尿AD7c-NTP联合尿甲醛、血清S100B在AD早期诊断中的价值及与认知水平的相关性
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摘要
目的探讨尿阿尔茨海默病相关神经丝蛋白(AD7c-NTP)联合尿甲醛、血清S100B蛋白在AD早期诊断中的价值及其与认知水平的相关性。方法选取113例AD患者作为研究组,70例健康者为水平和MMSE评分,分析联合检测的诊断价值及其与认知水平的相关性。结果研究组尿AD7c-NTP、尿甲醛、血清S100B水平均显著高于对照组(P <0.05),不同病情严重程度者比较差异有统计学意义(P <0.05);联合检测ROC曲线下面积0.947,敏感度100.00%,特异度72.00%。研究组中轻度组、中度组和重度组尿AD7c-NTP、尿甲醛、血清S100B水平比较评分呈负相关(P <0.05)。结论 AD患者尿AD7c-NTP、尿甲醛、血清S100B水平显著升高,且与认知功能损伤程度有关,三项指标的联合检测可提高早期AD诊断的价值,还有主语临床病情判断和治疗转归的评价。
Objective To investigate the value of urine neurofilament protein(AD7c-NTP)combinedwith urinary formaldehyde and serum S100 B protein in early diagnosis of Alzheimer disease and its correlation withcognitive level.Methods113 patients with AD were enrolled in the study group and 70 healthy volunteersentered the control group. Urine AD7c-NTP,urine formaldehyde,serum S100 B and MMSE scores were detectedand compared. Value of diagnosis and its correlation with the patients′ cognitive level were analyzed.ResultsLevelsof urine AD7c-NTP,formaldehyde and serum S100 B in the study group were higher than those of the control group(P < 0.05);there were significant differences among patients with different severity(P < 0.05). The area underROC curve of joint detection was 0.947,the sensitivity was 100% and the specificity was 72%. The differences ofurine AD7c-NTP,urine formaldehyde and serum S100 B in the mild,moderate and severe group of the study groupwere statistically significant(P < 0.05). The levels were negatively correlated with MMSE scores(P < 0.05).ConclusionsThe levels of urine AD7c-NTP,formaldehyde and serum S100 B were significantly higher in ADpatients and were related to the degree of cognitive impairment. It has important clinical value in AD diagnosis andevaluation of prognosis.
Objective To investigate the value of urine neurofilament protein(AD7c-NTP)combinedwith urinary formaldehyde and serum S100 B protein in early diagnosis of Alzheimer disease and its correlation withcognitive level.Methods113 patients with AD were enrolled in the study group and 70 healthy volunteersentered the control group. Urine AD7c-NTP,urine formaldehyde,serum S100 B and MMSE scores were detectedand compared. Value of diagnosis and its correlation with the patients′ cognitive level were analyzed.ResultsLevelsof urine AD7c-NTP,formaldehyde and serum S100 B in the study group were higher than those of the control group(P < 0.05);there were significant differences among patients with different severity(P < 0.05). The area underROC curve of joint detection was 0.947,the sensitivity was 100% and the specificity was 72%. The differences ofurine AD7c-NTP,urine formaldehyde and serum S100 B in the mild,moderate and severe group of the study groupwere statistically significant(P < 0.05). The levels were negatively correlated with MMSE scores(P < 0.05).ConclusionsThe levels of urine AD7c-NTP,formaldehyde and serum S100 B were significantly higher in ADpatients and were related to the degree of cognitive impairment. It has important clinical value in AD diagnosis andevaluation of prognosis.
引文
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[14]裴向东,周志东,孙静,等.星状神经节阻滞对老年患者术后血清Aβ-42及tau-181蛋白表达的影响[J].实用医学杂志,2016,32(7):1124-1127.
[15]黄隽超,尚兰,张建新,等.阿尔茨海默病患者血清S100B蛋白和抗脑抗体浓度与认知功能关系[J].中国心理卫生杂志,2017,31(7):523-527.
[2]潘逸茹,王亚岚,喻红之,等.晨尿AD7c-NTP水平与轻度认知障碍之间的关系[J].现代生物医学进展,2016,16(19):3676-3679.
[3]TONG Z,WANG W,LUO W,et al.Urine formaldehyde predicts cognitive impairment in post-stroke dementia and Alzheimer′s Disease[J].Jf Alzheimers Dis,2017,55(3):1031-1038.
[4]LIU X,ZHANG Y,WU R,et al.Acute formaldehyde exposure induced early Alzheimer-like changes in mouse brain[J].Toxicol Mech Methods,2018,28(2):95-104.
[5]刘丽萍,胡建.血清S100B蛋白水平与酒依赖患者认知功能损害的关系[J].临床精神医学杂志,2016,26(1):16-18.
[6]JACK C R Jr,ALBERT M S,KNOPMAN D S,等.美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:对阿尔茨海默病诊断指南的推荐和介绍[J].中华神经科杂志,2012,45(5):332-335.
[7]彭丹涛,张占军.神经心理认知量表操作指南[M].北京:人民卫生出版社,2015:5-9.
[8]谷星忠,石志鸿,郭宏,等.路易体痴呆与帕金森病痴呆认知及精神行为比较[J].实用医学杂志,2017,33(23):3876-3879.
[9]严峰,肖世富.尿AD7c-NTP水平在阿尔茨海默病早期诊断及轻度认知功能障碍诊断中的研究进展[J].世界临床药物,2016,37(5):356-359.
[10]李宁侠,付琳,董恒利,等.血浆Lp-PLA2与尿AD7c-NTP联合诊断AD的初步研究[J].西南国防医药,2016,26(10):1099-1101.
[11]赫荣乔.溶酶体异常与甲醛代谢失调及老年认知损害[J].生物化学与生物物理进展,2016,43(12):1197-1197.
[12]CUI Y,SU T,ZHANG S D,et al.Elevated urine formaldehyde in elderly patients with primary open angle glaucoma[J].Int JOphthalmol,2016,9(3):411-416.
[13]常静,沈仲夏,蔡敏.卒中后抑郁患者抗抑郁治疗血清S100B蛋白的变化分析[J].医学研究生学报,2016,29(7):737-740.
[14]裴向东,周志东,孙静,等.星状神经节阻滞对老年患者术后血清Aβ-42及tau-181蛋白表达的影响[J].实用医学杂志,2016,32(7):1124-1127.
[15]黄隽超,尚兰,张建新,等.阿尔茨海默病患者血清S100B蛋白和抗脑抗体浓度与认知功能关系[J].中国心理卫生杂志,2017,31(7):523-527.