黄花蒿在动物生产中的应用研究
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摘要
黄花蒿是一种草本植物,在我国传统医学中被广泛应用,具有抗炎、抗氧化、抗疟疾、驱虫和免疫调节等多种生物活性。此外,黄花蒿无毒无害、无耐药性,在动物生产方面具有极高的利用价值。本文综述了黄花蒿中生物活性物质的生理功能及其在动物生产中的具体应用,为黄花蒿的进一步研究提供参考。
Artemisia annua L. is an herbaceous plant that has been widely used in traditional Chinese medicine and has many biological activities such as anti-inflammation,anti-oxidation,anti-malarial,anthelmintic and immune regulation. In addition,due to its non-toxic,harmless and non-drug resistant,it has extremely high utilization value in animal production. This reviewsummarized the biological functions of Artemisia annua L.and its application in different animals ' production,aimed to provide references for the further application.
Artemisia annua L. is an herbaceous plant that has been widely used in traditional Chinese medicine and has many biological activities such as anti-inflammation,anti-oxidation,anti-malarial,anthelmintic and immune regulation. In addition,due to its non-toxic,harmless and non-drug resistant,it has extremely high utilization value in animal production. This reviewsummarized the biological functions of Artemisia annua L.and its application in different animals ' production,aimed to provide references for the further application.
引文
[1]宋春竹,陈昕雯,陈东红.药用植物黄花蒿内生菌的研究进展[J].生物技术通报,2016,32(1):1-7.
[2]王鸿博,肖皖,华会明,等.黄花蒿的化学成分研究进展[J].现代药物与临床,2011,26(6):430-433.
[3] FERREIRA J F S,LUTHRIA D,SASAKI T,et al.Flavonoids from Artemisia annua L. as antioxidants and their potential synergism w ith artemisinin against malaria and cancer[J]. M olecules,2010,15(5):3135-3170.
[4] MAGBOOL F A R,HUSSEIN S E O.Pharmacological aspect of artemisinin and aresunate as potent anti malarial agents-overview[J]. European Journal of Pharmaceutical and M edical Research,2018,5(2):101-108.
[5] KONSTATKORZENNY E,ASCENCIOARAGON J A,NIEZENLUGO S,et al.Artemisinin and its synthetic derivatives as a possible therapy for cancer[J].M edical Sciences,2018,6(1):19.
[6]施君.青蒿多糖药理作用的研究[D].硕士学位论文.南宁:广西大学,2014.
[7] KIM W S,CHOI W J,LEE S,et al.Anti-inflammatory,antioxidant and antimicrobial effects of artemisinin extracts from Artemisia annua L.[J]. The Korean Journal of Physiology and Pharmacology,2015,19(1):21-27.
[8]徐杰,邓龙兴,胡国元,等.青蒿素衍生物抗菌机理研究[J].天然产物研究与开发,2018,30(5):725-730.
[9] BILIA A R,SANTOMAURO F,SACCO C,et al.Essential oil of Artemisia annua L.:an extraordinary component w ith numerous antimicrobial properties[J]. Evidence:Based Complementary and Alternative M edicine,2014,2014:159819.
[10]薛明,田丽娟.青蒿多糖的抗肿瘤作用实验研究[J].时珍国医国药,2008,19(4):937-938.
[11]熊利芝,李子唯,欧阳文,等.超声醇提黄花蒿残渣总黄酮的工艺优化及抗氧化活性[J].精细化工,2013,30(11):1223-1228.
[12]熊利芝,欧阳文,李春,等.大孔吸附树脂纯化黄花蒿黄酮及其抗氧化活性[J].精细化工,2013,30(4):451-455.
[13]江晓波,王萌,张丽,等.黄花蒿残膏的挥发性成分分析及其抑菌和抗氧化活性研究[J].食品工业科技,2015,36(14):103-106.
[14]杨国恩,宝丽,张晓琦,等.黄花蒿中的黄酮化合物及其抗氧化活性研究[J].中药材,2009,32(11):1683-1686.
[15]姜晓东.青蒿多糖的超声提取及其免疫活性的研究[D].硕士学位论文.长春:吉林大学,2010.
[16]南旭梅,张敬,金小雪,等.青蒿浸膏对昆明小鼠和Wistar大鼠的急性毒性试验[J].中国兽医科学,2018,48(2):247-255.
[17]李文海,马旭平,孟万明,等.青蒿对家兔增重影响的研究[J].中国养兔,2005(2):7-8.
[18]潘存霞,刘卢生,张敏,等.青蒿提取物对獭兔的生长性能和免疫功能的影响[J].饲料博览(技术版),2007(6):9-12.
[19]沈金花,黄俊.青蒿提取物舒张小鼠气管平滑肌的作用机理[J].中南民族大学学报(自然科学版),2017,36(1):37-42.
[20]帅学宏,陈吉轩,施君,等.青蒿多糖的制备及体内抗炎作用的研究[J].西南大学学报(自然科学版),2016,38(9):102-106.
[21]帅学宏,陈吉轩,施君,等.青蒿多糖对小鼠血清中IL-1β,IL-2,IL-6,IFN-γ水平的影响[J].西南大学学报(自然科学版),2017,39(7):11-16.
[22]帅学宏,施君,陈吉轩,等.青蒿多糖对免疫抑制小鼠免疫器官的影响[J].动物医学进展,2015,36(11):59-62.
[23]唐荣锐,颜如冰.青蒿琥酯对大鼠蛛网膜下腔出血后早期脑损伤的保护作用[J].四川中医,2017,35(3):50-52.
[24]白纪红,梁志清,赵日红,等.青蒿琥酯对非酒精性脂肪肝小鼠肝脏TLR4及MyD88表达的影响[J].安徽医科大学学报,2017,52(10):1468-1471.
[25] LEE J Y,YE J P,GAO Z G,et al.Reciprocal modulation of Toll-like receptor-4 signaling pathw ays involving M yD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids[J]. Journal of Biological Chemistry,2003,278(39):37041-37051.
[26] SONG Z H,CHENG K,ZHENG X C,et al.Effects of dietary supplementation w ith enzymatically treated Artemisia annua on grow th performance,intestinal morphology,digestive enzyme activities,immunity,and antioxidant capacity of heat-stressed broilers[J]. Poultry Science,2018,97(2):430-437.
[27] GHOLAMREZAIE SANI L,MOHAMMADI M,JALALI SENDI J,et al.Extract and leaf pow der effect of Artemisia annua on performance,cellular and humoral immunity in broilers[J]. Iranian Journal of Veterinary Research,2013,14(1):15-20.
[28]宋志华,程康,张婧菲,等.酶解青蒿对热应激肉鸡消化功能的影响[J].南京农业大学学报,2018,41(1):126-131.
[29]宋志华,程康,万晓莉,等.青蒿叶对肉鸡生产性能和血清生化指标及消化酶活性的影响[J].中国畜牧杂志,2016,52(21):45-49.
[30] WAN X L,AHMAD H,ZHANG L L,et al. Dietary enzymatically treated Artemisia annua L. improves meat quality,antioxidant capacity and energy status of breast muscle in heat-stressed broilers[J]. Journal of the Science of Food and Agriculture,2018,98(10):3715-3721.
[31] WAN X L,JIANG L Y,ZHONG H R,et al.Effects of enzymatically treated Artemisia annua L. on grow th performance and some blood parameters of broilers exposed to heat stress[J]. Animal Science Journal,2017,88(8):1239-1246.
[32] WAN X L,ZHANG J F,HE J T,et al.Dietary enzymatically treated Artemisia annua L. supplementation alleviates liver oxidative injury of broilers reared under high ambient temperature[J]. International Journal of Biometeorology,2017,61(9):1629-1636.
[33] WAN X L,SONG Z H,NIU Y,et al. Evaluation of enzymatically treated Artemisia annua L. on grow th performance,meat quality,and oxidative stability of breast and thigh muscles in broilers[J]. Poultry Science,2016,96(4):844-850.
[34]黄鑫.青蒿粉抗鸡球虫的药效研究[D].硕士学位论文.北京:中国农业科学院,2017.
[35] WIEDOSARI E,WARDHANA A H.Anticoccidial activity of Artemisinin and extract of Artemesia annua leaves in chicken infected by Eimeria tenella[J].Journal Ilmu Ternak dan Veteriner,2018,22(4):196-204.
[36]郭红斌,弓素梅.青蒿素与青蒿水提液对感染柔嫩艾美耳球虫肉鸡的疗效评价[J].动物医学进展,2011,32(3):82-85.
[37] DRAGAN L,GYRKE A,FERREIRA J F S,et al.Effects of Artemisia annua and Foeniculum vulgare on chickens highly infected w ith Eimeria tenella(phylum Apicomplexa)[J]. Acta Veterinaria Scandinavica,2014,56:22.
[38] FENG Z H,LIU Z B,LI X,Set al.α-Tocopherol is an effective PhaseⅡenzyme inducer:protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells[J].The Journal of Nutritional Biochemistry,2010,21(12):1222-1231.
[39] BAUER M,BAUER I.Heme oxygenase-1:redox regulation and role in the hepatic response to oxidative stress[J]. Antioxidants&Redox Signaling,2002,4(5):749-758.
[40] SEELIG G F,MEISTER A.Glutathione biosynthesis;γ-glutamylcysteine synthetase from rat kidney[J].M ethods in Enzymology,1985,113:379-390.
[41]刘仕碧,田东升,范才良.青蒿对夏季公猪精液品质的影响[J].中兽医医药杂志,2013,32(5):34-36.
[42]康红军.青蒿活性成分对断奶仔猪和生长猪生产性能和免疫性能的影响[D].硕士学位论文.重庆:西南大学,2009.
[43]刘樱,丁度伟,高求炜,等.3种中药及其提取物体外抗猪繁殖与呼吸综合征病毒作用的研究[J].中国畜牧兽医,2016,43(10):2730-2735.
[44]宋霜.青蒿素和血呼平对猪附红细胞体病的疗效观察[D].硕士学位论文.延吉:延边大学,2014.
[45] KNOL B W. Stress and the endocrine hypothalamuspituitary-testis system:a review[J]. Veterinary Quarterly,1991,13(2):104-114.
[46]方热军,汤少勋,李铁军.复方中草药添加剂对地方肉鸡生长和物质代谢的影响[J].中国饲料,2000(7):9-11.
[47]任波.饲粮中添加黄花蒿乙醇提取物对奶牛产奶性能的影响[J].乡村科技,2017(22):76-77.
[48]斯琴毕力格,王丽芳,丁赫,等.饲粮中添加黄花蒿乙醇提取物对奶牛产奶性能及乳脂中共轭亚油酸含量的影响[J].动物营养学报,2017,29(11):4137-4142.
[49]王丽芳,卢德勋,高民,等.黄花蒿提取物对奶山羊乳腺动静脉血脂肪酸组成的影响[J].动物营养学报,2011,23(11):1932-1937.
[50]王小晶,董国忠,刘智波.青蒿提取物和大黄对山羊瘤胃发酵和甲烷产量的影响[J].畜禽业,2009(4):52-55.
[51] CABIDDU A,ADDIS M,PINNA G,et al.The inclusion of a daisy plant(Chrysanthemum coronarium)in dairy sheep diet.1:effect on milk and cheese fatty acid composition w ith particular reference to C18∶2 cis-9,trans-11[J]. Livestock Science,2006,101(1/2/3):57-67.
[52] KHIAOSAARD R,BRYNER S F,SCHEEDER M R L,et al.Evidence for the inhibition of the terminal step of ruminalα-linolenic acid biohydrogenation by condensed tannins[J]. Journal of Dairy Science,2009,92(1):177-188.
[53] EKANEM A P,BRISIBE E A.Effects of ethanol extract of Artemisia annua L. against monogenean parasites of Heterobranchus longifilis[J].Parasitology Research,2010,106(5):1135-1139.
[54]黄光中,胡辉,肖克宇,等.葡萄籽与青蒿提取物对黄鳝肠道消化酶活性及血液生化指标的影响[J].南方水产科学,2013,9(2):70-75.
[2]王鸿博,肖皖,华会明,等.黄花蒿的化学成分研究进展[J].现代药物与临床,2011,26(6):430-433.
[3] FERREIRA J F S,LUTHRIA D,SASAKI T,et al.Flavonoids from Artemisia annua L. as antioxidants and their potential synergism w ith artemisinin against malaria and cancer[J]. M olecules,2010,15(5):3135-3170.
[4] MAGBOOL F A R,HUSSEIN S E O.Pharmacological aspect of artemisinin and aresunate as potent anti malarial agents-overview[J]. European Journal of Pharmaceutical and M edical Research,2018,5(2):101-108.
[5] KONSTATKORZENNY E,ASCENCIOARAGON J A,NIEZENLUGO S,et al.Artemisinin and its synthetic derivatives as a possible therapy for cancer[J].M edical Sciences,2018,6(1):19.
[6]施君.青蒿多糖药理作用的研究[D].硕士学位论文.南宁:广西大学,2014.
[7] KIM W S,CHOI W J,LEE S,et al.Anti-inflammatory,antioxidant and antimicrobial effects of artemisinin extracts from Artemisia annua L.[J]. The Korean Journal of Physiology and Pharmacology,2015,19(1):21-27.
[8]徐杰,邓龙兴,胡国元,等.青蒿素衍生物抗菌机理研究[J].天然产物研究与开发,2018,30(5):725-730.
[9] BILIA A R,SANTOMAURO F,SACCO C,et al.Essential oil of Artemisia annua L.:an extraordinary component w ith numerous antimicrobial properties[J]. Evidence:Based Complementary and Alternative M edicine,2014,2014:159819.
[10]薛明,田丽娟.青蒿多糖的抗肿瘤作用实验研究[J].时珍国医国药,2008,19(4):937-938.
[11]熊利芝,李子唯,欧阳文,等.超声醇提黄花蒿残渣总黄酮的工艺优化及抗氧化活性[J].精细化工,2013,30(11):1223-1228.
[12]熊利芝,欧阳文,李春,等.大孔吸附树脂纯化黄花蒿黄酮及其抗氧化活性[J].精细化工,2013,30(4):451-455.
[13]江晓波,王萌,张丽,等.黄花蒿残膏的挥发性成分分析及其抑菌和抗氧化活性研究[J].食品工业科技,2015,36(14):103-106.
[14]杨国恩,宝丽,张晓琦,等.黄花蒿中的黄酮化合物及其抗氧化活性研究[J].中药材,2009,32(11):1683-1686.
[15]姜晓东.青蒿多糖的超声提取及其免疫活性的研究[D].硕士学位论文.长春:吉林大学,2010.
[16]南旭梅,张敬,金小雪,等.青蒿浸膏对昆明小鼠和Wistar大鼠的急性毒性试验[J].中国兽医科学,2018,48(2):247-255.
[17]李文海,马旭平,孟万明,等.青蒿对家兔增重影响的研究[J].中国养兔,2005(2):7-8.
[18]潘存霞,刘卢生,张敏,等.青蒿提取物对獭兔的生长性能和免疫功能的影响[J].饲料博览(技术版),2007(6):9-12.
[19]沈金花,黄俊.青蒿提取物舒张小鼠气管平滑肌的作用机理[J].中南民族大学学报(自然科学版),2017,36(1):37-42.
[20]帅学宏,陈吉轩,施君,等.青蒿多糖的制备及体内抗炎作用的研究[J].西南大学学报(自然科学版),2016,38(9):102-106.
[21]帅学宏,陈吉轩,施君,等.青蒿多糖对小鼠血清中IL-1β,IL-2,IL-6,IFN-γ水平的影响[J].西南大学学报(自然科学版),2017,39(7):11-16.
[22]帅学宏,施君,陈吉轩,等.青蒿多糖对免疫抑制小鼠免疫器官的影响[J].动物医学进展,2015,36(11):59-62.
[23]唐荣锐,颜如冰.青蒿琥酯对大鼠蛛网膜下腔出血后早期脑损伤的保护作用[J].四川中医,2017,35(3):50-52.
[24]白纪红,梁志清,赵日红,等.青蒿琥酯对非酒精性脂肪肝小鼠肝脏TLR4及MyD88表达的影响[J].安徽医科大学学报,2017,52(10):1468-1471.
[25] LEE J Y,YE J P,GAO Z G,et al.Reciprocal modulation of Toll-like receptor-4 signaling pathw ays involving M yD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids[J]. Journal of Biological Chemistry,2003,278(39):37041-37051.
[26] SONG Z H,CHENG K,ZHENG X C,et al.Effects of dietary supplementation w ith enzymatically treated Artemisia annua on grow th performance,intestinal morphology,digestive enzyme activities,immunity,and antioxidant capacity of heat-stressed broilers[J]. Poultry Science,2018,97(2):430-437.
[27] GHOLAMREZAIE SANI L,MOHAMMADI M,JALALI SENDI J,et al.Extract and leaf pow der effect of Artemisia annua on performance,cellular and humoral immunity in broilers[J]. Iranian Journal of Veterinary Research,2013,14(1):15-20.
[28]宋志华,程康,张婧菲,等.酶解青蒿对热应激肉鸡消化功能的影响[J].南京农业大学学报,2018,41(1):126-131.
[29]宋志华,程康,万晓莉,等.青蒿叶对肉鸡生产性能和血清生化指标及消化酶活性的影响[J].中国畜牧杂志,2016,52(21):45-49.
[30] WAN X L,AHMAD H,ZHANG L L,et al. Dietary enzymatically treated Artemisia annua L. improves meat quality,antioxidant capacity and energy status of breast muscle in heat-stressed broilers[J]. Journal of the Science of Food and Agriculture,2018,98(10):3715-3721.
[31] WAN X L,JIANG L Y,ZHONG H R,et al.Effects of enzymatically treated Artemisia annua L. on grow th performance and some blood parameters of broilers exposed to heat stress[J]. Animal Science Journal,2017,88(8):1239-1246.
[32] WAN X L,ZHANG J F,HE J T,et al.Dietary enzymatically treated Artemisia annua L. supplementation alleviates liver oxidative injury of broilers reared under high ambient temperature[J]. International Journal of Biometeorology,2017,61(9):1629-1636.
[33] WAN X L,SONG Z H,NIU Y,et al. Evaluation of enzymatically treated Artemisia annua L. on grow th performance,meat quality,and oxidative stability of breast and thigh muscles in broilers[J]. Poultry Science,2016,96(4):844-850.
[34]黄鑫.青蒿粉抗鸡球虫的药效研究[D].硕士学位论文.北京:中国农业科学院,2017.
[35] WIEDOSARI E,WARDHANA A H.Anticoccidial activity of Artemisinin and extract of Artemesia annua leaves in chicken infected by Eimeria tenella[J].Journal Ilmu Ternak dan Veteriner,2018,22(4):196-204.
[36]郭红斌,弓素梅.青蒿素与青蒿水提液对感染柔嫩艾美耳球虫肉鸡的疗效评价[J].动物医学进展,2011,32(3):82-85.
[37] DRAGAN L,GYRKE A,FERREIRA J F S,et al.Effects of Artemisia annua and Foeniculum vulgare on chickens highly infected w ith Eimeria tenella(phylum Apicomplexa)[J]. Acta Veterinaria Scandinavica,2014,56:22.
[38] FENG Z H,LIU Z B,LI X,Set al.α-Tocopherol is an effective PhaseⅡenzyme inducer:protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells[J].The Journal of Nutritional Biochemistry,2010,21(12):1222-1231.
[39] BAUER M,BAUER I.Heme oxygenase-1:redox regulation and role in the hepatic response to oxidative stress[J]. Antioxidants&Redox Signaling,2002,4(5):749-758.
[40] SEELIG G F,MEISTER A.Glutathione biosynthesis;γ-glutamylcysteine synthetase from rat kidney[J].M ethods in Enzymology,1985,113:379-390.
[41]刘仕碧,田东升,范才良.青蒿对夏季公猪精液品质的影响[J].中兽医医药杂志,2013,32(5):34-36.
[42]康红军.青蒿活性成分对断奶仔猪和生长猪生产性能和免疫性能的影响[D].硕士学位论文.重庆:西南大学,2009.
[43]刘樱,丁度伟,高求炜,等.3种中药及其提取物体外抗猪繁殖与呼吸综合征病毒作用的研究[J].中国畜牧兽医,2016,43(10):2730-2735.
[44]宋霜.青蒿素和血呼平对猪附红细胞体病的疗效观察[D].硕士学位论文.延吉:延边大学,2014.
[45] KNOL B W. Stress and the endocrine hypothalamuspituitary-testis system:a review[J]. Veterinary Quarterly,1991,13(2):104-114.
[46]方热军,汤少勋,李铁军.复方中草药添加剂对地方肉鸡生长和物质代谢的影响[J].中国饲料,2000(7):9-11.
[47]任波.饲粮中添加黄花蒿乙醇提取物对奶牛产奶性能的影响[J].乡村科技,2017(22):76-77.
[48]斯琴毕力格,王丽芳,丁赫,等.饲粮中添加黄花蒿乙醇提取物对奶牛产奶性能及乳脂中共轭亚油酸含量的影响[J].动物营养学报,2017,29(11):4137-4142.
[49]王丽芳,卢德勋,高民,等.黄花蒿提取物对奶山羊乳腺动静脉血脂肪酸组成的影响[J].动物营养学报,2011,23(11):1932-1937.
[50]王小晶,董国忠,刘智波.青蒿提取物和大黄对山羊瘤胃发酵和甲烷产量的影响[J].畜禽业,2009(4):52-55.
[51] CABIDDU A,ADDIS M,PINNA G,et al.The inclusion of a daisy plant(Chrysanthemum coronarium)in dairy sheep diet.1:effect on milk and cheese fatty acid composition w ith particular reference to C18∶2 cis-9,trans-11[J]. Livestock Science,2006,101(1/2/3):57-67.
[52] KHIAOSAARD R,BRYNER S F,SCHEEDER M R L,et al.Evidence for the inhibition of the terminal step of ruminalα-linolenic acid biohydrogenation by condensed tannins[J]. Journal of Dairy Science,2009,92(1):177-188.
[53] EKANEM A P,BRISIBE E A.Effects of ethanol extract of Artemisia annua L. against monogenean parasites of Heterobranchus longifilis[J].Parasitology Research,2010,106(5):1135-1139.
[54]黄光中,胡辉,肖克宇,等.葡萄籽与青蒿提取物对黄鳝肠道消化酶活性及血液生化指标的影响[J].南方水产科学,2013,9(2):70-75.