405例糖尿病患者弓形虫感染情况及其血糖水平和肝肾功能指标观察
摘要
目的观察405例糖尿病患者弓形虫感染情况及其对患者血糖、肝肾功能的影响。方法选择405例糖尿病患者(DM组)和150例健康体检者(对照组),检测两组血清弓形虫特异性抗体(Ig G、Ig M)和循环抗原(CAg),采集两组指尖末梢血检测糖化血红蛋白,抽取两组空腹外周静脉血3 m L检测两组血糖(GLU)、肝功能指标[总蛋白(TP)、白蛋白(ALB)、丙氨酸酰基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)]及肾功能指标[血肌酐(SCr)、尿素氮(BUN)、尿微量白蛋白/尿肌酐(m ALB/Ucr)]。结果 DM组与对照组弓形虫总感染率分别为19.75%(80/405)、6.67%(10/150),两组比较,P<0.05。DM组弓形虫感染阳性者、DM组弓形虫感染阴性者及对照组血糖分别为(11.23±2.27)、(9.24±2.74)、(5.01±0.84)mmol/L,组间两两比较,P均<0.05。DM组弓形虫感染阳性者、DM组弓形虫感染阴性者及对照组的Hb A1c分别为9.32%±1.98%、8.11%±1.27%、4.78%±0.59%,组间两两比较,P均<0.05。DM组弓形虫感染阳性者血浆TP、ALB水平均低于DM组弓形虫感染阴性者和对照组(P均<0.05),DM组弓形虫感染阳性者外周血ALT水平高于DM弓形虫感染阴性者和对照组(P均<0.05)。DM组弓形虫感染阳性者、DM组弓形虫感染阴性者及对照组的SCr分别为(85.92±19.14)、(66.92±12.68)、(58.19±10.83)μmol/L,组间两两比较,P均<0.05;弓形虫感染阳性者尿m ALB/Cr明显高于弓形虫感染阴性者及对照组(P<0.05)。结论糖尿病患者弓形虫感染率高于健康人群。弓形虫感染可能造成糖尿病患者血糖控制不佳且加重患者的肝肾功能损害。
引文
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[5]Jeon CY.Helicobacter pylori infection is associated with an increased rate of diabetes[J].Diabetes Care,2012,35(3):520-525.
[6]Torgerson PR,Mastroiacovo P.The global burden of congenital toxoplasmosis:a systematic review[J].Bull World Health Organ,2013,91(7):501-508.
[7]Yue X,Yin J,Ning J,et al.Seroepidemiology of human Toxoplasma gondii infection in China[J].Bmc Infect Dis,2010,10(1):1-5.
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[9]Freedman BI,Bowden DW,Smith SC,et al.Relationships between electrochemical skin conductance and kidney disease in Type2 diabetes.[J].J Diabet Comp,2014,31(28):56-60.
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