邵氏“五针法”治疗活动期溃疡性结肠炎临床观察
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摘要
目的观察邵氏"五针法"治疗活动期溃疡性结肠炎的临床疗效。方法采用随机对照法将57例活动期溃疡性结肠炎患者分为肺肠同治组28例、治肠组29例。肺肠同治组采用邵氏"五针法"加药物治疗,包括口服美沙拉嗪、柳氮磺吡啶栓纳肛、葛根芩连汤灌肠;治肠组采用药物治疗。两组均连续治疗4周,观察两组治疗前后Sutherland疾病活动指数(Sutherland DAI);记录两组治疗前后主要临床症状、体征评分。结果两组治疗后Sutherland DAI评分均较治疗前下降(P<0.05),组间比较差异有统计学意义(P<0.05);两组治疗后腹痛、腹泻、脓血便均较治疗前下降(P<0.05),组间比较差异有统计学意义(P<0.05);两组临床疗效比较,肺肠同治组优于治肠组(P<0.05)。结论邵氏"五针法"联合药物治疗能够快速缓解患者的临床症状、体征,减少Sutherland DAI,提高临床疗效。
Objective To observe the clinical efficacy of SHAO's five-needle therapy in treating active ulcerative colitis. Method By following a randomized controlled design, 57 patients with active ulcerative colitis were divided into a lung-intestine simultaneous treatment group of 28 cases and an intestine treatment group of 29 cases. The lung-intestine simultaneous treatment group was intervened by SHAO's five-needle therapy plus medications including oral administration of mesalazine, sulfasalazine suppositories via rectal insertion and Ge Gen Qin Lian decoction via enema; the intestine treatment group was intervened by medications. The two groups were both treated successively for4 weeks. The Sutherland Disease Activity Index(Sutherland DAI) was observed in the two groups and the release rate was also assessed; the main clinical symptom and sign scores of the two groups were recorded before and after treatment. Result The Sutherland DAI score dropped after treatment in both groups(P<0.05), and the between-group difference was statistically significant(P<0.05); the scores of abdominal pain, diarrhea and stool mixed with pus and blood declined after treatment in both groups(P<0.05), and the between-group differences were statistically significant(P<0.05); the lung-intestine simultaneous treatment group was superior to the intestine treatment group comparing plus medications the therapeutic efficacy regarding the symptoms and signs(P<0.05). Conclusion SHAO's five-needle therapy can rapidly release the clinical symptoms and body signs of active ulcerative colitis and enhance the clinical efficacy.
Objective To observe the clinical efficacy of SHAO's five-needle therapy in treating active ulcerative colitis. Method By following a randomized controlled design, 57 patients with active ulcerative colitis were divided into a lung-intestine simultaneous treatment group of 28 cases and an intestine treatment group of 29 cases. The lung-intestine simultaneous treatment group was intervened by SHAO's five-needle therapy plus medications including oral administration of mesalazine, sulfasalazine suppositories via rectal insertion and Ge Gen Qin Lian decoction via enema; the intestine treatment group was intervened by medications. The two groups were both treated successively for4 weeks. The Sutherland Disease Activity Index(Sutherland DAI) was observed in the two groups and the release rate was also assessed; the main clinical symptom and sign scores of the two groups were recorded before and after treatment. Result The Sutherland DAI score dropped after treatment in both groups(P<0.05), and the between-group difference was statistically significant(P<0.05); the scores of abdominal pain, diarrhea and stool mixed with pus and blood declined after treatment in both groups(P<0.05), and the between-group differences were statistically significant(P<0.05); the lung-intestine simultaneous treatment group was superior to the intestine treatment group comparing plus medications the therapeutic efficacy regarding the symptoms and signs(P<0.05). Conclusion SHAO's five-needle therapy can rapidly release the clinical symptoms and body signs of active ulcerative colitis and enhance the clinical efficacy.
引文
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[16]赵勇,王红,张淑文,等.复方清热颗粒治疗急性肺炎疗效观察[J].中国中医急症,2010,19(1):1-3.
[17]李晓霞,卢笑晖.“肺与大肠相表里”-大承气汤峻下热结方剂与急性呼吸窘迫综合征临床研究概况[J].实用中医内科杂志,2016,30(4):119-121.
[18]陆为民,周晓波,徐丹华.国医大师徐景藩教授论治溃疡性结肠炎的经验[J].中华中医药杂志,2014,29(1):124-126.
[19]王新月,孙慧怡.基于肺与大肠相表里理论探讨从肺论治溃疡性结肠炎[J].北京中医药大学学报,2011,34(3):153-155.
[20]权春分,邵素菊.“邵氏五针法”从肺论治慢性结肠炎23例[J].中国针灸,2015,35(8):840.
[2]倪小冬,李幼生,张永良,等.PEC途径行粪菌移植加肠内营养治疗复发性溃疡性结肠炎[J].肠外与肠内营养,2015,22(1):29-33,38.
[3]Iskandar HN,Dhere T,Farraye FA.Ulcerative colitis:update on medical management[J].Curr Gastroenterol Rep,2015,17(11):44-53.
[4]戴高中,陈晨,范先靖,等.白头翁汤加减灌肠方治疗左半结肠型急性期溃疡性结肠炎17例临床观察[J].中医杂志,2015,56(21):1862-1866.
[5]臧凯宏,吴建军,秦红岩,等.黄芪多糖对溃疡性结肠炎大鼠肠道黏膜屏障的影响[J].中药材,2017,40(1):208-211.
[6]刘又前,顾培青,张露,等.沈洪教授辨治溃疡性结肠炎的证治思想撷英[J].中国中医急症,2015,24(12):2127-2129.
[7]王鹏程,赵珊,冯健,等.基于NF-?B信号通路的中药抗溃疡性结肠炎研究进展[J].中草药,2015,46(10):1556-1561.
[8]中国中西医结合学会消化系统疾病专业委员会.溃疡性结肠炎中西医结合诊疗指南(草案)[J].中国中西医结合消化杂志,2011,19(1):61-65.
[9]中华中医药学会脾胃病分会.溃疡性结肠炎中医诊疗共识意见[J].中华中医药杂志,2010,25(6):891-895.
[10]Ramalho-Santos M,Melton DA,Mc Mahon AP.Hedgehog signals regulate multiple aspects of gastrointestinal development[J].Development,2000,127(12):2763-2772.
[11]Shu W,Lu MM,Zhang Y,et al.Foxp2 and Foxp1cooperatively regulate lung and esophagus development[J].Development,2007,134(10):1991-2000.
[12]郑秀丽,杨宇,唐洪屈,等.从肺与大肠的特异相关性探讨“肺与大肠相表里”[J].中华中医药杂志,2013,28(5):1492-1495.
[13]王宝家,杨宇,郑秀丽,等.基于肺肠微生态及TGF-?1/Smads/ERK信号通路探讨溃疡性结肠炎大鼠肺损伤的机制[J].中华中医药杂志,2014,29(11):3555-3559.
[14]顾大勇,李艳,陈莉,等.LPS的直接诱导对肺微血管内皮细胞IL-8的表达及对PMN趋化作用影响的研究[J].中国微循环,2003,7(4):214-217,223.
[15]韩俊阁,刘晓燕,张刘扛,等.“肺与大肠相表里”机理的研究-高氧刺激对肺肠黏膜免疫因子含量表达的影响[J].世界中医药,2015,10(1):80-85.
[16]赵勇,王红,张淑文,等.复方清热颗粒治疗急性肺炎疗效观察[J].中国中医急症,2010,19(1):1-3.
[17]李晓霞,卢笑晖.“肺与大肠相表里”-大承气汤峻下热结方剂与急性呼吸窘迫综合征临床研究概况[J].实用中医内科杂志,2016,30(4):119-121.
[18]陆为民,周晓波,徐丹华.国医大师徐景藩教授论治溃疡性结肠炎的经验[J].中华中医药杂志,2014,29(1):124-126.
[19]王新月,孙慧怡.基于肺与大肠相表里理论探讨从肺论治溃疡性结肠炎[J].北京中医药大学学报,2011,34(3):153-155.
[20]权春分,邵素菊.“邵氏五针法”从肺论治慢性结肠炎23例[J].中国针灸,2015,35(8):840.