我院婴幼儿喘息常见病原体分布特点分析
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摘要
目的探讨引起婴幼儿喘息的常见病原体,为临床用药提供依据。方法收集我院儿科2016年1月1日—2017年1月1日收住院婴幼儿呼吸道感染患儿315例,采用免疫荧光法检测肺炎支原体(MP)、肺炎衣原体(CP)、嗜肺军团菌(LP)、甲型流感病毒(ifuA)、乙型流感病毒(ifuB)、副流感病毒(pful)、呼吸道合胞病毒(RSV)、腺病毒(Adv)Ig M抗体。结果常见呼吸道病原体检出率为27.9%,其中MP-Ig M检出率13.0%、CP-Ig M检出率4.1%、LP-Ig M检出率2.9%、R SV-Ig M检出率2.9%、ifuA-Ig M检出率1.6%、ifuB-Ig M检出率1.3%、pful-Ig M检出率1.3%、Adv-Ig M检出率0.95%。喘息组、非喘息组MP、CP、LP、R SV感染率比较差异有统计学意义(P<0.05)。MP、R SV在婴儿期及幼儿期两年龄段感染率差异有统计学意义(P<0.05)。结论患呼吸道感染的婴幼儿,特别是喘息患儿,行MP、CP、LP及R SV病原学检测对临床治疗有积极意义。
Objective To explore the common pathogens causing wheezing in infants,and to provide theoretical basis for clinical use. Methods A total of 315 hospitalized infants of our hospital with respiratory infection from January 1,2016 to January 1,2017 were enrolled.Immunofluorescence assay was used for Mycoplasma pneumoniae(MP) and Chlamydia pneumoniae(CP),Legionella pneumophila(LP),influenza virus(ifuA),influenza B virus(ifuB),parainfluenza virus(pful),respiratory syncytial virus(RSV),adenovirus(Adv) Ig M antibody.Results The detection rate of common respiratory pathogens was 27.9%, including mp-igm detection rate of 13.0%, cp-igm detection rate of 4.1%, lp-igm detection rate of 2.9%,rsv-igm detection rate of 2.9%, ifua-igm detection rate of 1.6%, ifub-igm detection rate of 1.3%, pfu-igm detection rate of 1.3%,and Adv-igm detection rate of 0.95%.MP, CP, LP and RSV infection rates in the wheezing group and the non-wheezing group were significantly different(P<0.05).The infection rates of MP and RSV in infancy and early childhood were significantly different(P<0.05). Conclusion The detection of MP,CP,LP and RSV in patients with respirator infection,especially in patients with asthma,has positive significance for clinical treatment.
Objective To explore the common pathogens causing wheezing in infants,and to provide theoretical basis for clinical use. Methods A total of 315 hospitalized infants of our hospital with respiratory infection from January 1,2016 to January 1,2017 were enrolled.Immunofluorescence assay was used for Mycoplasma pneumoniae(MP) and Chlamydia pneumoniae(CP),Legionella pneumophila(LP),influenza virus(ifuA),influenza B virus(ifuB),parainfluenza virus(pful),respiratory syncytial virus(RSV),adenovirus(Adv) Ig M antibody.Results The detection rate of common respiratory pathogens was 27.9%, including mp-igm detection rate of 13.0%, cp-igm detection rate of 4.1%, lp-igm detection rate of 2.9%,rsv-igm detection rate of 2.9%, ifua-igm detection rate of 1.6%, ifub-igm detection rate of 1.3%, pfu-igm detection rate of 1.3%,and Adv-igm detection rate of 0.95%.MP, CP, LP and RSV infection rates in the wheezing group and the non-wheezing group were significantly different(P<0.05).The infection rates of MP and RSV in infancy and early childhood were significantly different(P<0.05). Conclusion The detection of MP,CP,LP and RSV in patients with respirator infection,especially in patients with asthma,has positive significance for clinical treatment.
引文
[1]卓珠琳.呼吸道九联检在小儿急性呼吸道疾病诊断中的临床价值[J].检验医学与临床,2015,12(24):3666-3670.
[2]HENDERSON J,GRANELL R,HERON J,et al.Associations of wheezing phenotypes in the first 6 years of life with atopy,lung func tion and airway responsiveness in mid-childhood[J].Thorax,2008,63:974-980.
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[6]ESPOSITO S,BLASI F,AROSIO C.Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing[J].Eur Respir J,2000,16(6):1142-1146.
[7]钱胜华,王晓花,张莉.婴幼儿喘息与肺炎支原体感染的关系探讨[J].中国当代儿科杂志,2016,18(11):1090-1093.
[8]陈广道,陈爱欢.儿童肺炎支原体感染相关喘息的研究进展[J].中华儿科杂志,2012,50(10):756-759.
[9]韩玉芳,魏琴,冯艳广,等.新乡市小儿肺炎支原体、肺炎衣原体感染情况[J].实用儿科临床杂志,2012,27(10):731.
[10]王华丽,吴移谋,郑江花,等.肺炎嗜衣原体CPAF重组蛋白致小鼠肺组织炎症及对炎症细胞因子的影响[J].中国免疫学杂志,2011,27(4):308-311.
[11]HAHN D L,AZENABOR A A,BEATTY W L,et al.Chlamydia pneumoniae as arespiratory pathogen[J].Front Biosei,2002,17:66.
[12]周连,崔亮亮,陈晓东.军团病流行特征的研究进展[J].环境与健康杂志,2013,30(6):553-556.
[13]廖嘉仪,张涛.13 198例急性呼吸道感染住院患儿肺炎支原体、肺炎衣原体及嗜肺军团菌分布特点分析[J].中国当代儿科杂志,2016,18(7):607-613.
[14]陈翊,朱冰,连广琬,等.2009-2010年广州地区儿童呼吸道合胞病毒感染分析[J].广东医学,2011,32(10):1297-1300.
[15]李宾,吴福玲,冯学斌,等.呼吸道合胞病毒毛细支气管炎与支气管哮喘的相关性研究[J].临床儿科杂志,2012,30(2):116-119.(收稿日期:)
[2]HENDERSON J,GRANELL R,HERON J,et al.Associations of wheezing phenotypes in the first 6 years of life with atopy,lung func tion and airway responsiveness in mid-childhood[J].Thorax,2008,63:974-980.
[3]TAUSSIG LM,WRIGHT AL,HOLBERG CJ,et al.Tucson Children's Respiratory Study:1980 to present[J].J Allergy Clin Immunol,2003,111:661-675.
[4]赵德育.婴幼儿喘息流行病学及发展趋势[J].中国实用儿科杂志,2014,29(6):401-404.
[5]魏秀芳.小儿喘息性肺炎发作与肺炎支原体感染及过敏的相关性研究[J].临床医学,2015,35(3):112-113.
[6]ESPOSITO S,BLASI F,AROSIO C.Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing[J].Eur Respir J,2000,16(6):1142-1146.
[7]钱胜华,王晓花,张莉.婴幼儿喘息与肺炎支原体感染的关系探讨[J].中国当代儿科杂志,2016,18(11):1090-1093.
[8]陈广道,陈爱欢.儿童肺炎支原体感染相关喘息的研究进展[J].中华儿科杂志,2012,50(10):756-759.
[9]韩玉芳,魏琴,冯艳广,等.新乡市小儿肺炎支原体、肺炎衣原体感染情况[J].实用儿科临床杂志,2012,27(10):731.
[10]王华丽,吴移谋,郑江花,等.肺炎嗜衣原体CPAF重组蛋白致小鼠肺组织炎症及对炎症细胞因子的影响[J].中国免疫学杂志,2011,27(4):308-311.
[11]HAHN D L,AZENABOR A A,BEATTY W L,et al.Chlamydia pneumoniae as arespiratory pathogen[J].Front Biosei,2002,17:66.
[12]周连,崔亮亮,陈晓东.军团病流行特征的研究进展[J].环境与健康杂志,2013,30(6):553-556.
[13]廖嘉仪,张涛.13 198例急性呼吸道感染住院患儿肺炎支原体、肺炎衣原体及嗜肺军团菌分布特点分析[J].中国当代儿科杂志,2016,18(7):607-613.
[14]陈翊,朱冰,连广琬,等.2009-2010年广州地区儿童呼吸道合胞病毒感染分析[J].广东医学,2011,32(10):1297-1300.
[15]李宾,吴福玲,冯学斌,等.呼吸道合胞病毒毛细支气管炎与支气管哮喘的相关性研究[J].临床儿科杂志,2012,30(2):116-119.(收稿日期:)