微RNA对结直肠癌耐药性的调控机制
摘要
<正>目前我国结直肠癌的发病率、病死率在恶性肿瘤中均位居第5位,且均呈上升趋势,严重威胁着国人的生命健康[1]。根治性切除术仍是结直肠癌治疗的首选方法,但术后的复发、转移使患者的远期生存率大大降低。随着抗肿瘤化学治疗(以下简称化疗)药物的不断应用,化疗的效果越来越得到认可。化疗不仅用于结直肠癌术前或术后的辅助治疗,还用于结直肠癌转移或因禁忌证而无法手术的患者,以达到延长患者生存期、改善其生活质量的目的。然而近年来结直肠癌细胞对化疗药物耐药性的
引文
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[5] ARLANOV R,LANG T,JEDLITSCHKY G,et al.Functional characterization of common protein variants in the efflux transporter ABCC11 and identification of T546M as functionally damaging variant[J].Pharmacogenomics J,2016,16(2):193-201.
[6] XU K,LIANG X,SHEN K,et al.MiR-297 modulates multidrug resistance in human colorectal carcinoma by down-regulating MRP-2[J].Biochem J,2012,446(2):291-300.
[7] BITARTE N,BANDRES E,BONI V,et al.MicroRNA-451 is involved in the self-renewal,tumorigenicity,and chemoresistance of colorectal cancer stem cells[J].Stem Cells,2011,29(11):1661-1671.
[8] TO K K,LEUNG W W,NG S S.Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresistance in colorectal cancer[J].Exp Cell Res,2015,338(2):222-231.
[9] BORRALHO P M,KREN B T,CASTRO R E,et al.MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells[J].FEBS J,2009,276(22):6689-6700.
[10] ZHANG Y,HU X,MIAO X,et al.MicroRNA-425-5p regulates chemoresistance in colorectal cancer cells via regulation of Programmed Cell Death 10[J].J Cell Mol Med,2016,20(2):360-369.
[11] VALERI N,GASPARINI P,BRACONI C,et al.MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)[J].Proc Natl Acad Sci U S A,2010,107(49):21098-21103.
[12] ZHOU Y,WAN G,SPIZZO R,et al.MiR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase[J].Mol Oncol,2014,8(1):83-92.
[13] SONG B,WANG Y,XI Y,et al.Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells[J].Oncogene,2009,28(46):4065-4074.
[14] ZHANG Y,GENG L,TALMON G,et al.MicroRNA-520g confers drug resistance by regulating p21 expression in colorectal cancer[J].J Biol Chem,2015,290(10):6215-6225.
[15] FESLER A,GUO S,LIU H,et al.Overcoming chemoresistance in cancer stem cells with the help of microRNAs in colorectal cancer[J].Epigenomics,2017,9(6):793-796.
[16] XU X T,XU Q,TONG J L,et al.MicroRNA expression profiling identifies miR-328 regulates cancer stem cell-like SP cells in colorectal cancer[J].Br J Cancer,2012,106(7):1320-1330.
[17] ZHAO Y,LIU H,LIU Z,et al.Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism[J].Cancer Res,2011,71(13):4585-4597.
[18] HE J,XIE G,TONG J,et al.Overexpression of microRNA-122 re-sensitizes 5-FU-resistant colon cancer cells to 5-FU through the inhibition of PKM2 in vitro and in vivo[J].Cell Biochem Biophys,2014,70(2):1343-1350.
[19] LI X,ZHAO H,ZHOU X,et al.Inhibition of lactate dehydrogenase A by microRNA-34a resensitizes colon cancer cells to 5-fluorouracil[J].Mol Med Rep,2015,11(1):577-582.
[20] BROWN R,CURRY E,MAGNANI L,et al.Poised epigenetic states and acquired drug resistance in cancer[J].Nat Rev Cancer,2014,14(11):747-753.