超微粉碎对白术饮片粉体学性质和溶出度的影响
|
摘要
目的研究超微粉碎技术对白术粉体学性质及体外溶出行为的影响,为中药制剂投料提供依据。方法采用振动磨制备白术不同粒径的超微粉,并与细粉进行微观特征、润湿性、比表面积与孔隙率、红外光谱等粉体学性质的对比;采用自身对照紫外分光光度法评价不同粒径粉体的溶出特性;利用热图和主成分分析对数据进行分析和综合评价。结果白术饮片经超微粉碎后粒径减小,比表面积显著增加,溶出度得到了有效改善,但润湿性略有降低;粉体红外特征谱图未发生变化;热图结果表明:粒径是影响溶出的关键因素。结论超微粉碎技术对于改善白术粉体的制剂学性质和溶出度具有一定的应用价值。
OBJECTIVE To investigate the dissolution behavior of the different size of Atractylodes macrocephala powders,andto build the feeding reference of traditional Chinese medicine. METHODS Compared the wettability,microscopiccharacteristics,specific surface area and porosity,and the infrared spectrum of the fine powder and ultrafine powder of A.macrocephala. Their dissolution were tested by using self-control ultraviolet spectrophotometry. Heat map and principalcomponent analysis were utilized to analyze and assess the results. RESULTS The particle size of A. macrocephala was reducedafter ultrafine grinding,the specific surface area and the dissolution were significantly increased,but the wettability was slightlydecreased. The infrared spectrum of the ultrafine particle did not changed. The heatmap results showed that particle size was a keyfactor affecting the dissolution. CONCLUSION The ultrafine grinding technology plays an important role in improving thepreparation properties and dissolution of A. macrocephala powder.
OBJECTIVE To investigate the dissolution behavior of the different size of Atractylodes macrocephala powders,andto build the feeding reference of traditional Chinese medicine. METHODS Compared the wettability,microscopiccharacteristics,specific surface area and porosity,and the infrared spectrum of the fine powder and ultrafine powder of A.macrocephala. Their dissolution were tested by using self-control ultraviolet spectrophotometry. Heat map and principalcomponent analysis were utilized to analyze and assess the results. RESULTS The particle size of A. macrocephala was reducedafter ultrafine grinding,the specific surface area and the dissolution were significantly increased,but the wettability was slightlydecreased. The infrared spectrum of the ultrafine particle did not changed. The heatmap results showed that particle size was a keyfactor affecting the dissolution. CONCLUSION The ultrafine grinding technology plays an important role in improving thepreparation properties and dissolution of A. macrocephala powder.
引文
[1]中华人民共和国国家药典委员会.中国药典[S].北京:中国医药科技版社,2015:611-614.
[2]钟赣生.中药学[M].北京:中国中医药出版社,2013:372-373.
[3]李凤生.药物粉体技术[M].北京:化学工业出版社,2007:150-155.
[4]陈金妹,谈萍,王建永.气体吸附法表征多孔材料的比表面积及孔结构[J].粉末冶金工业,2011,21(2):45-49.
[5]王小平.粒子设计改善中药粉体均一性与溶解性的工艺原理研究[D].成都:成都中医药大学硕士学位论文,2015:12-14.
[6]赵国巍,张晓辉,廖正根,等.中药超微粉碎的影响因素研究概况[J].江西中医学院学报,2011,23(1):98-100.
[7]王念明,张定堃,杨明,等.超微粉碎对黄芩粉体学性质的影响[J].中药材,2013,36(4):640-644.
[8]Matthew PM,Lauren EB,Rajesh ND,et al.Applying dry powder coatings to pharmaceutical powders using a comil for improving powder flow and bulk density[J].Powder Technology,2011,212:397-402.
[9]田景民,鞠爱华,庄志鹤,等.山沉香超微粉与普通粉HPLC指纹图谱的比较研究[J].华西药学杂志,2017,32(6):625-628.
[10]郭玉娟.紫外-可见分光光度法测定乳酸亚铁胶囊的溶出度[J].华西药学杂志,2016,31(4):401-403.
[11]郑晓媚,汤庆发,马钦海,等.GC-MS法分析超微粉碎对白术挥发油成分的影响[J].中国新药与临床药理,2015,26(6):822-824.
[2]钟赣生.中药学[M].北京:中国中医药出版社,2013:372-373.
[3]李凤生.药物粉体技术[M].北京:化学工业出版社,2007:150-155.
[4]陈金妹,谈萍,王建永.气体吸附法表征多孔材料的比表面积及孔结构[J].粉末冶金工业,2011,21(2):45-49.
[5]王小平.粒子设计改善中药粉体均一性与溶解性的工艺原理研究[D].成都:成都中医药大学硕士学位论文,2015:12-14.
[6]赵国巍,张晓辉,廖正根,等.中药超微粉碎的影响因素研究概况[J].江西中医学院学报,2011,23(1):98-100.
[7]王念明,张定堃,杨明,等.超微粉碎对黄芩粉体学性质的影响[J].中药材,2013,36(4):640-644.
[8]Matthew PM,Lauren EB,Rajesh ND,et al.Applying dry powder coatings to pharmaceutical powders using a comil for improving powder flow and bulk density[J].Powder Technology,2011,212:397-402.
[9]田景民,鞠爱华,庄志鹤,等.山沉香超微粉与普通粉HPLC指纹图谱的比较研究[J].华西药学杂志,2017,32(6):625-628.
[10]郭玉娟.紫外-可见分光光度法测定乳酸亚铁胶囊的溶出度[J].华西药学杂志,2016,31(4):401-403.
[11]郑晓媚,汤庆发,马钦海,等.GC-MS法分析超微粉碎对白术挥发油成分的影响[J].中国新药与临床药理,2015,26(6):822-824.