黄芪及黄芪组分通过调节心肌细胞能量代谢治疗慢性心力衰竭的机制探讨
摘要
以心肌能量代谢紊乱为切入点探讨补气中药黄芪及黄芪组分治疗慢性心力衰竭的机制,为能量代谢紊乱相关疾病提供新的研究思路。
引文
[1] 张健,张宇辉.多中心、前瞻性中国心力衰竭注册登记研究——病因、临床特点和资料情况初步分析[J].中国循环杂志,2015,30(5):413-416.
[2] 苏敬泽,林谦,农一兵.黄芪组分对乳鼠肥大心肌细胞ATP含量的影响[J].中国中医基础医学杂志,2011,17(5):500-502.
[3] INGWALL J S.Energy metabolism in heart failure and remodelling[J].Cardiovascular Research,2008,81(3):412-419.
[4] WANG Z V,LI D L,HILL J A.Heart failure and loss of metabolic control[J].Journal of Cardiovascular Pharmacology,2014,63(4):302-313.
[5] SANKARALINGAM S,LOPASCHUK G D.Cardiac energy metabolic alterations in pressure overload induced left and right heart failure (2013 Grover Conference Series)[J].Pulmonary Circulation,2015,5(1):15-28.
[6] ORMEROD J O,ASHRAFIAN H,FRENNEAUX M P.Impaired energetic in heart failure——a new therapeutic target[J].Pharmacol Ther,2008,119(3):264-274.
[7] JARRETA D,ORUS J,BARRIENTOS A,et al.Mitochondrial function in heart muscle from parents with idiopathic dilated cardiomyopathy[J].Cardiovasc Res,2000,45(4):860-865.
[8] 宋莹,王洪新,张晶,等.黄芪多糖对腹主动脉缩窄致大鼠心肌肥厚能量代谢紊乱的抑制作用[J].中国药理学与毒理学杂志,2012,26 (2):177-182.
[9] ROWE G C,JIANG A,ARANY Z.PGC-1 coactivators in cardiac development and disease[J].Circulation Research,2010,107(7):825-838.
[10] SCHILLING J,KELLY D P.The PGC-1 cascade as a therapeutic target for heart failure[J].Journal of Molecular & Cellular Cardiology,2011,51(4):578-583.
[11] 许放,郭斌,韩冠英,等.黄芪甲苷对H9C2心肌细胞能量代谢的影响及其机制[J].中药药理与临床,2015,31(6):36-39.
[12] 张素萍,栾爱娜,鲁美丽,等.黄芪甲苷对异丙肾上腺素诱导大鼠心肌肥厚及过氧化物酶体增殖活化受体γ辅助活化因子1α的影响[J].中药药理与临床,2014,30(3):65-69.
[13] 唐斌,张金国,谭洪勇,等.黄芪甲苷对慢性心衰大鼠心肌纤维化及能量代谢的影响[J].中国病理生理杂志,2017,33(3):411-416.
[14] MATHUR A,HONG Y,KEMP B K,et al.Evaluation of fluorescent dyes for the detection of mitochondrial membrane potential changes in cultured cardiomyocytes[J].Cardiovasc Res,2000,46(1):126-138.
[15] 张晶,王洪新,宋莹,等.黄芪甲苷抑制大鼠心肌肥厚及改善心肌能量代谢的作用观察[J].中成药,2012,34(5):924-928.
[16] 于妍,王硕仁,聂波,等.黄芪注射液在逆转心肌细胞肥大过程中对心肌细胞线粒体结构和功能的影响[J].中国中药杂志,2012,37(7):979-984.
[17] 苏敬泽,农一兵,林谦.黄芪组分对乳鼠肥大心肌细胞ATP合成酶F1亚单位β肽表达的影响[J].北京中医药,2011,30(2):143-146.
[18] TIMMERS L,SLUIJTER J P,VAN KEULEN J K,et al.Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction[J].Circ Res,2008,102(2):257-264.
[19] ZHANG C,LIN G,WAN W,et al.Resveratrol,a polyphenol phytoalexin,protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-κB signaling pathway[J].Int J Mol Med,2012,29(4):557-563.
[20] 梁灵君,王洪新,孙雪芳,等.Toll样受体4/NF-κB信号通路参与黄芪多糖对肿瘤坏死因子α诱导的乳大鼠心肌细胞肥大的抑制作用[J].中国药理学与毒理学杂志,2013,27(2):168-173.
[21] BERS D M.Cardiac excitation-contraction coupling[J].Nature,2002,415(6868):198-205.
[22] 孙娅楠,李思耐,马淑骅,等.黄芪、丹参注射液对乳鼠肥大心肌细胞钙瞬变的影响[J].中华中医药杂志,2013,28(5):1356-1360.
[23] 苏敬泽,农一兵,温志浩,等.黄芪组分配伍对乳鼠肥大心肌细胞肌酸激酶同工酶mRNA表达的影响[J].中国实验方剂学杂志,2008,14(5):40-43.
[2] 苏敬泽,林谦,农一兵.黄芪组分对乳鼠肥大心肌细胞ATP含量的影响[J].中国中医基础医学杂志,2011,17(5):500-502.
[3] INGWALL J S.Energy metabolism in heart failure and remodelling[J].Cardiovascular Research,2008,81(3):412-419.
[4] WANG Z V,LI D L,HILL J A.Heart failure and loss of metabolic control[J].Journal of Cardiovascular Pharmacology,2014,63(4):302-313.
[5] SANKARALINGAM S,LOPASCHUK G D.Cardiac energy metabolic alterations in pressure overload induced left and right heart failure (2013 Grover Conference Series)[J].Pulmonary Circulation,2015,5(1):15-28.
[6] ORMEROD J O,ASHRAFIAN H,FRENNEAUX M P.Impaired energetic in heart failure——a new therapeutic target[J].Pharmacol Ther,2008,119(3):264-274.
[7] JARRETA D,ORUS J,BARRIENTOS A,et al.Mitochondrial function in heart muscle from parents with idiopathic dilated cardiomyopathy[J].Cardiovasc Res,2000,45(4):860-865.
[8] 宋莹,王洪新,张晶,等.黄芪多糖对腹主动脉缩窄致大鼠心肌肥厚能量代谢紊乱的抑制作用[J].中国药理学与毒理学杂志,2012,26 (2):177-182.
[9] ROWE G C,JIANG A,ARANY Z.PGC-1 coactivators in cardiac development and disease[J].Circulation Research,2010,107(7):825-838.
[10] SCHILLING J,KELLY D P.The PGC-1 cascade as a therapeutic target for heart failure[J].Journal of Molecular & Cellular Cardiology,2011,51(4):578-583.
[11] 许放,郭斌,韩冠英,等.黄芪甲苷对H9C2心肌细胞能量代谢的影响及其机制[J].中药药理与临床,2015,31(6):36-39.
[12] 张素萍,栾爱娜,鲁美丽,等.黄芪甲苷对异丙肾上腺素诱导大鼠心肌肥厚及过氧化物酶体增殖活化受体γ辅助活化因子1α的影响[J].中药药理与临床,2014,30(3):65-69.
[13] 唐斌,张金国,谭洪勇,等.黄芪甲苷对慢性心衰大鼠心肌纤维化及能量代谢的影响[J].中国病理生理杂志,2017,33(3):411-416.
[14] MATHUR A,HONG Y,KEMP B K,et al.Evaluation of fluorescent dyes for the detection of mitochondrial membrane potential changes in cultured cardiomyocytes[J].Cardiovasc Res,2000,46(1):126-138.
[15] 张晶,王洪新,宋莹,等.黄芪甲苷抑制大鼠心肌肥厚及改善心肌能量代谢的作用观察[J].中成药,2012,34(5):924-928.
[16] 于妍,王硕仁,聂波,等.黄芪注射液在逆转心肌细胞肥大过程中对心肌细胞线粒体结构和功能的影响[J].中国中药杂志,2012,37(7):979-984.
[17] 苏敬泽,农一兵,林谦.黄芪组分对乳鼠肥大心肌细胞ATP合成酶F1亚单位β肽表达的影响[J].北京中医药,2011,30(2):143-146.
[18] TIMMERS L,SLUIJTER J P,VAN KEULEN J K,et al.Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction[J].Circ Res,2008,102(2):257-264.
[19] ZHANG C,LIN G,WAN W,et al.Resveratrol,a polyphenol phytoalexin,protects cardiomyocytes against anoxia/reoxygenation injury via the TLR4/NF-κB signaling pathway[J].Int J Mol Med,2012,29(4):557-563.
[20] 梁灵君,王洪新,孙雪芳,等.Toll样受体4/NF-κB信号通路参与黄芪多糖对肿瘤坏死因子α诱导的乳大鼠心肌细胞肥大的抑制作用[J].中国药理学与毒理学杂志,2013,27(2):168-173.
[21] BERS D M.Cardiac excitation-contraction coupling[J].Nature,2002,415(6868):198-205.
[22] 孙娅楠,李思耐,马淑骅,等.黄芪、丹参注射液对乳鼠肥大心肌细胞钙瞬变的影响[J].中华中医药杂志,2013,28(5):1356-1360.
[23] 苏敬泽,农一兵,温志浩,等.黄芪组分配伍对乳鼠肥大心肌细胞肌酸激酶同工酶mRNA表达的影响[J].中国实验方剂学杂志,2008,14(5):40-43.