子痫前期胎盘组织中血管内皮生长因子及雌激素受体的表达
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摘要
目的探讨分析子痫前期胎盘组织中血管内皮生长因子及雌激素受体的表达。方法研究对象为2015年2月至2017年2月在我院妇产科孕妇随机选取169例,依据是否处于子痫前期分为两组,其中子痫前期组为研究组83例,子痫前期组根据病情轻重程度分为轻度组37例及重度组46例,正常妊娠组为对照组86例。对比观察两组患者血管内皮生长因子及雌激素受体的表达情况以及血管内皮生长因子与雌激素受体之间的相关性。结果关于两组患者血管内皮生长因子表达情况,研究组(轻度组)阳性率为29.7%,研究组(重度组)阳性率为26.1%,对照组阳性率为83.7%,研究组血管内皮生长因子表达量明显低于对照组,且重度组明显低于轻度组,经统计学分析,P均<0.05。关于雌激素受体表达方面,研究组表达量明显高于对照组,经统计学分析,P均<0.05。雌激素受体与血管内皮生长因子之间存在负相关性(r值=-0.715,P<0.05),提示雌激素受体高表达,血管内皮生长因子低表达与子痫前期存在相关性。结论子痫前期孕妇胎盘组织中血管内皮生长及雌激素受体孕妇表达减少,雌激素受体较正常妊娠孕妇表达增加,且血管内皮生长因子与雌激素受体之间存在负相关性关系。
Objective:To invtestigate the expression of vascular endothelial growth factor and estrogen receptor in planceta tissue of pregnant women during preeclampsia. Methods:169 case of pregnant women,according to the complication of preeclampsia,were divided into two groups,there are 83 cases which were during preeclampsia,among which there were 37 cases of mild type and 46 cases of severe type,and 86 cases which were normal. The expression and correlation of VEGF and ER were compared. Results:On the expression of VEGF,the mild group had 29.7% total positive rate,the severe group had 26.1% total positive rate,while the control group had 83.7% total positive rate,the expression of the mild group was lower than that of the severe group,which was lower than that of the control group,the difference has significance(P<0.05). On the expression fo ER,the positive rate of the study group was 68.7%,while that of the control group was 41.7%,and the ecpression of ER in the study group was higher than that in the control group,the difference has significance(P<0.05). There was negative correlation between ER and VEGF(r value =-0.715,P<0.05),which indicates that there was correlation between the preclampsia and high ER expression、low VEGF expression. Conclusion:Compared with normal pregnant women,the pregnant women during preclampsia hda less VEGF and more ER expression,and there was negative correlation between VEGF expression and ER expression.
Objective:To invtestigate the expression of vascular endothelial growth factor and estrogen receptor in planceta tissue of pregnant women during preeclampsia. Methods:169 case of pregnant women,according to the complication of preeclampsia,were divided into two groups,there are 83 cases which were during preeclampsia,among which there were 37 cases of mild type and 46 cases of severe type,and 86 cases which were normal. The expression and correlation of VEGF and ER were compared. Results:On the expression of VEGF,the mild group had 29.7% total positive rate,the severe group had 26.1% total positive rate,while the control group had 83.7% total positive rate,the expression of the mild group was lower than that of the severe group,which was lower than that of the control group,the difference has significance(P<0.05). On the expression fo ER,the positive rate of the study group was 68.7%,while that of the control group was 41.7%,and the ecpression of ER in the study group was higher than that in the control group,the difference has significance(P<0.05). There was negative correlation between ER and VEGF(r value =-0.715,P<0.05),which indicates that there was correlation between the preclampsia and high ER expression、low VEGF expression. Conclusion:Compared with normal pregnant women,the pregnant women during preclampsia hda less VEGF and more ER expression,and there was negative correlation between VEGF expression and ER expression.
引文
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[9]赵虎,张凌,蔡一玲,等.妊娠期高血压疾病患者胎盘组织中VEGF与MMP-9表达水平与子痫前期病情的相关性[J].实用临床医药杂志,2016,20(15):63-65.
[10]Jesus GRRD,Nascimento APD,Porto LC,et al.68 s Flt-1,Pl GF and VEGF in differential diagnosis between preeclampsia and systemic lupus nephritis:Angiogenic factors[J].Pregnancy Hypertension An International Journal of Womens Cardiovascular Health,2016,6(3):170-170.
[11]Sandrim VC,Palei AC,Eleuterio N,et al.Antihypertensive therapy in preeclampsia is not modulated by VEGF polymorphisms.[J].Archives of Gynecology&Obstetrics,2015,291(4):799-803.
[12]刘志永,陈静伟,吴香丽,等.胎盘生长因子和可溶性血管内皮生长因子受体-1与子痫前期的关系研究[J].吉林医学,2016,37(9):2159-2161.
[13]蔡翼飞,孙丽洲.子痫前期患者组织因子、组织因子途径抑制物与血清可溶性血管内皮生长因子受体1的相关性[J].实用临床医药杂志,2016,20(15):71-75.
[14]张展,宋婉玉,张琳琳,等.血管生成因子、抗血管生成因子表达变化在子痫前期发病中的作用机制研究进展[J].山东医药,2017,57(15):112-114.
[15]Guo X,Feng L,Jia J,et al.Upregulation of VEGF by small activating RNA and its implications in preeclampsia[J].Placenta,2016,46:38.
[2]张彩,游泽山,李理,等.胎盘中血管内皮生长因子及其受体1改变与子痫前期的相关性研究[J].新医学,2015,46(8):520-523.
[3]孙颖,余艳红,周紫琼,等.内皮糖蛋白、血管内皮生长因子及其受体1在子痫前期中的表达和临床意义[J].中国生育健康杂志,2015,(2).
[4]Amosco MD,Villar VAM,Naniong JMA,et al.VEGF-A and VEGFR1 SNPs associate with preeclampsia in a Philippine population[J].Clinical&Experimental Hypertension,2016,38(7):578.
[5]王雨艳,黄达,沈秀敏,等.雌激素受体和孕激素受体在妊娠期高血压疾病胎盘组织中的表达[J].解剖科学进展,2015(6):621-623.
[6]吴桂梅,刘洪玲,王文杰,等.血管内皮生长因子和基质金属蛋白酶-9与子痫前期的相关性研究[J].中国计划生育和妇产科,2016,8(10):66-68.
[7]王彤洁.血管内皮生长因子及其受体在子痫前期早期诊断中的价值[J].山西医药杂志,2016,45(24):2904-2906.
[8]张晓丽,覃亦伟,赵晓勇.VEGF、IL-18和LP在子痫前期鼠模胎盘组织中的表达及影响[J].中国生育健康杂志,2015,26(1).
[9]赵虎,张凌,蔡一玲,等.妊娠期高血压疾病患者胎盘组织中VEGF与MMP-9表达水平与子痫前期病情的相关性[J].实用临床医药杂志,2016,20(15):63-65.
[10]Jesus GRRD,Nascimento APD,Porto LC,et al.68 s Flt-1,Pl GF and VEGF in differential diagnosis between preeclampsia and systemic lupus nephritis:Angiogenic factors[J].Pregnancy Hypertension An International Journal of Womens Cardiovascular Health,2016,6(3):170-170.
[11]Sandrim VC,Palei AC,Eleuterio N,et al.Antihypertensive therapy in preeclampsia is not modulated by VEGF polymorphisms.[J].Archives of Gynecology&Obstetrics,2015,291(4):799-803.
[12]刘志永,陈静伟,吴香丽,等.胎盘生长因子和可溶性血管内皮生长因子受体-1与子痫前期的关系研究[J].吉林医学,2016,37(9):2159-2161.
[13]蔡翼飞,孙丽洲.子痫前期患者组织因子、组织因子途径抑制物与血清可溶性血管内皮生长因子受体1的相关性[J].实用临床医药杂志,2016,20(15):71-75.
[14]张展,宋婉玉,张琳琳,等.血管生成因子、抗血管生成因子表达变化在子痫前期发病中的作用机制研究进展[J].山东医药,2017,57(15):112-114.
[15]Guo X,Feng L,Jia J,et al.Upregulation of VEGF by small activating RNA and its implications in preeclampsia[J].Placenta,2016,46:38.