ICU腹泻患者艰难梭菌感染分子流行病学特征和危险因素
|
摘要
<正>艰难梭菌是一种产芽孢专性厌氧革兰阳性杆菌,广泛分布在自然环境中,可在健康人肠道定植。当肠道微生态平衡遭到破坏时,肠道正常菌群受到抑制,艰难梭菌大量生长并释放毒素,引起艰难梭菌感染(Clostridium difficile infection,CDI)。CDI包括艰难梭菌相关性腹泻(Clostridium difficile associated diarrhea,CDAD)和伪膜性肠炎
引文
1 To KB, Napolitano LM. Closstridium difficile infection:update on diagnosis, epidemiology and treatment strategies[J]. Surg Infect, 2014, 15(5):490-502.
2 谢和宾,曾鸿,尹柯,等.我国住院腹泻患者艰难梭菌感染率的荟萃分析[J].中华医院感染学杂志,2017,27(5):961-964.
3 Lee JC, Hung YP, Lin HJ, et al. Clostridium difficile infections in medical intensive care units of a medical center in Southern Taiwan:variable seasonality and disease severity[J]. PLoS One, 2016, 11(8):e0160760.
4 陆晓凤,吴建祥,徐少毅,等.重症加强治疗病房腹泻患者艰难梭菌检测的敏感方法[J].中华危重病急救医学,2015,27(6):525-526.
5 Persson S, Torpdahl M, Olsen KE. New multiplex PCR method for the detection of Clostridium difficile toxin A(tcdA)and toxin B(tcd B)and the binary toxin(cdtA/cdtB)genes applied to a Danish strain collection[J].Clin Microbiol Infect, 2008, 14(11):1057-1064.
6 周芬芬,吴湜,徐少华,等.艰难梭菌临床分离株5年前后耐药性变化[J].中国感染与化疗杂志,2014,14(2):116-120.
7 曾勇彬,刘安超,李武,等. ICU患者艰难梭菌分离培养与流行病学特征研究[J].中国微生态学杂志,2018,30(4):424-437.
8 Griffiths D, Fawley W, Kachrimanidou M, et al. Multilocus sequence tying of Clostridium difficile[J]. J Clin Microbiol, 2010, 48(3):770-778.
9 杨靖,李志荣,赵建宏,等. 33株艰难梭菌临床分离株的多位点序列分型[J].中华检验医学杂志,2013,36(10):920-925.
10 贾红兵,杨辉,杜鹏程,等.艰难梭菌临床分离株的毒素检测和MLST分型[J].中华微生物学和免疫学杂志,2017,37(4):297-302.
11 Magill SS, Edwards JR, Bamberg W, et al. Multistate point-prevalence survey of health care-associated infections[J]. N Engl J Med, 2014, 370(13):1198-1208.
12 刘元元,刘文恩,简子娟,等.住院腹泻患者艰难梭菌检测与分析[J].中国感染控制杂志,2012,11(4):293-296.
13 张春莹,康梅,何超,等.艰难梭菌腹泻及实验室诊断[J].寄生虫病与感染性疾病,2012,10(2):68-72.
14 徐亚青,邓敏.难辨梭状芽孢杆菌医院感染的流行病学特征及感染控制现状分析[J].中华医院感染学杂志,2013,23(20):5073-5075.
15 金慧,吴建浓,韦凌娅,等.艰难梭菌分离培养与病原学分子特征研究[J].浙江预防医学,2014,26(6):602-603,609.
16 王晶,李春辉,杜鹏程,等.中国部分地区艰难梭菌PCR-核糖体分型及毒素基因多态性研究[J].中国感染控制杂志,2014,13(1):1-7.
17 Zahar JR, Schwebel C, Adrie C, et al. Outcome of ICU patients with Clostridium difficile infection[J]. Crit Care, 2012, 16(6):R215.
18 Yan Q, Zhang J, Chen C, et al. Multilocus sequence typing(MLST)analysis of 104 Clostridium difficile strains isolated from China[J]. Epidemiol Infect, 2013,141(1):195-199.
19 Chen YB, Gu SL, Wei ZQ, et al. Molecular epidemiology of Clostridium difficile in a tertiary hospital of China[J]. J Med Microbiol, 2014, 63(Pt 4):562-569.
20 Markelov A, Livert D, Kohli H. Predictors of fatal outcome after colectomy for fulminant Clostridium difficile colitis:a 10-year experience[J]. Am Surg,2011, 77(8):977-980.
21 Kelly CP, LaMont JT. Clostridium difficile--more difficult than ever[J]. N Engl J Med, 2008, 359(18):1932-1940.
22 Zacharioudakis IM, Zervou FN, Pliakos EE, et al. Colonization with toxinogenic C.difficile upon hospital adimission, and risk of infection:a systematic review and meta-analysis[J]. Am J Gastroenterol, 2015, 110(3):381-390.
23 Loo VG, Bourgault AM, Poirier L, et al. Host and pathogen factors for Clostridium difficile infection and colonization[J]. N Engl J Med, 2011, 365(18):1693-1703.
24 Wang R, Chen HX, Song LJ, et al. Molecular epidemiology and antimicrobial susceptibility of Clostridium difficile isolated from the Chinese People′s Liberation Army General Hospital in China[J]. Int J Infect Dis, 2018, 67(2):86-91.
25 叶关胜,许文芳,金法祥,等.难辨梭菌相关性腹泻老年患者68例免疫功能分析[J/CD].中华危重症医学杂志(电子版),2015,8(5):318-320.
26 Dubberke ER, Reske KA, Yan Y, et al. Clostridium difficile-associated disease in a setting of endemicity:identification of novel risk factors[J]. Clin Infect Dis,2007, 45(12):1543-1549.
27 Owens RC Jr, Donskey CJ, Gaynes RP, et al. Antimicrobial-associated risk factors for Clostridium difficile infection[J]. Clin Infect Dis, 2008(46 Suppl1 ):S19-S31.
28 Bignarde GE. Risk factors for Clotridium difficile infection[J]. J Hosp Infect, 1998, 40(1):1-15.
29 Lessa FC, Mu Y, Bamberg WM, et al. Burden of Clostridium difficile infection in the United States[J]. N Engl J Med, 2015, 372(9):825-834.
30 Gerding DN, Lessa FC. The epidemiology of Clostridium difficile infection inside and outside health care institutions[J]. Infect Dis Clin North Am, 2015, 29(1):37-50.
31 Hensgens MP, Cooarhuis A, Dekkers OM, et al. Time interval of increased risk for Clostridium difficile infection after exposure to antibiotics[J]. J Antimicrob Chemother, 2012, 67(3):742-748.
32 Keddis MT, Khanna S, Noheria A, et al. Clostridium difficile infection in patients with chronic kidney disease[J]. Mayo Clin Proc, 2012, 87(11):1046-1053.
33 Surawicz CM, Brandt LJ, Binion DG, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections[J]. Am J Gastroenterol, 2013, 108(4):478-498.
2 谢和宾,曾鸿,尹柯,等.我国住院腹泻患者艰难梭菌感染率的荟萃分析[J].中华医院感染学杂志,2017,27(5):961-964.
3 Lee JC, Hung YP, Lin HJ, et al. Clostridium difficile infections in medical intensive care units of a medical center in Southern Taiwan:variable seasonality and disease severity[J]. PLoS One, 2016, 11(8):e0160760.
4 陆晓凤,吴建祥,徐少毅,等.重症加强治疗病房腹泻患者艰难梭菌检测的敏感方法[J].中华危重病急救医学,2015,27(6):525-526.
5 Persson S, Torpdahl M, Olsen KE. New multiplex PCR method for the detection of Clostridium difficile toxin A(tcdA)and toxin B(tcd B)and the binary toxin(cdtA/cdtB)genes applied to a Danish strain collection[J].Clin Microbiol Infect, 2008, 14(11):1057-1064.
6 周芬芬,吴湜,徐少华,等.艰难梭菌临床分离株5年前后耐药性变化[J].中国感染与化疗杂志,2014,14(2):116-120.
7 曾勇彬,刘安超,李武,等. ICU患者艰难梭菌分离培养与流行病学特征研究[J].中国微生态学杂志,2018,30(4):424-437.
8 Griffiths D, Fawley W, Kachrimanidou M, et al. Multilocus sequence tying of Clostridium difficile[J]. J Clin Microbiol, 2010, 48(3):770-778.
9 杨靖,李志荣,赵建宏,等. 33株艰难梭菌临床分离株的多位点序列分型[J].中华检验医学杂志,2013,36(10):920-925.
10 贾红兵,杨辉,杜鹏程,等.艰难梭菌临床分离株的毒素检测和MLST分型[J].中华微生物学和免疫学杂志,2017,37(4):297-302.
11 Magill SS, Edwards JR, Bamberg W, et al. Multistate point-prevalence survey of health care-associated infections[J]. N Engl J Med, 2014, 370(13):1198-1208.
12 刘元元,刘文恩,简子娟,等.住院腹泻患者艰难梭菌检测与分析[J].中国感染控制杂志,2012,11(4):293-296.
13 张春莹,康梅,何超,等.艰难梭菌腹泻及实验室诊断[J].寄生虫病与感染性疾病,2012,10(2):68-72.
14 徐亚青,邓敏.难辨梭状芽孢杆菌医院感染的流行病学特征及感染控制现状分析[J].中华医院感染学杂志,2013,23(20):5073-5075.
15 金慧,吴建浓,韦凌娅,等.艰难梭菌分离培养与病原学分子特征研究[J].浙江预防医学,2014,26(6):602-603,609.
16 王晶,李春辉,杜鹏程,等.中国部分地区艰难梭菌PCR-核糖体分型及毒素基因多态性研究[J].中国感染控制杂志,2014,13(1):1-7.
17 Zahar JR, Schwebel C, Adrie C, et al. Outcome of ICU patients with Clostridium difficile infection[J]. Crit Care, 2012, 16(6):R215.
18 Yan Q, Zhang J, Chen C, et al. Multilocus sequence typing(MLST)analysis of 104 Clostridium difficile strains isolated from China[J]. Epidemiol Infect, 2013,141(1):195-199.
19 Chen YB, Gu SL, Wei ZQ, et al. Molecular epidemiology of Clostridium difficile in a tertiary hospital of China[J]. J Med Microbiol, 2014, 63(Pt 4):562-569.
20 Markelov A, Livert D, Kohli H. Predictors of fatal outcome after colectomy for fulminant Clostridium difficile colitis:a 10-year experience[J]. Am Surg,2011, 77(8):977-980.
21 Kelly CP, LaMont JT. Clostridium difficile--more difficult than ever[J]. N Engl J Med, 2008, 359(18):1932-1940.
22 Zacharioudakis IM, Zervou FN, Pliakos EE, et al. Colonization with toxinogenic C.difficile upon hospital adimission, and risk of infection:a systematic review and meta-analysis[J]. Am J Gastroenterol, 2015, 110(3):381-390.
23 Loo VG, Bourgault AM, Poirier L, et al. Host and pathogen factors for Clostridium difficile infection and colonization[J]. N Engl J Med, 2011, 365(18):1693-1703.
24 Wang R, Chen HX, Song LJ, et al. Molecular epidemiology and antimicrobial susceptibility of Clostridium difficile isolated from the Chinese People′s Liberation Army General Hospital in China[J]. Int J Infect Dis, 2018, 67(2):86-91.
25 叶关胜,许文芳,金法祥,等.难辨梭菌相关性腹泻老年患者68例免疫功能分析[J/CD].中华危重症医学杂志(电子版),2015,8(5):318-320.
26 Dubberke ER, Reske KA, Yan Y, et al. Clostridium difficile-associated disease in a setting of endemicity:identification of novel risk factors[J]. Clin Infect Dis,2007, 45(12):1543-1549.
27 Owens RC Jr, Donskey CJ, Gaynes RP, et al. Antimicrobial-associated risk factors for Clostridium difficile infection[J]. Clin Infect Dis, 2008(46 Suppl1 ):S19-S31.
28 Bignarde GE. Risk factors for Clotridium difficile infection[J]. J Hosp Infect, 1998, 40(1):1-15.
29 Lessa FC, Mu Y, Bamberg WM, et al. Burden of Clostridium difficile infection in the United States[J]. N Engl J Med, 2015, 372(9):825-834.
30 Gerding DN, Lessa FC. The epidemiology of Clostridium difficile infection inside and outside health care institutions[J]. Infect Dis Clin North Am, 2015, 29(1):37-50.
31 Hensgens MP, Cooarhuis A, Dekkers OM, et al. Time interval of increased risk for Clostridium difficile infection after exposure to antibiotics[J]. J Antimicrob Chemother, 2012, 67(3):742-748.
32 Keddis MT, Khanna S, Noheria A, et al. Clostridium difficile infection in patients with chronic kidney disease[J]. Mayo Clin Proc, 2012, 87(11):1046-1053.
33 Surawicz CM, Brandt LJ, Binion DG, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections[J]. Am J Gastroenterol, 2013, 108(4):478-498.