失语症患者静息态fMRI成像研究
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摘要
目的探讨应用局部区域一致性(ReHo)研究失语患者静息态下脑功能区活动改变情况。方法运用SIEMENS verio 3.0T磁共振对23名志愿者及21名失语患者行静息态BOLD-fMRI扫描,应用DPARSF软件进行时间层校正、头动校正、空间标准化、去线性、滤波(0.01Hz Objective To study the changes of functional brain areas in patients with aphasia under resting-state by using regional homogeneity(ReHo). Methods Resting-sate sequence scanning was performed using SIEMENS verio 3.0 T magnetic resonance scanner in all of 23 controls and 21 patients. After acquiring all the subjects resting-state images data, the data were then preprocessed by using DPARSF software, all resting-state data were processed in turn by slice timing, realignment, normalization, Detrend, fliter(0.01 Hz
引文
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[11] Long XY,Zuo XN,Kiviniemi V,et al.Default mode network as revealed with multiple methods for resting-state functional MRI analysis [J].J Neurosci Methods,2008,171(2):349-355.
[12] Raichle ME,MacLeod AM,Snyder AZ,et al.A default mode of brain function [J].ProcNatl Acad Sci USA,2001,98(5):676-682.
[13] He Y,Zang YF,Jiang TZ,et al.Detection of functional networks in the resting brain [J].ISBI,2004,20(8):980-983.
[14] Fransson P.Spontaneous low-frequency BOLD signal fluctuations:an fMRI investigation of the resting-state default mode of brain function hypothesis [J].HumBrain Mapp,2005,26(1):15-29.
[15] Maguire EA,Mummery CJ.Differential modulation of a common retrieval network revealed by positron emission tomography [J].Hippocampus,1999,9(1):54-61.
[16] Lau HC,Rogers RD,Ramnani N,et al.Willedaction and attention to the selection of responses [J].Neuroimage,2004,21(11):1407-1415.
[17] Craig BD.How do you feel interoception:the sense of the physiological condition of the body [J].Nat Rev Neurosci,2002,3(7):655-665.
[2] Wu X,Long Y,Zang L,et al.Regional homogeneity changes in patients with Parkinson’s disease [J].Hum Brain Mapp,2009,30(12):1502-1510.
[3] Liu Y,Wang K,Yu C,et al.Regional homogeneity,functional connectivity and imaging markers of Alzheimer's disease:are view of resting-state fMRI studies [J].Neuropsychologia,2008,46(6):1648-1656.
[4] Liu H,Liu Z,Liang M,et al.Decreased regional homogeneity in schizophrenia:a resting state functional magnetic resonance imaging study [J].Neuroreport,2006,17(1):19-22.
[5] Zhu CZ,Zang YF,Cao QJ,et al.Fisher discriminative analysis of resting-state brain function for attention deficit hyperactivity disorder [J].Neuroimage,2008,40(12):110-120.
[6] Yao Z,Wang L,Lu Q,et al.Regional homogeneity in depression and its relationship with separate depressive symptom clusters:a resting-state fMRI study [J].J Affect Disord,2009,115(3):430-438.
[7] Mankinen K,Long XY,Paakki JJ,et al.Alterations in regional homogeneity of baseline brain activity in pediatric temporal lobe epilepsy [J].Brain Res,2011,1373(3):221-229.
[8] 成文莲,钱志余,张志强,等.基于ReHo方法的颞叶癫痫功能磁共振成像研究 [J].生物物理学报,2008,24(6):460-464.
[9] 王维卓,王美豪,刘会茹,等.脑梗死运动性失语症患者静息态功能连接观察 [J].中华医学杂志,2014,94(27):2135-2138.
[10] Zang Y,Jiang T,Lu Y,et al.Regional homogeneity approach to fMRI data analysis [J].Neuroimage,2004,22(4):394-400.
[11] Long XY,Zuo XN,Kiviniemi V,et al.Default mode network as revealed with multiple methods for resting-state functional MRI analysis [J].J Neurosci Methods,2008,171(2):349-355.
[12] Raichle ME,MacLeod AM,Snyder AZ,et al.A default mode of brain function [J].ProcNatl Acad Sci USA,2001,98(5):676-682.
[13] He Y,Zang YF,Jiang TZ,et al.Detection of functional networks in the resting brain [J].ISBI,2004,20(8):980-983.
[14] Fransson P.Spontaneous low-frequency BOLD signal fluctuations:an fMRI investigation of the resting-state default mode of brain function hypothesis [J].HumBrain Mapp,2005,26(1):15-29.
[15] Maguire EA,Mummery CJ.Differential modulation of a common retrieval network revealed by positron emission tomography [J].Hippocampus,1999,9(1):54-61.
[16] Lau HC,Rogers RD,Ramnani N,et al.Willedaction and attention to the selection of responses [J].Neuroimage,2004,21(11):1407-1415.
[17] Craig BD.How do you feel interoception:the sense of the physiological condition of the body [J].Nat Rev Neurosci,2002,3(7):655-665.