多发性硬化伴抑郁的脑结构及功能磁共振成像研究进展
摘要
<正>多发性硬化(multiple sclerosis,MS)是一种最常见的中枢神经系统炎性脱髓鞘疾病,常伴多种情绪障碍,其中抑郁最为常见。文献报道MS伴抑郁的发生率约40%～50%,是普通人群的五倍以上,且发病率逐年升高,给患者、家庭及社会带来巨大负担,因此对MS伴抑郁的研究极为重要~[1]。常规MRI对MS病灶检出率较高,但不能显示脑的微观损伤、功能改变及其病理机制;结构及功能MRI是神经影像领域的新技术,为MS病理生理研究提供了新视角。本
引文
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2 Rabins PV,Brooks BR,O'Donnell P,et al. Structural brain correlates of emotional disorder in multiple sclerosis[J]. Brain,1986,109:585-597.
3 Pujol J,Bello J,Deus J,et al. Lesions in the left arcuate fasciculus region and depressive symptoms in multiple sclerosis[J]. Neurology,1997,49:1105-1110.
4 Feinstein A,Roy P,Lobaugh N,et al. Structural brain abnormalities in multiple sclerosis patients with major depression[J]. Neurology,2004,62:586-590.
5 Feinstein A,O'Connor P,Akbar N,et al. Diffusion tensor imaging abnormalities in depressed multiple sclerosis patients[J]. Mult Scler,2010,16:189-196.
6 Pravata E,Rocca MA,Valsasina P,et al. Gray matter trophism,cognitive impairment,and depression in patients with multiple sclerosis[J]. Mult Scler,2017,23:1864-1874.
7 Gobbi C,Rocca MA,Riccitelli G,et al. Influence of the topography of brain damage on depression and fatigue in patients with multiple sclerosis[J]. Mult Scler,2014,20:192-201.
8 Kiy G,Lehmann P,Hahn HK,et al. Decreased hippocampal volume,indirectly measured,is associated with depressive symptoms and consolidation deficits in multiple sclerosis[J]. Mult Scler,2011,17:1088-1097.
9 Gold SM,O'Connor MF,Gill R,et al. Detection of altered hippocampal morphology in multiple sclerosis-associated depression using automated surface mesh modeling[J]. Hum Brain Mapp,2014,35:30-37.
10 Gy?rfi O,Nagy H,Bokor M,et al. Reduced CA2-CA3 Hippocampal Subfield Volume Is Related to Depression and Normalized by l-DOPA in Newly Diagnosed Parkinson's Disease[J]. Front Neurol,2017,8:84.
11 Gold SM,Kern KC,O'Connor M,et al. Smaller Cornu Ammonis 2-3/Dentate Gyrus Volumes and Elevated Cortisol in Multiple Sclerosis Patients with Depressive Symptoms[J]. Biological Psychiatry,2010,68:553-559.
12 Stuke H,Hanken K,Hirsch J,et al. Cross-Sectional and Longitudinal Relationships between Depressive Symptoms and Brain Atrophy in MS Patients[J]. Front Hum Neurosci,2016,10:622.
13 Acosta-Cabronero J,Nestor PJ. Diffusion tensor imaging in Alzheimer's disease: insights into the limbic-diencephalic network and methodological considerations[J]. Front Aging Neurosci,2014,6:266.
14 Karlsgodt KH. Diffusion Imaging of White Matter In Schizophrenia: Progress and Future Directions[J]. Biol Psychiatry Cogn Neurosci Neuroimaging,2016,1:209-217.
15 Korgaonkar MS,Fornito A,Williams LM,et al. Abnormal structural networks characterize major depressive disorder: a connectome analysis[J]. Biol Psychiatry,2014,76:567-574.
16 Shen Y,Bai L,Gao Y,et al. Depressive symptoms in multiple sclerosis from an in vivo study with TBSS[J]. Biomed Res Int,2014,2014:148465.
17 Liao Y,Huang X,Wu Q,et al. Is depression a disconnection syndrome Meta-analysis of diffusion tensor imaging studies in patients with MDD[J]. J Psychiatry Neurosci,2013,38:49-56.
18 Gobbi C,Rocca MA,Pagani E,et al. Forceps minor damage and co-occurrence of depression and fatigue in multiple sclerosis[J]. Mult Scler,2014,20:1633-1640.
19 Nigro S,Passamonti L,Riccelli R,et al. Structural 'connectomic' alterations in the limbic system of multiple sclerosis patients with major depression[J]. Mult Scler,2015,21:1003-1012.
20 Zhang J,Wang J,Wu Q,et al. Disrupted Brain Connectivity Networks in Drug-Naive,First-Episode Major Depressive Disorder[J]. Biological Psychiatry,2011,70:334-342.
21 Rocca MA,Pravata E,Valsasina P,et al. Hippocampal-DMN disconnectivity in MS is related to WM lesions and depression[J]. Hum Brain Mapp,2015,36:5051-5063.
22 Colasanti A,Guo Q,Giannetti P,et al. Hippocampal Neuroinflammation,Functional Connectivity,and Depressive Symptoms in Multiple Sclerosis[J]. Biol Psychiatry,2016,80:62-72.
23 Hind D,Cotter J,Thake A,et al. Cognitive behavioural therapy for the treatment of depression in people with multiple sclerosis: a systematic review and meta-analysis[J]. BMC Psychiatry,2014,14:5.
24 Urban-Kowalczyk M,Rudecki T,Wróblewski D,et al. Electroconvulsive therapy in patient with psychotic depression and multiple sclerosis[J]. Neurocase,2014,20:452-455.
25 Bonavita S,Sacco R,Esposito S,et al. Default mode network changes in multiple sclerosis: a link between depression and cognitive impairment?[J]. Eur J Neurol,2017,24:27-36.
26 Riccelli R,Passamonti L,Cerasa A,et al. Individual differences in depression are associated with abnormal function of the limbic system in multiple sclerosis patients[J]. Mult Scler,2016,22:1094-1105.