多杀性巴氏杆菌免疫逃避机制
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摘要
多杀性巴氏杆菌(Pasteurella multocida,Pm)引起多种畜禽巴氏杆菌病,严重影响养殖业发展。该菌为了能在宿主体内建立感染,已具备了多样化的和复杂的策略来逃避宿主的免疫应答。已发现的多杀性巴氏杆菌的免疫逃避机制包括干扰或逃避宿主的吞噬作用,抵抗中性粒细胞、抗菌肽、补体介导的杀伤作用,降解免疫球蛋白或封闭抗体活性,形成生物膜等,除此之外,多杀性巴氏杆菌毒素(PMT)还参与多种免疫逃避活动。本文就针对多杀性巴氏杆菌的免疫逃避机制做一综述。
Pasteurella multocida( Pm) causes a variety of livestock Pasteurellosis,seriously affecting the breeding industry. In order to establish infection in the host,the pathogens have evolved diverse and sophisticated strategies to evade the immune responses of the host. The immune escape mechanisms of Pm have been found to include interfering with or evaporating host phagocytosis,resisting against the neutrophils,antimicrobial peptides,complement-mediated killing,and degrading immunoglobulins or blocking antibody activity and forming biofilms. In addition,Pasteurella multocida toxin( PMT) engages itself in a variety of immune evasion activities. In this paper,the studies on the immune evasion mechanisms of P. multocida were reviewed.
Pasteurella multocida( Pm) causes a variety of livestock Pasteurellosis,seriously affecting the breeding industry. In order to establish infection in the host,the pathogens have evolved diverse and sophisticated strategies to evade the immune responses of the host. The immune escape mechanisms of Pm have been found to include interfering with or evaporating host phagocytosis,resisting against the neutrophils,antimicrobial peptides,complement-mediated killing,and degrading immunoglobulins or blocking antibody activity and forming biofilms. In addition,Pasteurella multocida toxin( PMT) engages itself in a variety of immune evasion activities. In this paper,the studies on the immune evasion mechanisms of P. multocida were reviewed.
引文
[1]Harper M,Boyce J D,Adler B.Pasteurella multocida pathogenesis:125 years after Pasteur[J].FEMS Microbiol Lett,2006,265(1):1-10.
[2]Cao P,Guo D,Liu J,et al.Genome-wide analyses reveal genes subject to positive selection in pasteurella multocida[J].Front Microbiol,2017,8:961.
[3]Boyce J D,Adler B.The capsule is a virulence determinant in the pathogenesis of Pasteurella multocida M1404(B:2)[J].Infect Immun,2000,68(6):3463-3468.
[4]Poermadjaja B,Frost A.Phagocytic uptake and killing of virulent and avirulent strains of Pasteurella multocida of capsular serotype A by chicken macrophages[J].Vet Microbiol,2000,72:163-171.
[5]Deangelis P L,Padgett-mccue A J.Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F[J].J Biol Chem,2000,275(31):24124-24129.
[6]Deangelis P L,White C L.Identification and molecular cloning of a heparosan synthase from Pasteurella multocida type D[J].J Biol Chem,2002,277(9):7209-7213.
[7]Gangi Setty T,Cho C,Govindappa S,et al.Bacterial periplasmic sialic acid-binding proteins exhibit a conserved binding site[J].Acta Crystallogr D Biol Crystallogr,2014,70(7):1801-1811.
[8]Steenbergen S M,Lichensteiger C A,Caughlan R,et al.Sialic Acid metabolism and systemic pasteurellosis[J].Infect Immun,2005,73(3):1284-1294.
[9]Tatum F M,Tabatabai L B,Briggs R E.Sialic acid uptake is necessary for virulence of Pasteurella multocida in turkeys[J].Microb Pathog,2009,46(6):337-344.
[10]Srivastava S K.Outer membrane protein of Pasteurella multocida serotype B:2 is immunogenic and antiphagocytic[J].Indian J Exp Biol,1998,36(5):530-532.
[11]韦东,吾鲁木汗·那孜尔别克,段世雄,等.禽多杀性巴氏杆菌C48-3株外膜蛋白H的致病作用[J].中国生物工程杂志,2014,34(6):31-39.
[12]吉佳乐.牛源A型多杀性巴氏杆菌三聚体自转运蛋白功能研究[D].重庆:西南大学,2016.
[13]Dagleish M P,Finlayson J,Bayne C,et al.Characterization and time course of pulmonary lesions in calves after intratracheal infection with Pasteurella multocida A:3[J].J Comp Pathol,2010,142:157-169.
[14]Dowling A,Hodgson J C,Dagleish M P,et al.Pathophysiological and immune cell responses in calves prior to and following lung challenge with formalin-killed Pasteurella multocida biotype A:3 and protection studies involving subsequent homologous live challenge[J].Vet Immunol Immunopathol,2004,100:197-207.
[15]Praveena P E,Periasamy S,Kumar A A,et al.Cytokine profiles,apoptosis and pathology of experimental Pasteurella multocida serotype A1 infection in mice[J].Res Vet Sci,2010,89(3):332-339.
[16]Scapinello S,Brooks A S,Macinnes J I,et al.Bactericidal activity of porcine neutrophil secretions[J].Vet Immunol Immunopathol,2011,139:113-118.
[17]Harper M,Cox A D,St Michael F,et al.Natural selection in the chicken host identifies 3-deoxy-D-manno-octulosonic acid kinase residues essential for phosphorylation of Pasteurella multocida lipopolysaccharide[J].Infect Immun,2010,78(9):3669-3677.
[18]Boyce J D,Harper M,St Michael F,et al.Identification of novel glycosyltransferases required for assembly of the Pasteurella multocida A:1 lipopolysaccharide and their involvement in virulence[J].Infect Immun,2009,77(4):1532-1542.
[19]Chiang Y T,Shien J H,Tan D H,et al.Identification of the lic1ABCD operon that controls the phase-variable expression of phosphorylcholine on lipopolysaccharide from Avibacterium paragallinarum[J].Avian Pathol,2013,42(1):72-78.
[20]Harper M,Cox A,Michael F S,et al.Decoration of Pasteurella multocida lipopolysaccharide with phosphocholine is important for virulence[J].J Bacteriol,2007,189(20):7384-7391.
[21]Chung J Y,Wilkie I,Boyce J D,et al.Role of capsule in the pathogenesis of fowl cholera caused by Pasteurella multocida serogroup A[J].Infect Immun,2001,69(4):2487-2492.
[22]Boyce J D,Adler B.The capsule is a virulence determinant in the pathogenesis of Pasteurella multocida M1404(B:2)[J].Infect Immun,2000,68(6):3463-3468.
[23]Negrete-abascal E,Tenorio V R,De la garza M.Secretion of proteases from Pasteurella multocida isolates[J].Curr Microbiol,1999,38(1):64-67.
[24]Confer A W,Ayalew S.The Omp A family of proteins:roles in bacterial pathogenesis and immunity[J].Vet Microbiol,2013,163(3/4):207-222.
[25]Dabo S M,Confer A,Montelongo M,et al.Vaccination with Pasteurella multocida recombinant Omp A induces strong but non-protective and deleterious Th2-type immune response in mice[J].Vaccine,2008,26(34):4345-4351.
[26]Gatto N T,Dabo S M,Hancock R E,et al.Characterization of,and immune responses of mice to,the purified Omp A-equivalent outer membrane protein of Pasteurella multocida serotype A:3(Omp28)[J].Vet Microbiol,2002,87(3):221-235.
[27]潘婷婷.牛源A型多杀性巴氏杆菌PM0979蛋白的功能研究[D].重庆:西南大学,2017.
[28]Hildebrand D,Heeg K,Kubatzky K F.Pasteurella multocida toxinstimulated osteoclast differentiation is B cell dependent[J].Infect Immun,2011,79(1):220-228.
[29]Chakraborty S,Kloos B,Harre U,et al.Pasteurella multocida toxin triggers RANKL-independent osteoclastogenesis[J].Front Immunol,2017,8:185.
[30]Kubatzky K F,Kloos B,Hildebrand D.Signaling cascades of Pasteurella multocida toxin in immune evasion[J].Toxins(Basel),2013,5(9):1664-1681.
[31]Hildebrand D,Walker P,Dalpke A,et al.Pasteurella multocida Toxin-induced Pim-1 expression disrupts suppressor of cytokine signalling(SOCS)-1 activity[J].Cell Microbiol,2010,12(12):1732-1745.
[32]Preuss I,Hildebrand D,Orth J H,et al.Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways[J].Cell Microbiol,2010,12(8):1174-1185.
[33]Chakraborty S,Kloos B,Roetz N,et al.Influence of Pasteurella multocida Toxin on the differentiation of dendritic cells into osteoclasts[J].Immunobiology,2018,223(1):142-150.
[34]Kubatzky K F.Pasteurella multocida and immune cells[J].Curr Top Microbiol Immunol,2012,361:53-72.
[35]Jordan R W,Hamilton T D,Hayes C M,et al.Modulation of the humoral immune response of swine and mice mediated by toxigenic Pasteurella multocida[J].FEMS Immunol Med Microbiol,2003,39(1):51-59.
[36]Bagley K C,Abdelwahab S F,Tuskan R G,et al.Pasteurella multocida toxin activates human monocyte-derived and murine bone marrow-derived dendritic cells in vitro but suppresses antibody production in vivo[J].Infect Immun,2005,73(1):413-421.
[37]Hildebrand D,Sahr A,Wolfle S J,et al.Regulation of Toll-like receptor 4-mediated immune responses through Pasteurella multocida toxin-induced G protein signalling[J].Cell Commun Signal,2012,10(22):1-15.
[38]Orth J H,Aktories K,Kubatzky K F,Modulation of host cell gene expression through activation of STAT transcription factors by Pasteurella multocida toxin[J].J Biol Chem,2007,282(5):3050-3057.
[39]Hildebrand D,Heeg K,Kubatzky K F.Pasteurella multocida toxin manipulates T Cell differentiation[J].Front Microbiol,2015,6:1273.
[40]方仁东,雷桂花,杜慧慧,等.多杀性巴氏杆菌毒素的研究进展[J].中国兽医学报,2016,36(11):1990-1996.
[2]Cao P,Guo D,Liu J,et al.Genome-wide analyses reveal genes subject to positive selection in pasteurella multocida[J].Front Microbiol,2017,8:961.
[3]Boyce J D,Adler B.The capsule is a virulence determinant in the pathogenesis of Pasteurella multocida M1404(B:2)[J].Infect Immun,2000,68(6):3463-3468.
[4]Poermadjaja B,Frost A.Phagocytic uptake and killing of virulent and avirulent strains of Pasteurella multocida of capsular serotype A by chicken macrophages[J].Vet Microbiol,2000,72:163-171.
[5]Deangelis P L,Padgett-mccue A J.Identification and molecular cloning of a chondroitin synthase from Pasteurella multocida type F[J].J Biol Chem,2000,275(31):24124-24129.
[6]Deangelis P L,White C L.Identification and molecular cloning of a heparosan synthase from Pasteurella multocida type D[J].J Biol Chem,2002,277(9):7209-7213.
[7]Gangi Setty T,Cho C,Govindappa S,et al.Bacterial periplasmic sialic acid-binding proteins exhibit a conserved binding site[J].Acta Crystallogr D Biol Crystallogr,2014,70(7):1801-1811.
[8]Steenbergen S M,Lichensteiger C A,Caughlan R,et al.Sialic Acid metabolism and systemic pasteurellosis[J].Infect Immun,2005,73(3):1284-1294.
[9]Tatum F M,Tabatabai L B,Briggs R E.Sialic acid uptake is necessary for virulence of Pasteurella multocida in turkeys[J].Microb Pathog,2009,46(6):337-344.
[10]Srivastava S K.Outer membrane protein of Pasteurella multocida serotype B:2 is immunogenic and antiphagocytic[J].Indian J Exp Biol,1998,36(5):530-532.
[11]韦东,吾鲁木汗·那孜尔别克,段世雄,等.禽多杀性巴氏杆菌C48-3株外膜蛋白H的致病作用[J].中国生物工程杂志,2014,34(6):31-39.
[12]吉佳乐.牛源A型多杀性巴氏杆菌三聚体自转运蛋白功能研究[D].重庆:西南大学,2016.
[13]Dagleish M P,Finlayson J,Bayne C,et al.Characterization and time course of pulmonary lesions in calves after intratracheal infection with Pasteurella multocida A:3[J].J Comp Pathol,2010,142:157-169.
[14]Dowling A,Hodgson J C,Dagleish M P,et al.Pathophysiological and immune cell responses in calves prior to and following lung challenge with formalin-killed Pasteurella multocida biotype A:3 and protection studies involving subsequent homologous live challenge[J].Vet Immunol Immunopathol,2004,100:197-207.
[15]Praveena P E,Periasamy S,Kumar A A,et al.Cytokine profiles,apoptosis and pathology of experimental Pasteurella multocida serotype A1 infection in mice[J].Res Vet Sci,2010,89(3):332-339.
[16]Scapinello S,Brooks A S,Macinnes J I,et al.Bactericidal activity of porcine neutrophil secretions[J].Vet Immunol Immunopathol,2011,139:113-118.
[17]Harper M,Cox A D,St Michael F,et al.Natural selection in the chicken host identifies 3-deoxy-D-manno-octulosonic acid kinase residues essential for phosphorylation of Pasteurella multocida lipopolysaccharide[J].Infect Immun,2010,78(9):3669-3677.
[18]Boyce J D,Harper M,St Michael F,et al.Identification of novel glycosyltransferases required for assembly of the Pasteurella multocida A:1 lipopolysaccharide and their involvement in virulence[J].Infect Immun,2009,77(4):1532-1542.
[19]Chiang Y T,Shien J H,Tan D H,et al.Identification of the lic1ABCD operon that controls the phase-variable expression of phosphorylcholine on lipopolysaccharide from Avibacterium paragallinarum[J].Avian Pathol,2013,42(1):72-78.
[20]Harper M,Cox A,Michael F S,et al.Decoration of Pasteurella multocida lipopolysaccharide with phosphocholine is important for virulence[J].J Bacteriol,2007,189(20):7384-7391.
[21]Chung J Y,Wilkie I,Boyce J D,et al.Role of capsule in the pathogenesis of fowl cholera caused by Pasteurella multocida serogroup A[J].Infect Immun,2001,69(4):2487-2492.
[22]Boyce J D,Adler B.The capsule is a virulence determinant in the pathogenesis of Pasteurella multocida M1404(B:2)[J].Infect Immun,2000,68(6):3463-3468.
[23]Negrete-abascal E,Tenorio V R,De la garza M.Secretion of proteases from Pasteurella multocida isolates[J].Curr Microbiol,1999,38(1):64-67.
[24]Confer A W,Ayalew S.The Omp A family of proteins:roles in bacterial pathogenesis and immunity[J].Vet Microbiol,2013,163(3/4):207-222.
[25]Dabo S M,Confer A,Montelongo M,et al.Vaccination with Pasteurella multocida recombinant Omp A induces strong but non-protective and deleterious Th2-type immune response in mice[J].Vaccine,2008,26(34):4345-4351.
[26]Gatto N T,Dabo S M,Hancock R E,et al.Characterization of,and immune responses of mice to,the purified Omp A-equivalent outer membrane protein of Pasteurella multocida serotype A:3(Omp28)[J].Vet Microbiol,2002,87(3):221-235.
[27]潘婷婷.牛源A型多杀性巴氏杆菌PM0979蛋白的功能研究[D].重庆:西南大学,2017.
[28]Hildebrand D,Heeg K,Kubatzky K F.Pasteurella multocida toxinstimulated osteoclast differentiation is B cell dependent[J].Infect Immun,2011,79(1):220-228.
[29]Chakraborty S,Kloos B,Harre U,et al.Pasteurella multocida toxin triggers RANKL-independent osteoclastogenesis[J].Front Immunol,2017,8:185.
[30]Kubatzky K F,Kloos B,Hildebrand D.Signaling cascades of Pasteurella multocida toxin in immune evasion[J].Toxins(Basel),2013,5(9):1664-1681.
[31]Hildebrand D,Walker P,Dalpke A,et al.Pasteurella multocida Toxin-induced Pim-1 expression disrupts suppressor of cytokine signalling(SOCS)-1 activity[J].Cell Microbiol,2010,12(12):1732-1745.
[32]Preuss I,Hildebrand D,Orth J H,et al.Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways[J].Cell Microbiol,2010,12(8):1174-1185.
[33]Chakraborty S,Kloos B,Roetz N,et al.Influence of Pasteurella multocida Toxin on the differentiation of dendritic cells into osteoclasts[J].Immunobiology,2018,223(1):142-150.
[34]Kubatzky K F.Pasteurella multocida and immune cells[J].Curr Top Microbiol Immunol,2012,361:53-72.
[35]Jordan R W,Hamilton T D,Hayes C M,et al.Modulation of the humoral immune response of swine and mice mediated by toxigenic Pasteurella multocida[J].FEMS Immunol Med Microbiol,2003,39(1):51-59.
[36]Bagley K C,Abdelwahab S F,Tuskan R G,et al.Pasteurella multocida toxin activates human monocyte-derived and murine bone marrow-derived dendritic cells in vitro but suppresses antibody production in vivo[J].Infect Immun,2005,73(1):413-421.
[37]Hildebrand D,Sahr A,Wolfle S J,et al.Regulation of Toll-like receptor 4-mediated immune responses through Pasteurella multocida toxin-induced G protein signalling[J].Cell Commun Signal,2012,10(22):1-15.
[38]Orth J H,Aktories K,Kubatzky K F,Modulation of host cell gene expression through activation of STAT transcription factors by Pasteurella multocida toxin[J].J Biol Chem,2007,282(5):3050-3057.
[39]Hildebrand D,Heeg K,Kubatzky K F.Pasteurella multocida toxin manipulates T Cell differentiation[J].Front Microbiol,2015,6:1273.
[40]方仁东,雷桂花,杜慧慧,等.多杀性巴氏杆菌毒素的研究进展[J].中国兽医学报,2016,36(11):1990-1996.