一种同时测量鼻咽癌放疗剂量与几何畸变度的新型体模
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摘要
目的:设计一种新型体模,既能根据实际条件测量鼻咽癌放疗剂量,又能同时测量图像几何畸变度。方法:采用对放疗剂量极其敏感的热释光材料,构建头颈部U型槽作为载体,模拟病人实际头颈部肿瘤的大小轮廓、解剖结构和位置,将各个小组件组装拼接,构建新型头颈部放疗剂量测量体模,实现鼻咽癌放疗剂量测量;采用该新型测量模型,将同种形状模块按照一定规律排列和变化,测量图像三维几何畸变度。结果:与传统鼻咽癌放疗剂量的测量体模相比,新型体模能够根据病人实际条件进行精确调整,精确测量病人实际受照射剂量;与传统图像几何畸变度体模相比,新型体模能提供更多新型测量模型和排列方式来测量畸变度,显著提高测量精度。结论:新型体模将剂量测量体模和畸变度测量体模有机结合,既能准确测量鼻咽癌放疗剂量,又能精确测量几何畸变度,简单实用,在临床实际应用有很好的推广价值。
Objective To design a new phantom for measuring the radiotherapy dose and geometric distortion for nasopharyngeal carcinoma(NPC). Methods A thermoluminescence material highly sensitive to radiotherapy dose was used to prepare a U-shaped cast of the head and neck that simulated the size, profile, anatomical structure, and location of the head and neck tumors of patients. The components were assembled into a phantom for measurement of the radiotherapy dosimetry on the head and neck and in the NPC loci. Using this phantom, the three- dimensional geometric distortion was measured after adjustments of the modules. Results Compared with the conventional phantom for measuring radiotherapy dose for NPC, this new phantom allowed precise adaptive adjustment for individual patients for accurate dose measurement. Compared with the conventional phantom for measuring geometric distortion, this phantom provided more models and more variable arrangements for measurement of the distortion degree to improve the measurement accuracy. Conclusion The new phantom that integrates the conventional dosimetry phantom and distortion measurement phantom can achieve more accurate and convenient measurement of radiotherapy dose and geometric distortion in NPC patients.
Objective To design a new phantom for measuring the radiotherapy dose and geometric distortion for nasopharyngeal carcinoma(NPC). Methods A thermoluminescence material highly sensitive to radiotherapy dose was used to prepare a U-shaped cast of the head and neck that simulated the size, profile, anatomical structure, and location of the head and neck tumors of patients. The components were assembled into a phantom for measurement of the radiotherapy dosimetry on the head and neck and in the NPC loci. Using this phantom, the three- dimensional geometric distortion was measured after adjustments of the modules. Results Compared with the conventional phantom for measuring radiotherapy dose for NPC, this new phantom allowed precise adaptive adjustment for individual patients for accurate dose measurement. Compared with the conventional phantom for measuring geometric distortion, this phantom provided more models and more variable arrangements for measurement of the distortion degree to improve the measurement accuracy. Conclusion The new phantom that integrates the conventional dosimetry phantom and distortion measurement phantom can achieve more accurate and convenient measurement of radiotherapy dose and geometric distortion in NPC patients.
引文
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[11]陈超敏,唐木涛,周凌宏,等.调强放射治疗中剂量计算与射野参数优化研究[J].中华放射医学与防护杂志,2006,26(3):248-250.CHEN C M,TANG M T,ZHOU L H,et al.Dose calculation and optimization of field parameters in intensity-modulated radiation therapy[J].Chinese Journal of Radiological Medicine and Protection,2006,26(3):248-250.
[12]潘志华.鼻咽癌的断层解剖与CT表现[J].中华全科医学,2005,3(4):361-362.PAN Z H.Anatomy of the nasopharyngeal carcinoma and CT images[J].Chinese Journal of General Practice,2005,3(4):361-362.
[13]高莹,李毅,马瑾璐.肿瘤放射治疗剂量个体化验证仿真体模及其建立和应用:CN104258505A[P].2015-01-07.GAO Y,LI Y,MA J L.Individualized verification of phantom and its establishment and application in radiation therapy:CN104258505A[P].2015-01-07.
[14]余晓锷,蔡凡伟,何兴华,等.PET/CT图像融合精度测试体模与测试方法研究[J].中国测试,2014,40(3):13-15.YU X E,CAI F W,HE X H,et al.Study on the phantom and test method of PET/CT image fusion accuracy[J].China Measurement&Test,2014,40(3):13-15.
[15]张丽媛,康立丽,贺杰禹.MRI性能测试体模设计与实验验证[J].中国测试,2015,41(1):124-128.ZHANG L Y,KANG L L,HE J Y.Design and experimental test of MRI performance[J].China Measurement&Test,2015,41(1):124-128.
[2]王学涛,陈少文,戴振晖,等.瓦里安加速器6 MV X线小野数据测量与计算比较[J].中华放射肿瘤学杂志,2012,21(6):557-559.WANG X T,CHEN S W,DAI Z H,et al.Analysis and data comparison of Varian accelerator 6 MV in small field[J].Chinese Journal of Radiation Oncology,2012,21(6):557-559.
[3]王梦蛟.锥束CT几何畸变校正和临床应用关键问题研究[D].北京:清华大学,2014.WANG M J.Study on the correction of geometric distortion of conic-beam CT and the key problems in clinical application[D].Beijing:Tsinghua University,2014.
[4]王锐濠,张书旭,张国前,等.局部晚期鼻咽癌调强放疗解剖体积变化及其对剂量分布的影响[J].广东医学,2014,35(1):9-11.WANG R H,ZHANG S X,ZHANG G Q,et al.Anatomical volume changes of intensity modulated radiotherapy for locally advanced nasopharyngeal and its effect on dose distribution[J].Guangdong Medical Journal,2014,35(1):9-11.
[5]张达光,蒋胜鹏,李智华,等.鼻咽癌调强放疗中解剖结构改变及剂量分布变化的研究[J].中国医学物理学杂志,2013,30(4):25-28.ZHANG D G,JIANG S P,LI Z H,et al.Study on the changes of anatomical structure and dose distribution in intensity-modulated radiation therapy[J].Chinese Journal of Medical Physics,2013,30(4):25-28.
[6]肖锋,孙朝阳,石梅,等.鼻咽癌动态调强放疗计划的剂量学验证[J].现代肿瘤医学,2007,15(2):178-180.XIAO F,SUN C Y,SHI M,et al.Dosimetric verification of intensitymodulated radiotherapy for nasopharyngeal carcinoma dynamic[J].Journal of Modern Oncology,2007,15(2):178-180.
[7]陈建武,潘建基,柏鹏刚,等.MRI/CT影像融合对鼻咽癌靶区勾画的影响[J].肿瘤,2009,29(1):61-64.CHEN J W,PAN J J,BAI P G,et al.The effect of MRI/CT image fusion on the delineation of nasopharyngeal carcinoma target area[J].Tumor,2009,29(1):61-64.
[8]曹建忠,罗京伟,徐国镇,等.鼻咽癌调强放疗中解剖及剂量学改变再次计划必要性研究[J].中华放射肿瘤学杂志,2008,17(3):161-164.CAO J Z,LUO J W,XU G Z,et al.Study on the necessity of treatment re-planning for nasopharyngeal carcinoma due to anatomical and dosimetric changes after intensity modulated radiotherapy[J].Chinese Journal of Radiation Oncology,2008,17(3):161-164.
[9]黄劭敏,邓小武,赵充,等.鼻咽癌调强放疗中解剖结构改变对剂量分布影响研究[J].中华放射肿瘤学杂志,2010,19(5):404-408.HUANG S M,DENG X W,ZHAO C,et al.Study on the effect of anatomical structure changes on dose distribution in intensitymodulated radiation therapy[J].Chinese Journal of Radiation Oncology,2010,19(5):404-408.
[10]吕庆文,王立新.提高鼻咽癌放射治疗精度的研究[J].医疗装备,2003,16(5):11-14.LüQ W,WANG L X.Study on the improvement of radiotherapy accuracy[J].Chinese Journal of Medical Device,2003,16(5):11-14.
[11]陈超敏,唐木涛,周凌宏,等.调强放射治疗中剂量计算与射野参数优化研究[J].中华放射医学与防护杂志,2006,26(3):248-250.CHEN C M,TANG M T,ZHOU L H,et al.Dose calculation and optimization of field parameters in intensity-modulated radiation therapy[J].Chinese Journal of Radiological Medicine and Protection,2006,26(3):248-250.
[12]潘志华.鼻咽癌的断层解剖与CT表现[J].中华全科医学,2005,3(4):361-362.PAN Z H.Anatomy of the nasopharyngeal carcinoma and CT images[J].Chinese Journal of General Practice,2005,3(4):361-362.
[13]高莹,李毅,马瑾璐.肿瘤放射治疗剂量个体化验证仿真体模及其建立和应用:CN104258505A[P].2015-01-07.GAO Y,LI Y,MA J L.Individualized verification of phantom and its establishment and application in radiation therapy:CN104258505A[P].2015-01-07.
[14]余晓锷,蔡凡伟,何兴华,等.PET/CT图像融合精度测试体模与测试方法研究[J].中国测试,2014,40(3):13-15.YU X E,CAI F W,HE X H,et al.Study on the phantom and test method of PET/CT image fusion accuracy[J].China Measurement&Test,2014,40(3):13-15.
[15]张丽媛,康立丽,贺杰禹.MRI性能测试体模设计与实验验证[J].中国测试,2015,41(1):124-128.ZHANG L Y,KANG L L,HE J Y.Design and experimental test of MRI performance[J].China Measurement&Test,2015,41(1):124-128.