尼莫地平联合依达拉奉治疗老年急性脑梗死的临床效果
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摘要
目的分析尼莫地平联合依达拉奉对老年急性脑梗死的治疗效果。方法入选2017年4月至2018年10月重庆三峡中心医院神经内科老年急性脑梗死患者96例,随机数表法分为研究组和对照组,每组48例。对照组采用尼莫地平治疗,研究组采用尼莫地平联合依达拉奉治疗,对比2组患者临床疗效、美国国立卫生研究院脑卒中量表(NIHSS)评分、氧合血红蛋白(HbO_2)、还原血红蛋白(Hb)、脉搏血氧饱和度(SpO_2)、总血红蛋白(HbT)指标以及氧化应激反应指标超氧化物歧化酶(SOD)、丙二醛(MDA)、超敏C反应蛋白(hs-CRP)水平和不良反应。应用SPSS 22.0统计软件对数据进行分析。组间比较采用t检验或χ~2检验。结果研究组总有效率高于对照组[95.83%(46/48)vs 75.00%(36/48)],差异有统计学意义(χ~2=12.080,P=0.001)。研究组治疗后相比对照组HbO_2[(4.16±0.57)%vs(3.26±0.46)%]、SpO_2[(66.32±5.51)%vs(59.64±4.93)%]和HbT[(4.48±0.86)vs(3.62±0.88)g/L]明显增高,Hb[(0.42±0.16)vs(0.56±0.22)g/L]、SOD[(42.65±6.88)vs(48.56±8.09)U/ml]、MDA[(2.28±0.58)vs(3.78±0.85)mmol/L]、hs-CRP[(8.12±2.04)vs(12.87±4.26)mg/L]和NIHSS评分[(13.13±5.74)vs(18.92±4.60)]降低,差异均有统计学意义(P<0.05)。研究组相比对照组不良反应发生率低,差异有统计学意义[16.67%(8/48)vs 39.58%(18/48),χ~2=6.235,P=0.013]。结论尼莫地平联合依达拉奉治疗老年急性脑梗死患者临床效果显著。
Objective To analyze the efficacy of nimodipine combined with edaravone in the treatment of the elderly patients with acute cerebral infarction. Methods From April 2017 to October 2018, 96 elderly patients with acute cerebral infarction admitted in our department were recruited, and then randomly divided into study group(n=48) and control group(n=48). The control group was treated with nimodipine and the study group was treated with nimodipine combined with edaravone. The clinical efficacy; score of the National Institutes of Health Stroke scale(NIHSS); blood oxygen indices, such as, oxyhemoglobin(HbO_2), hemoglobin(Hb), pulse oxygen saturation(SpO_2), total hemoglobin(HbT), and oxidative stress response indices, including superoxide dismutase(SOD), malondialdehyde(MDA), high-sensitivity C-reactive protein(hs-CRP), and incidence of adverse reactions were compared between the 2 groups. SPSS statistics 22.0 was used for data analysis. Student′s t test or Chi-square test was employed for the com-parison between groups. Results The total effective rate was statistically higher in the study group than in the control group [95.83%(46/48) vs 75.00%(36/48), χ~2=12.080, P=0.001]. After treatment, the study group had significantly higher HbO_2 [(4.16±0.57)% vs(3.26±0.46)%], SpO_2 [(66.32±5.51)% vs(59.64±4.93)%] and HbT [(4.48±0.86) vs(3.62±0.88)g/L], and obviously lower Hb [(0.42±0.16) vs(0.56±0.22)g/L], SOD [(42.65±6.88) vs(48.56±8.09)U/ml],MDA [(2.28±0.58) vs(3.78±0.85)mmol/L], hs-CRP [(8.12±2.04) vs(12.87±4.26)mg/L] and NIHSS score [(13.13±5.74) vs(18.92±4.60)] when compared with the control group(all P<0.05). The incidence of adverse reactions was lower in the study group than in the control group [16.67%(8/48) vs 39.58%(18/48), χ~2=6.235, P=0.013]. Conclusion Nimodipine combined with edaravone is effective in the treatment of elderly patients with acute cerebral infarction.
Objective To analyze the efficacy of nimodipine combined with edaravone in the treatment of the elderly patients with acute cerebral infarction. Methods From April 2017 to October 2018, 96 elderly patients with acute cerebral infarction admitted in our department were recruited, and then randomly divided into study group(n=48) and control group(n=48). The control group was treated with nimodipine and the study group was treated with nimodipine combined with edaravone. The clinical efficacy; score of the National Institutes of Health Stroke scale(NIHSS); blood oxygen indices, such as, oxyhemoglobin(HbO_2), hemoglobin(Hb), pulse oxygen saturation(SpO_2), total hemoglobin(HbT), and oxidative stress response indices, including superoxide dismutase(SOD), malondialdehyde(MDA), high-sensitivity C-reactive protein(hs-CRP), and incidence of adverse reactions were compared between the 2 groups. SPSS statistics 22.0 was used for data analysis. Student′s t test or Chi-square test was employed for the com-parison between groups. Results The total effective rate was statistically higher in the study group than in the control group [95.83%(46/48) vs 75.00%(36/48), χ~2=12.080, P=0.001]. After treatment, the study group had significantly higher HbO_2 [(4.16±0.57)% vs(3.26±0.46)%], SpO_2 [(66.32±5.51)% vs(59.64±4.93)%] and HbT [(4.48±0.86) vs(3.62±0.88)g/L], and obviously lower Hb [(0.42±0.16) vs(0.56±0.22)g/L], SOD [(42.65±6.88) vs(48.56±8.09)U/ml],MDA [(2.28±0.58) vs(3.78±0.85)mmol/L], hs-CRP [(8.12±2.04) vs(12.87±4.26)mg/L] and NIHSS score [(13.13±5.74) vs(18.92±4.60)] when compared with the control group(all P<0.05). The incidence of adverse reactions was lower in the study group than in the control group [16.67%(8/48) vs 39.58%(18/48), χ~2=6.235, P=0.013]. Conclusion Nimodipine combined with edaravone is effective in the treatment of elderly patients with acute cerebral infarction.
引文
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[2] 李刚,吉萍,赵东刚,等.超早期溶栓治疗急性脑梗死的临床效果及安全性[J].中华老年多器官疾病杂志,2018,17(6):434-437.DOI:10.11915/j.issn.1671-5403.2018.06.097.Li G,Ji P,Zhao DG,et al.Clinical efficacy and safety of ultra-early intravenous thrombolytic therapy for acute cerebral infarc-tion[J].Chin J Mult Organ Dis Elderly,2018,17(6):434-437.DOI:10.11915/j.issn.1671-5403.2018.06.097.
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[5] 司可意,李志平.依达拉奉联合尼莫地平对急性大面积脑梗死相关生化指标的影响[J].中国实用神经疾病杂志,2017,20(19):71-73.DOI:10.3969/j.issn.1673-5110.2017.19.018.Si KY,Li ZP.Effect of edaravone combined with nimodipine on the biochemical indexes of large area acute cerebral infraction[J].Chin J Pract Nerv Dis,2017,20(19):71-73.DOI:10.3969/j.issn.1673-5110.2017.19.018.
[6] Ren X,Ma H,Zuo Z.Dexmedetomidine postconditioning reduces brain injury after brain hypoxia-ischemia in neonatal rats[J].J Neuroimmune Pharmacol,2016,11(2):238-247.DOI:10.1007/s11481-016-9658-9.
[7] 康聚贤,张培,马赟英,等.尼莫地平联合叶酸治疗伴H型高血压急性脑梗死的临床研究[J].中西医结合心脑血管病杂志,2017,15(9):1115-1118.DOI:10.3969/j.issn.1672-134 9.2017.09.034.Kang JX,Zhang P,Ma YY,et al.Clinical study of nimodipine combined with folic acid to treat acute cerebral infarction with H-type hypertension[J].Chin J Integr Med Cardio/Cerebrovasc Dis,2017,15(9):1115-1118.DOI:10.3969/j.issn.1672-1349.2017.09.034.
[8] 杨慧锋,朱超云,陆荣柱,等.依达拉奉联合尼莫地平治疗急性大面积脑梗死的疗效分析[J].中国药房,2017,28(9):1181-1183.DOI 10.6039/j.issn.1001-0408.2017.09.08.Yang HF,Zhu CY,Lu RZ,et al.Efficacy analysis of edaravone combined with nimodipine in the treatment of large area acute cerebral infarction[J].Chin Pharm,2017,28(9):1181-1183.DOI 10.6039/j.issn.1001-0408.2017.09.08.
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[10] 刘娟,张波,孙晓莉,等.氨氯地平联合瑞舒伐他汀钙对老年急性脑梗死合并高血压患者 CRP及D-二聚体的影响[J].实用临床医药杂志,2016,20(23):9-12.DOI:10.7619/jcmp.201623003.Liu J,Zhang B,Sun XL,et al.Influence of amlodipine combined with rosuvastatin calcium on CRP and D-dimer in elderly patients with acute cerebral infarction complicated with hypertension[J].J Clin Med Pract,2016,20(23):9-12.DOI:10.7619/jcmp.201623003.
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