氨基葡萄糖片对老年膝关节炎患者临床疗效及炎性因子的影响
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摘要
目的探讨氨基葡萄糖片对老年膝关节炎患者临床疗效及炎性因子的影响。方法选取2016年1月—2017年12月收治的老年膝关节炎患者100例,根据治疗方案不同将其分为观察组和对照组,每组50例。对照组予臭氧和玻璃磷酸钠注射液治疗,观察组在对照组基础上联合氨基葡萄糖片治疗。比较2组的临床疗效及不良反应情况,观察2组治疗前后血清C反应蛋白(CRP)、红细胞沉降率(ESR)以及关节液白介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-1(MMP-1)水平。结果观察组临床疗效优良率高于对照组(P<0.05)。治疗3个月后,2组血清CRP水平、ESR以及关节液IL-1、TNF-α和MMP-1水平均低于治疗前,且观察组低于对照组(P<0.05)。2组不良反应发生情况比较差异无统计学意义(P>0.05)。结论氨基葡萄糖片对老年膝关节炎患者临床疗效显著,能有效降低患者血清和关节液中炎性因子水平,安全性高。
Objective To investigate effectiveness of Glucosamine Tablets in treatment of elderly patients with gonarthritis and its effects on inflammatory factors. Methods A total of 100 elderly patients with gonarthritis admitted during January 2016 and December 2017 were divided into observation group and control group(n=50 in each group) according to different treatment schemes. Control group was treated with Ozone and Sodium Hyaluronate Injection, while observation group was added with Glucosamine Tablets on the basis of treatment for control group. In two groups, clinical effectiveness and incidence rate of adverse reactions were compared, and serum levels of C-reactive protein(CRP) and erythrocyte sedimentation rate(ESR), and levels of interleukin-1(IL-1), tumor necrosis factor-α(TNF-α) and matrix metalloproteinase-1(MMP-1) in synovia were observed before and after treatment. Results Excellent and good rate of clinical efficacy in observation group was significantly higher than that in control group(P<0.05). After 3 months of treatment, serum CRP and ESR levels, and IL-1, TNF-α and MMP-1 levels in synovia were significantly lower than those before treatment in two groups, and the levels in observation group were significantly lower than those in control group(P<0.05). There was no significant difference in incidence rate of adverse reactions between two groups(P>0.05). Conclusion Glucosamine Tablets have significant clinical effects in treatment of elderly patients with gonarthritis, and it may effectively reduce levels of inflammatory factors in serum and synovia with good safety.
Objective To investigate effectiveness of Glucosamine Tablets in treatment of elderly patients with gonarthritis and its effects on inflammatory factors. Methods A total of 100 elderly patients with gonarthritis admitted during January 2016 and December 2017 were divided into observation group and control group(n=50 in each group) according to different treatment schemes. Control group was treated with Ozone and Sodium Hyaluronate Injection, while observation group was added with Glucosamine Tablets on the basis of treatment for control group. In two groups, clinical effectiveness and incidence rate of adverse reactions were compared, and serum levels of C-reactive protein(CRP) and erythrocyte sedimentation rate(ESR), and levels of interleukin-1(IL-1), tumor necrosis factor-α(TNF-α) and matrix metalloproteinase-1(MMP-1) in synovia were observed before and after treatment. Results Excellent and good rate of clinical efficacy in observation group was significantly higher than that in control group(P<0.05). After 3 months of treatment, serum CRP and ESR levels, and IL-1, TNF-α and MMP-1 levels in synovia were significantly lower than those before treatment in two groups, and the levels in observation group were significantly lower than those in control group(P<0.05). There was no significant difference in incidence rate of adverse reactions between two groups(P>0.05). Conclusion Glucosamine Tablets have significant clinical effects in treatment of elderly patients with gonarthritis, and it may effectively reduce levels of inflammatory factors in serum and synovia with good safety.
引文
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[13] 张宏伟.玻璃酸钠联合康复训练治疗膝骨关节炎的效果观察[J].保健医学研究与实践,2015,12(4):40-42.
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[15] 陈明,王丹娜,高福明,等.曲安奈德、玻璃酸钠联合硫酸氨基葡萄糖治疗膝骨性关节炎疗效评价[J].中国卫生检验杂志,2016,26(12):1725-1728.
[16] 黄永红,魏国鹏,任学通,等.关节内臭氧玻璃酸钠注射及针刀松解粘连联合治疗膝关节骨性关节炎的临床观察[J].河北医学,2017,23(9):1537-1540.
[17] 成国华,蔡华安,王星娜,等.青藤碱电致孔透皮给药治疗老年膝骨性关节炎急性发作疗效及对滑膜液中炎性因子的影响[J].现代中西医结合杂志,2018,27(1):19-22.
[18] 高志.抗骨增生胶囊联合玻璃酸钠和氨基葡萄糖胶囊治疗膝骨关节炎的临床研究[J].现代药物与临床,2016,31(9):1390-1394.
[19] 胡天鑫,周游,熊靓,等.盐酸氨基葡萄糖胶囊联合复方骨肽注射液治疗膝骨关节炎的临床研究[J].现代药物与临床,2018,33(7):1793-1797.
[20] 刘恩雄,王维敏,吴昌国,等.中药外敷联合盐酸氨基葡萄糖胶囊治疗老年膝骨关节炎68例[J].环球中医药,2016,9(11):1357-1359.
[2] 王晶,敖传西,黄婉秋,等.玻璃酸钠注射液联合中药熏蒸治疗膝关节骨性关节炎的临床效果及对患者血清TNF-α水平的影响[J].现代生物医学进展,2016,16(29):5673-5676.
[3] Laba T L,Brien J A,Fransen M,et al.Patient preferences for adherence to treatment for osteoarthritis:the MEdication Decisions in Osteoarthritis Study(MEDOS)[J].BMC Musculoskelet Disord,2013,14:106.
[4] 张金虎.骨碎补总黄酮联合硫酸氨基葡萄糖对膝骨关节炎患者症状、骨代谢和炎症因子的影响[J].中国骨质疏松杂志,2018,24(7):884-887.
[5] 庄国柱.针灸联合关节腔内注射药物治疗膝关节骨性关节炎的探讨[J].保健医学研究与实践,2018,15(1):76-79.
[6] 胥少汀,葛宝丰,徐印坎.实用骨科学[M].3版.北京:人民军医出版社,2005.
[7] 范文江,刘庆.氨基葡萄糖联合臭氧治疗膝骨关节炎的临床研究[J].华西医学,2016,31(5):823-826.
[8] Bellamy N,Buchanan W W,Goldsmith C H,et al.Validation study of WOMAC:a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee[J].J Rheumatol,1988,15(12):1833-1840.
[9] 徐鸿丽.不同治疗方法在宫颈糜烂患者中的疗效对比观察及对ICMI-1及炎性细胞因子的影响[J].医学分子生物学杂志,2017,14(1):22-25.
[10] 钱炜,Bipin Kumar Rai,袁即山,等.骨性关节炎关节软骨中线粒体酶表达的变化[J].江苏大学学报:医学版,2014,24(6):505-509.
[11] 那键,刘艺,马克勇,等.老年性骨关节炎的分子生物学机制及治疗展望[J].中国老年学杂志,2010,30(20):3035-3037.
[12] 刘瑞霞,崔婷,宋冬明,等.类风湿关节炎患者骨代谢相关基因表达及信号通路的变化[J].江苏大学学报:医学版,2016,26(4):328-332.
[13] 张宏伟.玻璃酸钠联合康复训练治疗膝骨关节炎的效果观察[J].保健医学研究与实践,2015,12(4):40-42.
[14] 马丽敏,史东平,鲍杨,等.针刀联合臭氧治疗膝关节骨性关节炎的疗效观察[J].老年医学与保健,2016,22(4):238-240.
[15] 陈明,王丹娜,高福明,等.曲安奈德、玻璃酸钠联合硫酸氨基葡萄糖治疗膝骨性关节炎疗效评价[J].中国卫生检验杂志,2016,26(12):1725-1728.
[16] 黄永红,魏国鹏,任学通,等.关节内臭氧玻璃酸钠注射及针刀松解粘连联合治疗膝关节骨性关节炎的临床观察[J].河北医学,2017,23(9):1537-1540.
[17] 成国华,蔡华安,王星娜,等.青藤碱电致孔透皮给药治疗老年膝骨性关节炎急性发作疗效及对滑膜液中炎性因子的影响[J].现代中西医结合杂志,2018,27(1):19-22.
[18] 高志.抗骨增生胶囊联合玻璃酸钠和氨基葡萄糖胶囊治疗膝骨关节炎的临床研究[J].现代药物与临床,2016,31(9):1390-1394.
[19] 胡天鑫,周游,熊靓,等.盐酸氨基葡萄糖胶囊联合复方骨肽注射液治疗膝骨关节炎的临床研究[J].现代药物与临床,2018,33(7):1793-1797.
[20] 刘恩雄,王维敏,吴昌国,等.中药外敷联合盐酸氨基葡萄糖胶囊治疗老年膝骨关节炎68例[J].环球中医药,2016,9(11):1357-1359.