者的HR都有升高,观察组高于对照组,对比差异显著(P<0.05);治疗后,两组患者的NHISS评分以及TNF-α均有降低,观察组低于对照组,两组对比差异显著(P<0.05);治疗后,患者的IL-4、IL-6水平表达均有降低,观察组低于对照组,两组对比差异显著(P<0.05);治疗后,观察组总有效率93.33%高于对照组71.11%,两组对比差异显著(P<0.05);两组患者在治疗后均未出现恶心、呕吐、腹泻、腹胀以及头晕等不良反应,安全有效。结论:给予高血压脑出血患者脑血疏口服液联合硝苯地平治疗,能够有效降低患者炎症因子表达水平,促进患者神经功能恢复,改善患者的临床症状,效果显著。
Objective:To investigate the clinical effect of Naoxueshu Oral Liquid combined with nifedipine in the treatment of patients with hypertensive intracerebral hemorrhage and its influence on the prognosis of patients with hypertension.Methods:90 patients were selected from March 2015 to April 2016 in our hospital for treatment of hypertensive cerebral hemorrhage,randomly divided the patients into two groups,control group were treated with nifedipine treatment,the observation group were given cerebral blood patients with Naoxueshu Oral Liquid treatment,the patients were recorded before and after treatment,the hematoma volume edema around the hematoma volume,blood pressure,heart rate,NHISS score,TNF-α and inflammatory cytokines IL-4,IL-6 expression and clinical effect were compared between the two groups after treatment.Results:After treatment,the hematoma volume,patients with edema around the hematoma volume were decreased,the observation group were lower than in the control group,significant differences between two groups(P<0.05);after treatment,the serum DBP and SBP were decreased,and the observation group was lower than that of the control group,significant differences between two groups(P<0.05);after treatment,patients with HR have increased,the observation group than the control group,had significant differences(P<0.05);after treatment,two groups of patients with NHISS score and TNF-α were decreased,the observation group were lower than that of the control group,significant differences between two groups(P<0.05);after treatment,patients with IL-4,IL-6 expression levels were lower in observation group than in the control group,significant differences between two groups(P<0.05);after treatment,the total efficiency of the observation group was 93.33%,higher than the control group(71.11%),significant differences between two groups(P<0.05);two patients in the treatment group were nausea,vomiting,diarrhea,abdominal distension,dizziness,safe and effective.Conclusion:Naoxueshu Oral Liquid combined with nifedipine in the treatment of cerebral blood in patients with hypertensive cerebral hemorrhage,can effectively reduce the expression level of patients with inflammatory factors,promote the recovery of neurological function,improve the patients' clinical symptoms,significant effect.
Objective:To investigate the clinical effect of Naoxueshu Oral Liquid combined with nifedipine in the treatment of patients with hypertensive intracerebral hemorrhage and its influence on the prognosis of patients with hypertension.Methods:90 patients were selected from March 2015 to April 2016 in our hospital for treatment of hypertensive cerebral hemorrhage,randomly divided the patients into two groups,control group were treated with nifedipine treatment,the observation group were given cerebral blood patients with Naoxueshu Oral Liquid treatment,the patients were recorded before and after treatment,the hematoma volume edema around the hematoma volume,blood pressure,heart rate,NHISS score,TNF-α and inflammatory cytokines IL-4,IL-6 expression and clinical effect were compared between the two groups after treatment.Results:After treatment,the hematoma volume,patients with edema around the hematoma volume were decreased,the observation group were lower than in the control group,significant differences between two groups(P<0.05);after treatment,the serum DBP and SBP were decreased,and the observation group was lower than that of the control group,significant differences between two groups(P<0.05);after treatment,patients with HR have increased,the observation group than the control group,had significant differences(P<0.05);after treatment,two groups of patients with NHISS score and TNF-α were decreased,the observation group were lower than that of the control group,significant differences between two groups(P<0.05);after treatment,patients with IL-4,IL-6 expression levels were lower in observation group than in the control group,significant differences between two groups(P<0.05);after treatment,the total efficiency of the observation group was 93.33%,higher than the control group(71.11%),significant differences between two groups(P<0.05);two patients in the treatment group were nausea,vomiting,diarrhea,abdominal distension,dizziness,safe and effective.Conclusion:Naoxueshu Oral Liquid combined with nifedipine in the treatment of cerebral blood in patients with hypertensive cerebral hemorrhage,can effectively reduce the expression level of patients with inflammatory factors,promote the recovery of neurological function,improve the patients' clinical symptoms,significant effect.
引文
[1]牛庆东,王雪梅,叶平平,等.颅内血肿微创清除术联合脑血疏口服液治疗高血压脑出血的疗效观察[J].中华全科医学,2013,11(7):1048-1049.
[2]陈尚军,王海燕,左毅,等.脑血疏口服液治疗脑出血后继发神经功能损害的疗效观察[J].中西医结合心脑血管病杂志,2016,14(2):199-202.
[3]李书恒,韩小辉,姜广亚,等.颅内血肿微创清除术联合脑血疏口服液治疗高血压脑出血疗效观察[J].中国实用神经疾病杂志,2014,10(17):82-83.
[4]王明哲,张亮,姜文斐,等.益气化瘀豁痰法防治高血压脑出血后二次脑损伤的临床疗效及机制研究[J].世界中西医结合杂志,2016,11(11):1544-1547.
[5]杨春祥,王爱萍,邓超,等.硝苯地平联合甘露醇对高血压脑出血患者脑循环血流动力学参数的影响[J].中国医药导刊,2013,12(9):1471-1472.
[6]黄穗翔,叶劲超,陈伟新,等.血府逐瘀汤联合硝苯地平治疗高血压脑出血非手术患者的前瞻性随机对照研究[J].广州医科大学学报,2015,23(5):63-66.
[7]桂学辉.Heh高血压脑出血术后采用管喂口服降压药控制血压的应用[J].医学信息,2014,10(37):244-245.
[8]储佺兵,苑瑞敏,陈广生,等.不同降血压药物预防高血压脑出血后早期血肿扩大的研究[J].中华神经医学杂志,2013,12(3):278-281.
[9]Chen T,Xu G,Tan D,et al.Effects of platelet infusion,anticoagulant and other risk factors on the rehaemorrhagia after surgery of hypertensive cerebral hemorrhage[J].European review for medical and pharmacological sciences,2015,19(5):795-799.
[10]段淑霞,李冬梅,王戬萌,等.尼莫地平对老年高血压脑出血患者血清炎性因子的影响及疗效观察[J].中国老年学杂志,2015,12(11):2986-2987.
[11]陈国芳,刘雷婧,平蕾,等.尼莫地平注射液对急性高血压脑出血患者血压及疗效的影响[J].现代中西医结合杂志,2014,23(9):991-993.
[12]万丽萍.护理干预对尼莫地平治疗老年高血压脑出血患者依从性及满意度的影响[J].中国药业,2015,24(21):216-217.
[13]杜陈,刘伦波,冯爱平,等.尼莫地平在改善高血压脑出血患者脑血管动力学参数中的作用分析[J].河北医药,2014,45(7):1031-1032.
[14]Bele S,Proescholdt MA,Hochreiter A,et al.Continuous intraarterial nimodipine infusion in patients with severe refractory cerebral vasospasm after aneurysmal subarachnoid hemorrhage:a feasibility study and outcome results[J].Acta neurochirurgica,2015,157(12):2041-2050.
[15]易宇光,吴俊波,杨俊博,等.甘露醇与尼莫地平联合治疗高血压脑出血的疗效及对血流动力学的影响[J].中国医院用药评价与分析,2016,16(12):1654-1656.
[16]张秀梅,王志刚,许树民,等.护理干预在微量泵泵入尼莫地平治疗高血压脑出血微创手术患者的应用[J].河北医学,2016,22(6):1039-1041.
[17]王清芳,冯玉凤.神经节苷脂联合尼莫地平治疗高血压脑出血的疗效及对神经功能恢复的影响[J].中国实用神经疾病杂志,2017,20(1):108-110.
[18]杨鹤云,杨正宇,张红莲,等.尼莫地平对高血压脑出血患者脑血肿、水肿及神经功能恢复的影响[J].中国医药科学,2015,17(1):121-123.
[19]曹哲,李丽,刘刚,等.丹参注射液联合尼莫地平治疗高血压脑出血疗效与血清IL-1β、IL-6、CRP水平变化的相关性分析[J].临床合理用药杂志,2015,23(7):62-63.
[20]余国亮.尼莫地平对高血压脑出血急性期患者神经功能缺损程度评分、脑血流动力学参数及临床疗效的影响[J].中国基层医药,2017,24(9):1302-1307.
[21]Liu Z,Chen Q,Tian D,et al.Clinical significance of dynamic monitoring by transcranial doppler ultrasound and intracranial pressure monitor after surgery of hypertensiveintracerebral hemorrhage[J].International journal of clinical and experimental medicine,2015,8(7):11456-11462.
[22]曹哲,李丽,刘刚,等.丹参注射液联合尼莫地平治疗高血压脑出血患者对血清IL-1β、IL-6、CRP水平影响分析[J].临床合理用药杂志,2015,18(4):135-136.
[2]陈尚军,王海燕,左毅,等.脑血疏口服液治疗脑出血后继发神经功能损害的疗效观察[J].中西医结合心脑血管病杂志,2016,14(2):199-202.
[3]李书恒,韩小辉,姜广亚,等.颅内血肿微创清除术联合脑血疏口服液治疗高血压脑出血疗效观察[J].中国实用神经疾病杂志,2014,10(17):82-83.
[4]王明哲,张亮,姜文斐,等.益气化瘀豁痰法防治高血压脑出血后二次脑损伤的临床疗效及机制研究[J].世界中西医结合杂志,2016,11(11):1544-1547.
[5]杨春祥,王爱萍,邓超,等.硝苯地平联合甘露醇对高血压脑出血患者脑循环血流动力学参数的影响[J].中国医药导刊,2013,12(9):1471-1472.
[6]黄穗翔,叶劲超,陈伟新,等.血府逐瘀汤联合硝苯地平治疗高血压脑出血非手术患者的前瞻性随机对照研究[J].广州医科大学学报,2015,23(5):63-66.
[7]桂学辉.Heh高血压脑出血术后采用管喂口服降压药控制血压的应用[J].医学信息,2014,10(37):244-245.
[8]储佺兵,苑瑞敏,陈广生,等.不同降血压药物预防高血压脑出血后早期血肿扩大的研究[J].中华神经医学杂志,2013,12(3):278-281.
[9]Chen T,Xu G,Tan D,et al.Effects of platelet infusion,anticoagulant and other risk factors on the rehaemorrhagia after surgery of hypertensive cerebral hemorrhage[J].European review for medical and pharmacological sciences,2015,19(5):795-799.
[10]段淑霞,李冬梅,王戬萌,等.尼莫地平对老年高血压脑出血患者血清炎性因子的影响及疗效观察[J].中国老年学杂志,2015,12(11):2986-2987.
[11]陈国芳,刘雷婧,平蕾,等.尼莫地平注射液对急性高血压脑出血患者血压及疗效的影响[J].现代中西医结合杂志,2014,23(9):991-993.
[12]万丽萍.护理干预对尼莫地平治疗老年高血压脑出血患者依从性及满意度的影响[J].中国药业,2015,24(21):216-217.
[13]杜陈,刘伦波,冯爱平,等.尼莫地平在改善高血压脑出血患者脑血管动力学参数中的作用分析[J].河北医药,2014,45(7):1031-1032.
[14]Bele S,Proescholdt MA,Hochreiter A,et al.Continuous intraarterial nimodipine infusion in patients with severe refractory cerebral vasospasm after aneurysmal subarachnoid hemorrhage:a feasibility study and outcome results[J].Acta neurochirurgica,2015,157(12):2041-2050.
[15]易宇光,吴俊波,杨俊博,等.甘露醇与尼莫地平联合治疗高血压脑出血的疗效及对血流动力学的影响[J].中国医院用药评价与分析,2016,16(12):1654-1656.
[16]张秀梅,王志刚,许树民,等.护理干预在微量泵泵入尼莫地平治疗高血压脑出血微创手术患者的应用[J].河北医学,2016,22(6):1039-1041.
[17]王清芳,冯玉凤.神经节苷脂联合尼莫地平治疗高血压脑出血的疗效及对神经功能恢复的影响[J].中国实用神经疾病杂志,2017,20(1):108-110.
[18]杨鹤云,杨正宇,张红莲,等.尼莫地平对高血压脑出血患者脑血肿、水肿及神经功能恢复的影响[J].中国医药科学,2015,17(1):121-123.
[19]曹哲,李丽,刘刚,等.丹参注射液联合尼莫地平治疗高血压脑出血疗效与血清IL-1β、IL-6、CRP水平变化的相关性分析[J].临床合理用药杂志,2015,23(7):62-63.
[20]余国亮.尼莫地平对高血压脑出血急性期患者神经功能缺损程度评分、脑血流动力学参数及临床疗效的影响[J].中国基层医药,2017,24(9):1302-1307.
[21]Liu Z,Chen Q,Tian D,et al.Clinical significance of dynamic monitoring by transcranial doppler ultrasound and intracranial pressure monitor after surgery of hypertensiveintracerebral hemorrhage[J].International journal of clinical and experimental medicine,2015,8(7):11456-11462.
[22]曹哲,李丽,刘刚,等.丹参注射液联合尼莫地平治疗高血压脑出血患者对血清IL-1β、IL-6、CRP水平影响分析[J].临床合理用药杂志,2015,18(4):135-136.