剂量反应分析在食品微生物风险评估中的应用
|
摘要
微生物风险评估(Microbiological risk assessment, MRA)是食品安全管理的重要工具之一,一直是国际食品安全研究的热点。微生物剂量-反应分析是进行食品微生物风险评估中的重要工具,描述了特定人群中特定病原体(或其毒素)暴露引起特定反应的概率。本文综述了食品微生物风险评估中剂量-反应分析的研究现状,阐述了剂量反应分析研究中存在的问题,并对其进一步需开展的工作进行了展望,以期为我国食品微生物风险评估和食品安全监管提供参考。
Microbiological risk assessment(MRA) is one of the most important tools in food safety management and has been a hot spot in international food safety research. Microbial dose-response analysis is the key tool of food microbiological risk assessment, describing a specific group of people in specific pathogens(or toxins) causing a specific reaction probability of exposure. This paper summarized the research status of dose-response analysis in food microbial risk assessment, expounded the problems in dose-response analysis, and prospected the further work to be done, so as to provide reference for food microbial risk assessment and food safety supervision in China.
Microbiological risk assessment(MRA) is one of the most important tools in food safety management and has been a hot spot in international food safety research. Microbial dose-response analysis is the key tool of food microbiological risk assessment, describing a specific group of people in specific pathogens(or toxins) causing a specific reaction probability of exposure. This paper summarized the research status of dose-response analysis in food microbial risk assessment, expounded the problems in dose-response analysis, and prospected the further work to be done, so as to provide reference for food microbial risk assessment and food safety supervision in China.
引文
[1]国家卫生和计划生育委员会.国家卫生计生委办公厅关于2015年全国食物中毒事件情况的通报[EB/OL].[2016-04-01].http://www.nhc.gov.cn/yjb/s7859/201604/8d34e4c442c54d33909319954c43311c.shtml.National Health and Family Planning Commission.Report on the national food poisoning event in 2015[EB/OL].[2016-04-01].http://www.nhc.gov.cn/yjb/s7859/201604/8d34e4c442c54d33909319954c43311c.shtml.
[2]国家卫生和计划生育委员会.国家卫生计生委办公厅关于2014年全国食物中毒事件情况的通报[EB/OL].[2015-06-20].http://www.nhc.gov.cn/yjb/s3585/201502/91fa4b047e984d3a89c16194722ee9f2.shtml.National Health and Family Planning Commission.Report on the national food poisoning event in 2014[EB/OL].[2015-06-20].http://www.nhc.gov.cn/yjb/s3585/201502/91fa4b047e984d3a89c16194722ee9f2.shtml.
[3]Crossley SM.Food safety management tools(2nd edition)[M].Brussels:ILSI Europe Report Series,2011.
[4]Langerholc T,Lindqvist R,Sand S.Risk ranking of chemical and microbiological hazards in food[J].EFSA J,2018,16:26.
[5]Cassini A,Hathaway S,Havelaar A,et al.Microbiological risk assessment[J].EFSA J,2016,14:s0507.
[6]Haddad N,Johnson N,Kathariou S,et al.Next generation microbiological risk assessment-potential of omics data for hazard characterisation[J].Int J Food Microbiol,2018,287:28-39.
[7]董士昙.论我国食品安全风险评估机制[J].山东警察学院学报,2016,28(2):5-14.Dong ST.Mechanism of food safety risk assessment in China[J].JShandong Police Coll,2016,28(2):5-14.
[8]Haas CN.Microbial dose response modeling:past,present,and future[J].Environ Sci Technol,2015,49(3):1245-1259.
[9]Lee H,Lee S,Kim S,et al.Quantitative microbial risk assessment for clostridium perfringens in natural and processed cheeses[J].Asian-Australas J Anim Sci,2016,29(8):1188-1196.
[10]Almanza AV.Availability of microbial risk assessment guideline:Pathogenic microorganisms with focus on food and in water[J].Fed Regist,2012,77(147):45350.
[11]Ricci A,Allende A,Bolton D,et al.Listeria monocytogenes contamination of ready‐to‐eat foods and the risk for human health in the EU[J].EFSA J,2018,16(1):1764-1776..
[12]Aej D,Turner PJ,Hourihane J,et al.How does dose impact on the severity of food-induced allergic reactions,and can this improve risk assessment for allergenic foods:Report from an ILSI Europe food allergy task force expert group and workshop[J].Allergy,2018,73(7):1383-1392.
[13]Maul A.Heterogeneity:A major factor influencing microbial exposure and risk assessment[J].Risk Anal,2014,34:1606-1617.
[14]Buchanan RL,Smith JL,Long W.Microbial risk assessment:dose-response relations and risk characterization[J].Int J Food Microbiol,2000,58(3):159-172.
[15]Jiao X,Zhu J,Huang J,et al.Microbiological Risk Assessment in Food[M].Hoboken:John Wiley&Sons,Ltd,2017.
[16]Pereira SA,Alves,Ferreira V,et al.The impact of environmental stresses in the virulence traits of Listeria monocytogenes relevant to food safety[Z].2018.
[17]Pexara A,Govaris A.Bacillus cereus:An important foodborne pathogen[J].J Hell Vet Med Soc,2018,61(2):127-133.
[18]Dubois AEJ,Turner PJ,Hourihane J,et al.How does dose impact on the severity of food-induced allergic reactions,and can this improve risk assessment for allergenic foods?[J].Allergy,2018,73(7):1383-1392.
[19]Federal Register.Availability of microbial risk assessment guideline:Pathogenic microorganisms with focus on food and in water[Z].2012.
[20]Rahman A,Munther D,Fazil A,et al.Advancing risk assessment:Mechanistic dose-response modelling of Listeria monocytogenes infection in human populations[J].R Soc Open Sci,2018,5(8):180343.
[21]Al-Bahry SN,Mahmoud IY,Al-Musharafi SK,et al.Staphylococcus aureus contamination during food preparation,processing and handling[J].Int J Chem Eng Appl,2014,5(5):388-392.
[22]Haas CN,Rose JB,Gerba CP.Conducting the dose-response assessment[M].New Jersey:John Wiley&Sons,Inc,2014.
[23]Xie G,Roiko A,Stratton H,et al.Guidelines for use of the approximate beta-poisson dose-response model[J].Risk Anal,2017,37(7):1388-1402.
[24]Ha J,Lee H,Kim S,et al.Quantitative microbial risk assessment of Campylobacter jejuni in jerky in Korea[J].Asian-Austral J Anim,2019,32(2):274-281.
[25]Summary I.Risk assessment of Listeria monocytogenes in ready-to-eat foods[J].Annal Della FacoltàDi Med Vet Di Pisa,2004,59:29-45.
[26]Dong QL,Barker GC,Gorris LGM,et al.Status and future of quantitative microbiological risk assessment in China[J].Trends Food Sci Technol,2015,42(1):70-80.
[27]Campagnollo FB,Gonzales-Barron U,Pil?o-Cadavez VA,et al.Quantitative risk assessment of Listeria monocytogenes in traditional Minas cheeses:The cases of artisanal semi-hard and fresh soft cheeses[J].Food Control,2018,92:370-379.
[28]Condoleo R,Mezher Z,Marozzi S,et al.Risk assessment of human Listeriosis from semisoft cheeses made from raw sheep's milk in Lazio and Tuscany(Italy)[J].Risk Anal,2017,37(4):661-676.
[29]Lee H,Kim K,Choi KH,et al.Quantitative microbial risk assessment for Staphylococcus aureus in natural and processed cheese in Korea[J].JDairy Sci,2015,98(9):5931-5945.
[30]Lewin A,Delage G,Bernier F,et al.Banked human milk and quantitative risk assessment of Bacillus cereus infection in premature infants:Asimulation study[J].Can J Infect Dis Med Microbiol,2019,2019:6348281.
[31]Jeong J,Lee J,Lee H,et al.Quantitative microbial risk assessment for campylobacter foodborne illness in raw beef offal consumption in south Korea[J].J Food Prot,2017,80(4):609-618.
[32]Huang Y,Haas CN.Time-dose-response models for microbial risk assessment[J].Risk Anal,2009,29(5):648-61.
[33]Pouillot R,Hoelzer K,Chen Y,et al.Listeria monocytogenes dose response revisited--incorporating adjustments for variability in strain virulence and host susceptibility[J].Risk Anal,2015,35(1):90-108.
[34]Rahman SMA,Munther D,Fazil A,et al.Unraveling the dose-response puzzle of L.monocytogenes:A mechanistic approach[J].Infect Dis Model,2016,1(1):101-114.
[35]FAO and WHO(Food and Agriculture Organization of the United Nations and World Health Organization).Risk assessment of Listeria monocytogenes in ready-to-eat foods:Technical report[R].Rome:FAO,2004.
[36]Pouillot R,Klontz KC,Chen Y,et al.Infectious dose of Listeria monocytogenes in outbreak linked to ice cream,United States,2015[J].Emerg Infect Dis,2016,22(12):2113-2119.
[37]Hernández-Cortez C,Palma-Martínez I,Gonzalez-Avila LU,et al.Food poisoning caused by bacteria(food toxins)[Z].2017.
[38]Nilsen V,Wyller J.QMRA for drinking water:1.revisiting the mathematical structure of single-hit dose-response models[J].Risk Anal,2016,36(1):145-162.
[39]Havelaar AH,Garssen J,Takumi K,et al.A rat model for dose-response relationships of Salmonella enteritidis infection[J].J Applied Microbiol,2010,91(3):442-452.
[40]Membre′J MGS.Latest developments in foodborne pathogen risk assessment[J].Curr Opin Food Sci,2016,8:120-126.
[41]Ricci A,Allende A,Bolton D,et al.Guidance on the requirements for the development of microbiological criteria[J].EFSA J,2017,15(11):e05052.
[42]Hamilton KA,Weir MH,Haas CN.Dose response models and a quantitative microbial risk assessment framework for the Mycobacterium avium complex that account for recent developments in molecular biology,taxonomy,and epidemiology[J].Water Res,2016,109:310-326.
[43]韩荣伟,于忠娜,张莉,等.我国鸡肉产品中沙门氏菌风险评估的研究进展[J].食品科学,2015,36(23):372-376.Han RW,Yu ZN,Zhang L,et al.Advances in risk assessment of Salmonella spp.in chicken products in China[J].Food Sci,2015,36(23):372-376.
[44]Buchanan RL,Havelaar AH,Mary AS,et al.The key events dose-response framework:Its potential for application to foodborne pathogenic microorganisms[J].Crit Rev Food Sci,2009,49(8):718-728.
[45]Dix A,Vlaic S,Guthke R,et al.Use of systems biology to decipher host-pathogen interaction networks and predict biomarkers[J].Clin Microbiol Infect,2016,22(7):600-606.
[46]Weir MH,Mitchell J,Flynn W,et al.Development of a microbial dose response visualization and modelling application for QMRA modelers and educators[J].Environ Model Softw,2017,88:74-83.
[47]Dean K,Weir MH,Mitchell J.Development of a dose-response model for Naegleria fowleri[J].J Water Health,2019,17(1):63-71.
[2]国家卫生和计划生育委员会.国家卫生计生委办公厅关于2014年全国食物中毒事件情况的通报[EB/OL].[2015-06-20].http://www.nhc.gov.cn/yjb/s3585/201502/91fa4b047e984d3a89c16194722ee9f2.shtml.National Health and Family Planning Commission.Report on the national food poisoning event in 2014[EB/OL].[2015-06-20].http://www.nhc.gov.cn/yjb/s3585/201502/91fa4b047e984d3a89c16194722ee9f2.shtml.
[3]Crossley SM.Food safety management tools(2nd edition)[M].Brussels:ILSI Europe Report Series,2011.
[4]Langerholc T,Lindqvist R,Sand S.Risk ranking of chemical and microbiological hazards in food[J].EFSA J,2018,16:26.
[5]Cassini A,Hathaway S,Havelaar A,et al.Microbiological risk assessment[J].EFSA J,2016,14:s0507.
[6]Haddad N,Johnson N,Kathariou S,et al.Next generation microbiological risk assessment-potential of omics data for hazard characterisation[J].Int J Food Microbiol,2018,287:28-39.
[7]董士昙.论我国食品安全风险评估机制[J].山东警察学院学报,2016,28(2):5-14.Dong ST.Mechanism of food safety risk assessment in China[J].JShandong Police Coll,2016,28(2):5-14.
[8]Haas CN.Microbial dose response modeling:past,present,and future[J].Environ Sci Technol,2015,49(3):1245-1259.
[9]Lee H,Lee S,Kim S,et al.Quantitative microbial risk assessment for clostridium perfringens in natural and processed cheeses[J].Asian-Australas J Anim Sci,2016,29(8):1188-1196.
[10]Almanza AV.Availability of microbial risk assessment guideline:Pathogenic microorganisms with focus on food and in water[J].Fed Regist,2012,77(147):45350.
[11]Ricci A,Allende A,Bolton D,et al.Listeria monocytogenes contamination of ready‐to‐eat foods and the risk for human health in the EU[J].EFSA J,2018,16(1):1764-1776..
[12]Aej D,Turner PJ,Hourihane J,et al.How does dose impact on the severity of food-induced allergic reactions,and can this improve risk assessment for allergenic foods:Report from an ILSI Europe food allergy task force expert group and workshop[J].Allergy,2018,73(7):1383-1392.
[13]Maul A.Heterogeneity:A major factor influencing microbial exposure and risk assessment[J].Risk Anal,2014,34:1606-1617.
[14]Buchanan RL,Smith JL,Long W.Microbial risk assessment:dose-response relations and risk characterization[J].Int J Food Microbiol,2000,58(3):159-172.
[15]Jiao X,Zhu J,Huang J,et al.Microbiological Risk Assessment in Food[M].Hoboken:John Wiley&Sons,Ltd,2017.
[16]Pereira SA,Alves,Ferreira V,et al.The impact of environmental stresses in the virulence traits of Listeria monocytogenes relevant to food safety[Z].2018.
[17]Pexara A,Govaris A.Bacillus cereus:An important foodborne pathogen[J].J Hell Vet Med Soc,2018,61(2):127-133.
[18]Dubois AEJ,Turner PJ,Hourihane J,et al.How does dose impact on the severity of food-induced allergic reactions,and can this improve risk assessment for allergenic foods?[J].Allergy,2018,73(7):1383-1392.
[19]Federal Register.Availability of microbial risk assessment guideline:Pathogenic microorganisms with focus on food and in water[Z].2012.
[20]Rahman A,Munther D,Fazil A,et al.Advancing risk assessment:Mechanistic dose-response modelling of Listeria monocytogenes infection in human populations[J].R Soc Open Sci,2018,5(8):180343.
[21]Al-Bahry SN,Mahmoud IY,Al-Musharafi SK,et al.Staphylococcus aureus contamination during food preparation,processing and handling[J].Int J Chem Eng Appl,2014,5(5):388-392.
[22]Haas CN,Rose JB,Gerba CP.Conducting the dose-response assessment[M].New Jersey:John Wiley&Sons,Inc,2014.
[23]Xie G,Roiko A,Stratton H,et al.Guidelines for use of the approximate beta-poisson dose-response model[J].Risk Anal,2017,37(7):1388-1402.
[24]Ha J,Lee H,Kim S,et al.Quantitative microbial risk assessment of Campylobacter jejuni in jerky in Korea[J].Asian-Austral J Anim,2019,32(2):274-281.
[25]Summary I.Risk assessment of Listeria monocytogenes in ready-to-eat foods[J].Annal Della FacoltàDi Med Vet Di Pisa,2004,59:29-45.
[26]Dong QL,Barker GC,Gorris LGM,et al.Status and future of quantitative microbiological risk assessment in China[J].Trends Food Sci Technol,2015,42(1):70-80.
[27]Campagnollo FB,Gonzales-Barron U,Pil?o-Cadavez VA,et al.Quantitative risk assessment of Listeria monocytogenes in traditional Minas cheeses:The cases of artisanal semi-hard and fresh soft cheeses[J].Food Control,2018,92:370-379.
[28]Condoleo R,Mezher Z,Marozzi S,et al.Risk assessment of human Listeriosis from semisoft cheeses made from raw sheep's milk in Lazio and Tuscany(Italy)[J].Risk Anal,2017,37(4):661-676.
[29]Lee H,Kim K,Choi KH,et al.Quantitative microbial risk assessment for Staphylococcus aureus in natural and processed cheese in Korea[J].JDairy Sci,2015,98(9):5931-5945.
[30]Lewin A,Delage G,Bernier F,et al.Banked human milk and quantitative risk assessment of Bacillus cereus infection in premature infants:Asimulation study[J].Can J Infect Dis Med Microbiol,2019,2019:6348281.
[31]Jeong J,Lee J,Lee H,et al.Quantitative microbial risk assessment for campylobacter foodborne illness in raw beef offal consumption in south Korea[J].J Food Prot,2017,80(4):609-618.
[32]Huang Y,Haas CN.Time-dose-response models for microbial risk assessment[J].Risk Anal,2009,29(5):648-61.
[33]Pouillot R,Hoelzer K,Chen Y,et al.Listeria monocytogenes dose response revisited--incorporating adjustments for variability in strain virulence and host susceptibility[J].Risk Anal,2015,35(1):90-108.
[34]Rahman SMA,Munther D,Fazil A,et al.Unraveling the dose-response puzzle of L.monocytogenes:A mechanistic approach[J].Infect Dis Model,2016,1(1):101-114.
[35]FAO and WHO(Food and Agriculture Organization of the United Nations and World Health Organization).Risk assessment of Listeria monocytogenes in ready-to-eat foods:Technical report[R].Rome:FAO,2004.
[36]Pouillot R,Klontz KC,Chen Y,et al.Infectious dose of Listeria monocytogenes in outbreak linked to ice cream,United States,2015[J].Emerg Infect Dis,2016,22(12):2113-2119.
[37]Hernández-Cortez C,Palma-Martínez I,Gonzalez-Avila LU,et al.Food poisoning caused by bacteria(food toxins)[Z].2017.
[38]Nilsen V,Wyller J.QMRA for drinking water:1.revisiting the mathematical structure of single-hit dose-response models[J].Risk Anal,2016,36(1):145-162.
[39]Havelaar AH,Garssen J,Takumi K,et al.A rat model for dose-response relationships of Salmonella enteritidis infection[J].J Applied Microbiol,2010,91(3):442-452.
[40]Membre′J MGS.Latest developments in foodborne pathogen risk assessment[J].Curr Opin Food Sci,2016,8:120-126.
[41]Ricci A,Allende A,Bolton D,et al.Guidance on the requirements for the development of microbiological criteria[J].EFSA J,2017,15(11):e05052.
[42]Hamilton KA,Weir MH,Haas CN.Dose response models and a quantitative microbial risk assessment framework for the Mycobacterium avium complex that account for recent developments in molecular biology,taxonomy,and epidemiology[J].Water Res,2016,109:310-326.
[43]韩荣伟,于忠娜,张莉,等.我国鸡肉产品中沙门氏菌风险评估的研究进展[J].食品科学,2015,36(23):372-376.Han RW,Yu ZN,Zhang L,et al.Advances in risk assessment of Salmonella spp.in chicken products in China[J].Food Sci,2015,36(23):372-376.
[44]Buchanan RL,Havelaar AH,Mary AS,et al.The key events dose-response framework:Its potential for application to foodborne pathogenic microorganisms[J].Crit Rev Food Sci,2009,49(8):718-728.
[45]Dix A,Vlaic S,Guthke R,et al.Use of systems biology to decipher host-pathogen interaction networks and predict biomarkers[J].Clin Microbiol Infect,2016,22(7):600-606.
[46]Weir MH,Mitchell J,Flynn W,et al.Development of a microbial dose response visualization and modelling application for QMRA modelers and educators[J].Environ Model Softw,2017,88:74-83.
[47]Dean K,Weir MH,Mitchell J.Development of a dose-response model for Naegleria fowleri[J].J Water Health,2019,17(1):63-71.