温经汤治疗寒凝血瘀型原发性痛经Meta分析
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摘要
目的:对金匮温经汤治疗寒凝血瘀型原发性痛经的临床研究文献进行Meta分析,评价其疗效及安全性。方法:计算机检索Pub Med、EMBASE、Cochrane图书馆、万方、维普、CBM、CNKI数据库,收集温经汤治疗寒凝血瘀型原发性痛经的随机对照试验。由两名研究者按照Rev Man5.3软件推荐研究方法独立选择文献、提取资料,并进行Meta分析。结果:纳入研究文献15篇,合计1333例患者,其中试验组716例,西药对照组617例。Meta分析结果,以痛经症状积分为结局指标,温经汤与其他止痛药相比,MD=-0.32,95%CI(-0.76,0.11),Z=1.46,P=0.15;以痛经疼痛评分(VAS)为结局指标,温经汤与其他止痛药相比,MD=-1.30,95%CI(-2.31,-0.28),Z=2.50,P=0.01<0.05;以痛经总体疗效为结局指标,温经汤与其他止痛药相比,RR=1.25,95%CI(1.19,1.31),Z=8.55,P<0.00001。结论:温经汤治疗寒凝血瘀型原发性痛经具有一定的临床疗效,是可供临床选择的治疗方案。
Objective:To conduct a Meta-analysis on clinical study literatures for the effect of JinguiWenjing Decoction for treating primary dysmenorrhea with cold-stagnation and blood-stasis syndrome,in order to evaluate its efficacy and safty. Methods:Pub Med,EMBASE,the Cochrane Library,four Chinese medical databases[Chongqing VIP Chinese Science and Technology Periodical Database(VIP),and Wan Fang Database,Chinese Bio Medical Literature on disc(CBM),the Chinese Medical Database(CNKI)]were searched through computer to collect Wenjing Decoction for treating primary dysmenorrhea with cold-stagnation and blood-stasis syndrome in randomized controlled trials. Two researchers independently selected literatures,extracted data and conducted a Meta-analysis according to the study method recommended by Rev Man5.3 software. Results:Totally 15 study literatures involving 1333 cases were selected,including 716 cases in the test group and 617 cases in the control group. According to the result of the Meta-analysis,the comparison between both groups in the dysmenorrhea symptoms score showed,MD=-0.32,95% CI(-0.76,0.11),Z=1.46,P=0.15,and the comparison between both groups in the recent pain visual analogue scale(VAS)showed,MD=-1.30,95% CI(-2.31,-0.28),Z=2.50,P=0.01<0.05,the comparison between Wenjing decoction groups and control groups in the response rate showed,RR=1.25,95% CI(1.19,1.31),Z=8.55,P<0.00001. Conclusion:Wenjing Decoction showed a certain clinical efficacy for treating primary dysmenorrhea with cold-stagnation and blood-stasis syndrome and so can be used as a clinical therapeutic option.
Objective:To conduct a Meta-analysis on clinical study literatures for the effect of JinguiWenjing Decoction for treating primary dysmenorrhea with cold-stagnation and blood-stasis syndrome,in order to evaluate its efficacy and safty. Methods:Pub Med,EMBASE,the Cochrane Library,four Chinese medical databases[Chongqing VIP Chinese Science and Technology Periodical Database(VIP),and Wan Fang Database,Chinese Bio Medical Literature on disc(CBM),the Chinese Medical Database(CNKI)]were searched through computer to collect Wenjing Decoction for treating primary dysmenorrhea with cold-stagnation and blood-stasis syndrome in randomized controlled trials. Two researchers independently selected literatures,extracted data and conducted a Meta-analysis according to the study method recommended by Rev Man5.3 software. Results:Totally 15 study literatures involving 1333 cases were selected,including 716 cases in the test group and 617 cases in the control group. According to the result of the Meta-analysis,the comparison between both groups in the dysmenorrhea symptoms score showed,MD=-0.32,95% CI(-0.76,0.11),Z=1.46,P=0.15,and the comparison between both groups in the recent pain visual analogue scale(VAS)showed,MD=-1.30,95% CI(-2.31,-0.28),Z=2.50,P=0.01<0.05,the comparison between Wenjing decoction groups and control groups in the response rate showed,RR=1.25,95% CI(1.19,1.31),Z=8.55,P<0.00001. Conclusion:Wenjing Decoction showed a certain clinical efficacy for treating primary dysmenorrhea with cold-stagnation and blood-stasis syndrome and so can be used as a clinical therapeutic option.
引文
[1]黄智超.温经汤的临床应用与实验研究述评[J].陕西中医药大学学报,2016(5):131-134.
[2]徐丁洁,徐洪,董玉山,等.金匮温经汤对虚寒证原发性痛经患者子宫动脉血流动力学的影响[J].中医药导报,2016(13):36-38.
[3]李雯,朱雪琼,蔡进章,等.温经汤对无排卵型功血冲任虚寒血瘀证患者生殖激素分泌的影响[J].中华中医药学刊,2013(1):67-69.
[4]后山尚久.温经汤对排卵障碍和月经周期异常者LH的调节作用[J].国外医学:中医中药分册,2001(4):215.
[5]高剑虹,卞松,刘坤鹏.原发性痛经中医证候要素研究[J].长春中医药大学学报,2015,31(2):385-387.
[6]温景荣,夏阳.温经汤加减治疗阳虚寒凝血瘀型原发性痛经临床观察[J].黑龙江中医药,2010,39(5):9-10.
[7]陈文芳,魏爱民.温经汤加减治疗痛经120例疗效观察[J].右江医学,2005,33(4):381-382.
[8]杨声,郑艳.温经汤加减治疗虚寒型痛经50例[J].福建中医学院学报,2009,19(5):9-10.
[9]李红梅,马志毅.温经汤加减治疗痛经46例[J].湖北中医杂志,2010,32(9):41.
[10]金媛媛.加减温经汤治疗寒凝血瘀证原发性痛经的临床观察[D].武汉:湖北中医药大学,2011.
[11]冯金莲.温经汤治疗寒凝血瘀型原发性痛经30例临床观察[J].湖南中医杂志,2012,28(5):53-54.
[12]张天鹰.《金匮》温经汤治疗原发性痛经的临床疗效观察[J].内蒙古中医药,2014,33(26):34-35.
[13]梅慧.温经汤治疗寒凝血瘀型原发性痛经疗效观察[J].广西中医药,2014,37(4):26-27.
[14]刘玉春,王静,赵晶晶,等.加味温经汤治疗寒凝血瘀型原发性痛经的临床疗效观察[J].黑龙江中医药,2015,31(3):46-47.
[15]张俊兰,李杨.温经汤加减治疗寒凝血瘀型痛经140例疗效观察[J].甘肃科技,2015,31(12):96-97.
[16]蒋毅玲.温经汤加减治疗原发性痛经临床观察[J].海峡药学,2015,27(5):215-216.
[17]吴青燕.活血温经汤治疗原发性痛经51例[J].中国民间疗法,2015,23(11):31-32.
[18]徐丁洁,徐洪,董玉山,等.金匮温经汤对虚寒证原发性痛经患者子宫动脉血流动力学的影响[J].中医药导报,2016,22(13):36-38.
[19]王宁.加味温经汤治疗寒凝血瘀型原发性痛经的临床分析[J].中国卫生标准管理,2016,7(7):137-138.
[20]陈小娟.温经汤加减治疗原发性痛经60例疗效观察[J].大家健康,2016,10(9):51-52.
[21]徐丁洁,张碧溦,徐洪,等.虚寒证原发性痛经患者血清氧化应激的变化及金匮温经汤的干预机制[J].云南中医学院学报,2016,39(2):53-56.
[22]徐丁洁,张碧溦,杜晨光,等.金匮温经汤对虚寒证原发性痛经患者微炎症状态的影响[J].云南中医学院学报,2016,39(3):64-67.
[2]徐丁洁,徐洪,董玉山,等.金匮温经汤对虚寒证原发性痛经患者子宫动脉血流动力学的影响[J].中医药导报,2016(13):36-38.
[3]李雯,朱雪琼,蔡进章,等.温经汤对无排卵型功血冲任虚寒血瘀证患者生殖激素分泌的影响[J].中华中医药学刊,2013(1):67-69.
[4]后山尚久.温经汤对排卵障碍和月经周期异常者LH的调节作用[J].国外医学:中医中药分册,2001(4):215.
[5]高剑虹,卞松,刘坤鹏.原发性痛经中医证候要素研究[J].长春中医药大学学报,2015,31(2):385-387.
[6]温景荣,夏阳.温经汤加减治疗阳虚寒凝血瘀型原发性痛经临床观察[J].黑龙江中医药,2010,39(5):9-10.
[7]陈文芳,魏爱民.温经汤加减治疗痛经120例疗效观察[J].右江医学,2005,33(4):381-382.
[8]杨声,郑艳.温经汤加减治疗虚寒型痛经50例[J].福建中医学院学报,2009,19(5):9-10.
[9]李红梅,马志毅.温经汤加减治疗痛经46例[J].湖北中医杂志,2010,32(9):41.
[10]金媛媛.加减温经汤治疗寒凝血瘀证原发性痛经的临床观察[D].武汉:湖北中医药大学,2011.
[11]冯金莲.温经汤治疗寒凝血瘀型原发性痛经30例临床观察[J].湖南中医杂志,2012,28(5):53-54.
[12]张天鹰.《金匮》温经汤治疗原发性痛经的临床疗效观察[J].内蒙古中医药,2014,33(26):34-35.
[13]梅慧.温经汤治疗寒凝血瘀型原发性痛经疗效观察[J].广西中医药,2014,37(4):26-27.
[14]刘玉春,王静,赵晶晶,等.加味温经汤治疗寒凝血瘀型原发性痛经的临床疗效观察[J].黑龙江中医药,2015,31(3):46-47.
[15]张俊兰,李杨.温经汤加减治疗寒凝血瘀型痛经140例疗效观察[J].甘肃科技,2015,31(12):96-97.
[16]蒋毅玲.温经汤加减治疗原发性痛经临床观察[J].海峡药学,2015,27(5):215-216.
[17]吴青燕.活血温经汤治疗原发性痛经51例[J].中国民间疗法,2015,23(11):31-32.
[18]徐丁洁,徐洪,董玉山,等.金匮温经汤对虚寒证原发性痛经患者子宫动脉血流动力学的影响[J].中医药导报,2016,22(13):36-38.
[19]王宁.加味温经汤治疗寒凝血瘀型原发性痛经的临床分析[J].中国卫生标准管理,2016,7(7):137-138.
[20]陈小娟.温经汤加减治疗原发性痛经60例疗效观察[J].大家健康,2016,10(9):51-52.
[21]徐丁洁,张碧溦,徐洪,等.虚寒证原发性痛经患者血清氧化应激的变化及金匮温经汤的干预机制[J].云南中医学院学报,2016,39(2):53-56.
[22]徐丁洁,张碧溦,杜晨光,等.金匮温经汤对虚寒证原发性痛经患者微炎症状态的影响[J].云南中医学院学报,2016,39(3):64-67.