桂枝芍药知母汤治疗类风湿关节炎的系统评价及Meta分析
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摘要
目的将桂枝芍药知母汤治疗类风湿关节炎的随机对照试验文献进行搜集、筛选及评价,通过系统评价与Meta分析,探讨桂枝芍药知母汤治疗类风湿关节炎(RA)的临床疗效,为临床使用桂枝芍药知母汤治疗RA提供循证医学依据。方法检索PubMed、中国期刊全文数据库、万方数据库、维普期刊数据库和中国知网,检索桂枝芍药知母汤治疗RA的随机对照研究(RCT),将检索结果依据本次纳入标准、排除标准等筛选后得到最终纳入文献。由两名互不知情的研究者独立读取资料并进行方法学质量评估,数据分析采用RevMan 5.3软件进行统计分析。结果共选取13项试验研究,Meta分析结果显示,桂枝芍药知母汤治疗RA总有效率优于对照组;在改善晨僵时间、关节疼痛及肿胀个数、血沉、C反应蛋白、不良反应方面,与对照组比较差异均有统计学意义(P<0.05)。结论桂枝芍药知母汤治疗RA的总有效率、临床症状、生化指标、不良反应率均优于对照组,临床值得推广。
Objective To systematically evaluate the clinical effect of Guizhi Shaoyao Zhimu decoction on rheumatoid arthritis(RA). Methods PubMed,Chinese Journal Full-text Database,Wanfang Database,Weipu Journal Database and China HowNet were searched. Randomized controlled trials(RCT) of Guizhi Shaoyao Zhimu Decoction in the treatment of RA were searched. The data were extracted independently by two evaluators and the methodological quality was evaluated. The data were analyzed by RevMan 5.3 software. Results Thirteen experimental studies were selected. Meta analysis showed that the total effective rate of Guizhi Shaoyao Zhimu decoction in treating RA was better than that of control group. There were significant differences in improving morning stiffness, joint pain, joint swelling, ESR, CRP and adverse reactions between the two groups(P<0.05).Conclusion Guizhi Shaoyao Zhimu decoction is superior to control group in total effective rate,clinical symptoms,biochemical indicators,adverse reaction rate in the treatment of RA,which is worthy of promotion.
Objective To systematically evaluate the clinical effect of Guizhi Shaoyao Zhimu decoction on rheumatoid arthritis(RA). Methods PubMed,Chinese Journal Full-text Database,Wanfang Database,Weipu Journal Database and China HowNet were searched. Randomized controlled trials(RCT) of Guizhi Shaoyao Zhimu Decoction in the treatment of RA were searched. The data were extracted independently by two evaluators and the methodological quality was evaluated. The data were analyzed by RevMan 5.3 software. Results Thirteen experimental studies were selected. Meta analysis showed that the total effective rate of Guizhi Shaoyao Zhimu decoction in treating RA was better than that of control group. There were significant differences in improving morning stiffness, joint pain, joint swelling, ESR, CRP and adverse reactions between the two groups(P<0.05).Conclusion Guizhi Shaoyao Zhimu decoction is superior to control group in total effective rate,clinical symptoms,biochemical indicators,adverse reaction rate in the treatment of RA,which is worthy of promotion.
引文
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[2]范永升,姜德友.金匮要略[M].北京:中国中医药出版社.2014:71.
[3]谢斌,田雪飞.桂枝芍药知母汤治疗类风湿性关节炎60例临床观察[J].湖南中医学院学报,2003(5):49-51.
[4]邹蕴珏.桂枝芍药知母汤加味治疗类风湿关节炎30例临床观察[J].中国中医急症,2007,26(6):672-673.
[5]曹雨,邢锐.桂枝芍药知母汤治疗类风湿性关节炎30例临床观察[J].中国现代药物应用,2009,3(16):94.
[6]余建华,张衡.桂枝芍药知母汤治疗活动期类风湿关节炎72例临床观察[J].江苏中医药,2010,42(5):37-39.
[7]高坤,符发年.桂枝芍药知母汤加减治疗类风湿关节炎100例疗效观察[J].中国社区医师(医学专业),2010,12(31):121.
[8]张攀科,王芳.桂枝芍药知母汤治疗类风湿性关节炎28例疗效观察[J].中国现代医生,2011,49(3):43,47.
[9]刘波,安玉芳.桂枝芍药知母汤加减治疗类风湿性关节炎60例临床观察[J].中医药导报,2011,17(3):23-25.
[10]刘运霞.桂枝芍药汤在类风湿关节炎中的综合疗效研究[J].中国医药科学,2012,2(18):94-95.
[11]曹向东.桂枝芍药知母汤加减治疗类风湿性关节炎的临床疗效观察[J].内蒙古中医药,2014,33(35):28-29.
[12]李树东,王艳.桂枝芍药知母汤治疗类风湿关节炎临床研究[J].中外医疗,2014,33(25):147-148.
[13]李桂莲,燕迅之.桂枝芍药知母汤加减治疗类风湿性关节炎的临床分析[J].中国卫生标准管理,2015,6(19):136-138.
[14]马秉楠.用加味桂枝芍药知母汤治疗类风湿性关节炎的效果分析[J].当代医药论丛,2015,13(13):26-27.
[15]李小龙,龙宽斌,张小玲.桂枝芍药知母汤加减治疗类风湿性关节炎疗效观察[J].中国民间疗法,2015,23(2):54-55.
[16]王承德,沈丕安,胡荫奇.实用中医风湿病学[M].北京:人民卫生出版社,2009:501.
[17]温桂荣.桂枝芍药知母汤治疗杂病举隅[J].环球中医药,2012,5(4):305-307.