摘要
目的:探讨美罗培南治疗新生儿重症多重耐药菌感染的临床效果。方法:将62例2017年1月—2018年6月本院收治的重症多重耐药菌感染新生患儿随机分为研究组和对照组,每组31例。两组患儿入院后均接受常规治疗,对照组在常规治疗基础上采用头孢他啶进行治疗,研究组在常规治疗基础上采用美罗培南进行治疗。比较两组患儿的不良反应发生情况和治疗效果。结果:本研究选取的62例新生儿细菌培养结果均呈阳性,其中革兰氏阴性菌构成比为64.51%,革兰氏阳性菌、真菌构成比分别为24.20%、11.29%。研究组不良反应发生率(9.69%)低于对照组(35.49%),且组间差异明显(P<0.05)。研究组治疗总有效率(83.87%)高于对照组(61.29%),且组间差异明显(P<0.05)。结论:采用美罗培南治疗新生儿重症多重耐药菌感染疗效显著、不良反应少,具有较高的有效性和安全性。
Objective:To investigate the clinical effect of meropenem in the treatment of severe multidrug resistant bacteria infection in neonates.Methods:From January 2017 to June 2018,62 newborns with severe multidrug resistant bacteria infection were randomly divided into study group and control group with 31 cases in each group.The two groups received routine treatment after admission,the control group was treated with ceftazidime on the basis of routine treatment,and the study group was treated with meropenem on the basis of routine treatment.The incidence of adverse reactions and therapeutic effects were compared between the two groups.Results:The bacterial culture results of 62 newborns in this study were positive.The composition ratio of Gram-negative bacteria was 64.51%,Gram-positive bacteria and fungal composition ratio were 24.20%and 11.29%,respectively.The incidence of adverse reactions in the study group(9.69%) was lower than that in the control group(35.49%),and the difference between the two groups was signi?cant(P<0.05).The total effective rate in the study group(83.87%) was higher than that in the control group(61.29%),and the difference between the two groups was signi?cant(P<0.05).Conclusion:Meropenem is effective and safe in the treatment of severe multidrug resistant bacterial infections in neonates.
引文
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