鞣花酸类化合物在野牡丹科植物中的分布与药理活性研究
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摘要
野牡丹科为蔷薇亚纲中一个较大的科,全科共240属3 000余种植物,我国分布有25属,185种植物。野牡丹科植物主要含有鞣质与黄酮两大类成分,其中鞣花酸类化合物药理作用显著,是鞣质类化合物发挥药理活性的重要组成成分。该文对野牡丹科中已发现的鞣花酸类化合物及其衍生物的分布和该类化合物药理活性研究现状进行了总结;此外,为了更好的比较属间药效物质基础的差异,也对该科其他简单酚酸与鞣质类化合物的分布进行简单综述,在此基础上初步探讨该科植物的药用亲缘学关系,可为有效开发、合理利用野牡丹科药用植物资源提供重要的参考。
引文
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[2]陈冠,崔承彬,蔡兵,等.野牡丹科十属植物研究进展[J].天然产物研究与开发.2006,18(5):863-872.
[3]陆晶晶,丁轲,杨大进.保健品功能因子鞣花酸研究进展[J].食品科学,2010,31(21):451-454.
[4]姚亮亮,刘新亚.野牡丹属植物的化学成分、药理活性及临床应用研究概况[J].江西中医药大学学报,2010,22(6):52-55.
[5]杨嘉永,万春鹏,邱彦.东方肉穗草中酚酸类化学成分研究[J].中药材,2010,33(4):542-544.
[6]程忠泉,杨丹,赵友兴,等.金锦香的化学成分研究[J].安徽农学通报,2010,16(17):44-46.
[7]刘杰,陈海生,张卫东.金锦香属植物的研究概况[J].解放军药学学报,2001,17(3):151-153.
[8]Wang HS,Wang YH,Shi YN,et al.Chemical constituents in roots of Osbeckia opipara[J].China J Chin Mater Med,2009,34(4):414-418.
[9]Isaza JH,Ito H,Yoshida T.Oligomeric hydrolysable tannins from Monochaetum muliflorum[J].Phytochemistry,2004,65(3):359-367.
[10]Nono RN,Barboni L,Teponno RB,et al.Antimicrobial,antioxidant,antiinflammatory activities and phytoconstituents of extracts from the roots of Dissotis thollonii Cogn.(Melastomataceae)[J].S Afr J Bo,2014,93:19-26.
[11]Chen JJ,Cho JY,Lee TH.Ellagic acid derivatives and a ferulic acid ester derivative from the leaves and twigs of Pachycentria formosana[J].Planta Med,2010,76(12):1279.
[12]郭增军,谭林,徐颖,等.鞣花酸类化合物在植物界的分布及其生物活性[J].天然产物研究与开发,2010,22(3):519-524,540.
[13]Yoshida T,Nakata F,Hosotani K,et al.Dimeric hydrolysable tannins from Melastoma malabathricum[J].Phtochemistry,1992,31(8):2829-2833.
[14]Yoshida T,Arioka H,Fujita T,et al.Monomeric and dimmeric hydrolysable tannin from two Melastomataceous species[J].Phtochemistry,1994,37(3):863-866.
[15]Ito H,Isaza JH,Amakura Y,et al.30 Ellagitannin oligomers from Melastomataceous plants[J].Symp Chem Nat Prod,2001,43:175-180.
[16]Yoshida T,Nakata F,Hosotani K,et al.Tannins and related polyphenols of Melastomataceous plants.V.three new complex tannins from Melastoma malabathricum L.[J].Chem Pharm Bull,1992,40(7):1727-1732.
[17]陈冠.滇谷木抗肿瘤活性成分的研究[D].天津:天津大学,2006.
[18]Yoshida T,Ohbayashi H,Ishihara K,et al.Tannins and related polyphenols of Melastomataceous plants.Ⅰ.hydrolyzable tannins from Tibouchina semidecandra Cogn.[J].Chem Pharm Bull,1991,39(9):2233-2240.
[19]Yoshida T,Amakura Y,Yokura N,et al.Oligomeric hydrolysable tannins from Tibouchina multiflora[J].Phytochemistry,1999,52(8):1661-1666.
[20]Yoshida T,Nakata F,Okuda T.Tannins and related polyphenols of Melastomataceous plants.Ⅷ.Nobotanins L,Mand N,trimeric hydrolyzable tannins from Tibouchina semidecandra[J].Chem Pharm Bull,1999,47(6):824-827.
[21]Ito H,Isaza JH,Amakura Y,et al.Ellagitannin oligomers from Melastomataceous plants[A].Symposium on the chemistry of natural products,symposium papers[C].Okayama,Japan:Symposium on the Chemistry of Natural Products Steering Committee,2001:175-180.
[22]Su JD,Oswawa T,Kawakishi S.Tannin antioxidants from Osbeckia chinensis[J].Phytochemistry,1988,27(5):1315-1319.
[23]Tan HP,Wong DZ,Ling SK,et al.Neuroprotective activity of galloylated cyanogenic glucosides and hydrolysable tannins isolated from leaves of Phyllagathis rotundifolia[J].Fitoterapia,2012,83(1):223-229.
[24]Tan HP,Ling SK,Cheng HC.Characterisation of galloylated cyanogenic glucosides and hydrolysable tannins from leaves of Phyllagathis rotundifolia,by LC-ESI-MS/MS[J].Phytochem Anal,2011,22(6):516-525.
[25]Murugesan S,Chanemougame A,Salai G,et al.Phytochemical screening and antimicrobial activity of the leaves of Memecylon umbellatum Burm.f.[J].J Appl Pharm Sci,2011,1(1):42-45.
[26]Chen G,Cui CB,Qi AD,et al.Polyanthumin,a novel cyclobutane chalcone trimmer from Memecylon polyanthum[J].J Asian Nat Prod Res,2015,17(2):170-177.
[27]Yoshida T,Haba K,Nakata F,et al.Tannins and related polyphenols of Melastomataceous plants.Ⅲ.Nobotanins G,H and I,dimeric hydrolyzable tannins from Heterocentron roseum[J].Chem Pharm Bull,1992,40(1):66-71.
[28]Yoshida T,Haba K,Arata R,et al.Tannins and related polyphenols of Melastomataceous Plants.Ⅶ.nobotanins Jand K,trimeric and tetrameric hydrolyzable tanins from Heterocentron roseum[J].Chem Pharm Bull,1995,43(7):1101-1106.
[29]郑英俊,阳宁,彭荣章,等.鞣花酸对前列腺癌PC-3细胞生长和凋亡的影响[J].湖北职业技术学院学报,2009,12(2):101-105.
[30]王建红,赵宁,田晶,等.鞣花酸抗肝癌作用的相关分子[J].中国现代医学杂志,2013,23(11):36-39.
[31]李文仿,欧琴,张丹峰,等.鞣花酸对乳腺癌细胞MDA-MB-231增殖及SDF1α/CXCR4信号通路的影响[J].中华乳腺病杂志(电子版),2013,7(6):415-418.
[32]于玮,周芳,贾敏,等.鞣花酸通过下调ERK1/2抑制MCF-7乳腺癌细胞的增殖[J].现代肿瘤医学,2015,23(19):2723-2726.
[33]范才文,王建红,田晶,等.鞣花酸抑制鼻咽癌CNE2细胞的作用及作用分子探讨[J].安徽医科大学学报,2013,48(10):1156-1158.
[34]翟延君,佟苗苗,程飞,等.花旗松素和3,3'-二甲氧基鞣花酸-4-O-β-D-吡喃葡萄糖苷对肿瘤细胞的增殖抑制作用[J].中成药,2012,34(2):217-220.
[35]Umesalma S,Nagendraprabhu P,Sudhandiran G,et al.Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells[J].Mol Cell Biochem,2015,399(1-2):303-313.
[36]Mishra S,Vinayak M.Ellagic acid checks lymphoma promotion via regulation of PKC signaling pathway[J].Mol Biol Rep,2013,40(2):1417-1428.
[37]段婧,黄卫东.鞣花酸抗癌作用机制研究进展[J].农产品加工,2017,(1):112-114.
[38]Losso NJ,Bansode RR,Trappey A,et al.In vitro anti-proliferative activities of ellagic acid[J].J Nutr Biochem,2004,15(11):672-678.
[39]Hayeshi R,Mutingwende I,Mavengere W,et al.The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin[J].Food Chem Toxicol,2007,45(2):286-295.
[40]Mertens-Talcott SU,Lee JH,Percival SS,et al.Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes(Vitis rotundifolia)[J].J Agric Food Chem,2006,54(15):5336-5343.
[41]Larrosa M,Tomás-Barberán FA,Espín JC.The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2cells by using the mitochondrial pathway[J].J Nutr Biochem,2005,17(7):611-625.
[42]李小萍,梁琪,辛秀兰,等.红树莓果中鞣花酸提取物的抗氧化性研究[J].食品科技,2010,35(5):182-185.
[43]Srivastava A,Rao LJM,Shivanandappa T.Isolation of ellagic acid from the aqueous extract of the roots of Decalepis hamiltonii:antioxidant activity and cytoprotective effect[J].Food Chem,2007,103(1):224-233.
[44]Majid S,Khanduja KL,Gandhi RK,et al.Influence of ellagic acid on antioxidant defense system and lipid peroxidation in mice[J].Biochem Pharmacol,1991,42(7):1441-1445.
[45]梁俊,李建科,赵伟,等.石榴皮多酚体外抗脂质过氧化作用研究[J].食品与生物技术学报,2012,31(2):159-165.
[46]Ayrton AD,Lewis DF,Walker R,et al.Antimutagenicity of ellagic acid towards the food mutagen IQ:investigation into possible mechanisms of action[J].Food chem toxicol,1992,30(4):289-295.
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