湖北省301057名孕前健康检查女性TORCH感染状况分析
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摘要
目的了解湖北省2016年孕前优生健康检查中拟生育妇女TORCH感染情况及分布特征,并分析弓形虫感染的相关因素,为降低出生缺陷提供理论依据。方法以2016年湖北省孕前优生检查的数据作为分析资料,了解参检女性的TORCH感染状况。利用Excel和SPSS17.0软件对阳性检出率进行描述性分析和logistic回归,差异比较采用■检验。结果共有301 057名拟生育妇女接受TORCH检查,风疹病毒IgG抗体、巨细胞病毒IgG、IgM抗体及弓形虫IgG、IgM抗体阳性检出率分别为78.91%、73.09%、0.17%、5.32%、0.13%。所检测的3种病毒抗体阳性率在与城乡、年龄、生育状态均具有相关性,而近期感染仅与居住地相关。此外,密切接触猫狗均是弓形虫感染的相关因素。结论湖北省调查地区育龄女性TORCH感染状况不容乐观,且存在明显的地区、年龄、生育状态差异。
Objective To understand the TORCH infection and distribution characteristics of pre-pregnant women during pre-pregnancy health examination of Hubei province in 2016,and to study the related factors of toxoplasma infection,as well as to provide theoretical basis for reducing birth defects.Methods The data of pre-pregnancy health examination in Hubei province in 2016 was analyzed to understand the TORCH infection status of female participants.Excel and SPSS17.0 software were applicated to perform descriptive analysis and Logistic regression.The chi-square was performed to compare differences.Results 301 057 women who planned to get pregnant accepted TORCH detection.The positive rates of serum rubella virus IgG antibody,cytomegalovirus IgG and IgM antibodies,toxoplasma gondii IgG and IgM antibodies were 78.91%,73.09%,0.17%,5.32% and 0.13% respectively.The positive rate of the three antibodies detected in different cities in Hubei province was significantly different(P<0.001)in residence,age as well as in fertility status.In addition,close contact with dogs and cats was associated with toxoplasma infection.Conclusion The infection of TORCH in women of child-bearing age in Hubei province is not optimistic,and there are obvious differences between regional,age and fertility status.
Objective To understand the TORCH infection and distribution characteristics of pre-pregnant women during pre-pregnancy health examination of Hubei province in 2016,and to study the related factors of toxoplasma infection,as well as to provide theoretical basis for reducing birth defects.Methods The data of pre-pregnancy health examination in Hubei province in 2016 was analyzed to understand the TORCH infection status of female participants.Excel and SPSS17.0 software were applicated to perform descriptive analysis and Logistic regression.The chi-square was performed to compare differences.Results 301 057 women who planned to get pregnant accepted TORCH detection.The positive rates of serum rubella virus IgG antibody,cytomegalovirus IgG and IgM antibodies,toxoplasma gondii IgG and IgM antibodies were 78.91%,73.09%,0.17%,5.32% and 0.13% respectively.The positive rate of the three antibodies detected in different cities in Hubei province was significantly different(P<0.001)in residence,age as well as in fertility status.In addition,close contact with dogs and cats was associated with toxoplasma infection.Conclusion The infection of TORCH in women of child-bearing age in Hubei province is not optimistic,and there are obvious differences between regional,age and fertility status.
引文
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[3]左万超,付红霞,李莲,等.湖北某地区3980名育龄妇女TORCH检测结果分析[J].山西医药杂志,2016,45(23):2814-2816.
[4]陈敬林,黄湘,万志丹,等.2012-2013年中山市育龄期女性ToRCH筛查结果分析[J].现代预防医学,2016,43(1):62-64.
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[7]牛艳红,于周涛,冀会萍.TORCH感染与不良妊娠结局的关系研究[J].中华医院感染学杂志,2014,24(16):4103-4104,4107.
[8]刘丽娜.长安区孕前及孕早期妇女TORCH检查结果及其与不良妊娠结局的关系[J].临床医学研究与实践,2018,3(28):138-139.
[9]初文君,初慧君,李丽君,等.山东1035例孕前妇女TORCH感染情况调查分析[J].中国生育健康杂志,2019,30(1):42-43,67.
[10]段亚军,刘杏菊,张玲.1118例优生五项Ig M检测在早期妊娠妇女中的临床研究[J].中国医药指南,2012,10(20):552-553.
[11]刘金刚,刘莉,周江涛,等.已婚育龄妇女孕前TORCH感染筛查与治疗[J].内蒙古中医药,2010,29(11):17-18.
[12]游彩玲,王金华,陈秀清,等.TORCH感染与不良妊娠结局的关系[J].中国人兽共患病学报,2010,26(7):712-713.
[13]Jones JL,Dargelas V,Roberts JA,et al.Risk factors for toxoplasma gondii infection in the United States[J].Clinical Infectious Diseases,2009,49(6):878-884.
[14]李荣海,陈勋,韩文端,等.北京地区TORCH流行病学调查研究[J].标记免疫分析与临床,2018,25(10):1453-1459.
[15]吕福通,谢丹尼,陈美佳,等.广西地区免费孕前优生健康检查21万对象TORCH筛查结果分析[J].中国优生与遗传杂志,2014,22(2):80-82.
[16]彭国华,胡主花,葛军,等.2014年南昌市人群弓形虫感染情况调查分析[J].中国血吸虫病防治杂志,2016,28(5):545-549.
[17]张海亭,侯岩岩,亚里昆·买买提依明,等.2017年新疆民丰县农村居民弓形虫感染调查[J].疾病预防控制通报,2018,33(4):5-7,26.
[18]张利红,刘桂芬,刘东梅.河北隆化地区异常妊娠结局孕妇弓形虫感染血清学调查[J].中国血吸虫病防治杂志,2017,29(2):216-218.
[2]许婷姝,李娜.不良妊娠结局与TORCH感染相关性的临床探析[J].临床输血与检验,2018,20(1):61-64.
[3]左万超,付红霞,李莲,等.湖北某地区3980名育龄妇女TORCH检测结果分析[J].山西医药杂志,2016,45(23):2814-2816.
[4]陈敬林,黄湘,万志丹,等.2012-2013年中山市育龄期女性ToRCH筛查结果分析[J].现代预防医学,2016,43(1):62-64.
[5]程自想,王盟,王万海.郑州市1665例育龄妇女TORCH感染情况的调查[J].现代预防医学,2014,41(11):1999-2000,2009.
[6]满姗姗,刘义庆,郑大伟,等.山东地区不孕不育人群TORCH感染情况分析[J].中国优生与遗传杂志,2017,25(9):118-121,94.
[7]牛艳红,于周涛,冀会萍.TORCH感染与不良妊娠结局的关系研究[J].中华医院感染学杂志,2014,24(16):4103-4104,4107.
[8]刘丽娜.长安区孕前及孕早期妇女TORCH检查结果及其与不良妊娠结局的关系[J].临床医学研究与实践,2018,3(28):138-139.
[9]初文君,初慧君,李丽君,等.山东1035例孕前妇女TORCH感染情况调查分析[J].中国生育健康杂志,2019,30(1):42-43,67.
[10]段亚军,刘杏菊,张玲.1118例优生五项Ig M检测在早期妊娠妇女中的临床研究[J].中国医药指南,2012,10(20):552-553.
[11]刘金刚,刘莉,周江涛,等.已婚育龄妇女孕前TORCH感染筛查与治疗[J].内蒙古中医药,2010,29(11):17-18.
[12]游彩玲,王金华,陈秀清,等.TORCH感染与不良妊娠结局的关系[J].中国人兽共患病学报,2010,26(7):712-713.
[13]Jones JL,Dargelas V,Roberts JA,et al.Risk factors for toxoplasma gondii infection in the United States[J].Clinical Infectious Diseases,2009,49(6):878-884.
[14]李荣海,陈勋,韩文端,等.北京地区TORCH流行病学调查研究[J].标记免疫分析与临床,2018,25(10):1453-1459.
[15]吕福通,谢丹尼,陈美佳,等.广西地区免费孕前优生健康检查21万对象TORCH筛查结果分析[J].中国优生与遗传杂志,2014,22(2):80-82.
[16]彭国华,胡主花,葛军,等.2014年南昌市人群弓形虫感染情况调查分析[J].中国血吸虫病防治杂志,2016,28(5):545-549.
[17]张海亭,侯岩岩,亚里昆·买买提依明,等.2017年新疆民丰县农村居民弓形虫感染调查[J].疾病预防控制通报,2018,33(4):5-7,26.
[18]张利红,刘桂芬,刘东梅.河北隆化地区异常妊娠结局孕妇弓形虫感染血清学调查[J].中国血吸虫病防治杂志,2017,29(2):216-218.