民族药磨盘草研究进展及展望
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摘要
磨盘草是常用的民族药,具有清热解毒、化痰止咳、健脾止泻等功效,含有挥发油、脂肪酸、微量元素、香豆素、萜类、黄酮类、生物碱、酰胺类等多种化学成分,并表现出抗炎、抗菌、细胞毒、保肝利尿等多种药理学活性,对国内外磨盘草的研究文献进行分析和总结,总结出近年来对磨盘草的研究主要在化学成分、质量控制、药理作用等方面,该文对磨盘草的研究状况及药用价值进行综述,为进一步开发该民族药提供参考依据,并对磨盘草的未来研究方向提出展望,希望磨盘草能广泛应用于临床。
Abutilon indicum is a commonly used ethnic medicine,which has the functions of clearing away heat and detoxification,resolving phlegm and cough,strengthening spleen and stopping diarrhea. It contains volatile oil,fatty acids,trace elements,coumarin,terpenoids,flavonoids,alkaloids,amidesand other chemical constituents,and has many pharmacological activities,such as anti-inflammatory,antibacterial,cytotoxic,hepatoprotective and diuretic. Based on the analysis and summary of the research literatures of Abutilon indicum at home and abroad,this paper summarizes the main research aspects of Abutilon indicum in recent years,such as chemical composition,quality control,pharmacological action and so on. The research status and medicinal value of Abutilon indicum are reviewed in order to provide reference for the further development of Abutilon indicum. We hope to study the direction and hope that it can be widely applied in clinic.
Abutilon indicum is a commonly used ethnic medicine,which has the functions of clearing away heat and detoxification,resolving phlegm and cough,strengthening spleen and stopping diarrhea. It contains volatile oil,fatty acids,trace elements,coumarin,terpenoids,flavonoids,alkaloids,amidesand other chemical constituents,and has many pharmacological activities,such as anti-inflammatory,antibacterial,cytotoxic,hepatoprotective and diuretic. Based on the analysis and summary of the research literatures of Abutilon indicum at home and abroad,this paper summarizes the main research aspects of Abutilon indicum in recent years,such as chemical composition,quality control,pharmacological action and so on. The research status and medicinal value of Abutilon indicum are reviewed in order to provide reference for the further development of Abutilon indicum. We hope to study the direction and hope that it can be widely applied in clinic.
引文
[1]黄泰康,丁志遵,赵守训,等.现代本草纲目(下卷)[M].北京:中国医药科技出版社,2001:3173.
[2]全国中草药汇编编写组.全国中草药汇编(上册)[M].北京:人民出版社,1999:920.
[3]吴盛义.台湾青草药(第一册)[M].[出版地不详]:开山书店印行,1985:216.
[4]国家中医药管理局中华本草编委会.中华本草(第十四卷)[M].上海:上海科学技术出版社,1999:335.
[5]刘娜.磨盘草化学成分及质量标准的研究[D].沈阳:沈阳药科大学,2008.
[6]顾关云,蒋昱.磨盘草及苘麻属植物的化学成分与药理作用[J].现代药物与临床,2009,24(6):338-340.
[7]黄必奎.广西壮药磨盘草研究状况[J].右江民族医学院学报,2013,35(4):541-542.
[8]陈勇,杨晨,魏后超,等.磨盘草挥发油化学成分的GC-MS分析[J].中国民族民间医药,2010,19(3):25-26.
[9]陈勇,魏后超,农莉,等.气相色谱—质谱联用测定广西不同产地磨盘草的挥发油成分[J].环球中医药,2013,6(8):572-576.
[10]马家宝,韦丽富,周婷婷,等.磨盘草石油醚部位的GC-MS分析[J].中国民族民间医药,2016,25(9):31-32.
[11]陈勇,魏后超,韦韬,等.磨盘草醋酸乙酯部位化学成分研究[J].时珍国医国药,2012,23(7):1725-1726.
[12]刘娜,贾凌云,孙启时.中药磨盘草的化学成分[J].沈阳药科大学学报,2009,26(3):196-197,221.
[13]陈勇,杨晨,魏后超,等.磨盘草化学成分研究[J].时珍国医国药,2010,21(9):2245-2246.
[14]佚名.磨盘草的两个倍半萜内酯[J].国外医药(植物药分册),1990(4):179.
[15]Mat law s ka I,Sik orska M. Flavonoid compounds in the f lowers of Abutilon indicum(L.)Sw eet(Malvaceae)[J].Act aPol Pharm,2002,59(3):227-229.
[16]Kuo P C,Yang M L,Wu P L,et al. Chemical constituents from Abutilon indicum[J]. J Asian Nat Prod Res,2008,10(7/8):699-703.
[17]张昕,魏江存,阙祖亮,等.磨盘草乙酸乙酯部位的化学成分分析[J].广西医学,2018(14):1585-1590.
[18]张燕,张洪斌,陈忠荫,等.磨盘草微量元素的初级形态分析[J].时珍国医国药,2010,21(5):1068-1070.
[19]张燕,陈忠荫,陈光宙.磨盘草微量元素的次级形态分析[J].琼州学院学报,2009,16(5):49-52.
[20]姜建萍,廖月葵,林安平,等.磨盘草的生药鉴定[J].长春中医学院学报,2000(2):53-54.
[21]何报作,朱意麟,廖月葵,等.磨盘草与其易淆品苘麻的叶形态-脉序图谱的鉴别特征[J].中国中药杂志,2012,37(15):2262-2266.
[22]洪淑媛,朱纯.梅州曲滩村野生药用植物应用分析[J].农村经济与科技,2016,27(1):134,138.
[23]陈勇,魏后超,韦韬,等.磨盘草药材红外指纹图谱共有峰率和变异峰率双指标序列分析法[J].中华中医药杂志,2015,30(3):709-712.
[24]谢臻,马家宝,陈勇,等.广西民族药磨盘草高效液相指纹图谱及其不同产地品种的聚类分析[J].世界科学技术-中医药现代化,2015,17(1):162-166.
[25]陈勇,杨晨,魏后超,等.广西产磨盘草药材中总黄酮的含量测定[J].中华中医药学刊,2011,29(12):2721-2722.
[26]张燕,张洪斌,胡海强,等.磨盘草不同部位中鞣质含量测定[J].中国中医药信息杂志,2010,17(3):53-54.
[27]张燕,张洪斌,陈忠荫,等.磨盘草不同营养器官中总黄酮和总酚含量测定[J].安徽农业科学,2009,37(35):17487-17488,17495.
[28]张昕,周婷婷,韦丽富,等.不同产地磨盘草正丁醇部位提取物抗炎作用研究[J].时珍国医国药,2017,28(9):2049-2050.
[29]陈勇,杨晨,魏后超,等.磨盘草药材醇提物抗炎、利尿作用实验研究[J].亚太传统医药,2009,5(12):19-21.
[30]陈勇.磨盘草不同提取部位抗炎利尿药理实验研究[C]//第二届临床中药学学术研讨会论文集.北京:中华中医药学会中药基础理论分会,2009:4.
[31]韦丽富.韦丽富.磨盘草乙酸乙酯部位指纹图谱的建立及其对肝硬化腹水大鼠的干预作用和利尿活性成分的研究[D].南宁:广西中医药大学,2016.
[32]郑鸿娟,黄春阳,齐梁煜,等.磨盘草提取物的抗氧化活性研究[J].中国野生植物资源,2016,35(6):35-38.
[33]马家宝,黄丽贞,韦丽富,等.磨盘草石油醚部位改善异丙肾上腺素致大鼠心力衰竭的研究[J].中华中医药杂志,2016,31(7):2745-2748.
[34]韦丽富.磨盘草乙酸乙酯部位指纹图谱的建立及其对肝硬化腹水大鼠的干预作用和利尿活性成分的研究[D].南宁:广西中医药大学,2016.
[35]Porchezhian E,Ansari S H. Hepatoprotective activity of Abutilon in dicum on experim ental liver damage in rats[J].Phytomedicine,2005,12(1/2):62-64.
[36]Porchezhian E,Ansari S H. Effect of liquid extract from fresh Abutilon indicum leaves and Allium cepabulbs on paracetamol and carb ontet rachl oride induced hepatotoxicity[J]. Pharm azie,2000,55(9):702-703.
[37]Ahmed M,Amin S,Islam M,et al. Analgesi cprinciple from Abutilon indicum[J].Pharmazie,2000,55(4):314-316.
[38]Seetharam Y N,C halageri G,Setty S R,et al. Hypoglycemic activity of Abutilon in dicum leaf extracts in rats[J].Fitoterapia,2002,73(2):156-159.
[39]Yasmin S,Kashmin M A,Ahmad I,et al. Biological activity of extracts in relations hipto sructure of pureisolates of Abutilon indicum[J]. Pharm Biol,2008,46(10/11):673-676.
[40]IsshikiK,AsaiY,TanakaS,etal.Aurantiamide acetateaselectivecathepsininhibitorproducedby Aspergilluspenicilloides[J]. Biosci Biotechnol Biochem,2001,65(5):1195-1197.
[41]Beha E,Jung A,Wiesner J,et al. An timalarial activity of extracts of Abutilon grandiflorum G Don-a traditional Tanzanian medicinal plant[J].Phytother Res,2004,18(3):236-240.
[42]罗利青,罗长青,罗碧廉.中医综合疗法治疗脱发经验介绍[J].广西中医药,2012,35(1):33-34.
[43]莫礼滨.磨盘草、艾叶煎液浸浴治疗婴儿湿疹36例[J].广西中医药,2011,34(5):31-32.
[44]任忠.磨盘草治疗急性中耳炎46例[J].中级医刊,1997(7):60-61.
[45]肖子精.验方介绍[J].中国农村医学,1985(2):58-59.
[46]Paranihape A N,M eh ta A A.A study on clinical eff icacy of Abutilon indicum in treatment of bronchial asthma[J].Orie Pharm Exp Med,2006,6(4):330-336.
[47]张鹏云,李蓉,龙春霞,等.药食同源植物挥发油的研究进展[J].食品工业科技,2018,39(12):320-324,333.
[48]罗林,袁岸,党珏,等.不同大鼠模型探讨连翘挥发油解热、抗炎作用[J].天然产物研究与开发,2018,30(2):207-211,256.
[49]吴永祥,杨庆,李林,等.豆腐柴叶挥发油化学成分及其抗氧化和抑菌作用研究[J].天然产物研究与开发,2018,30(1):45-51,96.
[50]尹晓燕.不同剂量桂枝挥发油对人体面部蠕形螨虫杀灭作用比较研究[J].辽宁中医药大学学报,2015,17(12):109-111.
[51]许彩萍,王东方.微量元素与变应性鼻炎免疫机制及中医辨证关系探讨[J].辽宁中医药大学学报,2013,15(3):147-149.
[2]全国中草药汇编编写组.全国中草药汇编(上册)[M].北京:人民出版社,1999:920.
[3]吴盛义.台湾青草药(第一册)[M].[出版地不详]:开山书店印行,1985:216.
[4]国家中医药管理局中华本草编委会.中华本草(第十四卷)[M].上海:上海科学技术出版社,1999:335.
[5]刘娜.磨盘草化学成分及质量标准的研究[D].沈阳:沈阳药科大学,2008.
[6]顾关云,蒋昱.磨盘草及苘麻属植物的化学成分与药理作用[J].现代药物与临床,2009,24(6):338-340.
[7]黄必奎.广西壮药磨盘草研究状况[J].右江民族医学院学报,2013,35(4):541-542.
[8]陈勇,杨晨,魏后超,等.磨盘草挥发油化学成分的GC-MS分析[J].中国民族民间医药,2010,19(3):25-26.
[9]陈勇,魏后超,农莉,等.气相色谱—质谱联用测定广西不同产地磨盘草的挥发油成分[J].环球中医药,2013,6(8):572-576.
[10]马家宝,韦丽富,周婷婷,等.磨盘草石油醚部位的GC-MS分析[J].中国民族民间医药,2016,25(9):31-32.
[11]陈勇,魏后超,韦韬,等.磨盘草醋酸乙酯部位化学成分研究[J].时珍国医国药,2012,23(7):1725-1726.
[12]刘娜,贾凌云,孙启时.中药磨盘草的化学成分[J].沈阳药科大学学报,2009,26(3):196-197,221.
[13]陈勇,杨晨,魏后超,等.磨盘草化学成分研究[J].时珍国医国药,2010,21(9):2245-2246.
[14]佚名.磨盘草的两个倍半萜内酯[J].国外医药(植物药分册),1990(4):179.
[15]Mat law s ka I,Sik orska M. Flavonoid compounds in the f lowers of Abutilon indicum(L.)Sw eet(Malvaceae)[J].Act aPol Pharm,2002,59(3):227-229.
[16]Kuo P C,Yang M L,Wu P L,et al. Chemical constituents from Abutilon indicum[J]. J Asian Nat Prod Res,2008,10(7/8):699-703.
[17]张昕,魏江存,阙祖亮,等.磨盘草乙酸乙酯部位的化学成分分析[J].广西医学,2018(14):1585-1590.
[18]张燕,张洪斌,陈忠荫,等.磨盘草微量元素的初级形态分析[J].时珍国医国药,2010,21(5):1068-1070.
[19]张燕,陈忠荫,陈光宙.磨盘草微量元素的次级形态分析[J].琼州学院学报,2009,16(5):49-52.
[20]姜建萍,廖月葵,林安平,等.磨盘草的生药鉴定[J].长春中医学院学报,2000(2):53-54.
[21]何报作,朱意麟,廖月葵,等.磨盘草与其易淆品苘麻的叶形态-脉序图谱的鉴别特征[J].中国中药杂志,2012,37(15):2262-2266.
[22]洪淑媛,朱纯.梅州曲滩村野生药用植物应用分析[J].农村经济与科技,2016,27(1):134,138.
[23]陈勇,魏后超,韦韬,等.磨盘草药材红外指纹图谱共有峰率和变异峰率双指标序列分析法[J].中华中医药杂志,2015,30(3):709-712.
[24]谢臻,马家宝,陈勇,等.广西民族药磨盘草高效液相指纹图谱及其不同产地品种的聚类分析[J].世界科学技术-中医药现代化,2015,17(1):162-166.
[25]陈勇,杨晨,魏后超,等.广西产磨盘草药材中总黄酮的含量测定[J].中华中医药学刊,2011,29(12):2721-2722.
[26]张燕,张洪斌,胡海强,等.磨盘草不同部位中鞣质含量测定[J].中国中医药信息杂志,2010,17(3):53-54.
[27]张燕,张洪斌,陈忠荫,等.磨盘草不同营养器官中总黄酮和总酚含量测定[J].安徽农业科学,2009,37(35):17487-17488,17495.
[28]张昕,周婷婷,韦丽富,等.不同产地磨盘草正丁醇部位提取物抗炎作用研究[J].时珍国医国药,2017,28(9):2049-2050.
[29]陈勇,杨晨,魏后超,等.磨盘草药材醇提物抗炎、利尿作用实验研究[J].亚太传统医药,2009,5(12):19-21.
[30]陈勇.磨盘草不同提取部位抗炎利尿药理实验研究[C]//第二届临床中药学学术研讨会论文集.北京:中华中医药学会中药基础理论分会,2009:4.
[31]韦丽富.韦丽富.磨盘草乙酸乙酯部位指纹图谱的建立及其对肝硬化腹水大鼠的干预作用和利尿活性成分的研究[D].南宁:广西中医药大学,2016.
[32]郑鸿娟,黄春阳,齐梁煜,等.磨盘草提取物的抗氧化活性研究[J].中国野生植物资源,2016,35(6):35-38.
[33]马家宝,黄丽贞,韦丽富,等.磨盘草石油醚部位改善异丙肾上腺素致大鼠心力衰竭的研究[J].中华中医药杂志,2016,31(7):2745-2748.
[34]韦丽富.磨盘草乙酸乙酯部位指纹图谱的建立及其对肝硬化腹水大鼠的干预作用和利尿活性成分的研究[D].南宁:广西中医药大学,2016.
[35]Porchezhian E,Ansari S H. Hepatoprotective activity of Abutilon in dicum on experim ental liver damage in rats[J].Phytomedicine,2005,12(1/2):62-64.
[36]Porchezhian E,Ansari S H. Effect of liquid extract from fresh Abutilon indicum leaves and Allium cepabulbs on paracetamol and carb ontet rachl oride induced hepatotoxicity[J]. Pharm azie,2000,55(9):702-703.
[37]Ahmed M,Amin S,Islam M,et al. Analgesi cprinciple from Abutilon indicum[J].Pharmazie,2000,55(4):314-316.
[38]Seetharam Y N,C halageri G,Setty S R,et al. Hypoglycemic activity of Abutilon in dicum leaf extracts in rats[J].Fitoterapia,2002,73(2):156-159.
[39]Yasmin S,Kashmin M A,Ahmad I,et al. Biological activity of extracts in relations hipto sructure of pureisolates of Abutilon indicum[J]. Pharm Biol,2008,46(10/11):673-676.
[40]IsshikiK,AsaiY,TanakaS,etal.Aurantiamide acetateaselectivecathepsininhibitorproducedby Aspergilluspenicilloides[J]. Biosci Biotechnol Biochem,2001,65(5):1195-1197.
[41]Beha E,Jung A,Wiesner J,et al. An timalarial activity of extracts of Abutilon grandiflorum G Don-a traditional Tanzanian medicinal plant[J].Phytother Res,2004,18(3):236-240.
[42]罗利青,罗长青,罗碧廉.中医综合疗法治疗脱发经验介绍[J].广西中医药,2012,35(1):33-34.
[43]莫礼滨.磨盘草、艾叶煎液浸浴治疗婴儿湿疹36例[J].广西中医药,2011,34(5):31-32.
[44]任忠.磨盘草治疗急性中耳炎46例[J].中级医刊,1997(7):60-61.
[45]肖子精.验方介绍[J].中国农村医学,1985(2):58-59.
[46]Paranihape A N,M eh ta A A.A study on clinical eff icacy of Abutilon indicum in treatment of bronchial asthma[J].Orie Pharm Exp Med,2006,6(4):330-336.
[47]张鹏云,李蓉,龙春霞,等.药食同源植物挥发油的研究进展[J].食品工业科技,2018,39(12):320-324,333.
[48]罗林,袁岸,党珏,等.不同大鼠模型探讨连翘挥发油解热、抗炎作用[J].天然产物研究与开发,2018,30(2):207-211,256.
[49]吴永祥,杨庆,李林,等.豆腐柴叶挥发油化学成分及其抗氧化和抑菌作用研究[J].天然产物研究与开发,2018,30(1):45-51,96.
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