系统评价与Meta分析的内涵及价值
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摘要
系统评价与Meta分析今天已经成为广大研究者耳熟能详的术语,并成为相关领域研究者需要掌握的方法,然而对其内涵及价值的正确理解程度并不容乐观。本文从系统评价与Meta分析的发展、定义、两者的关系、价值及其与循证医学的关系这几个方面进行介绍,以期为读者正确理解及有效使用提供参考。
Systematic review and meta-analysis have been become familiar terms among researchers nowadays,and they are valuable tools in medical research;however,the understanding their connotations and application are sometimes insufficient among researchers.This article briefly introduces the origination,development,definition and application of systematic review and metaanalysis,and also their relationship with evidence-based medicine,in order to provide information for further understanding and effective use of them.
Systematic review and meta-analysis have been become familiar terms among researchers nowadays,and they are valuable tools in medical research;however,the understanding their connotations and application are sometimes insufficient among researchers.This article briefly introduces the origination,development,definition and application of systematic review and metaanalysis,and also their relationship with evidence-based medicine,in order to provide information for further understanding and effective use of them.
引文
[1]ZHAO J G,ZENG X T,WANG J,et al.Association between calcium or vitamin D supplementation and fracture incidence in community-dwelling older adults:A systematic review and meta-analysis[J].JAMA,2017,318(24):2466-2482.
[2]AUNG T,HALSEY J,KROMHOUT D,et al.Associations of omega-3 fatty acid supplement use with cardiovascular disease risks:meta-analysis of 10 trials involving77917 individuals[J].JAMA Cardiol,2018,3(3):225-234.
[3]CHALMERS I,HEDGES L V,COOPER H.A brief history of research synthesis[J].Eval Health Prof,2002,25(1):12-37.
[4]PEARSON K.Report on certain enteric fever inoculation statistics[J].Br Med J,1904,2(2288):1243-1246.
[5]曾宪涛,冷卫东,郭毅,等.Meta分析系列之一:Meta分析的类型[J].中国循证心血管医学杂志,2012,4(1):3-5.
[6]GLASS G.Primary,secondary and meta-analysis of research[J].Educ Res,1976,5:3-8.
[7]罗杰,冷卫东,主编.系统评价/Meta分析理论与实践[M].北京:军事医学科学出版社,2013.
[8]HEDGES L V,OLKIN I.Statistical Methods for MetaAnalysis.New York:Academic Press,1985.
[9]JARVINEN A.A meta-analytic study of the effects of female age on laying date and clutch size in the Great Tit Parus major and the Pied Flycatcher Ficedula hypoleuca[J].Ibis,1991,133(1):62-67.
[10]ARNQVIST G,WOOSTER D.Meta-analysis:synthesizing research findings in ecology and evolution[J].Trends Ecol Evol,1995,10(6):236-240.
[11]KORICHEVA J,GUREVITCH J,MENGERSEN K,eds.The handbook of meta-analysis in ecology and evolution[M].Princeton:Princeton University Press,2013.
[12]GUREVITCH J,KORICHEVA J,NAKAGAWA S,et al.Meta-analysis and the science of research synthesis[J].Nature,2018,555(7695):175-182.
[13]COCHRANE A L.Archie Cochrane in his own words.Selections arranged from his 1972 introduction to“Effectiveness and Efficiency:Random Reflections on the Health Services”1972[J].Control Clin Trials,1989,10(4):428-433.
[14]COCHRANE A L.Effectiveness and Efficiency:Random Reflections on Health Services[M].London:NuffiledProvincal Hospitals Trust,1972.
[15]MULROW C D.The medical review article:state of the science[J].Ann Intern Med,1987,106(3):485-488.
[16]CHALMERS I,ENKIN MW,KEIRSE MJNC.Aguide to effective care in pregnancy and childbirth[M].Oxford:Oxford University Press,1990.
[17]CLARKE M.Partially systematic thoughts on the history of systematic reviews[J].Syst Rev,2018,7(1):176.
[18]PORTA M.A Dictionary of epidemiology[M].5 edition.Oxford:Oxford University Press,2008.
[19]GLASS G.Primary,secondary and meta-analysis of research[J].Educ Res,1976,5:3-8.
[20]PETTICREW M.Systematic reviews from astronomy to zoology:myths and misconceptions[J].BMJ,2001,322(7278):98-101.
[21]CHALMERS I,ALTMAN D G.Systematic Reviews.London:BMJ Publications,1995.
[22]HIGGINS J P T,GREEN S.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[updated March 2011][M/OL].The Cochrane Collaboration,2011.http:∥www.cochrane-handbook.org.
[23]曾宪涛,任学群,主编.应用STATA做Meta分析[M].第2版.北京:中国协和医科大学出版社,2017.
[24]曾宪涛,任学群,主编.分子流行病学研究与系统评价/Meta分析[M].北京:中国协和医科大学出版社,2018.
[25]LI S,KWONG J S,ZENG X T,et al.Plasmakinetic resection technology for the treatment of benign prostatic hyperplasia:evidence from a systematic review and meta-analysis[J].Sci Rep,2015,5:12002.
[26]LUND H,BRUNNHUBER K,JUHL C,et al.Towards evidence based research[J].BMJ,2016,355:i5440.
[27]翁鸿,任学群,王行环,等.临床研究的选题原则及选题[J].中国循证心血管医学杂志,2017,9(3):257-260.
[28]王行环.基于临床实践的研究选题与转化[J].武警医学,2017,28(2):109-114.
[29]LIU Z,YAN S,WU J,et al.Acupuncture for chronic severe functional constipation:A randomized trial[J].Ann Intern Med,2016,165(11):761-769.
[30]Institute of Medicine.Guidelines for clinical practice:from development to use[M].Washington DC:National Academy Press,1992.
[31]Institute of Medicine.Clinical practice guidelines we can trust[M].Washington DC:National Academies Press,2011.
[32]World Health Organization.WHO Handbook for Guideline Development[M].Geneva:World Health Organization,2012.
[33]曾宪涛.再谈循证医学[J].武警医学,2016,27(7):88-93.
[34]SACKETT D L,ROSENBERG W M,GRAY J A,et al.Evidence based medicine:what it is and what it isn't[J].BMJ,1996,312(7023):71-72.
[35]曾宪涛,田国祥,张超,等.Meta分析系列之十五:Meta分析的进展与思考[J].中国循证心血管医学杂志,2013,5(6):561-563,587.
[2]AUNG T,HALSEY J,KROMHOUT D,et al.Associations of omega-3 fatty acid supplement use with cardiovascular disease risks:meta-analysis of 10 trials involving77917 individuals[J].JAMA Cardiol,2018,3(3):225-234.
[3]CHALMERS I,HEDGES L V,COOPER H.A brief history of research synthesis[J].Eval Health Prof,2002,25(1):12-37.
[4]PEARSON K.Report on certain enteric fever inoculation statistics[J].Br Med J,1904,2(2288):1243-1246.
[5]曾宪涛,冷卫东,郭毅,等.Meta分析系列之一:Meta分析的类型[J].中国循证心血管医学杂志,2012,4(1):3-5.
[6]GLASS G.Primary,secondary and meta-analysis of research[J].Educ Res,1976,5:3-8.
[7]罗杰,冷卫东,主编.系统评价/Meta分析理论与实践[M].北京:军事医学科学出版社,2013.
[8]HEDGES L V,OLKIN I.Statistical Methods for MetaAnalysis.New York:Academic Press,1985.
[9]JARVINEN A.A meta-analytic study of the effects of female age on laying date and clutch size in the Great Tit Parus major and the Pied Flycatcher Ficedula hypoleuca[J].Ibis,1991,133(1):62-67.
[10]ARNQVIST G,WOOSTER D.Meta-analysis:synthesizing research findings in ecology and evolution[J].Trends Ecol Evol,1995,10(6):236-240.
[11]KORICHEVA J,GUREVITCH J,MENGERSEN K,eds.The handbook of meta-analysis in ecology and evolution[M].Princeton:Princeton University Press,2013.
[12]GUREVITCH J,KORICHEVA J,NAKAGAWA S,et al.Meta-analysis and the science of research synthesis[J].Nature,2018,555(7695):175-182.
[13]COCHRANE A L.Archie Cochrane in his own words.Selections arranged from his 1972 introduction to“Effectiveness and Efficiency:Random Reflections on the Health Services”1972[J].Control Clin Trials,1989,10(4):428-433.
[14]COCHRANE A L.Effectiveness and Efficiency:Random Reflections on Health Services[M].London:NuffiledProvincal Hospitals Trust,1972.
[15]MULROW C D.The medical review article:state of the science[J].Ann Intern Med,1987,106(3):485-488.
[16]CHALMERS I,ENKIN MW,KEIRSE MJNC.Aguide to effective care in pregnancy and childbirth[M].Oxford:Oxford University Press,1990.
[17]CLARKE M.Partially systematic thoughts on the history of systematic reviews[J].Syst Rev,2018,7(1):176.
[18]PORTA M.A Dictionary of epidemiology[M].5 edition.Oxford:Oxford University Press,2008.
[19]GLASS G.Primary,secondary and meta-analysis of research[J].Educ Res,1976,5:3-8.
[20]PETTICREW M.Systematic reviews from astronomy to zoology:myths and misconceptions[J].BMJ,2001,322(7278):98-101.
[21]CHALMERS I,ALTMAN D G.Systematic Reviews.London:BMJ Publications,1995.
[22]HIGGINS J P T,GREEN S.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[updated March 2011][M/OL].The Cochrane Collaboration,2011.http:∥www.cochrane-handbook.org.
[23]曾宪涛,任学群,主编.应用STATA做Meta分析[M].第2版.北京:中国协和医科大学出版社,2017.
[24]曾宪涛,任学群,主编.分子流行病学研究与系统评价/Meta分析[M].北京:中国协和医科大学出版社,2018.
[25]LI S,KWONG J S,ZENG X T,et al.Plasmakinetic resection technology for the treatment of benign prostatic hyperplasia:evidence from a systematic review and meta-analysis[J].Sci Rep,2015,5:12002.
[26]LUND H,BRUNNHUBER K,JUHL C,et al.Towards evidence based research[J].BMJ,2016,355:i5440.
[27]翁鸿,任学群,王行环,等.临床研究的选题原则及选题[J].中国循证心血管医学杂志,2017,9(3):257-260.
[28]王行环.基于临床实践的研究选题与转化[J].武警医学,2017,28(2):109-114.
[29]LIU Z,YAN S,WU J,et al.Acupuncture for chronic severe functional constipation:A randomized trial[J].Ann Intern Med,2016,165(11):761-769.
[30]Institute of Medicine.Guidelines for clinical practice:from development to use[M].Washington DC:National Academy Press,1992.
[31]Institute of Medicine.Clinical practice guidelines we can trust[M].Washington DC:National Academies Press,2011.
[32]World Health Organization.WHO Handbook for Guideline Development[M].Geneva:World Health Organization,2012.
[33]曾宪涛.再谈循证医学[J].武警医学,2016,27(7):88-93.
[34]SACKETT D L,ROSENBERG W M,GRAY J A,et al.Evidence based medicine:what it is and what it isn't[J].BMJ,1996,312(7023):71-72.
[35]曾宪涛,田国祥,张超,等.Meta分析系列之十五:Meta分析的进展与思考[J].中国循证心血管医学杂志,2013,5(6):561-563,587.