阳性症状为主型精神分裂症脑半球间功能连接的静息态功能MRI研究
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摘要
目的采用静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)基于体素镜像同伦连接(voxel-mirrored homotopic connectivity,VMHC)方法研究精神分裂症患者双侧半球间的功能连通性。方法选取18例精神分裂症阳性症状为主型患者(患者组)及年龄和性别相匹配的正常对照22名(对照组)进行rs-fMRI扫描,应用基于VMHC方法进行数据分析,比较患者组与对照组的全脑VMHC图像。结果与对照组相比,患者组在双侧眶额回(t=-5.31, P<0.01)、颞叶梭状回(t=-6.09, P<0.01)及枕中回(t=-4.86, P<0.01)的VMHC值减低。结论精神分裂症阳性症状为主型患者在静息状态下存在双侧眶额回、梭状回及枕中回两侧半球间的功能连接异常。
Objective To investigate functional connectivity between the two hemispheres in patients with positive symptoms of schizophrenia using voxel-mirrored homotopic connectivity( VMHC) based on resting-state functional magnetic resonance imaging(rs-fMRI). Methods Eighteen patients with positive symptoms of schizophrenia and 22 healthy controls underwent the rs-fMRI. The whole brain VMHC was calculated in order to provide imaging basis for the study of the pathological mechanism of schizophrenia. Results Compared to the controls, VMHC values were decreased in the bilateral orbitofrontal cortex(t=-5.31, P<0.01), fusiform gyrus(t=-5.16, P<0.01), middle occipital gyrus(t=-5.31, P<0.01) in patients with positive symptoms of schizophrenia. Conclusion The functional coordination between homotopic brain regions is impaired in patients with positive symptoms of schizophrenia.
Objective To investigate functional connectivity between the two hemispheres in patients with positive symptoms of schizophrenia using voxel-mirrored homotopic connectivity( VMHC) based on resting-state functional magnetic resonance imaging(rs-fMRI). Methods Eighteen patients with positive symptoms of schizophrenia and 22 healthy controls underwent the rs-fMRI. The whole brain VMHC was calculated in order to provide imaging basis for the study of the pathological mechanism of schizophrenia. Results Compared to the controls, VMHC values were decreased in the bilateral orbitofrontal cortex(t=-5.31, P<0.01), fusiform gyrus(t=-5.16, P<0.01), middle occipital gyrus(t=-5.31, P<0.01) in patients with positive symptoms of schizophrenia. Conclusion The functional coordination between homotopic brain regions is impaired in patients with positive symptoms of schizophrenia.
引文
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[17]CHEN X, LIU C, HE H, et al. Transdiagnostic differences in the resting-state functional connectivity of the prefrontal cortex in depression and schizophrenia[J]. J Affect Disord, 2017, 217:118-124.
[18]HE Z, DENG W, LI M, et al. Aberrant intrinsic brain activity and cognitive deficit in first-episode treatment-naive patients with schizophrenia[J]. Psychol Med, 2013, 43(4):769-780.
[19]XIAO Y, LUI S, DENG W, et al. Altered cortical thickness related to clinical severity but not the untreated disease duration in schizophrenia[J]. Schizophr Bull, 2015, 41(1):201-210.
[20]WANG YM, ZOU LQ, XIE WL, et al. Altered grey matter volume and cortical thickness in patients with schizo-obsessive comorbidity[J]. Psychiatry Res Neuroimaging, 2018, 276:65-72.
[21]WEINER KS, ZILLES K. The anatomical and functional specialization of the fusiform gyrus[J]. Neuropsychologia, 2016, 83:48-62.
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[24]LIU Y, GUO W, ZHANG Y, et al. Decreased resting-state interhemispheric functional connectivity correlated with neurocognitive deficits in drug-naive first-episode adolescent-onset schizophrenia[J]. Int J Neuropsychopharmacol, 2017,21(1):33-41.
[25]GUO W, LIU F, CHEN J, et al. Family-based case-controlstudy of homotopic connectivity in first-episode,drug-naive schizophrenia at rest[J]. Sci Rep, 2017, 7:43312.
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[27]王莹,王肖依,龙雨君,等.精神分裂症首次发病患者及其同胞的脑静息态局部一致性分析[J].中华精神科杂志,2018,51(4):235-241.
[28]梁家云,谢世平,万德燕,等.不同症状为主的精神分裂症患者静息态功能磁共振成像研究[J].临床精神医学杂志,2017, 27(2):98-100.
[29]MENNIGEN E, JIANG W, CALHOUN VD, et al. Positive and general psychopathology associated with specific gray matter reductions in inferior temporal regions in patients with schizophrenia[J]. Schizophr Res, 2019[2019-2-25]. http://dx.doi.org/10.1016/j.schres.2019.02.010.
[30]TOHID H, FAIZAN M, FAIZAN U. Alterations of the occipital lobe in schizophrenia[J]. Neurosciences(Riyadh),2015, 20(3):213-224.
[31]CHEN X, DUAN M, XIE Q, et al. Functional disconnection between the visual cortex and the sensorimotor cortex suggests a potential mechanism for self-disorder in schizophrenia[J].Schizophr Res, 2015, 166(1-3):151-157.
[32]MARTINEZ A, HILLYARD SA, BICKEL S, et al. Consequences of magnocellular dysfunction on processing attended information in schizophrenia[J]. Cereb Cortex, 2012, 22(6):1282-1293.
[33]SEHATPOUR P, DIAS EC, BUTLER PD, et al. Impaired visual object processing across an occipital-frontal-hippocampal brain network in schizophrenia:an integrated neuroimaging study[J].Arch Gen Psychiatry, 2010, 67(8):772-782.
[34]FUJIMOTO T, OKUMURA E, TAKEUCHI K, et al. Dysfunctional cortical connectivity during the auditory oddball task in patients with schizophrenia[J]. Open neuroimag J, 2013, 7:15.
[2]KAY SR, FISZBEIN A, OPLER LA. The positive and negative syndrome scale(PANSS)for schizophrenia[J]. Schizophr Bull,1987, 13(2):261-276.
[3]ANDREASEN NC, OLSEN S. Negative v positive schizophrenia:Definition and validation[J]. Arch Gen Psychiatry, 1982, 39(7):789-794.
[4]ZUO XN, XING XX. Test-retest reliabilities of resting-state FMRI measurements in human brain functional connectomics:a systems neuroscience perspective[J]. Neurosci Biobehav Rev,2014, 45:100-118.
[5]HOPTMAN MJ, ZUO XN, D'ANGELO D, et al. Decreased interhemispheric coordination in schizophrenia:a resting state fMRI study[J]. Schizophr Res, 2012, 141(1):1-7.
[6]GUO W, XIAO C, LIU G, et al. Decreased resting-state interhemispheric coordination in first-episode, drug-naive paranoid schizophrenia[J]. Prog Neuropsychopharmacol Biol Psychiatry,2014, 48:14-19.
[7]GUO W, LIU F, CHEN J, et al. Family-based case-control study of homotopic connectivity in first-episode,drug-naive schizophrenia at rest[J]. Sci Rep, 2017, 7:43312.
[8]刘慧华,郑金瓯.单侧颞叶癫痫患者双侧大脑半球间的功能协同性研究[J].中国神经精神疾病杂志,2016, 42(10):616-622.
[9]GUO W, LIU F, DAI Y, et al. Decreased interhemispheric resting-state functional connectivity in first-episode, drug-naive major depressive disorder[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2013, 41:24-29.
[10]HAHAMY A, BEHRMANN M, MALACH R. The idiosyncratic brain:distortion of spontaneous connectivity patterns in autism spectrum disorder[J]. Nat Neurosci, 2015, 18(2):302.
[11]LI J, YUAN Y, WANG M, et al. Decreased interhemispheric homotopic connectivity in Parkinson's disease patients with freezing of gait:A resting state fMRI study[J]. Parkinsonism Relat Disord, 2018, 52:30-36.
[12]KRINGELBACH ML. The human orbitofrontal cortex:linking reward to hedonic experience[J]. Nat Rev Neurosci, 2005, 6(9):691-702.
[13]VENTURA J, THAMES AD, WOOD RC, et al. Disorganization and reality distortion in schizophrenia:a meta-analysis of the relationship between positive symptoms and neurocognitive deficits[J]. Schizophr Res, 2010, 121(1-3):1-14.
[14]ZALD DH, MCHUGO M, RAY KL, et al. Meta-Analytic Connectivity Modeling Reveals Differential Functional Connectivity of the Medial and Lateral Orbitofrontal Cortex[J]. Cereb Cortex,2014, 24(1):232-248.
[15]SHUKLA DK, CHIAPPELLI JJ, SAMPATH H, et al. Aberrant Frontostriatal Connectivity in Negative Symptoms of Schizophrenia[J]. Schizophr Bull, 2018[2018-12-21]. http://dx.doi.org/10.1093/schbul/sbyl65.
[16]XU Y, QIN W, ZHUO C, et al. Selective functional disconnection of the orbitofrontal subregions in schizophrenia[J]. Psychol Med, 2017,47(9):1637-1646.
[17]CHEN X, LIU C, HE H, et al. Transdiagnostic differences in the resting-state functional connectivity of the prefrontal cortex in depression and schizophrenia[J]. J Affect Disord, 2017, 217:118-124.
[18]HE Z, DENG W, LI M, et al. Aberrant intrinsic brain activity and cognitive deficit in first-episode treatment-naive patients with schizophrenia[J]. Psychol Med, 2013, 43(4):769-780.
[19]XIAO Y, LUI S, DENG W, et al. Altered cortical thickness related to clinical severity but not the untreated disease duration in schizophrenia[J]. Schizophr Bull, 2015, 41(1):201-210.
[20]WANG YM, ZOU LQ, XIE WL, et al. Altered grey matter volume and cortical thickness in patients with schizo-obsessive comorbidity[J]. Psychiatry Res Neuroimaging, 2018, 276:65-72.
[21]WEINER KS, ZILLES K. The anatomical and functional specialization of the fusiform gyrus[J]. Neuropsychologia, 2016, 83:48-62.
[22]GAUTHIER I, SKUDLARSKI P, GORE JC, et al. Expertise for cars and birds recruits brain areas involved in face recognition[J]. Nature neuroscience, 2000, 3(2):191.
[23]ADOLPHS R. Neural systems for recognizing emotion[J]. Curr Opin Neurobio, 2002, 12(2):169-177.
[24]LIU Y, GUO W, ZHANG Y, et al. Decreased resting-state interhemispheric functional connectivity correlated with neurocognitive deficits in drug-naive first-episode adolescent-onset schizophrenia[J]. Int J Neuropsychopharmacol, 2017,21(1):33-41.
[25]GUO W, LIU F, CHEN J, et al. Family-based case-controlstudy of homotopic connectivity in first-episode,drug-naive schizophrenia at rest[J]. Sci Rep, 2017, 7:43312.
[26]GUO W, LIU F, CHEN J, et al. Treatment effects of olanzapine on homotopic connectivity in drug-free schizophrenia at rest[J].World J Biol Psychiatry, 2018, 19(sup3):S106-S114.
[27]王莹,王肖依,龙雨君,等.精神分裂症首次发病患者及其同胞的脑静息态局部一致性分析[J].中华精神科杂志,2018,51(4):235-241.
[28]梁家云,谢世平,万德燕,等.不同症状为主的精神分裂症患者静息态功能磁共振成像研究[J].临床精神医学杂志,2017, 27(2):98-100.
[29]MENNIGEN E, JIANG W, CALHOUN VD, et al. Positive and general psychopathology associated with specific gray matter reductions in inferior temporal regions in patients with schizophrenia[J]. Schizophr Res, 2019[2019-2-25]. http://dx.doi.org/10.1016/j.schres.2019.02.010.
[30]TOHID H, FAIZAN M, FAIZAN U. Alterations of the occipital lobe in schizophrenia[J]. Neurosciences(Riyadh),2015, 20(3):213-224.
[31]CHEN X, DUAN M, XIE Q, et al. Functional disconnection between the visual cortex and the sensorimotor cortex suggests a potential mechanism for self-disorder in schizophrenia[J].Schizophr Res, 2015, 166(1-3):151-157.
[32]MARTINEZ A, HILLYARD SA, BICKEL S, et al. Consequences of magnocellular dysfunction on processing attended information in schizophrenia[J]. Cereb Cortex, 2012, 22(6):1282-1293.
[33]SEHATPOUR P, DIAS EC, BUTLER PD, et al. Impaired visual object processing across an occipital-frontal-hippocampal brain network in schizophrenia:an integrated neuroimaging study[J].Arch Gen Psychiatry, 2010, 67(8):772-782.
[34]FUJIMOTO T, OKUMURA E, TAKEUCHI K, et al. Dysfunctional cortical connectivity during the auditory oddball task in patients with schizophrenia[J]. Open neuroimag J, 2013, 7:15.